Search Results (189)

Spatially fractionated radiotherapy (SFRT) is emerging as a powerful tool in cancer therapy for patients who are ineligible for treatment with clinically established irradiation techniques. Microbeam radiotherapy (MRT) is characterized by spatial dose fractionation in the micrometre range. This presents challenges in both treatment planning and dosimetry. While a dosimetry system with a spatial resolution of 10 µm and an option for real-time readout already exists, this system can only record dose in a very small volume. Thus, we are exploring dosimetry in an N-isopropylacrylamide (NIPAM) gel as an option for 3D dose visualization and, potentially, also three-dimensional dosimetry in larger volumes. In the current study, we have recorded the geometric patterns of single- and multiport irradiation with microbeam arrays in NIPAM gel. Data for 3D dose distribution was acquired in a 7T small animal MRI scanner. We found that the resolution of the gel is well suited for a detailed 3D visualization of microbeam patterns even in complex multiport geometries, similar to that of radiochromic film, which is well established for recording 2D dose distribution in MRT. The results suggest that a dose–response calibration is required for reliable quantitative dosimetry. Full article

Accumulative rolling bonding (ARB) Cu/Nb nanolaminates have been widely observed to exhibit unique and large numbers of interface-based plasticity mechanisms, and these have been associated with the many extraordinary properties of the material system, especially resistances in extreme engineering environments (mechanical/pressure, thermal, irradiation, etc.) and ability to self-heal defects (microstructural, as well as radiation-induced). Recently, anisotropy in the interface shearing mechanisms in the material system has been observed and much discussed. The Cu/Nb nanolaminates appear to shear on the interface planes to a much larger extent in the transverse direction (TD) than in the rolling direction (RD). Related to that, in this present study we observe interface rotation in Cu/Nb ARB nanolaminates under constrained and unconstrained loading conditions. Although the primary driving force for interface shearing was expected only in the RD, additional shearing in the TD was observed. This is significant as it represents an interface rotation, while there was no external rotational driving force. First, we observed interface rotation in in situ rectangular micropillar compression experiments, where the interface is simply sheared in one particular direction only, i.e., in the RD. This is rather unexpected as, in rectangular micropillar compression, there is no possibility of extra shearing or driving force in the perpendicular direction due to the loading conditions. This motivated us to subsequently perform in situ microbeam bending experiments (microbeam with a pre-made notch) to verify if similar interface rotation could also be observed in other loading modes. In the beam bending mode, the notch area was primarily under tensile stress in the direction of the beam longitudinal axis, with interfacial shear also in the same direction. Hence, we expect interface shearing only in that direction. We then found that interface rotation was also evident and repeatable under certain circumstances, such as under an offset loading. As this behaviour was consistently observed under two distinct loading modes, we propose that it is an intrinsic characteristic of Cu/Nb interfaces (or FCC/BCC interfaces with specific orientation relationships). This interface rotation represents another interface-based or interface-mediated plasticity mechanism at the nanoscale with important potential implications especially for design of metallic thin films with extreme stretchability and other emerging applications. Full article

Optical transmission gratings with quasi-sinusoidal surface-relief profiles were inscribed in IOG and Pyrex glasses and in Bi₁₂GeO₂₀, Er: LiNbO_3, and Er: Fe: LiNbO₃ crystals by microbeams of carbon, nitrogen, and oxygen ions at ion energies of 5, 6, and 10.5 MeV. Grating constants were 4, 8, and 16 μm. Amplitudes of the surface-relief gratings were in the 10–2000 nm range. The diffraction efficiency of the gratings was measured at a wavelength of 640 nm. Maximum diffraction efficiencies were close to the theoretical maximum of 33% for thin gratings. Grating profiles were measured by optical microscopic profilometry. Measurement of the diffraction efficiencies at higher orders and Fourier analysis of the grating profiles revealed the dependence of the residual nonlinearity of the grating profiles on the implanted ion fluence. The ion microbeam-written gratings can be used as light coupling elements in integrated optics for sensors and telecommunication. Full article

As MEMS design encounters growing challenges, particularly stiction between movable and stationary electrodes, dielectric charging, pull-in instability, and multi-valued response characteristics, the integration of dimple-equipped structures has emerged as a pivotal solution to mitigate these fundamental issues. Consequently, this study investigates the dynamic behavior of an electrostatically actuated double-clamped microbeam incorporating dimples and contact pads. While the dimples enhance the beam’s travel range, they may also induce an impact mode upon contact with the landing pads, leading to complex nonlinear dynamic phenomena. A reduced-order model was developed to numerically solve the governing equation of motion. The microbeam’s response was analyzed both with and without dimples using multiple analytical techniques, including bifurcation diagrams and discrete excitation procedures near the impacting regime. The findings demonstrate that the inclusion of dimples effectively suppresses stiction, pull-in instability, and multi-valued responses. The results indicate that upon contacting the landing pads, the beam exhibits pronounced nonlinear dynamic behaviors, manifesting as higher-period oscillations such as period-3, period-4 and period-5 and then fully developed chaotic attractors. Indeed, this specifically demonstrates the potential of using the dynamic transition from a steady-state to a chaotic response to build novel MEMS sensors. Full article

Explaining the relative timing of consonant and vowel articulations (C-V timing) is an important function of speech production models. This article explores how C-V timing might be studied from the perspective of the C/D Model, particularly the prediction that articulations are coordinated with respect to an abstract syllable pulse. Gestural landmarks were extracted from kinematic data from English CVC monosyllabic words in the Wisconsin X-Ray Microbeam Corpus. The syllable pulse was identified using velocity peaks, and temporal lags were calculated among landmarks and the syllable pulse. The results directly follow from the procedure used to identify pulses: onset consonants exhibited stable timing to the pulse, while vowel-to-pulse timing was comparably stable with respect to C-V timing. Timing relationships with jaw displacement and jaw-based syllable pulse metrics were also explored. These results highlight current challenges for the C/D Model, as well as opportunities for elaborating the model to account for C-V timing. Full article

Cell migration assays provide valuable insights into pathological conditions, such as tumor metastasis and immune cell infiltration, and the regenerative capacity of tissues. In vitro tools commonly used for cell migration studies exploit commercial transwell systems, whose functionalities can be improved through engineering of the pore pattern. In this context, we propose the fabrication of a transwell-like device pursued by combining the proton beam writing (PBW) technique with wet etching onto thin layers of polydimethylsiloxane (PDMS). The resulting transwell-like device incorporates a PDMS membrane with finely controllable pore patterning that was used to study the arrangement and migration behavior of HCMEC/D3 cells, a well-established human brain microvascular endothelial cell model widely used to study vascular maturation in the brain. A comparison between commercial polycarbonate membranes and the PBW-holed membranes highlights the impact of the ordering of the pattern and porosity on cellular growth, self-organization, and transmigration by combining fluorescent microscopy and advanced digital processing. Endothelial cells were found to exhibit distinctive clustering, alignment, and migratory behavior close to the pores of the designed PBW-holed membrane. This is indicative of activation patterns associated with cytoskeletal remodeling, a critical element in the angiogenic process. This study stands up as a novel approach toward the development of more biomimetic barrier models (such as organ-on-chips). Full article

In this study, growth mechanisms are proposed to understand how banded dendritic crystal aggregates in poly(1,4-butylene adipate) (PBA) transform into straight dendrites upon dilution with a large quantity of poly(ethylene oxide) (PEO) (25–90 wt.%). In growth packing, crystal plates are deformed in numerous ways, such as bending, scrolling, and twisting in self-assembly, into final aggregated morphologies of periodic bands or straight dendrites. Diluting PBA with a significant amount of PEO uncovers intricate periodic banded assemblies, facilitating better structural analysis. Both circularly banded and straight dendritic PBA aggregates have similar basic lamellar patterns. In straight dendritic PBA spherulites, crystal plates can twist from edge-on to flat-on, similar to those in ring-banded spherulites. Therefore, twists—whether continuous or discontinuous—are not limited to the conventional models proposed for classical periodic-banded spherulites. Thus, it would not be universally accurate to claim that the periodic circular bands observed in polymers or small-molecule compounds are caused by continuous lamellar helix twists. Straight dendrites, which do not exhibit optical bands, may also involve alternate crystal twists or scrolls during growth. Iridescence tests are used to compare the differences in crystal assemblies of straight dendrites vs. circularly banded PBA crystals. Full article

Cellulose nanofiber (CNF) treatments can enhance the structure and performance of regenerated cellulose fibers. This study investigates the effects of CNF treatment on the mechanical properties, water absorption behavior, and humidity dependence of regenerated cellulose fibers. Tensile testing demonstrated that CNF-treated fibers exhibit improved elasticity and reduced swelling in aqueous environments. Scanning electron microscopy revealed the adsorption of CNF components onto the fiber surfaces. Microbeam X-ray diffraction indicated structural differences between untreated and CNF-treated fibers, with the latter containing cellulose I crystals. Small-angle X-ray scattering revealed alterations in the internal fibrillar structure due to CNF treatment. FT-IR spectroscopy highlighted humidity-dependent variations in molecular vibrations, with peak intensities increasing under higher humidity conditions. Additionally, CNF treatment inhibited water absorption in high-humidity conditions, contributing to reduced expansion rates and increased elastic modulus during water absorption. Overall, CNF treatment enhanced both the mechanical strength and water resistance of regenerated cellulose fibers, making them suitable for advanced textile applications. This study provides valuable insights into the role of CNF-treated fibers in improving the durability and functional performance of regenerated cellulose-based textile. Full article

The results of radiotherapy in patients with primary malignant brain tumors are extremely dissatisfactory: the overall survival after a diagnosis of glioblastoma is typically less than three years. The development of spatially fractionated radiotherapy techniques could help to improve this bleak prognosis. In order to develop technical equipment and organ-specific therapy plans, dosimetry studies as well as radiobiology studies are conducted. Although perfect spheres are considered optimal phantoms by physicists, this does not reflect the wide variety of head sizes and shapes in our patient community. Depth from surface and X-ray dose absorption by tissue between dose entry point and target, two key parameters in medical physics planning, are largely determined by the shape and thickness of the skull bone. We have, therefore, designed and produced a biomimetic tool to correlate measured technical dose and biological response in human cancer cells: a brain phantom, produced from tissue-equivalent materials. In a first pilot study, utilizing our phantom to correlate technical dose measurements and metabolic response to radiation in human cancer cell lines, we demonstrate why an anthropomorphic phantom is preferable over a simple spheroid phantom. Full article

Synchrotron radiation light sources have been successfully utilized in material science, biomedicine, and other fields due to their high intensity, excellent monochromaticity, coherence, and collimation. In recent years, synchrotron radiation has significantly expedited the advancement of medical applications, particularly through innovations in imaging and radiotherapy. For instance, synchrotron X-ray imaging has enabled high-contrast and spatial–temporal resolution images for early-stage diagnosis of breast cancer and cardiovascular diseases, offering superior diagnostic accuracy compared to conventional methods. Additionally, novel synchrotron radiation-based radiotherapy techniques, such as microbeam therapy and stereotactic radiotherapy, have shown great potential for clinical application by enabling precise tumor targeting while minimizing damage to surrounding healthy tissues. These advancements are projected to redefine imaging diagnostics and therapeutic strategies, particularly for resistant cancers, by offering enhanced precision, reduced radiation doses, and improved therapeutic outcomes. This review provides an overview of synchrotron radiation beamline characteristics, recent breakthroughs in imaging and radiotherapy, and their emerging applications in treating heart, breast, lung, bone, and brain conditions. Full article

In this paper, the bending behavior of microbeams resting on elastic foundations is analyzed. Due to the widespread use of Micro-Electro-Mechanical Systems (MEMSs) in sensing and actuation applications, various approaches have been developed for modeling such beams. Numerous specialized analytical and numerical models exist for specific configurations of beams and elastic foundations. This work proposes a novel approach. Separate models for the beam and the elastic foundation are developed using the finite element method. These models are then coupled using a variable reduction technique, in which only the degrees of freedom of the beam are retained in the solving system. This approach enables the coupling of any beam and foundation model and allows for independent refinement of the foundation mesh without increasing the size of the solving system. This method is particularly effective for analyzing configurations where the substrate exhibits nonlinear or non-homogeneous characteristics, or where gaps are present between the beam and the substrate. The nonlocal effects due to the small scale of the beam are also considered. This paper focuses on both the static deformation and frequency response of the microbeam. The proposed approach is validated against previously published models. Compared with existing models, the method presented here offers a simpler and more flexible formulation, while allowing the inclusion of nonlinearities in both the beam and foundation, as well as the modeling of gaps. Full article

Background: Microbeam radiation therapy (MRT) is an advanced preclinical approach in radiotherapy that utilizes spatially fractionated dose distributions by collimating x-rays into micrometer-wide, planar beams. While the benefits of temporal fractionation are well established and widely incorporated into conventional radiotherapy protocols, the interplay between MRT and temporal dose fractionation remains largely unexplored. In this study, we investigate the effects of combining temporal and spatial dose fractionation by assessing clonogenic cell survival following temporally fractionated MRT with varying irradiation angles, compared to conventional broad-beam (BB) irradiation. Methods: A lung tumor cell line (A549) and a normal lung cell line (MRC-5) were irradiated with a total number of four fractions with a 24 h interval between each fraction. We compared a temporally fractionated BB regime to two temporally fractionated MRT schemes with either overlapping MRT fields or MRT fields with a 45° rotation per fraction. Subsequently, the clonogenic cell survival assay was used by analyzing the corresponding survival fractions (SFs). Results: The clonogenic survival of A549 tumor cells differed significantly between microbeam radiation therapy with rotation (MRT + R) and overlapping MRT. However, neither MRT + R nor overlapping MRT showed statistically significant differences compared to the broad-beam (BB) irradiation for A549. In contrast, the normal tissue cell line MRC-5 exhibited significantly higher clonogenic survival following both MRT + R and overlapping MRT compared to BB. Conclusions: This study demonstrates that combining temporal and spatial fractionation enhances normal tissue cell survival while maintaining equivalent tumor cell kill, potentially increasing the therapeutic index. Our findings support the feasibility of delivering temporally fractionated doses using different MRT modalities and provide clear evidence of the therapeutic benefits of temporally fractionated MRT. Full article

A method for automated orientation and diffraction intensity (AODI) mapping on a curved surface has been established at the Shanghai Synchrotron Radiation Facility (SSRF). In our method, the curved surface of the sample is measured as the three-dimensional positional changes in the sample stage during scanning of the sample surface using a laser rangefinder. The diffraction intensity at each scanning point is measured with micro-beam Laue diffraction technology; after crystal orientation is automatically determined, the orientation and diffraction intensity are mapped on the curved surface of the sample. Our method has been applied in the measurement and representation of the crystal orientation of a nickel-based single-crystal turbine blade. An AODI mapping approach can locate orientation or misorientation changes directly on the curved surface of the single-crystal sample. Therefore, the developed AODI mapping strategy demonstrates a straightforward solution for a spatially resolved microstructure study of single-crystal workpieces, which would have an impact on their research and industrial applications. Full article

The advancement of microfluidic technology has introduced new requirements for the sensitivity of microflow sensors. To address this, this paper presents a novel high-sensitivity thermal microflow sensor incorporating a heat-insulating cavity structure. The sensor utilizes porous silicon as the substrate and employs vanadium dioxide as the thermistor element. This study employed COMSOL Multiphysics finite element software 5.6 to investigate the impact of materials and structural factors on the sensor’s sensitivity, as well as considering the dynamic laws governing their influence. Additionally, the effects of thermal expansion and thermal stress on the microstructure of the sensor are thoroughly examined. The research results show that the sensitivity of the sensor was influenced by key factors such as the distance between the heater and the thermistors, the diameter of the flow channel, the power of the heater, and the presence of an insulation cavity. The utilization of B-phase vanadium dioxide, known for its high temperature coefficient of resistance and suitable resistivity, led to a significant reduction in sensor size and a remarkable improvement in sensitivity. The implementation of four thermistors forming a Wheatstone full bridge further enhanced the sensor’s sensitivity. The sensor’s sensitivity was substantially higher when employing a porous silicon substrate compared with a silicon substrate. Moreover, the integration of a micro-bridge and four micro-beams composed of silicon nitride into the sensor’s structure further improved its sensitivity. The proposed design holds promise for enhancing the sensitivity of thermal microflow sensors and offers valuable insights for future advancements in MEMS technology. Full article

This study aims to investigate the behavior of viscoelastic materials exhibiting complex mechanical behavior characterized by both elastic and viscous properties. They are widely used in various engineering applications, such as structural components, transportation systems, energy storage devices, microelectromechanical systems (MEMS), and earthquake research and detection. Accurate modeling of viscoelastic behavior is crucial for predicting its performance under dynamic loading conditions. In this study, we modify the equations governing the thermoelastic resistance to describe the thermal variables of a thermoelastic micro-beam supported by a two-parameter Pasternak viscoelastic foundation by using a fractional Moore–Gibson–Thompson (MGT) model in the context of non-locality. The temperature, bending displacement, and moment were computed and graphically displayed using the Laplace transform method. Different theoretical approaches have been compared in order to explain how the phase delay affects physical phenomena. Numerical results show that the wave fluctuations of variables in thermoelastic micro-beams are slightly smaller for the studied model and that the speed of these plane waves depends on fractional and non-local parameters. Full article