Search Results (20,466)

The building sector accounts for nearly 40% of total energy consumption in Europe, with heritage buildings posing a critical challenge due to conservation constraints. This study investigates two protected heritage sites—Palazzo Ruspoli in Cerveteri and Palazzo Vitelleschi in Tarquinia—to identify effective energy retrofit strategies integrating high-efficiency windows, HVAC and lighting systems, and photovoltaic (PV) solutions for both on-site and virtual self-consumption within Renewable Energy Communities (RECs). Energy surveys, modeling, and simulations were performed to evaluate technical, environmental, and economic impacts. The results show contrasting outcomes between the two cases: at Palazzo Vitelleschi, the combination of efficient systems and rooftop PV reduced non-renewable primary energy demand and CO₂ emissions by 73.5%, with a 10.7-year payback period; at Palazzo Ruspoli, REC-based virtual self-consumption achieved net-negative carbon emissions (−240%), a 95% reduction in non-renewable energy demand, and a 19.4-year payback period. These findings demonstrate that heritage buildings can move beyond carbon neutrality and actively offset emissions through shared renewable generation. The proposed simulation-based framework provides a replicable method to balance conservation and sustainability, supporting the decarbonization of the historical built environment. Full article

Technological decoupling, geopolitical tensions, and carbon neutrality pressures have created systemic risks, making supply chain security a global concern. Digital-driven new quality productivity (NQP), as a key driver of supply chain upgrading, plays a crucial role in restructuring modern supply chain systems and enhancing resilience. Based on data from Chinese supply chain data from listed companies (2012–2023), this study integrates enterprise-level NQP and applies complex network methods and the Hadamard product model to analyze how NQP regulates supply chain resilience. The results show that NQP affects network resilience through three nonlinear coupling mechanisms: strengthening defense at fixed points, promoting recovery through chain reinforcement, and enhancing sustainability via network expansion. Its impact is stage-dependent—showing partial vulnerability during early technology diffusion but significantly improving overall resilience at maturity, with structural imbalance remaining a potential risk. This study provides theoretical and practical insights for optimizing supply chain structures and improving risk prevention and collaborative capabilities. Full article

Therapeutics involving small interfering RNA (siRNA) have enormous potential for treating a number of diseases, but their effective delivery to target cells remains a major challenge. We studied the influence of the structure and combination of targeted (folate conjugated, F13) and shield lipoconjugates (P1500, diP1500) on the ability of cationic liposomal formulations based on the 2X3-DOPE system to deliver siRNA into cells in vitro and in vivo. The loop-structured PEG lipoconjugate equipped with two hydrophobic anchor groups (diP1500) demonstrated superior performance across multiple evaluation criteria. The F13/diP1500 composition maintained a compact particle size (126.0 ± 23.0 nm), while F13/P1500 with the same PEG chain equipped with one anchor group maintained an increased particle size of 241.8 ± 65.7 nm. Most critically, F13/diP1500 preserved substantial positive surface charges (21.6–30.5 mV) across all N/P ratios, demonstrating superior ability in avoid the “PEG dilemma”, whereas F13/P1500 suffered substantial charge neutralization (3.9–9.1 mV). Competitive inhibition with free folate confirmed receptor-mediated cellular accumulation of siRNA mediated by F13 containing liposomal compositions. In vivo biodistribution revealed statistically significant circulation advantages: DSPE-PEG2000/diP1500 achieved the highest plasma concentration at 15 min (1.84 ± 0.01 pmol/mL), representing the first direct in vivo comparison of compositions with PEG lipoconjugates of the same length, but formed different structures in the liposomes due to the presence of one or two anchor groups. Our findings provide critical insights for the rational design of targeted liposomal delivery systems, highlighting the importance of balanced optimization between folate targeting functionality and PEG shielding for effective siRNA delivery both in vitro and in vivo. Full article

Marine-derived natural products have attracted increasing attention due to their promising pharmacological potential against various diseases. The present study investigated the hypolipidemic properties of the alkaloid caulerpin, a secondary metabolite of green algae of the genus Caulerpa, through an ex vivo approach with Precision-Cut Tissue Slices (PCTSs) of Mytilus galloprovincialis digestive glands. PCTSs were exposed to caulerpin (CAU) (100 µM) and fenofibrate (FFB) (100 µM) for 24, 48, and 72 h. Analyses of molecular and cellular responses pertaining to lipid metabolism suggested a similar mechanism of action between CAU and FFB in marine invertebrate species, resulting in a decrease in neutral lipid content ranging from 50 to 70%. CAU’s hypolipidemic action was not associated with increased prooxidant conditions, and slower metabolism of the natural alkaloid compared to FFB was indicated by the response of biotransformation and excretion pathways. Overall, these findings provide initial insights into the potential valorization of CAU for pharmaceutical and nutraceutical applications, highlighting the need for further investigation into its mechanisms of action, possible side effects, and interactions with other drugs. Full article

Amid global efforts to reach carbon neutrality, quantifying the cradle-to-gate carbon footprint of panel kitchen cabinets is vital for the transformation of China’s furniture industry to low carbon emissions. This study aims to quantify and compare the cradle-to-gate carbon footprints of three L-shaped panel cabinets made of different materials and to identify the most effective carbon reduction strategies for the Chinese furniture industry. The emission factor method proposed by the Intergovernmental Panel on Climate Change (IPCC) was utilized. The results revealed significant differences in the carbon footprints among the three cabinet products. Specifically, Product A, featuring a DuPont stone countertop from the United States and domestically produced double-sided decorative door panels, exhibited the highest carbon footprint which was 998.5 kgCO₂eq. Product B, with an Italian natural marble countertop and single-sided acrylic door panels, had the lowest carbon footprint which was 610.7 kgCO₂eq. The carbon footprints indicated that key stages such as cabinet bodies, countertops, hardware, and cabinet doors were substantial contributors. Raw material production and processing emerged as the primary sources of carbon emissions, with countertop transportation also contributing significantly. Based on the results, this paper proposed several carbon reduction suggestions. These include optimizing material selection, enhancing energy efficiency in raw material production and processing, optimizing transportation methods, emphasizing the carbon reduction potential of hardware components, and strengthening carbon footprint monitoring and management. Full article

The Goose/Guandong lineage of highly pathogenic avian influenza virus [A/Goose/Guangdong/1/1996(H5N1)] is the progenitor of the currently circulating Eurasian-lineage highly pathogenic avian influenza H5N1 clade 2.3.4.4b and has been the most consequential highly pathogenic avian influenza lineage globally. Despite increased reports of infections, the extent of exposure and role of wild mammals in the ecology and transmission dynamics of the virus remains poorly understood. We surveyed wild mammals in Ohio, United States to investigate the potential spillover of highly pathogenic H5N1 avian influenza clade 2.3.4.4b. While no active infections—defined as positive results indicative of viral replication and potential propagation—were detected by swab-based molecular tests, serological assays revealed antibodies against multiple avian influenza virus antigens in raccoons and opossums. Specifically, antibodies to avian influenza virus nucleoprotein were detected in 54.9% (n = 61) of samples using enzyme-linked immunosorbent assay; antibodies to Eurasian-lineage highly pathogenic avian influenza H5 clade 2.3.4.4b and North American low pathogenic avian influenza H5 were detected in 43.2% (n = 48) and 22.5% (n = 25) of samples, respectively, using virus neutralization assays; and antibodies to avian influenza virus neuraminidase were detected in 44.1% (n = 49) of samples using enzyme-linked lectin assay. All seropositive animals were sampled at Ohio marshes with previously confirmed highly pathogenic avian influenza H5N1 detections in waterfowl. These findings suggest prior exposure of wild mammals to these viruses without mortality events. Wild mammals may play an intermediary role in the mammalian adaptation of avian influenza A viruses. Therefore, ongoing surveillance of wild mammals is crucial for assessing the risk to public health. Full article

The segmentation and classification of color are crucial stages in image processing, computer vision, and pattern recognition, as they significantly impact the results. The diverse, hand-labeled datasets in the literature are applied for monochromatic or color segmentation in specific domains. On the other hand, synthetic datasets are generated using statistics, artificial intelligence algorithms, or generative artificial intelligence (AI). This last one includes Large Language Models (LLMs), Generative Adversarial Neural Networks (GANs), and Variational Autoencoders (VAEs), among others. In this work, we propose VitralColor-12, a synthetic dataset for color classification and segmentation, comprising twelve colors: black, blue, brown, cyan, gray, green, orange, pink, purple, red, white, and yellow. VitralColor-12 addresses the limitations of color segmentation and classification datasets by leveraging the capabilities of LLMs, including adaptability, variability, copyright-free content, and lower-cost data—properties that are desirable in image datasets. VitralColor-12 includes pixel-level classification and segmentation maps. This makes the dataset broadly applicable and highly variable for a range of computer vision applications. VitralColor-12 utilizes GPT-5 and DALL·E 3 for generating stained-glass images. These images simplify the annotation process, since stained-glass images have isolated colors with distinct boundaries within the steel structure, which provide easy regions to label with a single color per region. Once we obtain the images, we use at least one hand-labeled centroid per color to automatically cluster all pixels based on Euclidean distance and morphological operations, including erosion and dilation. This process enables us to automatically label a classification dataset and generate segmentation maps. Our dataset comprises 910 images, organized into 70 generated images and 12 pixel segmentation maps—one for each color—which include 9,509,524 labeled pixels, 1,794,758 of which are unique. These annotated pixels are represented by RGB, HSL, CIELAB, and YCbCr values, enabling a detailed color analysis. Moreover, VitralColor-12 offers features that address gaps in public resources such as violin diagrams with the frequency of colors across images, histograms of channels per color, 3D color maps, descriptive statistics, and standardized metrics, such as ΔE76, ΔE94, and CIELAB Chromacity, which prove the distribution, applicability, and realistic perceptual structures, including warm, neutral, and cold colors, as well as the high contrast between black and white colors, offering meaningful perceptual clusters, reinforcing its utility for color segmentation and classification. Full article

Hydrogels based on poly (methacrylic acid), carboxymethyl cellulose, and nanocellulose fibers were successfully synthesized, characterized, and tested as topical carriers for the controlled release of hydrophobic resveratrol and hydrophilic acetyl glucosamine, active substances used in skin protection. Carrier composition was confirmed by Fourier-transform infrared spectroscopy (FTIR). Scanning electron microscopy (SEM) revealed the pore size variations with alterations in the neutralization degree of methacrylic acid and changes in the pore-wall roughness caused by different mass fractions of nanocellulose. The neutralization degree of methacrylic acid had a substantial impact on the swelling behaviour, while only a slight change in swelling was caused by various contents of nanocellulose in hydrogels. Mechanical properties of the hydrogels accessed by compressive strength measurement at various percentages of strain were improved by the addition of nanocellulose. Hydrogels containing 0.5% nanocellulose achieved the highest compressive strength. The neutralization of methacrylic acid reduced the mechanical properties. Hydrogels with optimal properties showed outstanding potential in encapsulation, and controlled the simultaneous release of resveratrol and N-acetyl glucosamine. The different nature of the active compounds, however, affected the release kinetics and mechanism, as confirmed by the Korsmeyer–Peppas model. Full article

Comets are chemically rich and thermally extreme, spanning surface temperatures from ~50 K in the Oort Cloud to >1000 K for sungrazing bodies. These conditions may support key steps of prebiotic chemistry, including the synthesis of nucleic acid precursors. This study present a thermodynamic evaluation of seven candidate reactions, producing nitrogenous bases, sugars, nucleosides, and nucleotides, across the cometary temperature spectrum, 50–1000 K. Purine nucleobase synthesis, including adenine formation via aminoacetonitrile polymerization and HCN polymerization, is strongly exergonic at all temperatures. Sugar formation from formaldehyde is also exergonic, while intermediate pathways, e.g., 2-aminooxazole synthesis, become thermodynamically viable only above ~700 K. Nucleoside formation is thermodynamically neutral at low T but becomes favorable at elevated temperatures, whereas phosphorylation to AMP, i.e., adenosine-monophosphate, a nucleotide serving as a critical regulator of cellular energy status, remains highly endergonic under the entire T range studied. My analysis suggests that, under standard-state assumptions, comets can thermodynamically support formation routes of nitrogenous bases and simple sugars but not a complete nucleotide assembly. This supports a dual-phase origin scenario, where comets act as molecular reservoirs, with further polymerization and biological activation occurring post-delivery on planetary surfaces. Importantly, these findings represent purely thermodynamic assessments under standard-state assumptions and do not address kinetic barriers, catalytic influences, or adsorption effects on ice or mineral surfaces. The results should therefore be viewed as a baseline map of feasibility, subject to modifications in more complex chemical environments. Full article

Understanding strawberry thermal resilience is crucial for optimizing cultivation in the face of climate change. However, its thermal niche remains underexplored. We assessed the thermal vulnerability of leaves and flowers in four day-neutral strawberry varieties cultivated in Chile and evaluated potential shifts in their suitable cultivation areas under warming scenarios. Tolerance to freezing, heat (LT₅₀), and Thermal Tolerance Breadth (TTB) were determined, and habitat suitability was modeled using MaxEnt under two climate change projections and time periods. Heat LT₅₀ of leaves and flowers was similar across strawberry varieties, averaging 56 °C. Conversely, the average freezing LT₅₀ of flowers was 12 K less negative than that of leaves across varieties. The TTB of leaves was generally broader than that of flowers, except for San Andreas, with Monterrey displaying the broadest TTB difference (14.6 K). Climatic models indicated slight southward shifts in suitable cultivation areas under warming in Chile and globally. Nevertheless, the potential for strawberry cultivation in the more southern regions will depend on the development and implementation of cultivation strategies that effectively minimize the risk of freezing damage to the flowers. This highlights the need to plan cultivation areas according to each variety’s thermal tolerance to enhance resilience and sustainability in a changing climate. Full article

The anti-correlation between the equivalent width of the neutral narrow Fe K$\alpha$ line and the 2–10 keV luminosity (the Iwasawa–Taniguchi effect) in the nuclear regions of active galactic nuclei has been debated in recent years. With the high angular resolution of Chandra, an increasing number of Compton-thick sources have been found to show extended narrow Fe K$\alpha$ emission on scales from tens of parsecs to kiloparsecs, attributed to reprocessing of nuclear radiation by surrounding Compton-thick material. We analyze eight Compton-thick sources with prominent extended Fe K$\alpha$ emission. We confirm the Iwasawa–Taniguchi effect in the extended component relative to the reflection spectrum, with a steeper slope, indicating reduced production efficiency of neutral Fe K$\alpha$ photon outside the nucleus. Both the reflection spectrum and Fe K$\alpha$ luminosities correlate positively with intrinsic AGN luminosity, suggesting that the nucleus drives the extended emission. Finally, we find a linear relationship between redshift and the equivalent width of the nuclear Fe K$\alpha$ line, with no such trend in the extended component. Full article

Background: We investigated the effect of mental fatigue (MF) on artistic swimmers’ (AS) physiological and cognitive responses and physical and technical AS performance. Methods: Twelve young female ASs completed a free team routine (FT) involving 4 × 4 min trials separated by a 2 min rest in two sessions a week apart. Pre- and post-FT, athletes performed three “boosts” for vertical displacement and a 50 m maximum effort front crawl swim. Before each session, a 30 min MF test (Stroop condition; SC) or an emotionally neutral video (control condition; CC) were implemented in counterbalanced order. Choice reaction time and central executive function tests were applied before and after the completion of both conditions. Technical performance was evaluated by five official judges. Heart rate was continuously recorded, whilst blood lactate was measured before the start and after the second and fourth FT. Rating of perceived exertion (RPE) was recorded after each FT. Results: Technical performance scores during FT were lower in SC than CC (6.82 ± 0.92 vs. 7.17 ± 0.69, p < 0.001, and d = 0.43). The choice reaction time was decreased by 3.4 ± 9.3% in SC but increased 4.4 ± 8.1% in CC (p < 0.05). Central executive function was no different between conditions despite a medium effect size in SC (d = 0.58). The “boost” height was lower in SC compared to CC (70 ± 5 vs. 72 ± 5 cm, p < 0.05, and d = 0.45). Heart rate, RPE, and 50 m time did not differ between conditions (p > 0.05), but blood lactate was higher in the CC compared to SC (5.3 ± 2.6 vs. 4.6 ± 2.9 mmol/l, p < 0.05, and d = 0.25). Conclusion: Mental fatigue may impair technical performance during FT, primarily via cognitive dysfunction, with reduced glycolytic activation as a potential additional factor. Full article

Viologens are promising candidates for next-generation electrochromic devices due to their reversible color changes, low operating voltages, and structural tunability. However, their practical performance is often constrained by limited color range, stability issues, and poor charge delocalization. In this study, we present a detailed density functional theory (DFT) and time-dependent DFT (TD-DFT) investigation of asymmetric viologens based on the Benzyl-4,4′-dipyridyl-R (BnV-R) framework. A series of electron-donating and electron-withdrawing substituents (CN, COOH, PO₃H₂, CH₃, OH, NH₂) were introduced via either benzyl or phenyl linkers. Geometry optimizations for neutral, radical cationic, and dicationic states were performed at the CAM-B3LYP/6-31+G(d,p) level with C-PCM solvent modeling. Electronic structure, frontier orbital distributions, and redox potentials were correlated with substituent type and linkage mode. Natural Bond Orbital analysis showed that electron-withdrawing groups stabilize reduced states, while electron-donating groups enhance intramolecular charge transfer and switching kinetics. TD-DFT calculations revealed significant bathochromic and hyperchromic shifts dependent on substitution patterns, with phenyl linkers promoting extended conjugation and benzyl spacers minimizing aggregation. Radical cation stability, quantified via ΔE_red and comproportionation constants, highlighted cyano- and amine-substituted systems as particularly promising. These insights provide predictive design guidelines for tuning optical contrast, coloration efficiency, and electrochemical durability in advanced electrochromic applications. Full article

Building energy conservation through the development of transparent thermal insulation materials that selectively block near-infrared radiation while maintaining visible light transmittance has emerged as a key strategy for global carbon neutrality. WO₃ is a semiconductor oxide with near-infrared absorption capabilities. However, the limited absorption efficiency and narrow spectral coverage of pure WO₃ significantly diminish its overall transparent thermal insulation performance, thereby restricting its practical application in energy-saving glass. Therefore, this study successfully prepared Sn-doped WO₃ materials using a one-step hydrothermal method, controlling the Sn:W molar ratio from 0.1:1 to 2.0:1. Through evaluation of transparent thermal insulation performance of a series of Sn-doped WO₃ samples, we found that Sn:W = 0.9:1 exhibited the most excellent performance, with NIR shielding efficiency reaching 93.9%, which was 1.84 times higher than pure WO₃. Moreover, this sample demonstrated a transparent thermal insulation index (THI) of 4.38, representing increases of 184% and 317%, respectively, compared to pure WO₃. These enhancements highlight the strong NIR absorption capability achieved by Sn-doped WO₃ through structural regulation. When Sn doping reaches a certain concentration, it triggers a structural transformation of WO₃ from monoclinic to tetragonal phase. After reaching the critical solubility threshold, phase separation occurs, forming a multiphase structure composed of a Sn-doped WO₃ matrix and secondary SnO₂ and WSn₀.₃₃O₃ phases, which synergistically enhance oxygen vacancy formation and W⁶⁺ to W⁵⁺ reduction, achieving excellent NIR absorption through small polaron hopping and localized surface plasmon resonance effects. This study provides important insights for developing high-performance transparent thermal insulation materials for energy-efficient buildings. Full article

Silicon carbide (SiC) is widely used in high-power, high-frequency, and high-temperature electronic devices due to its excellent physical and chemical properties. However, its high hardness and chemical inertness make it difficult to achieve efficient and damage-free ultra-smooth surface processing with traditional polishing methods. This paper proposes a novel ultrasonic-assistance microarc plasma polishing (UMPP) method for high-quality and high-efficiency polishing of 4H-SiC. This study introduces a novel Ultrasonic-assisted Microarc Plasma Polishing (UMPP) method for achieving high-efficiency, high-quality surface finishing of 4H-SiC. The technique innovatively combines ultrasonic vibration with microarc plasma oxidation in a neutral NaCl electrolyte to overcome the limitations of conventional polishing methods. The UMPP process first generates a soft, porous oxide layer (primarily SiO₂) on the SiC surface through plasma discharge, which is then gently removed using soft CeO₂ abrasives. The key finding is that ultrasonic assistance synergistically enhances the oxidation process, leading to a thicker and more porous oxide layer that is more easily removed. Experimental results demonstrate that UMPP achieves a remarkably high material removal rate (MRR) of 21.7 μm/h while simultaneously delivering an ultra-smooth surface with a roughness (Ra) of 0.54 nm. Compared to the process without ultrasonic assistance, UMPP provides a 21.9% increase in MRR and a 28% reduction in Ra. This work establishes UMPP as a highly promising and efficient polishing strategy for hard and inert materials like SiC, offering a superior combination of speed and surface quality that is difficult to achieve with existing techniques. Full article