Search Results (5,273)

This study addresses the multi-objective optimization of characterizing a flat glass processing plant. To assess the operational conditions required for a flat glass processing small and medium-sized enterprise (SME) to become a prosumer compatible with renewable energy community (REC) participation. This work is motivated by the presence of more than 300 SMEs in Italy, like this, where RECs represent one of the few viable strategies for achieving the European Union’s 2050 decarbonization targets. The research is carried out in two scenarios; Scenario-I includes Stage-i and Stage-ii with the mutual goal of forecasting and optimizing. Forecasting is used in Stage-i to optimize the factory load, and in Stage-ii to shift and curtail energy loads based on the forecast, considering the Italian national energy price and the regional price bands (“fasce orarie”) F1, F2, and F3. Forecasting and the indicators of environmental and social performance are the means to ensure the best energy utilization and management, as they prove that the reduction in CO${}_2$ emissions and benefits on the community level can be both obtainable. Subsequently, the techno-economic analysis and evaluation of prosumer-readiness conditions are carried out through the optimization of industrial energy demand: three optimization objectives are assessed in this study (i) energy cost, (ii) carbon emission, and (iii) load curtailment. Four algorithms are put into effect to solve the tri-objective optimization: multi-objective particle swarm optimization (MOPSO), multi-objective ant nesting algorithm (MOANA), non-dominated sorting genetic algorithm (NSGA-II), and multi-objective grey wolf optimization (MOGWO). The algorithms are validated in Stage-ii to find the desired optimum in the cost of energy, reduce peak formation, and carbon emissions. To achieve this goal, a stochastic approach based on Monte Carlo simulations and VIKOR is used to optimally select the results. The findings show that the NSGA-II, MOPSO, and MOANA are more effective in solving the problem, while the MOGWO algorithm more quickly finds the optimal solution. Based on the defined objectives, a new configuration for the energy community is introduced, together with a community well-being index and an evaluation of the resulting benefits for the factory. In Scenario-II, the PV plants’ installation on the factory is sized, and the excess energy shared with the grid is evaluated. The Scenario-II results show that 497.184 MWh (33.9%) of energy is shared with the grid. Both results suggest how optimized industrial demand profiles improve SME participation in future RECs. Full article

Background: Simultaneous pancreas–kidney (SPK) transplantation can restore renal function and insulin independence, but non-technical pancreas graft dysfunction remains difficult to anticipate. Methods: We conducted an exploratory single-centre retrospective biomarker-modelling study to determine whether day-zero recipient serum Fourier-transform infrared (FTIR) spectra are associated with subsequent loss of insulin independence after SPK transplantation. Results: Among 104 screened recipients, 51 met predefined sample-availability, spectral-quality, data-linkage and endpoint-adjudication criteria; 30 maintained pancreas graft function and 21 developed dysfunction. Cases dominated by early technical surgical failure were excluded. Clinical-only, FTIR-only and FTIR–clinical Naïve Bayes models were evaluated using leave-one-out cross-validation with Fast Correlation-Based Filter feature selection. In locked-feature internal validation, the best FTIR-only model used second-derivative spectra with vector normalization and nine selected wavenumbers, achieving AUC 0.997 (95% CI 0.985–1.000) and accuracy 0.961 (95% CI 0.902–1.000). A fixed-feature permutation analysis exceeded label-randomized performance (empirical p = 0.001). The secondary Group 1 versus Group 3 analysis suggested discrimination of pancreas dysfunction despite preserved kidney function (AUC 0.992; accuracy 0.930). Conclusions: Given the small cohort, high-dimensional input, non-nested feature selection, selection-bias risk and absence of external validation, serum FTIR should be considered a candidate risk-enrichment platform requiring prospective multicentre validation. Full article

In light of the rapid development of the electric vehicle market, permanent magnet synchronous motors (PMSMs) are becoming essential components of propulsion systems. This is due to their high efficiency, remarkable power density, and ability to deliver high torque over a wide speed range. However, the optimal control of these motors under dynamic conditions remains a major challenge due to system nonlinearities, parameter variations, and external disturbances. Conventional strategies such as field-oriented control (FOC), direct torque control (DTC), and fuzzy logic control (FLC) show variable performance in terms of current quality, robustness, and energy efficiency. To overcome these limitations, this study proposes an intelligent control strategy based on artificial neural networks (ANNs), which ensures efficient operation and high control performance under various operating conditions. This approach leverages the learning capabilities of deep neural networks to improve control accuracy, system stability, and overall energy performance. The results obtained show a significant reduction in the current’s total harmonic distortion (THD) as well as an improvement in the stator’s current quality and the electromagnetic torque’s dynamic behavior compared to conventional methods. This improvement reduces overall losses in the electric drive system, thereby contributing to increased vehicle energy efficiency. As a result, the electric vehicle’s range is extended, and the dynamic performance of the PMSM is optimized. These results confirm the potential of artificial intelligence techniques for developing intelligent, robust, and adaptive control systems designed for modern electric propulsion applications. Full article

Flow-cell ultrasonication of gelatinized rice flour slurries alters cultivar-dependent water solubility, viscosity, and retrogradation of pregelatinized rice flour, properties important for plant-based beverages and convenience foods. We tested whether cultivar-level composition descriptors, amylose, protein, and fiber, can represent cultivar-associated variation in ultrasonication responses while separating process-only prediction, within-domain cultivar representation, and unseen-cultivar transfer. Six rice cultivars were processed across nine amplitude-time combinations and two slurry concentrations. Water solubility index, apparent viscosity at a shear rate of 50 s⁻¹, and setback viscosity were modeled using ElasticNet, partial least squares regression, support vector regression, random forest, and extreme gradient boosting. Three input formulations were compared: process variables alone, process variables plus composition descriptors, and process variables plus cultivar identity. Repeated nested group cross-validation showed insufficient process-only prediction and substantial improvement from composition descriptors. Within-domain validation showed comparable composition-descriptor and cultivar-identity performance under nonlinear algorithms. However, because cultivar identity is undefined for absent cultivars, leave-one-cultivar-out transfer of the composition-descriptor model remained uncertain. Cross-fitted Shapley additive explanations showed predictions used process and composition variables. For the validated cultivar-process domain, this approach can screen cultivar-process combinations for beverage and convenience-food applications, but replacing categorical source identifiers with continuous descriptors requires explicit transfer validation. Full article

The pathological mechanism of autism spectrum disorder (ASD) exhibits dual heterogeneity: abnormal local energy metabolism and brain-wide high-order topological failure. To synergistically characterize these complex signals captured by advanced neuroimaging sensors, we propose the Quantum-Enhanced Graph Convolutional Wide Residual Network (QG-WRN), a modality-specific, decoupled parallel dual-stream architecture. In the classical branch, to accurately capture the spatial distribution of local metabolic abnormalities, we employ a wide residual network (WRN) to extract amplitude of low-frequency fluctuation (ALFF) features, leveraging its expanded feature channels to effectively mine regional neurodynamic properties. Furthermore, to overcome the representational bottlenecks of classical linear operators in parsing hidden, long-range network connections, we introduce quantum computing, exploiting its exponentially expansive state space and intrinsic low-parameter regularization mechanism. Guided by these properties, the quantum branch utilizes a variational quantum graph convolutional (QGCN) module—featuring a trainable circular encoding strategy and a hardware-efficient 4-qubit configuration—with a 2-layer nested message passing structure to process the functional connectivity (FC) matrix, harnessing quantum interference in Hilbert space to parse complex topology while effectively mitigating overfitting on small-sample medical data. A unified training scheme achieves full-dimensional fusion of node activity and topology. Achieving 68.49% accuracy, our method outperforms 10 classic and recent new baselines, providing a powerful computational intelligence tool for sensor-based ASD clinical diagnosis. Furthermore, interpretability analysis successfully maps core disease hubs to standard AAL116 atlas coordinates, providing a powerful tool for computationally aided ASD diagnosis. Full article

This work proposes an Adaptive Neural Control for the asymptotic stabilization of a chain of integrators at the origin. The proposed approach addresses the stabilization of the integrator chain by means of a control law whose applied signal is structurally bounded to $(-1,1)$ by the hyperbolic tangent architecture, i.e., $u\left(t\right)=tanh\left(z\right)$, where z represents a weighted linear combination of the system states and a bias term. Furthermore, an adaptation law for the weights is proposed, based on the classical backpropagation algorithm for neural networks. The stability analysis is conducted using singular perturbation theory, demonstrating that, under a sufficiently high learning rate, the closed-loop system exhibits a Standard Singular Perturbation Form. This formulation allows for the analysis of the system across two distinct time scales: the adaptation dynamics (fast subsystem) and the state dynamics (slow subsystem). Based on this formulation, explicit conditions on the learning rate and the initial conditions are derived to guarantee local asymptotic stability using Tikhonov’s theorem. These conditions characterize the region of attraction and ensure that the adaptive neural controller stabilizes the system. Numerical simulations were carried out to evaluate the controller’s performance under three different scenarios: ideal conditions, initialization outside the region of attraction, and a low learning rate. These scenarios illustrate the closed-loop system behavior and validate the theoretical conditions required for asymptotic stability. Furthermore, comparative numerical simulations were conducted on an Inverted Pendulum on a Cart system to benchmark the proposed Adaptive Neural Control against Linear Quadratic Regulator, Sliding Mode Control, and Nested Saturation Function controllers. Based on the Integral of Time-weighted Squared Error performance index, the Adaptive Neural Control demonstrated a significant reduction in control effort, achieving performance improvements of up to 95.02% compared to the aforementioned strategies. Full article

The diversity of mating systems in fish is unparalleled among vertebrates. This variability is shaped by a long evolutionary history associated with differences in selection pressures and plasticity within species. However, there is also significant intraspecific variability within species, often related to differences in environments among populations. Herein, I explore how habitat features (temperature, oxygen, turbidity and vegetation) and availability of mates or mating resources (nest sites, population density, sex ratio and alternative mating strategies) can affect the distribution of reproductive success in a population. The literature reviewed here indicates that differences in the intensity of sexual selection and variation in mating-system structure can be directly related to differences in breeding habitat. The way in which habitat affects mating-system structure is complex, with both abiotic and biotic factors interacting to influence different aspects of breeding behavior and success. Thus far, our understanding of variation in mating systems in fishes is based on very well-studied species, and more exploration is needed to provide an overview of habitat and mating-system structure. This is critical as we face human-induced changes in breeding habitats that can alter mating systems and potentially affect variation and viability of fish populations. Full article

For hydrological parameterization in high-Andean catchments, it is necessary to understand whether near-surface hydro-structural soil properties can provide a surrogate signal of particle-size composition when direct texture information is sparse. This study evaluated the extent to which sand, silt, and clay fractions can be approximated from organic matter ($\mathrm{OM}$), bulk density (${\rho }_b$), and saturated hydraulic conductivity ($K_{\mathrm{sat}}$) in the Zamora Huayco (ZH) and Irquis catchments, southern Ecuador. A harmonized dataset ($n=44$) was analyzed through exploratory statistics, compositional assessment, correlation analysis, PCA, fraction-wise regression, $\mathrm{ILR}$-based modeling, AIC/BIC term reduction, sensitivity analysis excluding $\mathrm{OM}$, nested $\mathrm{LOOCV}$, and bootstrap-based uncertainty intervals. Among LULC classes, samples classified as paramo occupied a distinct high-Andean hydro-edaphic domain, characterized by a differentiated relationship between soil physical properties and hydrological behavior. PCA showed that the dominant covariance structure involved $\mathrm{OM}$, ${\rho }_b$, $K_{\mathrm{sat}}$, and the redistribution between sand and silt. The BIC-reduced $\mathrm{ILR}$ model provided the most balanced formulation, with positive nested $\mathrm{LOOCV}$ performance for sand, silt, and clay ($R_{\mathrm{LOOCV}}^2=0.147$, $0.704$, and $0.124$, respectively) and exact $100\%$ compositional closure after inverse transformation. Silt was the most stable predicted fraction, whereas sand and clay retained larger residual uncertainty, stronger tail departures, and partial compression of the observed variability. The proposed equations provide local hydro-pedotransfer support, although their predictive signal remains dependent on further refinement, uncertainty assessment, and external validation before regional application. Full article

This study examines the structural determinants of behavioral intention to use a City Airport Terminal (CAT) in Ulsan using a structural equation modeling (SEM) framework. Whereas prior literature has predominantly explained CAT adoption in terms of accessibility, this study investigates whether usage intention can be sufficiently explained by accessibility alone or whether it reflects a broader multi-factor structure involving service quality and safety, economic efficiency, infrastructure convenience, and perceived public value. To this end, five latent constructs were specified, and a survey of 500 Ulsan residents was conducted. The confirmatory factor analysis indicated an acceptable measurement structure for the five latent constructs. The structural model results show that perceived public value and regional development was the only construct with a statistically significant direct path to CAT usage intention, whereas the baseline accessibility-only model provided a statistically insufficient explanation. A nested model comparison further indicated that non-accessibility constructs collectively contributed additional explanatory value beyond what accessibility alone could provide. These findings suggest that CAT usage intention is not adequately explained by accessibility alone but is better understood through a multi-factor conceptualization of CAT adoption. This study contributes to the literature by providing structural evidence that public value—encompassing regional development expectations and community-level benefits—should be explicitly considered in sustainable airport infrastructure planning. The results highlight the importance of a multi-dimensional approach to CAT implementation policy, integrating service quality and safety, economic efficiency, infrastructure convenience, and community-level value perceptions alongside physical accessibility. From a sustainable mobility perspective, the findings offer useful implications for sustainable airport access planning and air transport management. Full article

This paper examines global equity market integration, commodity-price exposure, and volatility spillovers in Ghana’s frontier equity market. Using daily data from January 2011 to December 2025, we estimate a multi-factor asset pricing model nested within a GARCH framework for the Ghana Stock Exchange Composite Index (GSECI) and the Financial Sector Index (GSEFSI). The model jointly estimates first-moment return exposures and second-moment volatility spillovers from a global equity market and three key global commodity markets: gold, crude oil, and cocoa, while controlling for asymmetric volatility, return serial dependence, and domestic macro-financial shifts associated with banking sector recapitalization and the Domestic Debt Exchange Programme (DDEP). The Ghanaian equity market is exposed to the global equity market, indicating measurable but economically modest global integration, with stronger exposure in the financial sector. Commodity-price exposures are selective, with gold and crude oil exposures concentrated in the financial sector, whereas the cocoa factor is negatively associated with returns on both indices. The variance results show persistent volatility, inverse asymmetric volatility responses, and differentiated volatility spillovers from global equity and commodity markets. The DDEP period is associated with significant equity market repricing, particularly in the financial sector. These findings indicate that Ghana’s equity market dynamics are shaped jointly by global equity and commodity market information, frontier market frictions, and sovereign–bank conditions. Full article

Background/Objectives: Parathyroid hormone (PTH) has emerged as a novel biomarker in heart failure (HF), reflecting neurohormonal, renal, and metabolic dysregulation within the cardiorenal–mineral axis. However, its independent prognostic value and incremental contribution remain unclear when evaluated through formal nested structures Therefore, this study aimed to evaluate the association between PTH and all-cause mortality in patients with heart failure with reduced ejection fraction (HFrEF) and to determine whether PTH provides additional prognostic information beyond NT-proBNP. Methods: In this retrospective cohort study, 1594 patients with HFrEF (LVEF ≤ 40%) were analyzed. Serum PTH and NT-proBNP levels were log-transformed and evaluated as predictors of all-cause mortality. Patients were stratified according to PTH levels, and survival analysis was performed. Incremental model fit was evaluated using nested likelihood ratio tests. Stratified multivariable Cox models and formal interaction tests were executed across predefined clinical strata (age, renal function, and heart failure etiology). Results: During a median follow-up of 36 months, 525 deaths occurred. Elevated PTH levels were associated with worse survival outcomes. In multivariable Cox regression analysis, both LnPTH (HR: 1.233, p = 0.0147) and LnNT-proBNP (HR: 1.374, p < 0.0001) were independent predictors of mortality. Combined elevation of PTH and NT-proBNP identified patients at the highest risk. The addition of LnPTH to the baseline model significantly improved global model fit (χ² = 4.242, p = 0.0394). Importantly, the prognostic value of LnPTH was significantly modified by age (P_interaction = 0.026) and renal function (P_interaction = 0.038), demonstrating independent predictive power specifically in patients aged < 65 years (HR: 1.402) and those with eGFR ≥ 60 mL/min/1.73 m² (HR: 1.454), but not in older or advanced renal impairment strata. Conclusions: PTH is independently associated with mortality in patients with HFrEF and provides incremental prognostic value beyond NT-proBNP by optimizing global model fit. These findings support its role as a complementary biomarker within a multimarker strategy for improved risk stratification of the cumulative metabolic and cardiovascular burden. Full article

Background/Objectives: The “small-n-large-p” dilemma in mammography artificial intelligence (AI)—where the number of candidate imaging features far exceeds the number of labeled cases—commonly results in model overfitting, unstable feature selection, and poor generalization across clinical settings. This study aims to reassess the internal performance of the HiTopology-GOA-CSA (Grasshopper Optimization Algorithm–Crow Search Algorithm) feature-selection framework for mammography using a larger real Curated Breast Imaging Subset of Digital Database for Screening Mammography (CBIS-DDSM) cohort and a stricter leakage-aware evaluation strategy. Methods: In this retrospective computational study using public anonymized datasets, an expanded internal cohort of 98 CBIS-DDSM mass cases (49 benign, 49 malignant) was assembled from digital imaging and communications in medicine (DICOM) region of interest (ROI) series. A total of 1074 features were extracted per case, including 88 handcrafted radiomic descriptors and 986 EfficientNet-B5 deep features. HiTopology-GOA-CSA selected 102 features, corresponding to 91% feature reduction. Two internal evaluation modes were compared: Mode A, which matched the original pilot methodology by performing feature selection once on the full cohort before cross-validation, and Mode B, which used strict nested feature selection within training folds. Performance was assessed with 5-fold stratified cross-validation using a multilayer perceptron (MLP) classifier. Results: On the expanded cohort, Mode A achieved an area under the receiver operating characteristic curve (AUC) of 0.726 (95% CI: 0.594–0.858), sensitivity of 0.658, specificity of 0.651, and F1-score of 0.644. Under the stricter nested evaluation, Mode B achieved AUC of 0.683 (95% CI: 0.549–0.817), sensitivity of 0.598, specificity of 0.631, and F1-score of 0.595. Mean pairwise Jaccard similarity across nested folds was 0.604, indicating moderate feature stability. Benchmark comparisons showed that the proposed method was competitive but did not outperform standard baselines; LASSO logistic regression achieved the highest AUC of 0.739, while the proposed HiTopology-GOA-CSA + MLP achieved an AUC of 0.683. Real external validation on the locked VinDr-Mammo subset (n = 25) remained near-random (AUC of 0.500 [95% CI: 0.304–0.696]), with complete prediction collapse (sensitivity of 1.000, specificity of 0.000). Conclusions: The framework demonstrated feasibility for structured feature selection and stress testing in a small-cohort mammography AI setting; however, external validation revealed near-random discrimination and prediction collapse, indicating limited generalizability. These findings emphasize the need for benchmark comparisons, transparent uncertainty reporting, patient-level validation, and larger multicenter datasets before clinical translation. Full article

The taxonomy of the East Mediterranean species of the Crematogaster scutellaris complex, Crematogaster schmidti (Mayr, 1853) and C. ionia Forel, 1911 sensu lato, have not yet been investigated via modern approaches like morphometric analyses. We collected morphometric data of 201 workers from 68 nests of Crematogaster schmidti and C. ionia s. l. from Slovenia, Croatia, Montenegro, North Macedonia, the Greek mainland, Crete, Bulgaria, Samos, Karpathos, Rhodes, Turkish Thrace, and Anatolia. Nest-centroid clustering suggested four distinct entities with different geographic distributions: C. schmidti from Slovenia southwards to Greece and Turkish Thrace, and three species which have been so far summarized under C. ionia: one from the Greek mainland and North Macedonia, one from Crete, and one from Samos, Karpathos, Rhodes, and Anatolia. We described two new species: the Cretan entity as Crematogaster ariadnae sp. n. and the Balkan mainland entity as Crematogaster graeca sp. n. A key and (re)descriptions for the East Mediterranean members of the Crematogaster scutellaris complex are provided. The four species show different geographic distribution patterns, do not occur together at the same localities, and are most likely speciated through long-term geographic isolation. Full article

Accurate and automated extraction of solid waste sites from remote-sensing imagery constitutes a pivotal demand for contemporary environmental regulation and risk mitigation. However, in high-resolution remote-sensing imagery, solid waste sites are typically represented as a single semantic image object (SIO), which is composed of multiple physical image parcels (PIPs) exhibiting significant variations in scale, morphology, and spectral properties. This intrinsic heterogeneity substantially increases the complexity and uncertainty of multi-class site identification. To address this challenge, this paper proposes WasteMOE Net (WMN), which is developed based on the core concept of modeling the SIO–PIP relationship. WMN adopts a heterogeneous expert selection mechanism combined with a nested mixture-of-experts architecture. It thus enables adaptive perception of complex PIPs across diverse scenarios and their integrated discrimination at the SIO level. In addition, by incorporating the explicit nonlinear representation capability of the KAN network, WMN effectively improves multi-class recognition accuracy while maintaining computational efficiency. Furthermore, this study constructs a high-resolution solid waste site dataset in accordance with the SIO–PIP-aware annotation principle, encompassing five representative categories: tailings ponds (TP), construction spoil sites (CSS), landfill sites (LS), garbage dump sites (GDS), and excavation sites (ES). Experimental results show that WMN achieves mAP50 values of 74.2% (GDS), 63.5% (CSS), 80.9% (ES), 85.4% (TP), and 83.1% (LS) in detection tasks, and 75.4%, 64.1%, 83.0%, 86.7%, and 84.1% for the corresponding categories in segmentation tasks. It achieves competitive performance compared with state-of-the-art methods in both tasks. Further, in a real-world application over Loudi City, China, WMN completed the processing of a 490.67 km² area within 1.34 h. The recognition accuracies for GDS and ES reached 54.8% and 65.3%, respectively. Finally, the proposed method has been successfully integrated into a GIS-based solid waste pollution risk prevention system, which markedly boosts the overall efficiency of environmental monitoring and on-site inspections. Full article

Animals with knockout of the dopamine transporter gene (DAT-KO) display hyperdopaminergic phenotypes, including attention-deficit/hyperactivity-like behaviors. A previous behavioral analysis of heterozygous rats with partial knockout (DAT-HET) suggested increased susceptibility to addictive behaviors. The aim of this study was to investigate elements of addictive behaviors and the mechanisms underlying dopamine release in DAT-HET rats. Offspring derived from DAT-knockout breeding underwent genotyping and behavioral assessment using the marble burying test, a manipulative behavior test using nesting material, and a modified version of the Iowa Gambling Task. Feeding behavior was studied using a binge-eating model. Reinforcing properties were investigated using intracranial self-stimulation under fixed-ratio (FR) and variable-ratio (VR) schedules. Dopamine (DA) release and clearance dynamics were assessed using fast-scan cyclic voltammetry (FSCV). DAT-HET rats exhibited moderate hyperactivity, increased impulsive choice, and compulsive responses. Male DAT-HET rats also showed increased compulsive overeating compared with wild-type (WT) rats of both sexes and female DAT-HET rats. In addition, DAT-HET rats demonstrated a preference for VR self-stimulation, which resembles risk- and thrill-seeking behavior in humans. In DAT-KO rats, impaired DA clearance resulted from complete loss of dopamine transporter function. In DAT-HET rats, increased DA release amplitude was observed, and dopamine persisted longer in the extracellular space than in WT rats. These findings underscore the importance of the DAT-HET model for studying impulsivity, compulsivity, and factors underlying the predisposition to addictive behavior. Full article