Search Results (1,518)

The female reproductive system represents a highly complex regulatory network governing critical physiological functions, encompassing reproductive capacity and endocrine regulation that maintains female physiological homeostasis. The in vitro simulation system provides a novel tool for biomedical research and can be used as physiological and pathological models to study the female reproductive system. Recent advances in this technology have evolved from 2D and 3D printing to organ-on-a-chip (OOC) and microfluidic systems, which has emerged as a transformative platform for modeling the female reproductive system. These microphysiological systems integrate microfluidics, 3D cell culture, and biomimetic scaffolds to replicate key functional aspects of reproductive organs and tissues. They have enabled precise simulation of hormonal regulation, embryo-endometrium interactions, and disease mechanisms such as endometriosis and gynecologic cancers. This review highlights the current state of female reproductive OOCs, including ovary-, uterus-, and fallopian tube-on-a-chip system, their applications in assisted reproduction and disease modeling, and the technological hurdles to their widespread application. Though significant barriers remain in scaling OOCs for high-throughput drug screening, standardizing protocols for clinical applications, and validating their predictive value against human patient outcomes, OOCs have emerged as a transformative platform to model complex pathologies, offering unprecedented insights into disease mechanisms and personalized therapeutic interventions. Future directions, including multi-organ integration for systemic reproductive modeling, incorporation of microbiome interactions, and clinical translation for mechanisms of drug action, will facilitate unprecedented insights into reproductive physiology and pathology. Full article

This study presents the development and deployment of a modular digital twin system designed to enhance sustainable facility management within a smart campus context. The system was implemented at the Faculty of Engineering, Chiang Mai University, and integrates 3D spatial modeling, real-time environmental and energy sensor data, and multiscale dashboard visualization. Grounded in stakeholder-driven requirements, the platform emphasizes energy management, which is the top priority among campus administrators and technicians. The development process followed a four-phase methodology: (1) stakeholder consultation and requirement analysis; (2) physical data acquisition and 3D model generation; (3) sensor deployment using IoT technologies with NB-IoT and LoRaWAN protocols; and (4) real-time data integration via Firebase and standardized APIs. A suite of dashboards was developed to support interactive monitoring across faculty, building, floor, and room levels. System testing with campus users demonstrated high usability, intuitive spatial navigation, and actionable insights for energy consumption analysis. Feedback indicated strong interest in features supporting data export and predictive analytics. The platform’s modular and hardware-agnostic architecture enables future extensions, including occupancy tracking, water monitoring, and automated control systems. Overall, the digital twin system offers a replicable and scalable model for data-driven facility management aligned with sustainability goals. Its real-time, multiscale capabilities contribute to operational transparency, resource optimization, and climate-responsive campus governance, setting the foundation for broader applications in smart cities and built environment innovation. Full article

Modern healthcare systems are under growing strain from aging populations, urbanization, and rising chronic disease burdens, creating an urgent need for real-time monitoring and informed decision-making. This survey examines how the convergence of Integrated Sensing and Communication (ISAC) and digital-twin technologies can meet that need by analyzing how ISAC unifies sensing and communication to gather and transmit data with high timeliness and reliability and how digital-twin platforms use these streams to maintain continuously updated virtual replicas of patients, devices, and care environments. Our synthesis compares ISAC frequency options across sub-6 GHz, millimeter-wave, and terahertz bandswith respect to resolution, penetration depth, exposure compliance, maturity, and cost, and it discusses joint waveform design and emerging 6G architectures. It also presents reference architecture patterns that connect heterogeneous clinical sensors to ISAC links, data ingestion, semantic interoperability pipelines using Fast Healthcare Interoperability Resources (FHIR) and IEEE 11073, and digital-twin synchronization, and it catalogs clinical and operational applications, together with validation and integration requirements. We conduct a targeted scoping review of peer-reviewed literature indexed in major scholarly databases between January 2015 and July 2025, with inclusion restricted to English-language, peer-reviewed studies already cited by this survey, and we apply a transparent screening and data extraction procedure to support reproducibility. The survey further reviews clinical opportunities enabled by data-synchronized twins, including personalized therapy planning, proactive early-warning systems, and virtual intervention testing, while outlining the technical, clinical, and organizational hurdles that must be addressed. Finally, we examine workflow adaptation; governance and ethics; provider training; and outcome measurement frameworks such as length of stay, complication rates, and patient satisfaction, and we conclude that by highlighting both the integration challenges and the operational upside, this survey offers a foundation for the development of safe, ethical, and scalable data-driven healthcare models. Full article

This study aims to identify the key factors contributing to time and cost deviations in educational infrastructure projects in Colombia, using a data-driven approach based on open government datasets. By examining 175 procurement records from Colombia’s public data platform, the research seeks to uncover patterns and variables that influence project performance, offering a transparent alternative to traditional expert-based assessments. The results show an average time deviation of 77.73% and a cost deviation of 22.17%, with a significant correlation between both metrics. Project type, contract value, and process type were significant for both deviations. Additional cost-related factors included initial duration, award growth, and number of bidders, while time deviations were influenced by project intensity and time suspended. These findings highlight the need for integrated planning and procurement strategies to improve efficiency in public infrastructure delivery. Although the methodology ensures robustness, limitations include the focus on finalized educational projects and the exclusion of qualitative factors such as stakeholder behavior and site-specific challenges. The insights are valuable for policymakers, public sector managers, and researchers seeking to enhance infrastructure outcomes through evidence-based decision-making and better resource allocation. Full article

This study presents a flutter answer analysis of the Romanian IAR-99 HAWK advanced trainer aircraft equipped with multiple external store configurations. A high-fidelity finite element model (FEM) of the complete aircraft, including pylons and external stores, was coupled with a Doublet Lattice Method (DLM) aerodynamic model. The aeroelastic framework was validated against Ground Vibration Test (GVT) data to ensure structural accuracy. Four representative configurations were assessed: (A) RS-250 drop tanks on inboard pylons and PRN 16 × 57 unguided rocket launchers on outboard pylons; (B) four B-250 bombs; (C) eight B-100 bombs mounted on twin racks; and (D) a hybrid layout with B-100 bombs inboard and PRN 32 × 42 launchers outboard. Results show that spanwise distribution governs aeroelastic stability more strongly than total carried mass. Distributed stores lower wing-bending frequencies and densify the modal spectrum, producing critical pairs and subsonic crossings near M ≈ 0.82 at sea level, whereas compact heavy loads remain subsonic-stable. A launcher-specific modal family around ≈29.8 Hz is also identified in the hybrid layout. The validated FEM–DLM framework captures store-driven mode families (≈4–7 Hz) and provides actionable guidance for payload placement, certification, and modernization of the IAR-99 and similar platforms. Full article

Humanized mouse models offer human-specific platforms for investigating complex host–pathogen interactions, addressing shortcomings of conventional preclinical models that often fail to replicate human immune responses accurately. This integrative review examines the intersection of advanced morphological phenotyping and artificial intelligence (AI) to enhance predictive capacity and translational relevance in infectious disease research. A structured literature search was conducted across PubMed, Scopus, and Web of Science (2010–2025), applying defined inclusion and exclusion criteria. Evidence synthesis highlights imaging modalities, AI-driven phenotyping, and standardization strategies, supported by comparative analyses and quality considerations. Persistent challenges include variability in engraftment, lack of harmonized scoring systems, and ethical governance. We propose recommendations for standardized protocols, risk-of-bias mitigation, and collaborative training frameworks to accelerate adoption of these technologies in translational medicine. Full article

Green development serves as the foundation for high-quality development. As one of the most commonly used macroeconomic regulation policies, taxation is a crucial component of the modernization of the national governance system and governance capacity, playing an irreplaceable role in accelerating the comprehensive green transformation of economic and social development. Based on panel data from 30 provinces (municipalities, autonomous regions) from 2011 to 2021, this paper empirically analyzes the impact of green taxation on green transformation. The study finds that green taxation can significantly promote urban green transformation, and there is significant regional heterogeneity in the impact of green taxation on urban green transformation. Mechanism tests further reveal that green taxation influences the scale of urban investment platform debt, thereby driving urban green transformation. Full article

Digital contact-tracing (CT) systems differ in how they process risk and expose data, and the centralized–decentralized dichotomy obscures these choices. We propose a modular six-model classification and evaluate 18 platforms across 12 countries (July 2020–April 2021) using a 24-indicator rubric spanning privacy, security, functionality, and governance. Methods include double-coding with Cohen’s $\mathsf{\kappa }$ for inter-rater agreement and a 1000-draw weight-sensitivity check; assumptions and adversaries are stated in a concise threat model. Results: No single model dominates; Bulletin Board and Custodian consistently form the top tier on privacy goals, while Fully Centralized eases verification/notification workflows. Timelines show rapid GAEN uptake and near-contemporaneous open-source releases, with one late outlier. Contributions: (i) A practical, generalizable classification that makes compute-locus and data addressability explicit; (ii) a transparent indicator rubric with an evidence index enabling traceable scoring; and (iii) empirically grounded guidance aligning deployments with goals G1–G3 (PII secrecy, notification authenticity, unlinkability). Limitations include reliance on public documentation and architecture-level (not mechanized) verification; future work targets formal proofs and expanded double-coding. The framework and findings generalize beyond COVID-19 to privacy-preserving digital-health workflows. Full article

Urban regeneration has increasingly become a global strategy for promoting sustainable urban development, with the renewal of deteriorating residential communities serving as a key dimension of this process. Within the framework of a people-centered development paradigm, growing attention has been directed toward the necessity of securing residents’ satisfaction in community renewal initiatives. This study employs advanced textual analysis of resident submissions collected from government–citizen interaction platforms to investigate the determinants of satisfaction with renewal projects. Leveraging the semantic comprehension capabilities of large language models (LLMs), we identify both salient keywords and sentiment orientations embedded in residents’ narratives. Guided by the theoretical framework of resident satisfaction, the extracted keywords are organized into seven thematic domains: basic infrastructure improvement, quality-enhancement renovation, solicitation of residents’ preferences, residents’ decision-making power, policy transparency, construction governance, and community-level communication. Regression modeling is subsequently applied to assess the relative influence of these thematic domains on residents’ satisfaction. The findings suggest that insufficient integration of residents’ preferences at the preliminary stages of participation constitutes a principal source of dissatisfaction during the implementation of renewal projects. Furthermore, the study compares Latent Dirichlet Allocation (LDA) topic modeling with LLMs-based topic clustering, revealing the latter’s superior capacity to capture thematic structures in complex, long-form textual data. These results underscore the potential of LLMs to enhance the analytical rigor of research on urban regeneration and citizen participation. Full article

Environmental, Social, and Governance (ESG) performance has become a vital instrument for corporations to integrate sustainable development principles into business operations. Against the dual backdrop of disruptions in the international order and economic instability, investigating the impact of corporate ESG performance on total factor productivity (TFP) under environmental uncertainty is of significant importance. Utilizing data from Chinese A-share listed companies spanning the period 2011 to 2022, this study employs a baseline regression model, a mediation effect model, a moderation effect model, and a moderated mediation model to examine the impact of corporate ESG performance on TFP under conditions of environmental uncertainty. The results indicate that (1) corporate ESG performance exerts a positive influence on TFP, particularly in tertiary industry firms, state-owned enterprises (SOEs), and enterprises with lower environmental risks; (2) improving ESG performance helps alleviate financing constraints, enhance human capital, and boost innovation capability, thereby strengthening TFP; and (3) environmental uncertainty moderates the pathway through which ESG performance affects TFP, amplifying its positive effect. Based on these findings, it is recommended that countries collaborate to establish a global, cross-industry platform for sharing ESG practices, develop a stable ESG policy framework and incentive mechanisms, and encourage enterprises to enhance their ESG management and resilient governance capabilities to promote sustainable economic development. Full article

Museums play a crucial role in sustainable urban regeneration by maintaining and promoting cultural identity, fostering education, enhancing economic growth, among other factors. The purpose of this study is to scrutinize the dynamic connection between the role of museums and the viable development of cities as well as the salience of this interdependence. Using a qualitative approach, case study and comparative analysis, we examine social, economic, cultural, technological, and environmental criteria as a framework, aiming to elucidate and highlight the significance of implementing cultural policies for the sustainable development of cities in contemporary globalized societies. The correlation under investigation is revealed by evaluating and comparing Athens and Singapore based on the landmark museum of each city. The main argument, derived from the analysis, is that traditional practices function as custodians of heritage, operating as interdisciplinary platforms that foster innovation, inclusivity, and cultural diplomacy. Despite differences in governance and orientation, both case studies reveal how tailored cultural policies can utilize the assets of each institution to support cohesive urban identities and foster cross-cultural engagement. Full article

To analyze the dynamic response of tension leg platform (TLP) tendons under irregular ocean wave action, the governing equations of coupled vibration between the platform and tendon under irregular wave action are established based on Hamilton’s principle and the Kirchhoff hypothesis. Using the spectrum representation–random function method, the power spectral density function of the irregular wave load is derived, and the lateral wave forces at different tendon locations are calculated. The coupled lateral and axial responses of the tendon system are obtained through the fourth-order Runge–Kutta method. Considering the parametric vibrations of both the platform and tendon, the extreme lateral deflection of the tendon is employed as the control index to derive the probability density curves of the tendon deflection under irregular wave load. The results show that the amplitude of the wave load increases gradually along the height of the tendon, with a faster growth rate at locations closer to the water surface. The tendon’s lateral deflection response changes more drastically due to coupled parametric vibration of the platform. Based on 628 complete samples of irregular wave loads, the probability density curve and cumulative distribution curve of the extreme lateral deflection of the tendon under irregular wave loads are obtained. Under typical sea state conditions generated from the P-M wave spectrum, the reliability of the tendon under irregular wave load increases with the initial tension force. Full article

Biomimetic nanocarriers, particularly membrane-based systems, have emerged as promising platforms for drug delivery. A thorough understanding of the molecular interactions that govern their assembly, stability, and cargo-loading efficiency is essential for optimizing their design and performance. Equally important are their interactions with biological components such as proteins, lipids, nucleotides, and cells, which significantly influence delivery efficacy. Among various techniques for characterizing these nanocarriers, isothermal titration calorimetry (ITC) has proven to be an invaluable tool to study their molecular interactions. ITC enables direct quantification of key thermodynamic parameters, such as binding affinity, stoichiometry, enthalpy, and entropy changes, without the need for molecular labeling or immobilization. This review highlights the application of ITC in the study of biomimetic nanocarriers, focusing on solid lipid nanoparticles, liposomes, extracellular vesicles, cell-derived vesicles and live cells. For each type of nanocarrier, the ITC applications in specific areas and the resulting information are discussed. For example, ITC was used to characterize drug interaction and protein adsorption for solid nanoparticles. In contrast, many aspects of liposomes were explored by ITC, including membrane solubilization and stabilization, peptide interactions, and macromolecule and protein adsorption. Overall, this review aims to provide a conceptual and practical framework for employing ITC in the investigation of biomimetic nanocarrier systems, facilitating their rational design and improved therapeutic performance. Furthermore, the discussion encourages further development of strategies to increase the application in cell-derived vesicles and live cells. Full article

Natural disasters often strike unexpectedly, leaving thousands of victims and affected individuals each year. Effective disaster preparedness is critical to reducing these consequences and accelerating recovery. This paper presents Eghatha, a blockchain-based decentralized system designed to optimize humanitarian aid delivery during crises. By enabling secure and transparent transfers of donations and relief from donors to beneficiaries, the system enhances trust and operational efficiency. All transactions are immutably recorded and verified on a blockchain network, reducing fraud and misuse while adapting to local contexts. The platform is volunteer-driven, coordinated by civil society organizations with humanitarian expertise, and supported by government agencies involved in disaster response. Eghatha’s design accounts for disaster-related constraints—including limited mobility, varying levels of technological literacy, and resource accessibility—by offering a user-friendly interface, support for local currencies, and integration with locally available technologies. These elements ensure inclusivity for diverse populations. Aligned with Morocco’s “Digital Morocco 2030” strategy, the system contributes to both immediate crisis response and long-term digital transformation. Its scalable architecture and contextual sensitivity position the platform for broader adoption in similarly affected regions worldwide, offering a practical model for ethical, decentralized, and resilient humanitarian logistics. Full article

Since the 20th century, quality has become a major strategic concern for both researchers and organizations, serving as a lever for performance and a key factor of differentiation in an increasingly digital environment. However, despite the development of e-government services, the exploration and evaluation of their success, particularly concerning civil servants, remains limited. The implications suggest that for the success of such systems, governments must prioritize satisfaction and trust for the users in their technology strategies. This paper presents a comprehensive bibliometric analysis, based on the PRISMA model, focusing on the relationship between quality and electronic services (e-services). Using the Scopus database, 626 articles were initially identified, of which 204 were selected following strict inclusion and exclusion criteria. Covering the period from 2014 to 2024, the analysis highlights publication trends, journal distribution, author contributions, and keyword frequency. Special attention was given to 17 key publications, allowing for an in-depth exploration of the dynamics between perceived quality and the performance of e-services, using the VOSviewer tool. The findings reveal a strong interdependence between quality dimensions and the development of electronic services, particularly through technologies such as automation, intelligent interfaces, and interactive platforms. These elements play a crucial role in enhancing user experience, customer satisfaction, and operational efficiency. Full article