Search Results (17)

A systematic review was conducted to assess the effects of microgravity and space radiation on astronauts’ oral health. This review aimed to determine if these conditions increase the risk of dental and periodontal diseases, identify pre-mission dental care strategies, and specify relevant dental emergencies for astronauts to manage during missions. Following PRISMA guidelines, the review was registered on PROSPERO (CRD42023472765). Databases including PubMed, Scopus, Web of Science, Cochrane Library, and OVID Medline were searched. Of the 13 studies identified, 7 were eligible for qualitative synthesis. The included studies revealed that space conditions compromise oral health. Findings indicate changes in saliva composition, with a significant decline in salivary lysozyme levels during missions lasting 28 to 84 days. Salivary IgA levels also increased before and peaked after flights (microgravity alters fluid shear and protein folding). Viral reactivation was a key finding, with latent viruses such as Epstein–Barr virus (EBV), cytomegalovirus (CMV), and varicella zoster virus (VZV) being reactivated during missions (immune suppression and gene expression shifts under spaceflight stress). Data from a study found that 50% of crew members shed viruses in their saliva or urine, and 38% tested positive for herpesviruses. The included studies also documented alterations in the oral microbiome, including increased gastrointestinal and decreased nasal microbial diversity. This suggests alterations in salivary biomarkers, viral shedding, and microbiome changes in astronauts during long-duration missions. These changes appear associated with immune dysregulation and stress, but causality remains uncertain due to observational designs, small heterogeneous samples, and confounding factors. Although current evidence is indicative rather than definitive, these findings highlight the need for preventive dental measures prior to missions and preparedness for managing oral emergencies in-flight. Future studies should address the mechanistic separation of microgravity and radiation effects, with implications for upcoming Moon and Mars missions. Full article

All forms of life on Earth are dependent on microbes. In vertebrates, the oral cavity and the gastrointestinal tract are colonized by large numbers of microorganisms, which includes species from many life forms: bacteria, fungi, archaea, and protozoa; this collection of microorganisms are commonly referred to as the microbiome. This article reviews the literature, providing a summary of oral and gastrointestinal microbial composition in health and during various disease states. Interactions are explored between microbes in the oral cavity and gastrointestinal tract. This study explores the influence of changed diet, lifestyle, and living conditions in order to examine the link between the oral and gastrointestinal microbiome and changes in their composition, and how this may affect human health. This study also investigates potential microbiome dysbiosis and disease causation in the space environment. The role of prebiotics, probiotics and postbiotics in oral health is discussed, with extension into the unexplored territory of probable oral and gastrointestinal bacterial population changes during long-duration (exportation class) space missions (ECSM). Full article

The Harrist Church in Ivory Coast, West Africa, emerged from the ministry of Liberian William Wadé Harris who baptized between 100,000 and 200,000 people during his eighteen-month evangelistic tour, 1913–1915. This story is full of linguistic complexities and anomalies. Harris himself spoke only English and his own local Liberian Glebo language. He was therefore compelled to work through expatriate English-speaking merchants, knowledgeable of and conversant in local languages, as interpreters and translators in addressing the twelve ethnic groups who heard and accepted his message. Harris encouraged new converts to compose hymns in their own indigenous languages by transforming musical genres embedded in their local musical traditions. Additionally fascinating is that during this early colonial period, the twelve ethnic groups impacted by Harris’s ministry lived in almost total isolation from each other and developed their own hymn traditions for thirty-five years (1914–1949), unaware of the existence of churches and worship patterns in neighboring ethnic districts. Only in 1949 did they suddenly become acquainted with the broader, multi-musical, multilingual reality of the Harrist movement. Since then, individual musicians and choirs from local congregations have gradually begun to sing a few of each other’s songs, though the challenge of becoming a truly multicultural, multiethnic church remains a work in progress. Documentation of these developments include written colonial and early Protestant and Catholic missionary sources and a large number of eye-witness interviews. Primary research methods employed here come from four intersecting disciplines and theoretical frameworks: orality studies, with particular focus on oral sources in constructing historical narrative; religious phenomenology; mission history; and ethnodoxological research. Full article

The Torah is central to Judaism. Jesus’s relationship with it sparks conflict with Christianity. Some Jews think that Jesus violated the Torah, while some Christians believe that he sinlessly followed it. This clash escalated on 22 June 2023, when Ultra-Orthodox Jews protested a Messianic convention in Jerusalem. Social media videos and comments highlighted Jesus’s purported Torah compliance, placing Matthew 5:17 at the center stage. The comments proved indicative of the gaps within the literature as neither determined all the unique Written and Oral Torahic/legal issues raised within the Gospels nor quantified the extent of Jesus’s compliance. To address these gaps, this study employs artificial intelligence (LDA), statistics, and legal analysis and exegesis to determine Jesus’s compliance with the Torah, Mishnah, Talmud, and Mishneh Torah. The findings show the Gospels’ consensus: Mark, Luke, and John reflect that Jesus was non-Torah-compliant (14.80, 43.80, and 0.00%, respectively); Matthew states otherwise (70.80%). Overall, the study revealed that Jesus kept 79 of 162 Written and Oral Torah laws (48.80%). This study has significant implications for Christian doctrines, the definition(s) of sin, and the missionizing ethnoreligion members and serves as a case study that illustrates AI’s impact on religious authority (i.e., clergy, scholarship, and doctrines). Full article

From his arrival in China in 1888 to his departure in 1930, Canadian missionary, Donald MacGillivray (季理斐), was in China for more than 40 years. According to changes in the Chinese missionary situation, the key target of his mission was frequently adjusted. From his initial work in the early days in North Honan, to his work with officials and intellectuals in Shanghai in the late Qing Dynasty, then to students, women, and children in the Republic of China, Donald MacGillivray continued to preach to both the masses and the elites. His approach was flexible, ranging from oral preaching to academic publications. Relying on his interpersonal network, MacGillivray paid close attention to the social changes occurring in modern China. An evaluation of his activities in China can not only reveal the impact of individual missionaries in the process of Western learning and the transformation of Chinese knowledge in modern times, but also provide insight into the integration of Christianity into the indigenization process of China. Full article

One of the main challenges to be faced in deep space missions is to protect the health and ensure the maximum efficiency of the crew by preparing methods of prevention and in situ diagnosis. Indeed, the hostile environment causes important health problems, ranging from muscle atrophy, osteopenia, and immunological and metabolic alterations due to microgravity, to an increased risk of cancer caused by exposure to radiation. It is, therefore, necessary to provide new methods for the real-time measurement of biomarkers suitable for deepening our knowledge of the effects of space flight on the balance of the immune system and for allowing the monitoring of the astronaut’s health during long-term missions. APHRODITE will enable human space exploration because it fills this void that affects both missions in LEO and future missions to the Moon and Mars. Its scientific objectives are the design, production, testing, and in-orbit demonstration of a compact, reusable, and reconfigurable system for performing the real-time analysis of oral fluid samples in manned space missions. In the frame of this project, a crew member onboard the ISS will employ APHRODITE to measure the selected target analytes, cortisol, and dehydroepiandrosterone sulfate (DHEA-S), in oral fluid, in four (plus one additional desired session) separate experiment sessions. The paper addresses the design of the main subsystems of the analytical device and the preliminary results obtained during the first implementations of the device subsystems and testing measurements on Earth. In particular, the system design and the experiment data output of the lab-on-chip photosensors and of the front-end readout electronics are reported in detail along with preliminary chemical tests for the duplex competitive CL-immunoassay for the simultaneous detection of cortisol and DHEA-S. Different applications also on Earth are envisaged for the APHRODITE device, as it will be suitable for point-of-care testing applications (e.g., emergency medicine, bioterrorism, diagnostics in developing countries, etc.). Full article

This paper examines a female Yiguandao (一貫道) leader’s lifelong history of practising the faith: Huang Shih-Yen (黃世妍, 1940–), the Elder (qianren 前人) of the subdivision Baoguang Chongzheng (寶光崇正). The journey begins with her conversion to Yiguandao and devotion to its religious practices, followed by her assuming leadership of a subdivision and expanding overseas proselytising missions. Female leaders are not uncommon in modern and contemporary Yiguandao; however, Huang presents a different image from that of conventional female leadership in popular Chinese religions. First, unlike most female leaders who refuse marriage, Huang is a wife and mother; she has shouldered both sacred and secular duties. Second, when she gained leadership, her husband, who was also an Elder of Baoguang Chongzheng, followed and assisted her in managing the temple affairs. Third, she was personally and actively involved in missionary outreach rather than being a spiritual mentor. The materials used to investigate Huang’s life history were predominantly oral history and my own participant observations. This paper illustrates that women’s contributions to religious practices may be on par with their male counterparts, but their stories have been overlooked. Full article

Much has been written about the theological, cultural, and social foundations of the Zionist movement and its historical development. While scholars have discussed the immigration of the first Hasidim to the Land of Israel in the late eighteenth century, little attention has been paid to the Hasidic leaders who were active in Mandatory Palestine between the two World Wars, some of whom had a positive attitude toward Zionism. My article addresses this scholarly gap and focuses on one figure: the Rebbe painter (Admor ha-Tsayar) Avraham Yaakov Shapira (1886–1962) of the Drohobych dynasty. In this first academic study examining his sermon book Netivot Shalom, I will show how he coherently used the Hasidic homiletic style, as well as textual and oral traditions, to reinforce a commitment to the settlement of Zion and cultivate a positive attitude toward the Jewish people, including the secular settlers. Following in his father’s footsteps, he fervently taught that the way to the hearts of secular settlers was not through rebuke, but through peace, shared mission, and unity. He viewed the activists’ approach to settling Zion as an act of divine action revealing the “new Torah”, and saw their success as a miracle manifested through nature. Full article

Medicinal plants are rich sources of valuable molecules with various profitable biological effects, including antimicrobial activity. The advantages of herbal products are their effectiveness, relative safety based on research or extended traditional use, and accessibility without prescription. Extensive and irrational usage of antibiotics since their discovery in 1928 has led to the increasing expiration of their effectiveness due to antibacterial resistance. Now, medical research is facing a big and challenging mission to find effective and safe antimicrobial therapies to replace inactive drugs. Over the years, one of the research fields that remained the most available is the area of natural products: medicinal plants and their metabolites, which could serve as active substances to fight against microbes or be considered as models in drug design. This review presents selected flavonoids (such as apigenin, quercetin, kaempferol, kurarinone, and morin) and tannins (including oligomeric proanthocyanidins, gallotannins, ellagitannins, catechins, and epigallocatechin gallate), but also medicinal plants rich in these compounds as potential therapeutic agents in oral infectious diseases based on traditional usages such as Agrimonia eupatoria L., Hamamelis virginiana L., Matricaria chamomilla L., Vaccinium myrtillus L., Quercus robur L., Rosa gallica L., Rubus idaeus L., or Potentilla erecta (L.). Some of the presented compounds and extracts are already successfully used to maintain oral health, as the main or additive ingredient of toothpastes or mouthwashes. Others are promising for further research or future applications. Full article

Human alpha herpesviruses herpes simplex virus (HSV-1) and varicella zoster virus (VZV) establish latency in various cranial nerve ganglia and often reactivate in response to stress-associated immune system dysregulation. Reactivation of Epstein Barr virus (EBV), VZV, HSV-1, and cytomegalovirus (CMV) is typically asymptomatic during spaceflight, though live/infectious virus has been recovered and the shedding rate increases with mission duration. The risk of clinical disease, therefore, may increase for astronauts assigned to extended missions (>180 days). Here, we report, for the first time, a case of HSV-1 skin rash (dermatitis) occurring during long-duration spaceflight. The astronaut reported persistent dermatitis during flight, which was treated onboard with oral antihistamines and topical/oral steroids. No HSV-1 DNA was detected in 6-month pre-mission saliva samples, but on flight day 82, a saliva and rash swab both yielded 4.8 copies/ng DNA and 5.3 × 10⁴ copies/ng DNA, respectively. Post-mission saliva samples continued to have a high infectious HSV-1 load (1.67 × 10⁷ copies/ng DNA). HSV-1 from both rash and saliva samples had 99.9% genotype homology. Additional physiological monitoring, including stress biomarkers (cortisol, dehydroepiandrosterone (DHEA), and salivary amylase), immune markers (adaptive regulatory and inflammatory plasma cytokines), and biochemical profile markers, including vitamin/mineral status and bone metabolism, are also presented for this case. These data highlight an atypical presentation of HSV-1 during spaceflight and underscore the importance of viral screening during clinical evaluations of in-flight dermatitis to determine viral etiology and guide treatment. Full article

Analog space missions were created to study the human factor in extraordinary conditions that would occur in future space habitats. Isolation has been shown to cause stress and disrupt individuals’ daily routine, which can also affect their oral hygiene and lead to an increased risk of dental caries and gingivitis. The astronauts’ specific freeze-dried diet is associated with “lazy” chewing, potential dehydration and vitamin A deficiency, which may adversely affect their saliva. The aim of this study is to investigate the influence of the freeze-dried diet on selected oral hygiene indicators in analog astronauts (AA) enduring strict isolation conditions during six consecutive analog space missions at the LunAres Research Station. During the experiment the oral hygiene and gingival inflammation status measurements were conducted on the group of AAs at the beginning and at the end of each mission. Measurements included four oral hygiene indicators: API, sOHI, PI by Silness and Loe and GBI by Ainamo and Bay. Each AA’s individual scores were noted and analyzed. Statistically significant reduction in the amount of plaque and intensity of gingival bleeding was observed over the course of the study, which could indicate positive results of applied oral hygiene procedures despite unfavorable dietary and stressful isolation conditions. Full article

Translated western hymns have a bad reputation in missiology. The term “translated” seems to convey a less than authentic expression of Christian faith. However, that was not how it happened when the Lisu of southwest China were evangelized by missionaries from the China Inland Mission in the 1920s and 1930s. The Lisu people exerted much more agency over their translated western hymns than the term “translated” implies. While the kernel of melody and message remained intact, four-part harmonies replaced unison singing. A cappella replaced piano or organ accompaniment. Phrases meaningful in a Victorian context were transformed into phrases meaningful in a Lisu mountain context. Abstract theological terms were replaced by concrete phrases. Western rhyming schemes were laid aside and Lisu poetic couplets were used instead. The end result is that in the everyday arena, in the practical living out of what it means to be a Christian for a communal and still largely oral-preference people such as the Lisu, the Lisu Christian hymns are the centerpiece of worship and devotion, of prayer and penitence. In other words, in the process of cross-cultural transmission, the Lisu hymns were not so much translated, as they were transformed. Full article

Military personnel of all armed forces receive multiple vaccinations and have been doing so since long ago, but relatively few studies have investigated the possible negative or positive interference of simultaneous vaccinations. As a contribution to fill this gap, we analyzed the response to the live trivalent measles/mumps/rubella (MMR), the inactivated hepatitis A virus (HAV), the inactivated trivalent polio, and the trivalent subunits influenza vaccines in two cohorts of Italian military personnel. The first cohort was represented by 108 students from military schools and the second by 72 soldiers engaged in a nine-month mission abroad. MMR and HAV vaccines had never been administered before, whereas inactivated polio was administered to adults primed at infancy with a live trivalent oral polio vaccine. Accordingly, nearly all subjects had baseline antibodies to polio types 1 and 3, but unexpectedly, anti-measles/-mumps/-rubella antibodies were present in 82%, 82%, and 73.5% of subjects, respectively (43% for all of the antigens). Finally, anti-HAV antibodies were detectable in 14% and anti-influenza (H1/H3/B) in 18% of the study population. At mine months post-vaccination, 92% of subjects had protective antibody levels for all MMR antigens, 96% for HAV, 69% for the three influenza antigens, and 100% for polio types 1 and 3. An inverse relationship between baseline and post-vaccination antibody levels was noticed with all the vaccines. An excellent vaccine immunogenicity, a calculated long antibody persistence, and apparent lack of vaccine interference were observed. Full article

Study Design: Descriptive review article. Objective: The purpose of this article is to provide guidelines and recommendations for how to safely resume dental and craniomaxillofacial STSMs. The following considerations will be discussed: the need for extensive collaboration between organizations and local leadership, the importance of COVID-19 testing, use and management of personal protective equipment, team selection and training, social distancing protocols, and criteria for patient and case selection. Methods: A literature review was completed, identifying resources and current data regarding the safe resumption clinical activities during the COVID-19 pandemic. Results: At this time, there are no protocols developed regarding the safe resumption of STSMs. Primary resources, including the CDC, WHO, and FDA should be closely monitored so that developed protocols from these recommendations reflect the latest information. Conclusion: This paper outlines general considerations and recommendations for dentists, oral health specialists, and craniomaxillofacial surgeons seeking to safely resume STSMs. These recommendations are designed to minimize the risk of exposure to COVID-19 by reinforcing social distancing protocols, reviewing criteria for patient and case selections, encouraging collaboration between organizations and local leadership, and team training. These guidelines should be tailored to fit the needs of each individual mission while keeping the safety as the main objective. Full article

The pages of early modern natural histories expose the plasticity of the natural world, and the variegated nature of the encounter between human and animal in this period. Descriptions of the flora and fauna reflect this kind of negotiated encounter between the world that is seen, that which is heard about, and that which is constructed from the language of the sacred text of scripture. The natural histories of Greenland that form the basis of this analysis exemplify the complexity of human–animal encounters in this period, and the intersections that existed between natural and unnatural, written authority and personal testimony, and culture, belief, and ethnography in natural histories. They invite a more nuanced understanding of the ways in which animals and people interact in the making of culture, and demonstrate the contribution made by such texts to the study of animal encounters, cultures, and concepts. This article explores the intersection between natural history and the work of Christian mission in the eighteenth century, and the connections between personal encounter, ethnography, history, and oral and written tradition. The analysis demonstrates that European natural histories continued to be anthropocentric in content and tone, the product of what was believed, as much as what was seen. Full article