Search Results (62)

Background/Objectives: Patients with adrenal insufficiency (AI) are at an increased risk of adverse events (AEs) during cardiovascular hospitalization. However, the association between AI and takotsubo cardiomyopathy (TCM) remains unclear. We investigated the association between AI and cardiovascular outcomes in patients with TCM. Methods: We analyzed data on patients with TCM included in the 2019 Nationwide Readmissions Database to compare in-hospital outcomes between patients with and without AI. The primary outcome measure was inpatient mortality. Secondary outcomes included the odds of all-cause 90-day readmission, acute kidney injury (AKI), mechanical ventilation use, vasopressor use, cardiogenic shock, length of stay (LOS), and total hospitalization charges (THC). Multivariate regression models were used to adjust for confounding variables. Results: Among 30,987 cases, 0.59% (n = 183) had concomitant AI. AI was associated with higher odds of in-hospital mortality (adjusted odds ratio [aOR] 3.32, 95% confidence interval [CI] 1.43–7.74, p = 0.005), cardiogenic shock (aOR 5.28, 95% CI 3.16–8.82, p < 0.001), mechanical ventilation use (aOR 3.20, 95% CI 1.78–5.74, p < 0.001), AKI (aOR 1.96, 95% CI 1.11–3.48, p = 0.021), vasopressor use (aOR 4.59, 95% CI 1.56–13.47, p = 0.006), longer LOS (6.84 vs. 3.67 days, p < 0.001), and higher THC ($97,419 vs. $54,574, p < 0.001). Additionally, AI was associated with lower odds of all-cause 90-day readmissions (aOR 0.44, 95% CI 0.25–0.79, p = 0.006). Conclusions: Among patients with TCM, AI was associated with higher odds of fatal and non-fatal adverse events. Further studies are required to confirm these findings and better understand how to improve outcomes in this high-risk population. Full article

Background/Objectives: Completion of perioperative systemic therapy is essential for improving survival in patients with locally advanced gastric adenocarcinoma; however, many patients do not receive planned adjuvant therapy because of surgical complications or inadequate recovery. Robotic gastrectomy may improve postoperative recovery and facilitate adjuvant therapy delivery, but contemporary national data remain limited. This study evaluated the association between surgical approach and adjuvant systemic therapy utilization. Methods: Adults with non-metastatic, locally advanced (>pT2N0 or received neoadjuvant chemotherapy) gastric adenocarcinoma who underwent gastrectomy from 2016 to 2021 were identified from the National Cancer Database. Patients who met the criteria for adjuvant systemic therapy were included. Propensity score matching was performed to compare robotic gastrectomy (RG) with laparoscopic gastrectomy (LG) and open gastrectomy (OG). The primary outcome was receipt of adjuvant systemic therapy (ASTx). The secondary outcomes included days from surgery to ASTx initiation, perioperative outcomes, oncologic quality metrics, and overall survival. Results: Among 5853 eligible patients, 17.8% underwent RG. After propensity score matching, ASTx utilization was similar between RG and LG (43.6% vs. 43.9%, p = 0.946) and between RG and OG (44.5% vs. 48.0%, p = 0.144), with no differences in days from surgery to ASTx initiation. Compared with LG, RG was associated with higher R0 resection rates but higher unplanned 30-day readmission rates. Compared with OG, RG was associated with higher R0 resection rates, greater regional lymph node examination, shorter length of stay, and lower 90-day mortality rates. Overall survival rates did not significantly differ between approaches. Conclusions: In this contemporary national analysis, RG did not result in improved delivery or timing of adjuvant systemic therapy despite favorable perioperative outcomes. These findings suggest that considering surgical approach alone is insufficient to address barriers to completion of multimodality therapy in gastric cancer. Full article

Background: Inflammatory bowel disease (IBD), comprising Crohn’s disease (CD) and ulcerative colitis (UC), has been associated with elevated cardiovascular risks. However, the impact of IBD on outcomes following percutaneous coronary intervention (PCI) remains underexplored. We aimed to evaluate the clinical and procedural outcomes of PCI in patients with concurrent IBD. Methods: This study utilized the National Readmission Database from 2016 to 2020 to evaluate outcomes such as all-cause mortality and post-PCI complications, including various cardiovascular and gastrointestinal (GI) complications in IBD patients undergoing PCI. Patients with concurrent IBD and PCI were compared to non-IBD controls via multivariable logistic regression. Results: On propensity-score-matching analysis, IBD patients undergoing PCI had a higher prevalence of GI complications, including acute liver failure (Odds ratio (OR) 1.48, 95% confidence interval (CI) 1.13–1.93, p = 0.004), mesenteric ischemia (OR 5.34, 95% CI 1.56–18.40, p = 0.007), and need for blood transfusion (OR 1.74, 95% CI 1.46–2.08, p < 0.001). There was also a higher rate of cardiac complications (OR 1.31, 95% CI 1.05–1.64, p = 0.017). No significant difference in all-cause mortality (OR 0.86, 95% CI 0.72–1.04, p = 0.113) was observed. Conclusions: IBD patients undergoing PCI face increased GI and cardiovascular complications without a significant mortality difference. These findings highlight the complex interplay between systemic inflammation, vascular integrity, and procedural outcomes in IBD patients. Full article

Background/Objectives: The transition from the intensive care unit (ICU) to the hospital ward is a critical high-risk period for patients. Early ICU discharge reduces costs and frees up ICU resources but can lead to readmission or unexpected death if patients are discharged prematurely. Despite the availability of risk stratification tools such as the Stability and Workload Index for Transfer (SWIFT) score, predicting ICU readmission remains challenging and inconsistent. However, artificial intelligence (AI) and machine learning (ML) techniques have recently shown promise in improving clinical decision support systems, particularly in the ICU. This study aimed to identify the risk factors and assess the performance of AI models in predicting readmission or death within seven days of ICU discharge using the MIMIC-IV (between 2008 and 2019) and Kangwon National University Hospital (KNUH, between 1 January 2016 and 28 February 2023) databases. Methods: This retrospective cohort study utilized the MIMIC-IV database for model training and internal validation and the KNUH database for external validation. Various machine learning and deep learning models have been developed to predict ICU readmission or death within seven days of discharge. The performance of the primary model, GRU-D++, was compared to the SWIFT score. Statistical analysis focused on the area under the receiver operating characteristic curve (AUROC) data to evaluate model accuracy. Results: The GRU-D++ model outperformed the SWIFT score, achieving AUROC of 0.802 and 0.756 for internal and external validations, respectively. Both datasets demonstrated that the GRU-D++ model provided better predictive performance for ICU readmission or death within seven days than the traditional SWIFT score. Conclusions: Our findings suggest that the GRU-D++ deep learning model is a valuable tool for the early detection of patient deterioration after ICU discharge, potentially aiding the prevention of ICU readmission. This study highlights the potential of AI to improve clinical decision-making in intensive care settings. Full article

Background/Objectives: With the global rise in chronic diseases among older adults, rehabilitation services have become essential, particularly for those with cerebrovascular and central nervous system (CNS) disorders, which lead to significant long-term disabilities. To determine the impact of designated rehabilitation medical institutions on the readmission rates of older patients with CNS disorders who receive surgical interventions. Methods: This was a population-based cohort study. Data was obtained from the National Health Insurance Service database (2002–2019). Fifteen designated institutions participated in the pilot project for convalescent rehabilitation. We analyzed the data of 1019 patients before and after the implementation of the designated rehabilitation institution. The study sample included (1) patients admitted to 15 designated institutions participating in the pilot project for convalescent rehabilitation and (2) patients diagnosed with conditions classified under the rehabilitation patient group, Rehabilitation Impairment Category 1 to 7. The intervention was the pilot project for designated rehabilitation institutions, launched in October 2017. The primary outcome of interest was the readmission rate of older patients with CNS disorders who received surgical interventions. Interrupted time series analysis with segmented regression was used to assess changes in the 30-day readmission rates. Results: Post-intervention, an 8% reduction in 30-day readmission rates (estimate, 0.9225; 95% confidence interval: 0.9129–0.9322, p < 0.0001) was observed. Subgroup analysis showed a significant decline in readmission rates across various patient groups, including those with disabilities, high Charlson Comorbidity Index scores, and extended hospital stays. The regions outside Seoul (capital city), particularly Gyeonggi/Incheon (areas around Seoul) and other areas (i.e., rural), also showed a significant decrease in readmission trends after the intervention. Conclusions: Designated rehabilitation medical institutions led to a significant reduction in readmission rates of older patients with CNS disorders, suggesting that these institutions effectively support recovery and reduce the burden of readmission for patients with severe conditions and those residing in non-capital cities. Full article

Background: The “weekend effect” describes the concern that patients treated on weekends experience worse outcomes due to differences in staffing, resource availability, and workflow. Evidence for a weekend effect in elective orthopedic surgery is limited and inconsistent, and most prior work does not ensure that surgery itself actually occurs on the weekend. We aimed to evaluate whether weekend admission and surgery are associated with worse in-hospital or 90-day outcomes in a contemporary nationwide cohort of elective primary total knee arthroplasty performed on hospital day 0. Methods: We conducted a retrospective cohort study using the U.S. Nationwide Readmissions Database (NRD) from 2020 to 2022. Adult patients (≥18 years) undergoing elective primary TKA with surgery on hospital day 0 were identified using ICD-10-PCS procedure codes in the primary procedure position. Weekend admissions (Saturday–Sunday) were compared with weekday admissions (Monday–Friday). Baseline demographics, comorbidities, and hospital characteristics were assessed. Outcomes included length of stay, total hospital charges, in-hospital mortality, major postoperative complications, and 90-day all-cause readmissions, time to readmission, readmission length of stay, and procedures during readmission. Continuous variables were compared using t-tests and categorical variables using chi-square or Fisher’s exact tests (two-sided α = 0.05). Results: Among 437,121 elective day-0 TKA admissions, 435,822 (99.7%) occurred on weekdays and 1299 (0.3%) on weekends. Baseline characteristics were highly similar between groups. No clinically meaningful differences were observed in in-hospital complications, mortality, or 90-day readmission outcomes. Small statistical differences in blood transfusion, blood-loss anemia, and postoperative pain did not follow a pattern consistent with a weekend effect. Conclusions: In this large contemporary national cohort of elective primary TKA with surgery on hospital day 0, weekend admission and surgery were not associated with worse in-hospital outcomes or higher 90-day readmission rates. Within standardized perioperative pathways, elective TKA appears safe when performed on weekends, without evidence of a weekend effect. Full article

Introduction/Background: Treatment of localized prostate cancer includes radical prostatectomy (RP) with or without pelvic lymph node dissection (PLND). While multiple guidelines recommend PLND for staging purposes, recent data has shown questionable therapeutic benefit. Thus, understanding the morbidity associated with PLND is important for counseling patients. We used the American College of Surgeons National Surgical Quality Improvement Program (ACS NSQIP) targeted prostatectomy database to quantify real-world 30-day postoperative outcomes of patients undergoing contemporary robot-assisted PLND at the time of RP for prostate cancer to quantify the incremental morbidity. Methods: We conducted a retrospective cohort study using the NSQIP database of adult patients undergoing radical prostatectomy from 2019 to 2022. The primary outcomes were procedure-specific outcomes such as lymphocele and rectal injury. Secondary outcomes included a composite of any of the following 30-day major postoperative outcomes: mortality, reoperation, cardiac or neurologic event, as well as the individual components of this outcome, as well as infectious and other complications. We also analyzed yearly trends associated with PLND. Groups were balanced using propensity score matching (PSM) with a 1:1 ratio using demographic characteristics, prior medical history, and cancer staging data. Likelihood of complications was assessed by conditional logistic regression. Results: We identified 13,413 patients between 2019 and 2022 who underwent robotic prostatectomy: 11,341 (85%) had PLND while 2072 (15%) did not. After PSM, our cohort included 2071 matched pairs of patients with and without PLND. Patients who underwent PLND were more likely to be diagnosed with lymphocele (2.14% vs. 0.68%, OR 4.17; 95% CI 2.00, 8.68), have unplanned readmission (4.22% vs. 3.27%, OR 1.31; 95% CI 1.03, 1.65), and develop organ-site/space SSI (1.18% vs. 0.60%) (OR 1.97, 95% CI 1.20, 3.23). There was no significant association between the receipt of PLND and the likelihood of urinary leak or fistula, or ureteral obstruction. There were no significant differences between the two groups with respect to secondary outcomes of interest. Conclusion: Contemporary robotic PLND is associated with a 3-fold increased likelihood of lymphocele, as well as increased likelihood of unplanned readmission and organ-site SSI, though no significant differences in major postoperative complications were identified. We found that the odds of lymphoceles, readmission, and SSI in our study are lower than previously reported. These data provide real-world data to guide patient counseling and optimize patient selection for PLND at the time of RALP. Full article

Background/Objectives: Cesarean section (C-section) is a common surgical procedure associated with an increased risk of 30-day postpartum hospital readmissions. This study utilized machine learning (ML) to predict readmissions using a nationwide database. Methods: A retrospective analysis of the National Surgical Quality Improvement Project (2012–2022) included 54,593 patients who underwent C-sections. Random Forests (RF) and Extreme Gradient Boosting (XGBoost) models were developed and compared to logistic regression (LR) using demographic, preoperative, and perioperative data. Results: Of the cohort, 1306 (2.39%) patients were readmitted. Readmitted patients had higher rates of being of African American race (17.99% vs. 9.83%), diabetes (11.03% vs. 8.19%), and hypertension (11.49% vs. 4.68%) (p < 0.001). RF achieved the highest performance (AUC = 0.737, sensitivity = 72.03%, specificity: 61.33%), and a preoperative-only RF model achieved a sensitivity of 83.14%. Key predictors included age, BMI, operative time, white blood cell count, and hematocrit. Conclusions: ML effectively predicts C-section readmissions, supporting early identification and interventions to improve patient outcomes and reduce healthcare costs. Full article

Background/Objective: Anterior cervical discectomy and fusion (ACDF) or posterior cervical foraminotomy (PCF) are common treatments for cervical radiculopathy. This study compared post-operative outcomes between ACDF and PCF utilizing the American College of Surgeons-National Surgical Quality Improvement Program database. Methods: An observational study following STROBE and TRIPOD + AI guidelines compared hospital resource utilization and quality of care between single-level ACDF and PCF (2005–2022). Primary outcomes compared operative time, length of stay (LOS), and post-operative complications. Propensity-scored stabilized inverse probability of treatment weighting adjusted for confounders, specifically demographics, lifestyle-related factors, pre-operative labs, pre-existing comorbidities, and surgery-related factors. Subgroup analysis compared baseline characteristics and outcomes, stratified by 30-day re-admission and re-operation. Results: PCF group demonstrated shorter LOS (MD −0.7 days, 95% CI −0.9 to −0.5 days, p < 0.001), operative time (MD −32.9 min, 95% CI −35.7 to −30.1 min, p < 0.001), higher rate of re-admission associated with overall SSI (PD 1.2%, 95% CI 0.7–1.7%, p < 0.001), deep incisional SSI (PD 0.8%, 95% CI 0.4–1.2%, p < 0.001), and organ/space SSI (PD 0.3%, 95% CI 0.0–0.5%, p = 0.011). Furthermore, the PCF group had greater systemic sepsis (PD 0.8%, 95% CI 0.4–1.3%, p < 0.001), overall post-operative SSI (PD 2.8%, 95% CI 2.0–3.6%, p < 0.001), superficial SSI (PD 1.9%, 95% CI 1.2–2.5%, p < 0.001), and deep incisional SSI (PD 0.8%, 95% CI 0.4–1.2%, p < 0.001) rates. Subgroup analysis showed increased early post-operative re-operation rates in the PCF cohort (PD 23.4%, 95% CI 9.5–37.4%, p = 0.001) and increased early post-operative re-admission associated with post-operative overall SSI (PD 35.3%, 95% CI 22.7–48.0%, p < 0.001). Conclusions: Although the PCF cohort demonstrated lower hospital utilization, it had reduced quality of care and increased post-operative complications. Full article

Background/Objectives: Radial head arthroplasty (RHA) and open reduction and internal fixation (ORIF) have emerged as predominant methods of surgical management for radial head fractures. The objective of this study was to evaluate national trends in management of radial head fractures among ABOS oral examination candidates and to compare complication rates between RHA and ORIF. Methods: A search of the American Board of Orthopaedic Surgery (ABOS) oral examination database identified radial head fractures treated with RHA or ORIF between 2003 and 2021 in patients 18 years or older. Results: RHA cases increased significantly from 2003–2021 (p < 0.001). Patients undergoing RHA were older (52.4 years vs. 42.9 years, p < 0.001) and predominantly female (60.8% vs. 45.7%, p < 0.001). Medical and surgical complications within 60 days were higher after RHA (2.9% vs. 1.6%, p = 0.012; 24.9% vs. 20.4%, p = 0.001), most commonly stiffness (10.8% vs. 7.1%, p < 0.001), nerve injury (3.3% vs. 2.7%, p = 0.26), and implant failure (3.4% vs. 2.4%, p = 0.064). Non-union or delayed union (0.5% vs. 2.5%, p < 0.001) was significantly higher after ORIF, and fracture (1.1% vs. 0.3%, p = 0.008) was significantly higher after RHA. The highest proportion of RHA to ORIF was performed by surgeons with shoulder and elbow fellowship training (p < 0.001). Conclusions: Among ABOS Candidates, RHA volume surpassed ORIF for radial head fractures in 2010. Surgical complication rates for radial head fractures are high at 60 days follow-up for both procedures. RHA is associated with higher complication rates, especially stiffness; however, similar reoperation and readmission rates suggest that RHA may have been selected for more complex injuries. Full article

Background/Objectives: Chronic ulcers represent a major public health concern, being associated with substantial morbidity, impaired quality of life, and significant costs to healthcare systems. Against the backdrop of an aging population and increasing prevalence of chronic comorbid conditions, this study aimed to profile hospitalized patients with chronic ulcers in Romania and to examine their differential patterns of healthcare resource utilization. Methods: We conducted a retrospective analysis of the national administrative hospitalization database between 2017 and 2022, including adult patients with at least two admissions coded with a primary diagnosis of chronic ulcer. Sociodemographic, clinical, and healthcare utilization indicators were extracted, standardized, and analyzed using the K-means clustering algorithm to derive utilization-based phenotypes. Results: Two distinct patient clusters were identified: the first comprised predominantly elderly patients with multiple comorbidities, prolonged hospitalizations, and frequent readmissions, representing a high-burden profile; the second included relatively younger patients with fewer comorbidities, shorter hospital stays, and lower readmission rates, reflecting a more stable clinical profile. The high-burden cluster accounted for a disproportionate share of inpatient resource consumption, underscoring its impact on the healthcare system. Conclusions: These findings highlight the importance of early identification of potential high-burden patients, enabling the implementation of personalized care strategies and more efficient allocation of hospital resources, with the potential to improve health outcomes and support healthcare system sustainability. Full article

Given the rising use of neoadjuvant chemotherapy (NACT) followed by interval debulking surgery (IDS) in advanced epithelial ovarian cancer (EOC), we sought to assess practice trends in overall survival (OS), complete gross resection (R0), and postoperative mortality following debulking surgery. The National Cancer Database (NCDB) was used to identify 34,982 stage IIIC and IV EOC patients between 2010 and 2017 who underwent surgery. Annual proportions of patients receiving IDS and PDS were calculated. Median OS was estimated using the Kaplan–Meier method. Joinpoint models were fitted to evaluate surgical trends. Statistics were performed using SPSS and Joinpoint. Of 34,982 patients, 10,460 (29.9%) underwent IDS. IDS patients were older, more likely to have stage IV disease, and more likely to be non-White. Median OS was higher in the PDS group (54 vs. 38.8 months, p < 0.001). Postoperative 90-day mortality was lower in the PDS group (1.7% vs. 2.4%, p < 0.001), though IDS patients had a lower 30-day readmission rate (6.2% vs. 3.1%, p < 0.001). IDS patients were less likely to undergo extensive surgery (27.4% vs. 36.7%, p < 0.001) and more likely to achieve R0 resection (42% vs. 38.6%, p < 0.001). The IDS rate increased from 18.9% to 40.6% (annual percentage change (APC): 11.8%, p < 0.05) from 2010 to 2017. Median OS improved from 46.6 to 51 months (APC: 1.9%, p < 0.05), driven by the PDS cohort. The R0 resection rate rose from 34.8 to 41% (APC: 2.65%, p < 0.01), driven by the PDS cohort (APC: 2.83%, p < 0.01). Postoperative 90-day mortality decreased from 2.4% to 1.5% (APC: −4.64%, p < 0.05), due to a reduction in PDS patients (APC: −6.83%, p < 0.05). There was no change in the rate of extensive surgery over time. In conclusion, from 2010 to 2017, increased triage of patients to NACT was accompanied by a higher R0 resection rate and reduced postoperative mortality in PDS patients, with no observed detriment to OS. This data suggests improvement in case selection between IDS and PDS. Full article

Background/Objectives: There has been growing interest in understanding the impact of social determinants of health (SDoHs) on health outcomes. Since 2015, healthcare providers have begun to document patients’ SDoH systematically using ICD-10 Z-codes. Methods: We extracted claims data from a nationally representative hospital chargemaster database for 586,929 eligible HF patients between January 2019 and December 2021. We investigated the association between SDoH Z-codes and 30-day hospital readmission for heart failure (HF) patients in U.S. hospitals using a Chi square test and adjusted odds ratios from logistic regression models. Results: We found that four major SDoH Z-code categories and five specific sub-Z-code factors within the major categories are significantly associated with 30-day readmission for HF patients. We also found that patients with two or more SDoH Z-codes have a higher risk of readmission than those with one. Conclusions: Our study indicates that ICD-10 Z-codes are useful in identifying SDoH risk factors for hospital readmission among HF patients. Policymakers and healthcare providers should consider Z-codes when assessing HF readmission risk and developing interventions to lower HF readmission rates. Full article

Background and Objectives: Diabetes mellitus (DM) significantly impacts post-surgical recovery and fracture healing; however, few studies have specifically investigated the impact of DM on outcomes in patients undergoing surgical stabilization of rib fractures (SSRF). This study investigated the potential influence of DM on perioperative outcomes following SSRF, using data from Taiwan’s National Health Insurance Research Database (NHIRD). Materials and Methods: Data of 1603 patients with multiple rib fractures who underwent SSRF between 2001 and 2019 were retrospectively analyzed. Patients were categorized into three groups: no DM, DM without chronic complications, and DM with chronic complications. The associations between DM status and perioperative outcomes, including hospital length of stay (LOS), in-hospital mortality, readmission rates, and complications such as pneumonia, surgical site infection (SSI), acute myocardial infarction (AMI), and total hospital costs were determined using univariate and multivariable regression analyses. Results: The mean age of the 1603 patients was 52.0 years, and 71% were male. Patients with DM and chronic complications had higher risks of 14-day readmission (adjusted odds ratio [aOR] = 2.99; 95% confidence interval [CI]: 1.18–7.62), 15–30 day readmission (aOR = 3.28; 95% CI: 1.25–8.60), SSI (aOR = 2.90; 95% CI: 1.37–6.14), AMI (aOR = 3.44; 95% CI: 1.28–9.24), and acute respiratory distress syndrome (ARDS) (aOR = 1.96; 95% CI: 1.03–3.74). In conclusion, DM, particularly DM with chronic complications, significantly increases the risk of adverse short-term outcomes following SSRF. Conclusions: These findings emphasize the need for enhanced care for patients with DM to optimize the outcomes of SSRF. Full article

Background: Chronic mitral regurgitation (MR) is categorized into primary and secondary MR (SMR). While primary MR arises from structural abnormalities of the mitral valve apparatus, SMR is a consequence of cardiac remodeling, typically due to heart failure or atrial fibrillation. Management strategies differ significantly, with primary MR requiring direct valvular intervention and SMR necessitating a comprehensive approach incorporating guideline-directed medical therapy (GDMT), revascularization, and resynchronization strategies. The MitraClip, a transcatheter edge-to-edge repair (TEER) device, has emerged as a recommended intervention for symptomatic severe SMR despite optimal GDMT. Objectives: This study aims to evaluate national trends in MitraClip placements in the U.S. from 2016 to 2021 and to assess 90-day readmission events following the procedure. Additionally, we analyze patient and socioeconomic factors associated with heart failure readmissions post-MitraClip placement to optimize patient selection criteria. Methods: The study utilized data from the National Inpatient Sample (NIS) for the years 2016–2021 and the National Readmissions Database (NRD) for 2021. Patients who underwent MitraClip placement were identified using ICD-10 code 02UG3JZ. We stratified the population based on demographics, hospital resource utilization, and comorbidities. Index admissions were classified based on the presence or absence of heart failure remissions within 90 days post-procedure. Statistical analyses, including ANOVA and logistic regression, were conducted to identify factors associated with readmissions. Results: MitraClip utilization demonstrated a rising trend from 2016 to 2021, with total annual procedures increasing from 869 to 2488. Mean patient age remained stable at 76–79 years, with a nearly equal sex distribution. In-hospital mortality remained low (1–3%) throughout the study period. A steady increase in hospital charges was observed, alongside a decline in the mean length of stay. Analysis of 4918 index admissions for MitraClip placement in 2021 identified 780 total readmissions within 90 days, with 206 (26.4%) attributed to heart failure. Factors significantly associated with increased risk of heart failure readmissions included atrial fibrillation (OR 3.77, CI 1.82–4.23), pulmonary hypertension (OR 3.96, CI 1.49–5.55), and chronic lung disease (OR 1.91, CI 1.32–2.77). Conclusions: The increasing adoption of MitraClip underscores its growing role in managing SMR. However, heart failure readmissions remain a significant concern. Identifying high-risk patient profiles can refine selection criteria and enhance post-procedural management strategies to improve clinical outcomes. Further research is needed to optimize patient selection and refine risk stratification for MitraClip interventions. Full article