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Keywords = piezoelectric antibacterial gel

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30 pages, 12571 KB  
Article
Injectable and Conductive Polyurethane Gel with Load-Responsive Antibiosis for Sustained Root Canal Disinfection
by Bo Mu, Xiaoyu Lei, Yinglong Zhang, Jingzheng Zhang, Qingda Du, Yuping Li, Dongyu Huang, Li Wang, Jidong Li, Yubao Li and Yi Zuo
Gels 2025, 11(5), 346; https://doi.org/10.3390/gels11050346 - 7 May 2025
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Abstract
To address the limitations of conventional antibacterial therapies, we developed an injectable, conductive polyurethane-based composite gel system for sustained root canal disinfection. This gel incorporates piezoelectric nanoparticles (n-BaTiO3) and conductive segments (aniline trimer, AT) within a polyurethane matrix, which synergistically interact [...] Read more.
To address the limitations of conventional antibacterial therapies, we developed an injectable, conductive polyurethane-based composite gel system for sustained root canal disinfection. This gel incorporates piezoelectric nanoparticles (n-BaTiO3) and conductive segments (aniline trimer, AT) within a polyurethane matrix, which synergistically interact with a static antimicrobial agent (n-ZnO) to achieve dynamic, mechano-responsive antibacterial activity. Under cyclic compression (simulating mastication), the piezoelectric gels exhibited enhanced electroactivity via the mechano-electric coupling effect, generating 2-fold higher voltage and a 1.8–1.9× increase in current compared to non-piezoelectric controls. The dynamic electroactivity of the gels enabled superior long-term performance, achieving 92–97% biofilm eradication, significantly higher than the static n-ZnO-only gel (88%). XPS and UV-vis spectroscopy analyses confirmed mechano-electrochemically amplified reactive oxygen species (ROS) generation, which contributed to improved biofilm disruption. The ISO-compliant gel provides durable, load-responsive disinfection while maintaining good biocompatibility, offering a promising solution to prevent post-treatment reinfection. Full article
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