Search Results (342)

A malignant leakage presents a significant challenge in drilling engineering, particularly within carbonate formations, where such a leakage is frequently encountered. Currently, there is no effective solution to this problem. In this study, a water-reactive polyurethane sealing agent was developed using multifunctional polypropylene glycol and 1,4-butanediol (BDO) as soft segments, diphenylmethane diisocyanate (MDI) as the hard segment, and a composite catalyst consisting of N, N-dimethyl cyclohexylamine (PC-8) and dibutyltin dilaurate (T-12). The material reacts rapidly with water to form a high-strength gel, with the reaction time being controllable. Through experimental optimization, it was determined that the BDO mass fraction was 1%, and the molar ratio of isocyanate group to hydroxyl group was 1.8. Additionally, the gelation time can be controlled by adjusting the mass fraction of the composite catalyst. Experimental results from sand-bed and fracture-plate tests indicated that the material could withstand pressures exceeding 3 MPa at 93 °C and exhibited resistance to saturated NaCl and CaCl₂ environments. The plugging mechanism was investigated using scanning electron microscopy (SEM), thermogravimetric analysis (TGA), and Fourier-transform infrared (FTIR) spectroscopy. The results demonstrated that the agent formed a compact, micron-scale porous structure upon reacting with water, exhibiting excellent thermal stability and dual plugging performance through both physical and chemical mechanisms. Due to its water-reactive characteristics, a multi-stage injection process was adopted for field application design. This material shows promising potential for mitigating large-fracture-type malignant leakages in drilling operations. Full article

Background/Objectives: Rigid bronchoscopy poses safety challenges due to airway leakage. Although apnoeic oxygenation is a potential strategy, concerns over carbon dioxide (CO₂) retention have limited its adoption. The introduction of high-flow nasal cannula (HFNC) has renewed interest by potentially mitigating CO₂ accumulation during prolonged apnoea. This study investigated changes in the arterial partial pressure of CO₂ (PaCO₂) during apnoeic oxygenation using Optiflow™. Methods: We retrospectively analysed patients undergoing rigid bronchoscopy with HFNC (70 L·min⁻¹) from 2020 to 2022. The apnoeic period was defined from the onset of apnoeic oxygenation to ventilation resumption. Arterial blood gas levels and complications, including arrhythmia and desaturation, were evaluated. Regression analysis was used to evaluate changes over time. Results: Apnoeic oxygenation was performed in 10 male patients (mean age 65 ± 14 years; body mass index 24.75 ± 4.18 kg·m⁻²). The mean duration of apnoea was 33.7 ± 13.7 min, with PaCO₂ rising linearly at 1.50 mmHg/min. No interventions were required to maintain SpO₂ above 91% for all patients. Except for one case of atrial fibrillation that occurred during emergence rather than the apnoeic period, no significant complications were observed. Conclusions: The observed increase in PaCO₂ was lower than in previously reported studies using HFNC via the nares, suggesting that direct delivery of oxygen to the distal airway via bronchoscopy may enhance CO₂ clearance through more effective washout. Apnoeic oxygenation with HFNC could potentially overcome airway leakage for selected patients, but vigilant monitoring remains essential throughout the apnoeic period. Further research is warranted to enhance patient safety. Full article

Paraffin-based phase change materials (PCMs) have emerged as promising candidates for thermal energy storage (TES) applications due to their high latent heat, chemical stability, and low cost. However, their inherently low thermal conductivity and the risk of leakage during melting–solidification cycles significantly limit their practical performance. To address these limitations, numerous studies have investigated composite PCMs in which paraffin is incorporated into porous supporting matrices. Among these, diatomite has garnered particular attention due to its high porosity, large specific surface area, and chemical compatibility with organic materials. Serving as both a carrier and stabilizing shell, diatomite effectively suppresses leakage and enhances thermal conductivity, thereby improving the overall efficiency and reliability of the PCM. This review synthesizes recent research on paraffin–diatomite composites, with a focus on impregnation methods, surface modification techniques, and the influence of synthesis parameters on thermal performance and cyclic stability. The mechanisms of heat and mass transport within the composite structure are examined, alongside comparative analyses of paraffin–diatomite systems and other inorganic or polymeric supports. Particular emphasis is placed on applications in energy-efficient buildings, passive heating and cooling, and hybrid thermal storage systems. The review concludes that paraffin–diatomite composites present a promising avenue for stable, efficient, and sustainable phase change materials (PCMs). However, challenges such as the optimization of pore structure, long-term durability, and large-scale manufacturing must be addressed to facilitate their broader implementation in next-generation energy storage technologies. Full article

Olive pomace (OP), an olive mill byproduct, poses environmental risks if mismanaged due to its high phenolic content, acidic pH, organic load, and electrical conductivity. This study evaluated the impact of olive pomace filtrate (OPF) at varying doses (OP-5, OP-10, OP-15) on broad bean (Vicia faba L.) growth, secondary metabolites, and nutrient accumulation. The highest OPF dose (OP-15) exhibited a clear negative, dose-dependent phytotoxic effect, causing stem discoloration, reduced root growth, necrosis, and chlorosis, while untreated controls showed vigorous growth. This significantly (p < 0.05) reduced leaf development, average number of leaves, and total leaf area, even at the lowest concentration (5%). Consequently, OP-15 reduced dry and fresh biomass by over 50% and shoot/root lengths by up to 61.55% compared to the control. Liquid chromatography mass spectrometry (LC-MS/MS) analysis revealed a positive dose-dependent effect of OPF on beneficial phenol and flavonoid accumulation, with significantly higher amounts of ferulic, isoferulic, caffeic, chlorogenic, and 4-hydroxybenzoic acids, as well as luteolin-4′-rutinoside and 4,7-dihydroxyflavone. OP application significantly (p < 0.05) decreased relative water content and increased electrolyte leakage and malondialdehyde, indicating stress. Furthermore, OP decreased the uptake of K, P, Fe, S, Zn, and Cu. Therefore, the intrinsic phytotoxicity of OPF suggests that mitigation measures are essential before considering environmental application to prevent potential adverse effects on sensitive crops and the wider ecosystem. Full article

Late spring frosts and transient cold spells constrain tomato productivity. This study presents a comparative analysis of the chilling response of two Solanum lycopersicum cultivars, MoneyMaker (MM) and Micro-Tom (MT), and the wild relative S. lycopersicoides. The assessment integrated physiological parameters, such as electrolyte leakage and PSII efficiency, expression levels of CBF1–3 genes (via qPCR), and fatty acid composition dynamics of membrane lipids (via gas-liquid chromatography-mass spectrometry). The results revealed distinct response strategies. S. lycopersicoides exhibited comprehensive tolerance and was coordinated across biological levels. Its key mechanisms include superior membrane integrity, sustained PSII photochemical efficiency, stable upregulation of CBF genes (with predominant CBF3 induction), and consistently high α-linolenic acid content. This integration prevented membrane damage and sustained photosynthesis. Conversely, the MM cultivar displayed high sensitivity, characterized by transient CBF1 upregulation, an absence of adaptive lipid remodelling, rapid membrane damage, and severe photoinhibition, explaining its poor recovery. The MT genotype demonstrated an intermediate phenotype, featuring delayed but persistent CBF activation, and the partial lipid profile shifted toward the wild-type pattern, indicating a partial adaptive capacity for membrane adjustment. These findings establish S. lycopersicoides as a vital genetic resource for breeding cold-tolerant tomatoes, while MT provides a model for studying adaptation mechanisms in cultivated varieties. Full article

Sediment erosion is a persistent problem that leads to the deterioration of hydro-turbines over time, ultimately causing blade failure. This paper analyzes the dynamics of sediment in water and its effects on a small Kaplan turbine. Flow data is obtained independently and transferred to a separate Lagrangian-based finite element code, which tracks particles throughout the computational domain to determine local impacts and erosion rates. This solver uses a random walk approach, along with statistical descriptions of particle sizes, numbers, and release positions. The turbine runner features significantly twisted blades with rounded corners, and complex three-dimensional (3-d) flow related to leakage and secondary flows. The results indicate that flow quality, particle size, concentration, and the relative position of the blades against the vanes significantly influence the distribution of impacts and erosion intensity, subsequently the local eroded mass is cumulated for each element face and averaged across one pitch of blades. At the highest concentration of 2500 mg/m³, the results show a substantial erosion rate from the rotor blades, quantified at 4.6784 × 10⁻³ mg/h and 9.4269 × 10⁻³ mg/h for the nominal and maximum power operating points, respectively. Extreme erosion is observed at the leading edge (LE) of the blades and along the front part of the pressure side (PS), as well as at the trailing edge (TE) near the hub corner. The distributor vanes also experience erosion, particularly at the LE on both sides, although the erosion rates in these areas are less pronounced. These findings provide essential insights into the specific regions where protective coatings should be applied, thereby extending the operational lifespan and enhancing overall resilience against sediment-induced wear. Full article

Over the past five decades, the Tallet Alsauda district of Aleppo (Syria) has experienced multiple catastrophic collapses, attributed to a network of subsurface chalk cavities formed through historic quarrying and possible natural karstification. Yet, no comprehensive investigation has previously been conducted to characterise the cavities or clarify the governing failure mechanisms. Such assessments are particularly difficult in historic urban environments, where void geometries are irregular, subsurface data scarce, and underground access limited. This study addresses these challenges through an integrated programme of fourteen boreholes, laboratory testing, and inverse-distance interpolation to reconstruct subsurface geometry and overburden thickness. These data-informed three-dimensional finite element simulations are designed to test the hypothesis that chalk deterioration, driven by both natural and anthropogenic processes, controls the instability of cavity roofs. Rock mass parameters, particularly the Geological Strength Index (GSI), were progressively reduced and evaluated against the site’s documented collapse history. The simulations revealed that a modest decline in GSI from ~53 to 47 precipitated abrupt displacements (>300 mm) and upward-propagating plastic zones, consistent with field evidence of past collapses. These results confirm that instability is governed by threshold reductions in material strength, with sewer leakage identified as a principal trigger accelerating chalk softening and roof destabilisation. Full article

The transport sector requires compact, reliable, and energy-efficient power units for modernization of road, rail, maritime, and aerial systems. Conventional piston and rotary machines often face limitations related to vibration, sealing losses, and manufacturing complexity. This study investigates birotor machines (BM), a class of positive-displacement devices combining synchronized rotation of the rotor and housing. This configuration ensures smooth kinematics, near-complete dynamic balance, and simplified design. The working principle enables continuous volumetric transformation with reduced friction and leakage, enhancing efficiency and durability. Using generalized mathematical models (GMM) developed through statistical experimental design, optimal geometric parameters were determined with a root-mean-square error below 3%. A prototype birotor compressor (BC) designed for subway rolling stock achieved equivalent output performance (0.43 m³/min at 0.8 MPa) with 82% efficiency and a mass reduction from 130 kg to 32 kg. Comparative simulations and preliminary testing of BM-based internal combustion engines (BRICE) demonstrated 3–4 times smaller and lighter units with improved reliability and environmental characteristics. The results confirm that BM technology provides a feasible and manufacturable alternative to conventional designs, suitable for integration into next-generation transport and unmanned vehicle systems. Full article

Thai medicinal flowers, namely Mesua ferrea L. (Bunnak), Mammea siamensis T. Anderson (Saraphi), and Clitoria ternatea (Anchan) have long been valued for their traditional medicinal. This study investigated their phytochemical composition and bioactivities, with a particular focus on antioxidant and antibacterial properties. Methods: Ethanolic flower extracts were analyzed by high-performance liquid chromatography (HPLC) and liquid chromatography–mass spectrometry (LC–MS). Antioxidant activities were determined by DPPH, ABTS, and FRAP assays. Antibacterial activity against Escherichia coli, E. coli O157:H7, Salmonella Typhi, Shigella dysenteriae, and Vibrio cholerae were assessed by agar well diffusion, broth dilution methods, and time–kill assays. Biofilm formation, biofilm disruption, and bacterial adhesion to Caco-2 cells were evaluated. Morphological changes in E. coli O157:H7 were examined using scanning electron microscopy (SEM), and leakage of intracellular contents (DNA, RNA, proteins) were quantified. Results: HPLC analysis revealed the highest level of gallic acid in M. ferrea and quercetin in M. siamensis. LC–MS analysis identified fifteen putative metabolites across the flower extracts, including quercetin, kaempferol, catechin, and luteolin derivatives, with species-specific profiles. C. ternatea extract exhibited the greatest total flavonoid content and antioxidant activity. Among the extracts, M. ferrea exhibited the strongest inhibitory effect, with inhibition zone of 13.00–15.00 mm and MIC/MBC values of 31.25–62.5 mg/mL. All extracts exhibited time-dependent bactericidal activity, significantly inhibited biofilm formation, disrupted established biofilms, and reduced bacterial adhesion to intestinal epithelial cells. SEM revealed membrane disruption in E. coli O157:H7 and leakage of intracellular components. Conclusions: Thai medicinal flower extracts, particularly M. ferrea, possess strong antioxidant and antibacterial activities. Their ability to inhibit biofilm formation, interfere with bacterial adhesion, and disrupt bacterial membranes highlights their potential as natural alternatives for preventing or controlling enteric bacterial infections. Full article

Background: Despite considerable advances to improve colorectal cancer (CRC) survival over the last decade, therapeutic challenges remain due to the rapid metastatic dissemination of primary tumors. This study revealed the apoptotic and anti-growth mechanism of VTD, a previously used anti-hypertensive supplement, can elevate UBXN2A, a known tumor suppressor protein in CRC, and simultaneously enhance intrinsic and extrinsic apoptosis in metastatic cancer cells. Methods and Results: An AOM/DSS mouse model of CRC showed that UBXN2A haplosufficient (UBXN2A +/−) mice treated with VTD had less tumor burden than mice with the full UBXN2A gene treated with vehicle. We have previously shown that casein-coated mesoporous silica nanoparticles (MSNs) offer an effective local delivery of drugs at tumor sites. Our findings demonstrate that the high rate of extracellular release of matrix metalloproteinases (MMPs), particularly MMP-7, by metastatic colon cancer cells, triggers the release of VTD from casein-coated mesoporous MSNs. This shows the “Zip Code” mechanism for the local enrichment of VTD at the tumor sites. After in vitro drug release verification, two independent mouse experiments, a xenograft and a splenolepatic metastatic mouse model of CRC, were used to evaluate the therapeutic efficacy of VTD-loaded and casein-coated carboxylated mesoporous silica nanoparticles, MSN-COOH/VTD/CAS (VTD, 0.2 mg/kg). Animal experiments revealed that MSN-COOH/VTD/CAS (VTD, 0.2 mg/kg) slows down the progress of tumors. Mass spectrometry (MS) revealed improved pharmacokinetics (PK) profile as MSN-COOH/VTD/CAS had less VTD accumulation in non-cancerous organs compared to pure VTD. We further improved nanoparticle targeting and drug release by shifting to calcium-based particles (CBPs). The engineered CBPs demonstrated higher drug-releasing performance. Without the MMPs trigger, MSNs show slow and continuous “drug leak” over longer period of time whereas CCSMPs stops leakage within an hour. Additionally, CBPs showed higher sensitivity to MMP-7 than MMP-9, enhancing the targetability of CBPs for CRC metastatic tumors with excessive extracellular MMP-7. Conclusions: This study introduces a new platform utilizing nanoparticle-based site-specific delivery of a plant-based anti-metastatic molecule, veratridine, with enhanced safety and therapeutic efficacy for the treatment of metastatic CRC. Full article

This work reviews percolation-related phenomena in porous organosilica glass (OSG) low-k dielectrics and their critical impact on mass transport, electrical conductivity, mechanical integrity, and dielectric breakdown. We discuss how leakage current arises from the formation of minimal percolating conductive paths along pores and defect chains, while dielectric breakdown requires system-spanning pore connectivity, resulting in a higher effective percolation threshold. Mechanical properties similarly degrade when pores coalesce into a connected network, exhibiting multiple percolation thresholds due to both chemical network modifications and porosity. Experimental trends demonstrate that leakage current increases sharply at low porosity, whereas breakdown voltage and mechanical stiffness collapse at higher porosity levels (~20%–30%). We highlight that distinct percolation classes govern transport, mechanical, and nonlinear phenomena, with correlation length and diffusion timescales providing a unified framework for understanding these effects. The analysis underscores the fundamental role of network connectivity in determining the performance of organosilicate glass-based ultra-low-k dielectrics and offers guidance for material design strategies aimed at simultaneously improving electrical, mechanical, and chemical robustness. Full article

The large lakes and reservoirs of the northeastern Tibetan Plateau play a key role in regional water resources, yet their influence on terrestrial water storage (TWS) changes at different spatial scales remains unclear. This study employed the constrained forward modeling (CFM) method to correct leakage errors in level-2 spherical harmonic (SH) coefficients from the Gravity Recovery and Climate Experiment and its follow-on missions (GRACE/GRACE-FO) at three spatial scales: two circular regions covering 90,000 km² and 200,000 km², respectively, and a 220,000 km² region based on the shape of mass concentration (Mascon). TWS changes derived from SH solutions after leakage correction through CFM were compared with level-3 Mascon solutions. Individual water storage components, including lake and reservoir water storage (LRWS), groundwater storage (GWS), and soil moisture storage (SMS), were quantified, and their relationships with precipitation were assessed. From 2003 to 2022, the CFM method effectively mitigated signal leakage, revealing an overall upward trend in TWS at all spatial scales. Signals from Qinghai Lake and Longyangxia Reservoir dominated the long-term trend and amplitude variations of LRWS, respectively. LRWS explained more than 47% of the TWS changes, and together with GWS, accounted for over 85% of the changes. Both CFM-based and Mascon-based TWS changes indicated a consistent upward trend from January 2003 to September 2012, followed by declines from November 2012 to May 2017 and October 2018 to December 2022. During the decline phases, GWS contributions increased, while LRWS contributions and component exchange intensity decreased. LRWS, SMS, and TWS changes were significantly correlated with precipitation, with varying time lags. These findings underscore the value of GRACE/GRACE-FO data for monitoring multiscale TWS dynamics and their climatic drivers in lake- and reservoir-dominated regions. Full article

A small-scale electro-hydrostatic actuator, termed miniHydrA, was developed based on biomechanical requirements for gait and integrated into an ankle exoskeleton. The key advantage of this actuator concept lies in its compact size and the low mass of its output stage, combined with the ability to deliver high support torques, sufficient for full human assistance. During development, hydraulic cylinder leakage and friction were identified as key challenges. To address control requirements, a dedicated control strategy was proposed and implemented. The prototype exoskeleton was evaluated for joint torque tracking performance across a range of torques (0–120 Nm), both in benchtop tests and during treadmill walking trials. In benchtop experiments, zero-torque tracking was achieved with a mean absolute error ranging from 0.03 to 2.26 Nm across frequencies from 0 to 5 Hz. During treadmill walking, torque tracking errors ranged from 0.70 to 0.95 Nm, with no observable deviations in ankle joint kinematics among the three test subjects. These results show the feasibility of the miniHydrA for remote actuation. Compared to Bowden cables, commonly used in exoskeletons and exosuits, the proposed actuator concept offers two key advantages: it is better suited for high-torque applications, and its friction characteristics can be more accurately predicted and modeled, enabling more effective feedforward control. Full article

During drilling, different kick locations significantly impact the formation-wellbore temperature (FWT) profile under the co-existence of kick and leakage condition (CKL). To ensure safety and efficiency during drilling, we study the effect of different kick locations on the FWT under the CKL. In this paper, a full transient heat transfer model based on the first law of thermodynamics is established to obtain four distinct WFT profiles under CKL conditions, incorporating both convective heat transfer and variable mass flow effects. Compared with the actual temperature measurement data, the reliability of the developed model is verified. The case studies show that the annular temperature (AT) is lower under the single-point leakage (SL), continuous leakage (CL), and CKL conditions than that in the normal drilling condition. Wellhead temperature in CKL differs significantly from that in normal drilling (ND). As the kick location gets closer to the bottom hole, the AT gets higher, and the temperature difference between the formation and annular gets smaller. Compared with the wellbore temperature profile under ND, the kick location can be detected by real-time monitoring of the FWT profile under the CKL. Full article

Growing ozone (O₃) pollution in industrial cities urgently requires in-depth mechanistic research. This study utilized multi-year observational data from Datong City, China, from 2020 to 2024, integrating time trend diagnostics, correlation dynamics analysis, Environmental Protection Agency Positive Matrix Factorization 5.0 (EPA PMF 5.0) model simulations, and a grey prediction model (GM (1,1)) projection method to reveal the coupling mechanisms among O₃ precursors. Key breakthroughs include the following: (1) A ratio of volatile organic compounds (VOCs) to nitrogen oxides (NO_x) of 1.5 clearly distinguishes between NO_x-constrained (winter) and VOC-sensitive (summer) modes, a conclusion validated by the strong negative correlation between O₃ and NO_x (r = −0.80, p < 0.01) and the dominant role of NO titration. (2) Aromatic compounds (toluene, xylene) used as solvents in industrial emissions, despite accounting for only 7.9% of VOC mass, drove 37.1% of ozone formation potential (OFP), while petrochemical and paint production (accounting for 12.2% of VOC mass) contributed only 0.3% of OFP. (3) Quantitative analysis of OFP using PMF identified natural gas/fuel gas use and leakage (accounting for 34.9% of OFP) and solvent use (accounting for 37.1% of OFP) as key control targets. (4) The GM (1,1) model predicts that, despite a decrease in VOC concentrations (−15.7%) and an increase in NO_x concentrations (+2.4%), O₃ concentrations will rise to 169.7 μg m⁻³ by 2025 (an increase of 7.4% compared to 2024), indicating an improvement in photochemical efficiency. We have established an activity-oriented prioritization framework targeting high-OFP species from key sources. This provides a scientific basis for precise O₃ emission reductions consistent with China’s 15th Five-Year Plan for synergistic pollution/carbon governance. Full article