Search Results (6,541)

Microbial hydrocarbon degradation mediated by natural/modified clay minerals represents an eco-friendly and economically viable remediation strategy for hydrocarbon contamination. However, its effects are not always positive as they depend on multiple factors, including clay mineral types, modification methods, microbial species, and hydrocarbon substrates. This review systematically synthesizes existing fragmented studies concerning the impacts of natural clay minerals, modified clay minerals (acid/alkali/thermal/organic/metal ion), and clay minerals containing composite materials on microbial hydrocarbon biodegradation. Based on current findings, future research should prioritize the following recommendations: (1) avoid using concentrated strong acids in acid activation; (2) exclude metal cations that induce strong adsorption (reducing hydrocarbon bioavailability) or trigger excessive interlayer hydrolysis (some trivalent cations) in metal cation modification; (3) eliminate biologically toxic agents during organic modification; and (4) expand understanding of alkali/thermally modified clay minerals and clay mineral-containing composite materials in this direction. Natural/modified clay mineral-mediated microbial degradation is a highly promising remediation technology for hydrocarbon contamination and poised to advance and achieve breakthroughs through continuous synthesis of knowledge and innovation. Full article

Climate change is expected to negatively impact agricultural production, leading to phenological and metabolic changes, increased water demands, diminished yields, and changed organoleptic characteristics, restricting the positive geographic productivity potential. As an adaptive strategy, agriculture in mountainous regions has gained prominence despite the fact that it entails new challenges. Indeed, mountain-specific conditions and limitations need to be considered, compared to the traditional productive regions. Consequently, there is a lack of information about the most suitable locations because the new conditions and limitations need to be accounted for. This study provides a crop suitability assessment approach to be used in mountainous regions where data about crop yield or development is scarce or nonexistent. Specifically, we evaluated the suitability of vineyards and apple orchards in the southern Pyrenees and Pre-Pyrenees. Using Geographical Information System (GIS) techniques, integrated with fuzzy logic and the Analytic Hierarchy Process (AHP), we combined traditional climatic, soil, and topographic indicators with factors relevant to mountainous regions. Our results indicated that the most suitable areas were primarily in lower basins and sunny hillsides, with smaller water needs. Vineyards would benefit from a very low risk of late spring frosts and elevated solar radiation, whereas apple orchards from a reduced risk of hailstorms, a very low risk of late spring frosts, and mild slopes. The fuzzy membership functions combined with the AHP facilitated the integration of indicators, effectively identifying areas with high potential for crop development. This approach contributes to landscape management and planning by offering a modifiable tool for assessing crop suitability in mountainous regions. Full article

Functional magnetic resonance imaging (fMRI) is commonly used to investigate the neural bases of aging and psychological disorders. However, the BOLD signal captured by fMRI is affected by many factors that are non-neural in origin. We tested how vascular health risks, which often go unmeasured in neuroimaging studies, and aging interact to modify the shape and/or timing of the HRF, which then affect the differences in patterns of brain activity in a task-evoked memory encoding paradigm. Adult participants (aged 20–74) answered questions about their health and underwent two fMRI tasks: viewing a flashing checkerboard and a memory encoding task. Aging and vascular risk had the largest impacts on the maximum peak value of the HRF. Using a subject-specific HRF resulted in a dampening of brain activity in task-positive and task-negative regions. Across three vascular risk factors, using a subject-specific HRF resulted in more consistent brain regions that reached significance and larger effect sizes compared with the canonical HRF. These findings serve as a cautious tail when interpreting task-evoked fMRI activity, especially in populations experiencing alterations to brain vasculature including many older adults and people with neurocognitive disorders like Alzheimer’s disease and related dementias. Full article

Background/Objectives: Severe dengue infection remains a major public health burden in Thailand, where timely identification of high-risk patients is essential for effective clinical management. Existing predictive models are often complex and less feasible in routine practice. This study aimed to develop a simple risk scoring system to predict dengue severity based on patient characteristics and routine clinical data. Methods: Retrospective data of adult dengue patients from nine general hospitals in Thailand from 2019 to 2022 were reviewed. Dengue infection was classified into two groups using the WHO 2009 modified criteria: non-severe (n = 577) and severe (n = 107). Demographic data, clinical characteristics, and laboratory findings were analyzed using logistic regression. Regression coefficients of significant predictors of severe dengue were converted into weighted item scores. Total scores were categorized into three risk levels based on probability distribution cut-off points. Results: The severity score stratified patients into three risk groups with significantly different prognoses: ≤2.0 points (low risk), 2.5–5.0 points (moderate risk), and ≥5.5 points (high risk). The positive likelihood ratios for low-, moderate-, and high-risk groups were 0.12, 1.05, and 28.76, respectively. The distribution of severity scores differed significantly between non-severe and severe cases. The scoring system discriminated between non-severe and severe dengue with an area under the receiver operating characteristic curve (AUROC) of 88.04% (95% CI, 83.99–92.08). Conclusions: The derived dengue severity scoring system classified patients into low, moderate, and high risk with excellent discriminatory performance, effectively distinguishing non-severe from severe dengue infection. Full article

This study investigates the influence of ball burnishing (BB) path strategies on the surface integrity and functional performance of laser-cladded Inconel 718. Three BB strategies—(1) BB-Longitudinal, (2) BB-Transverse, and (3) BB-Crosshatch—relative to the laser scan trajectory were evaluated and compared against ground surfaces as a baseline. Post-processing BB treatment were demonstrated to be effective in modifying the subsurface layer of the cladded Inconel 718 material, extending to depths of up to 100 µm, increasing dislocation density by over 2.5 times, and enhancing hardness from 260 HV5 (ground) to as high as 461 HV5. These microstructural improvements led to significant gains in corrosion and impact resistance, despite a rise in surface roughness from Ra 0.35 µm (ground) to up to 2.38 µm for BB-Longitudinal surfaces. Impact testing revealed up to 35% reduction in indentation volume, particularly with BB-Transverse and BB-Crosshatch strategies. Nonetheless, sliding wear tests did not confirm improvements in wear resistance, as wear depths exceeded the hardened layer and abrasive wear remained dominant. Electrochemical testing in 3.5 wt.% NaCl solution showed a positive shift in corrosion potential (E_corr) exceeding 200 mV compared to the ground condition, indicating reduced corrosion susceptibility for BB-Longitudinal condition. Among the tested strategies, BB-Transverse offered the most balanced enhancements, highlighting the complex interplay between laser cladding heterogeneities and post-processing response in optimizing surface and mechanical properties of Inconel 718 claddings. Full article

Background/Objectives: Menopause is a significant, universal hormonal transition, with symptoms impacting ~80% of women. Research shows that menopause can be professionally disruptive, contributing to decreased productivity, absenteeism, and early exit from the workplace. The objective of this study was to describe the landscape of menopause among Canadian women physicians and explore its potential impact on work performance, job satisfaction, and absenteeism. Methods: In this exploratory cross-sectional study, Canadian physicians self-identifying as women and peri-menopausal or menopausal were invited to participate in an online survey between May–September 2023. Demographic and practice characteristics data were collected. A modified Menopause Rating Scale (MRS) was used to quantify symptom burden. Qualitative data describing the menopausal experience were collected as well. Primary outcome was self-reported work performance. Secondary outcomes included perceived impact of menopause on promotional opportunities, absenteeism, and job satisfaction. Multivariable regression was used to examine associations between MRS scores and outcomes of interest. Results: Among 217 respondents, 47.7% reported a severe menopausal symptom burden; 40% felt menopause negatively impacted work performance, and 16.1% expressed job dissatisfaction. However, fewer than 10 respondents (4.6%) ever took time off for menopausal symptoms. Increasing MRS scores were significantly associated with negative perceived work performance (p < 0.001), fewer promotional opportunities (p < 0.001), and lower job satisfaction (p = 0.006) when controlling for confounders. Qualitative responses were provided by 43 participants, 6 of whom reported positive aspects of the menopausal transition, whereas 20 elaborated on the challenges. Conclusions: Canadian women physicians can experience severe menopausal symptoms, often without support. This needs assessment highlights an important occupational health issue and suggests that opportunities remain for medical institutions and employers to formally recognize and study this life stage of women physicians to improve well-being for this valuable workforce. Full article

Background: Previous research has found an association between attractiveness and personality traits, but the neural mechanisms are largely unknown. Method: We used a Stroop-like paradigm combined with EEG recordings to investigate how personality traits affect the perception of facial and vocal attractiveness. Twenty-three female participants classified the attractiveness of male faces and male voices paired with positive or negative personality trait words. Results: The behavioral results indicate that personality trait words that are semantically congruent with attractiveness levels facilitate the perception of attractiveness, whereas incongruent trait information produces the opposite effect. Event-related potentials revealed that the influence of personality trait words on facial attractiveness was primarily related to motivated attention as indicated by the late positive component. In the voice task, personality trait words impacted vocal attractiveness processing first during semantic integration (N400 component) and then modulated motivated attention. Conclusions: These results suggest that alleged personality traits modify attractiveness processing in faces and voices in relatively late and partially modality-specific stages. Full article

This study, via a combination of experiments and numerical simulations, investigates the structural tensile failure mechanisms of battle-damaged aluminum alloy flat panels and stiffened panels, the variation in their residual strength with hole characteristics, and modifies the calculation formula of the net-section failure criterion for evaluating damaged panels’ residual strength. Experimental and simulation results demonstrate that hole size and position exert a significant influence on panels’ residual strength: larger hole size and greater eccentricity both diminish load-bearing capacity, stiffened panels with web damage exhibit lower load-bearing capacity than those with flange damage. Different hole positions induce edge effects that alter stress distribution at the hole cross-section. Introducing a stress averaging coefficient modifies the residual strength evaluation of flat panels, which is further extended to stiffened panels with high result accuracy. This study presents a rapid method for evaluating damaged panels’ residual strength and serves as a reference for aircraft battle damage repair (ABDR) design. Full article

Background: Graves–Basedow disease (GBD) is an autoimmune thyroid disorder characterized by loss of tolerance to the thyrotropin receptor, with clinical manifestations such as a hyperadrenergic state, goiter, orbitopathy, and myxedema, inter alia. Selenium is a micronutrient, essential for the synthesis of selenoproteins. Selenium deficiency has been linked to an increased risk and exacerbation of GBD and GBD orbitopathy; therefore, it has been suggested that supplementation with this micronutrient could modify some outcomes associated with both conditions. Objectives: The objective of this scoping review was to synthesize and analyze the clinical trials that have evaluated the effectiveness of selenium on different outcomes in patients with GBD or GBD orbitopathy. Methods: The following databases were consulted: PubMed/Medline, Scopus, Biosis, ProQuest, Web of Science, and Google Scholar; and the search terms ‘Graves-Basedow disease’ or ‘Graves’ disease’ or ‘hyperthyroidism’ or ‘Graves’ hyperthyroidism’ or ‘selenium or selenium supplementation’ and ‘effectiveness’ were used. The search was limited to articles published in English between January 2000 and March 2025. To reduce selection bias, each article was reviewed independently by three authors using the Rayyan web tool and the JBI Critical Appraisal Checklist. Results: A total of 15 studies were identified (11 on patients with GBD and 4 on patients with GBD orbitopathy). In GBD, selenium supplementation was associated with significant improvements in TSH, FT4, FT3, TPOAb, TgAb, and TRAb levels; while in GBD orbitopathy, a positive effect of selenium supplementation was found on multiple clinical outcomes. Conclusions: Selenium supplementation in patients with GBD or GBD orbitopathy is associated with favorable biochemical and clinical outcomes. Full article

Background and Objectives: Apathy and sleep problems are frequently observed among non-motor symptoms (NMSs) in Parkinson’s disease (PD), but the relationship between the two has not been well investigated. This study aimed to determine the extent to which apathy and sleep disturbances are present in people with early PD and whether apathy affects sleep quality. Materials and Methods: Patients diagnosed with early PD, defined as modified Hoehn and Yahr (mHY) stages 1-3 and a disease duration of no more than 5 years, were included in the study. Demographic characteristics were collected, and motor and NMSs including apathy and sleep disturbance were investigated with relevant scales. Results: Of 302 patients with PD, apathy was found in 97 (32.1%) patients. Patients with apathetic PD had significantly less formal education, a more advanced mHY stage, and higher scores on the Unified Parkinson’s Disease Rating Scale (UPDRS) part II, total Non-Motor Symptom Scale (NMSS), Beck Depression Inventory (BDI), Apathy Evaluation Scale (AES), and Pittsburgh Sleep Quality Index (PSQI) global scores than patients with non-apathetic PD. The PSQI global score showed significant associations with years of education, UPDRS-II, total NMSS, Mini-Mental State Examination, BDI, and AES scores. For each component of the PSQI, only sleep latency was different between patients with apathetic and non-apathetic PD. Partial correlation analyses for determining the association between apathy and sleep disturbance revealed a significant positive correlation. Conclusions: Apathy is common and associated with poor sleep quality in patients with early PD. These findings suggest that recognizing and addressing apathy may be relevant for managing sleep disturbances in this population. Full article

To investigate the three-dimensional spatial distribution characteristics of fluids during the combined production of coalbed methane from multi-coal reservoirs (MCR), a physical simulation test platform was established, and a quantitative characterization parameter calculation principle for fluid migration was developed. The influence of fluid pressure difference and in situ stress difference on the three-dimensional spatial distribution of fluids and their quantitative characterization parameters was analyzed. The results indicate that the dynamic pressure equilibrium between the coal reservoir and the wellbore forces fluids from high-pressure reservoirs to intrude into low-pressure reservoirs, altering the flow state of fluids in the latter. Consequently, the relative flow velocity in the low-pressure reservoir becomes negative, with the relative deflection angle approaching 180°, while the relative flow velocity in the high-pressure reservoir remains positive. An increase in the relative flow rate of 0.08 and 0.007 corresponds to a 1 MPa increase in fluid pressure difference and geostress difference, respectively. During the co-production of coalbed methane from MCR, the existing pressure difference and in situ stress difference between reservoirs modify the fluid migration patterns, leading to fluid interaction and interference effects. This results in centrifugal flow patterns in low-pressure reservoirs and centripetal flow patterns in high-pressure reservoirs. Compared to in situ stress difference, the fluid pressure difference exerts a more significant influence on the fluid migration patterns. Full article

Background: Cytokines participate in regulating the immune response of lymphocytes. Interleukin 2 (IL-2) is the main modulator of T lymphocyte development, homeostasis, and function, whereas interleukin 7 (IL-7) regulates the development and homeostasis of immune cells and plays a crucial role in the maintenance of memory cells. The study aims to assess the blood IL-2 and IL-7 concentration in relation to the obtained cellular and humoral response in adults, six months after vaccination against COVID-19. Methods: We measured the concentration of IL-2 and IL-7 with ELISA, CoV2-IgG with an indirect chemiluminescence test, and the levels of IFN-γ with interferon gamma release assay (IGRA) post SARS-CoV-2 antigen stimulation. The study group (n = 76; F = 66, M = 10) was divided into 41 individuals, who did not report any chronic disorder (ChrD-Neg), and 35, who did (ChrD-Pos). Results: ChrD-Pos group presented higher IL-7 compared to ChrD-Neg (p = 0.023). Negative correlations were observed in the entire study population between IL-2 and age (R = −0.252, p = 0.028), as well as between IL-7 and IFN-γ (R = −0.295, p = 0.010). We found a positive correlation between IL-2 and IL-7 concentrations in the entire study population (R = 0.305, p = 0.007) and the ChrD-Pos group (R = 0.358, p = 0.035), and people with a positive IGRA result (R = 0.359, p = 0.005). Conclusions: The interaction of IL-2 and IL-7 may be important for achieving post-vaccination immunity, especially in adults with chronic diseases. Age is a factor modifying the post-vaccination response (decreased IL-2), whereas IL-7 may be an important factor in achieving a satisfactory post-vaccine response in people with chronic diseases. Full article

This paper addresses a well-known puzzle at the intersection of morphology and syntax: the categorical exclusion of adjectives modified by evaluative morphology from prenominal position in Italian. While Italian allows many adjectives to occur both pre- and postnominally, adjectives like piccolino, ‘little-dim’, are strictly postnominal (cane piccolino, lit. ‘dog little-dim’ vs. *piccolino cane, ‘little-dim dog’), a distribution not fully explained by their proposed predicative or intersective nature. Drawing on degree semantics and trope theory, we argue that this constraint arises from an incompatibility between two distinct interpretive strategies. Prenominal adjectives undergo a syntactically driven semantic shift, whereby the noun triggers a trope-based interpretation of the adjective, redefining the meaning of the A-N complex. In contrast, evaluative morphology operates through a pragmatically driven strategy, contributing speaker-oriented, context-sensitive meaning to the adjective. Crucially, these two strategies are mutually exclusive: an adjective modified by evaluative morphology has already undergone pragmatic reinterpretation and cannot simultaneously participate in the compositional syntactic process required for prenominal placement. This explains why adjectives with evaluative suffixes are excluded from prenominal contexts, despite often yielding intersective interpretations postnominally. Our proposal accounts for this distributional asymmetry without resorting to stipulations and suggests that certain interpretive procedures are not recursively applicable across syntax and pragmatics. Ultimately, this study sheds new light on a principled interface constraint linking syntactic distribution, morphological derivation and pragmatic interpretation. Full article

Primary hip and knee arthroplasties are common surgeries in the U.S., with periprosthetic joint infection (PJI) being the leading cause of implant revision. Systemic antibiotics often fail to achieve sufficient local concentrations, driving interest in localized drug delivery. Titanium (Ti) implants modified with titania nanotubes (TNTs) provide an increased surface area for drug loading and controlled release. Previous studies have shown that gentamicin-loaded TNTs inhibit Staphylococcus aureus growth in vitro without compromising osteoblast viability. This study investigated the effect of gentamicin–chitosan (GC)-coated TNT implants in a murine model, hypothesizing a positive impact on osseointegration. Titanium alloy (Ti6Al4V) wires were anodized to form TNTs and then coated with gentamicin–chitosan (GC) via electrophoretic deposition. Implants (Bare, TNT, TNT+GC; n = 30) were inserted bilaterally into femoral canals of C57BL/6J mice. After > 1 month, osseointegration was assessed by histological point counting, scanning electron microscopy (SEM)-based areal analysis, and mechanical pull-out testing. ANOVA was used to identify differences between groups, and linear regression was applied to account for harvest time, bone contact area, and anatomical section. Bone area fraction (BAF) around the implant measured by the SEM–areal method was significantly higher around TNT+GC (18.4% ± 1.1) and TNT (16.5% ± 1.4) versus Bare (9.0% ± 2.3) (p < 0.0028) implants. The maximum fixation strength was higher for TNT (0.878 ± 0.175 N/mm²) and TNT+GC (0.853 ± 0.215N/mm²) when compared to bare implants 0.316 ± 0.082 N/mm²) (p = 0.048 and p = 0.050, respectively). No significant differences appeared between TNT and TNT+GC. These findings indicate that GC coatings on TNT implants do impair osseointegration and may even enhance bone–implant integration. Such coatings may therefore provide dual benefits, offering antibacterial protection while improving bone fixation, making them a promising strategy for PJI prevention. Further long-term studies are needed to confirm durability and clinical translation. Full article

Atrial fibrillation (AF) and ventricular arrhythmias (VAs) are common pathological arrhythmias of dogs and are both associated with a poor prognosis in those with cardiac disease. This study aimed to assess the ability of 2 to 5 min electrocardiography (routine ECG) to detect the presence and severity of concomitant VAs in dogs with secondary AF. Continuous 24 h ECG monitoring (Holter) was used as the reference standard to identify VAs, quantify the number of premature ventricular ectopic complexes (VPCs) and evaluate the degree of their organization using a modified Lown–Wolf classification scale. In light of the Holter findings, VAs were classified as severe based on two criteria: the presence of more than 100 VPCs and a Lown–Wolf grade ≥ 4. Thirty-five dogs with secondary AF were included, where all exhibited VAs on Holter monitoring. Most dogs had severe VAs, according to both the VPC count (69%) and Lown–Wolf classification (77%). However, only 13 dogs (37%) had VAs detectable on routine ECG. A significant positive correlation was found between the presence of VAs on routine ECG and the severity of VAs identified via Holter. Nevertheless, the diagnostic accuracy of routine ECG in predicting severe VAs was only moderate (68.6% based on VPC count and 60% based on Lown–Wolf grade). Overall, a 2 to 5 min ECG appears to be a highly specific but relatively insensitive tool for detecting VAs in dogs with secondary AF. Full article