Search Results (740)

With the increasing integration of variable renewable energy into power systems, the frequency regulation capability of hydroelectric units has become crucial for ensuring grid stability. In response to grid disturbances, where Primary Frequency Regulation (PFR) and Automatic Generation Control (AGC) are activated sequentially in actual operation, this paper employs parameter characteristic analysis to systematically investigate the influence of several factors—including turbine operating head, PWM parameters, and governor parameters—on the active power regulation process of hydroelectric units. The study first compares the response characteristics under different heads and PWM/pulse parameters within the AGC framework. It then examines the effects of pulse duration limits and integral adjustments on guide vane movement and correction efficiency. Finally, under the PFR framework, the impacts of head, steady-state slip coefficient, and integral gain on the amplitude and speed of frequency response are analyzed. Simulation results demonstrate that as the set value of Tkmax increases, the operating range of the guide vane opening within the pulse cycle expands, and the time required for power correction is significantly reduced. Specifically, when Tkmax is increased from 0.2 to 0.55, the regulation time is shortened by 44%. These findings offer theoretical guidance and practical insights for parameter optimization and operational scheduling of hydropower units. Full article

The tail boom is a critical structural component of a helicopter, and accurately capturing its dynamic characteristics is essential; however, the inherent geometric and material complexity of the tail boom usually leads to large-scale finite element models whose system matrices are of very high order, and as the matrix order increases the computational effort grows exponentially. To further accelerate the condensation process for a truss-type tail-boom FE model, this paper presents a substructure-based secondary condensation method in which the global structure is partitioned into several substructures, each secondary substructure is first condensed onto its boundary nodes and then assembled into the primary structure, and the primary structure—now enriched with the condensed secondary substructures—is finally reduced to the target degrees of freedom, repeatedly operating on low-order matrices instead of a single high-order one to markedly shorten overall computation time. The proposed method is compared with both overall secondary IRS condensation and overall secondary SEREP condensation. All three secondary-condensation strategies yield six-degree-of-freedom coupled-spring equivalent models whose accuracy errors are very small in modal, frequency-domain, and time-domain analyses: frequency errors remain within 1%, and the goodness-of-fit of the time-history response curves exceeds 0.9, while the computational time is reduced by more than 70%, demonstrating that the substructure-based secondary condensation method is highly effective, delivering much higher computational efficiency without sacrificing accuracy. Full article

Based on 0.1° × 0.1° soil moisture reanalysis data from 1950 to 2024, combined with remote sensing ecological products such as Enhanced Vegetation Index (EVI) and gross primary productivity (GPP), this study systematically investigates the spatiotemporal evolution, transition process, and ecological responses of flash droughts and slowly evolving droughts (including seasonal and cross-seasonal droughts) in the Dongjiang River Basin of China. The results indicate the following: (1) The average occurrence frequencies of flash droughts, seasonal droughts, and cross-seasonal droughts within the basin were 4.1%, 7.8%, and 8.4%, respectively. (2) The vast majority of flash droughts (approximately 90.1%) further developed into longer-lasting, slowly evolving droughts, indicating that flash droughts serve as a critical precursor to persistent drought events. Moreover, winter was identified as the key season for the occurrence of flash droughts and their transition to slowly evolving droughts. (3) In terms of ecological response, droughts significantly suppressed vegetation growth, but ecosystem resilience exhibited notable differences: although flash droughts caused relatively mild initial suppression, they were accompanied by a severe lack of ecosystem resilience; in contrast, cross-seasonal droughts, despite inducing stronger suppression, were met with higher ecosystem resilience. This study underscores the importance of the early monitoring and warning of flash droughts, and the findings provide a scientific basis for drought risk management in humid basins. Full article

This study examines the forced vibration behavior of a hydroelastic system composed of a functionally graded material (FGM) plate, a barotropic compressible Newtonian viscous fluid, and an adjacent rigid wall. The fluid occupies the gap between the plate and the wall. A time-harmonic force, applied in and along the free surface of the FGM plate, excites vibrations within the system. The plate’s motion is modeled using the exact equations of elastodynamics, while the fluid dynamics are described by the linearized Navier–Stokes equations for compressible viscous flow. The governing equations, which feature variable coefficients, are solved using a discrete analytical approach. Boundary conditions enforce impermeability at the rigid wall and continuity of both forces and velocities at the fluid–plate interface. The investigation focuses on the plane strain state of the plate coupled with the corresponding two-dimensional fluid flow. Numerical analyses are conducted to evaluate normal stresses and velocity distributions along the interface. The primary objective is to assess how the graded material properties of the plate influence the frequency-dependent responses of stresses and velocities at the plate–fluid boundary. Full article

Research on Mesoscale Convective Systems (MCSs) in Ecuador has focused on regional studies. However, it lacks a thorough and general examination of their relationship with the nation’s diverse orography and large-scale phenomena. This study conducts a climatological analysis of MCS occurrence throughout Ecuador’s natural regions. We perform this study using Sen’s Slope and the Mann–Kendall test. Teleconnections from the Pacific and Atlantic Oceans are studied through wavelet decomposition between time series and Pacific and Atlantic oceanic indices. The main factors that control MCS formation depend on the region. The Intertropical Convergence Zone (ITCZ) at the large scale affects the entire territory. In western Ecuador, MCS formation is mostly related to the El Niño current and the Chocó Low-Level Jet (CLLJ). The Orinoco Low-Level Jet (OLLJ) and evapotranspiration and nocturnal convection display the largest roles in the east. A progressive intensification of activity from Highlands-North in SON is detected (0.143 MCSs per year). MCSs contribute 26% of total precipitation on average, with regional variations from Coast-South (16.41%) to Amazon-North (44.13%). The research confirms existing knowledge about El Niño’s strong relationship (ρ = 0.7) with MCS occurrence in coastal areas while uncovering new complex patterns. The Trans-Nino Index (TNI) functions as a critical two-sided modulator that conventional analysis methods fail to detect. It produces null correlations over conventional time series of MCS occurrence yet emerges as a primary driver of low-frequency variability in the proposed six natural zones of Ecuador. Wavelet decomposition reveals contrasting TNI responses: Amazon-North shows positive correlation (0.73) while Amazon-South exhibits negative correlation (−0.70) at low frequencies. This affects Walker circulations dynamics over the Pacific Ocean. This research establishes fundamental knowledge about MCSs in Ecuador. It builds on a database with strong methodology as a backbone. The research provides essential information about the factors leading to convection in the country. This will help improve seasonal forecast accuracy and risk management effectiveness. Full article

Background/Objectives: Understanding the durability of immunity induced by mRNA COVID-19 vaccines, especially in individuals with chronic health conditions, remains essential for guiding booster strategies. We conducted a longitudinal study to evaluate humoral and cellular immune responses up to 21 months after a primary two-dose BNT162b2 vaccination followed by a booster, either homologous (BNT162b2) or heterologous (mRNA-1273). Methods: Twenty-eight adults, mostly with chronic conditions, were assessed at approximately 9, 12 and 21 months post-primary vaccination. Serum anti-trimeric Spike IgG levels were quantified, and peripheral blood mononuclear cells were analyzed at 21 months for Spike-specific memory B-cell and T-cell responses by flow cytometry. Results: Participants were stratified by booster type, prior SARS-CoV-2 infection and health status. Anti-Spike IgG persisted in all participants but declined over time. The heterologous mRNA-1273 booster induced higher antibody titers at 9 months, while the homologous BNT162b2 booster led to more sustained antibody levels and higher frequencies of Spike-specific memory B cells at 21 months. Prior infection significantly enhanced antibody titers, particularly in homologous booster recipients. Surprisingly, individuals with chronic health conditions exhibited equal or higher antibody levels compared to healthy participants at all time points. At 21 months, robust Spike-specific class-switched memory B cells and polyfunctional CD4⁺ and CD8⁺ T-cell responses were detected. Conclusions: These findings demonstrate that BNT162b2 vaccination elicits durable, multi-layered immunity lasting nearly two years, even in individuals with chronic conditions, and support the use of both homologous and heterologous mRNA boosters to sustain protection in diverse populations. Full article

This study aims to reduce reverse power and improve frequency regulation performance in hydropower systems. To achieve this objective, a refined hydropower plant (HPP) simulation model is developed and coupled with a battery energy storage system (BESS), implementing an Integrated Adaptive Virtual Droop Control (IAVDC) strategy. The refined HPP model achieves a simulation accuracy of 98.5%, representing a 26.2% improvement over conventional simplified models. With the BESS integrated under the IAVDC strategy, reverse power is completely eliminated, and frequency regulation time is substantially shortened. The results demonstrate that the joint HPP-BESS frequency regulation effectively mitigates the adverse impact of water hammer, while the proposed IAVDC strategy enhances system responsiveness and reduces frequency recovery time, thereby improving the quality of primary frequency control. Full article

By applying the Non-Perturbative Approach (NPA), the corresponding linear differential equation is obtained. Aimed at organizational investigation, the resulting linear equation is used. Strong agreement between numerical calculations and the precise frequency is demonstrated, and the reliability of the results acquired is established by the correlation with the numerical solution. Additionally, this study explores a new control process to affect the stability and behavior of dynamic motorcycle systems that vibrate nonlinearly. A multiple time-scale method (MTSM) is applied to examine the analytical solution of the nonlinear differential equations describing the aforementioned system. Every instance of resonance was taken out of the second-order approximations. The simultaneous primary and 1:1 internal resonance case ($\mathsf{\Omega }\approx {\omega }_{eq},$${\omega }_2\approx {\omega }_{eq}$) is recorded as the worst resonance case caused while working on the model. We investigated stability with frequency–response equations and bifurcation. Numerical solutions for the system are covered. The effects of the majority of the system parameters were examined. In order to mitigate harmful vibrations, the controller under investigation uses (PD) proportional derivatives with (PPF) positive position feedback as a new control technique. This creates a new active control technique called PDPPF. A comparison between the PD, PPF, and PDPPF controllers demonstrates the effectiveness of the PDPPF controller in reducing amplitude and suppressing vibrations. Unwanted consequences like chaotic dynamics, limit cycles, or loss of stability can result from bifurcation, which is the abrupt qualitative change in a system’s behavior as a parameter. The outcomes showed how effective the suggested controller is at reducing vibrations. According to the findings, bifurcation analysis and a control are crucial for designing vibrating dynamic motorcycle systems for a range of engineering applications. The MATLAB software is utilized to match the analytical and numerical solutions at time–history and frequency–response curves (FRCs) to confirm their comparability. Additionally, case studies and numerical simulations are presented to show how well these strategies work to control bifurcations and guarantee the desired system behaviors. An analytical and numerical solution comparison was prepared. Full article

This paper proposes a multi-objective collaborative optimization method based on a two-layer optimization framework to address the problem of difficult coordinated optimization of multi-parameter coupling in the frequency regulation performance of heating units under deep peak shaving conditions. The upper-level optimization of this method focuses on the dynamic performance of primary frequency modulation and improves the fast response capability through multi-objective optimization of overshoot and adjustment time. Lower-level optimization is based on the optimal control parameter set output by the upper level, with comprehensive power deviation as the indicator, focusing on suppressing the deviation of frequency modulation power and the steady-state deviation of heating power. Propose a comprehensive quantitative index for frequency modulation performance and characterize the optimization effect of frequency modulation performance. Introducing a dynamic perturbation factor mechanism to generate an improved HO algorithm for dual-layer optimization solutions, preventing it from getting stuck in local optima and solving the problem of global search capability imbalance. The effectiveness of the method was verified based on actual unit calculations, and the obtained control parameter set met the objectives of optimal primary frequency regulation dynamic performance and optimal comprehensive power deviation performance, significantly improving the frequency regulation performance of heating units under deep peak shaving. After optimization, the overshoot performance score of the unit increased by 16.9%, the regulation time performance score increased by 25.1%, the frequency modulation power deviation score increased by 14.2%, the heating power deviation score increased by 17.7%, and the total frequency modulation performance score increased from 75.26 to 95.95, with a comprehensive optimization range of 27.5%. Full article

Current ringing in dual-active bridge (DAB) converters significantly degrades efficiency and reliability, particularly due to resonant interactions in the magnetic tank impedance network. We propose a novel impedance resonant channel shaping technique to suppress the ringing by systematically modifying the converter’s equivalent impedance model. The method begins with establishing a high-fidelity network representation of the magnetic tank, incorporating transformer parasitics, external inductors, and distributed capacitances, where secondary-side components are referred to the primary via the turns ratio squared. Critical damping is achieved through a rank-one modification of the coupling denominator, which is analytically normalized to a second-order form with explicit expressions for resonant frequency and damping ratio. The optimal series–RC damping network parameters are derived as functions of leakage inductance and winding capacitance, enabling precise control over the effective damping factor while accounting for core loss effects. Furthermore, the integrated network with the damping network dynamically shapes the impedance response, thereby attenuating ringing currents without compromising converter dynamics. Experimental validation confirms that the proposed approach reduces peak ringing amplitude by over 60% compared to the conventional snubber-based methods, while maintaining full soft-switching capability. Full article

This study investigates the primary frequency regulation dynamic characteristics of industrial steam extraction turbine units under deep peak regulation conditions. A high-fidelity integrated dynamic model was established, incorporating the governor system, steam turbine with extraction modules, and interconnected pipeline dynamics. Through comparative simulations and experimental validation, the model demonstrates high accuracy in replicating real-unit responses to frequency disturbances. For the power grid system in this study, the frequency disturbance mainly comes from three aspects: first, the power imbalance formed by the random mutation of the load side and the intermittence of new energy power generation; second, transformation of the energy structure directly reduces the available frequency modulation resources; third, the system-equivalent inertia collapse effect caused by the integration of high permeability new energy; the rotational inertia provided by the traditional synchronous unit is significantly reduced. In the cogeneration unit and its control system in Guangxi involved in this article, key findings reveal that increased peak regulation depth (30~50% rated power) exacerbates nonlinear fluctuations. This is due to boiler combustion stability thresholds and steam pressure variations. Key parameters—dead band, power limit, and droop coefficient—have coupled effects on performance. Specifically, too much dead band (>0.10 Hz) reduces sensitivity; likewise, too high a power limit (>4.44%) leads to overshoot and slow recovery. The robustness of parameter configurations is further validated under source-load random-intermittent coupling disturbances, highlighting enhanced anti-interference capability. By constructing a coordinated control model of primary frequency modulation, the regulation strategy of boiler and steam turbine linkage is studied, and the optimization interval of frequency modulation dead zone, adjustment coefficient, and frequency modulation limit parameters are quantified. Based on the sensitivity theory, the dynamic influence mechanism of the key control parameters in the main module is analyzed, and the degree of influence of each parameter on the frequency modulation performance is clarified. This research provides theoretical guidance for optimizing frequency regulation strategies in coal-fired units integrated with renewable energy systems. Full article

Candida infections pose a significant health threat, and conventional antifungal drugs like nystatin are limited due to poor solubility, skin permeability, and frequent dosage requirements. Nystatin effectively targets Candida species by disrupting cell membranes, but formulation issues hinder clinical use. Lipid-based vesicular carriers, or novasomes, provide controlled, prolonged drug release and enhanced skin penetration. This study focuses on developing nystatin-loaded novasomal gels as an advanced drug delivery system to enhance therapeutic efficacy, bioavailability, and patient compliance. The formulation was prepared using a modified ethanol injection technique, combining stearic acid, oleic acid, Span 60, cholesterol, and Carbopol to produce a stable transdermal gel. Comprehensive in vitro characterization using FTIR, SEM, XRD, and thermal analysis confirmed the chemical compatibility, morphological uniformity, and physical stability of the nystatin-loaded novasomal gel. Entrapment efficiency differed significantly among the formulations (p < 0.05), with F7 achieving the highest value (80%). All formulations maintained pH levels within the skin-friendly range of 5.5 to 7.0. Viscosity measurements, ranging from 3900 ± 110 to 4510 ± 105 cP, confirmed their appropriate consistency for dermal use. Rheological analysis showed a dominant elastic response, as indicated by storage modulus values consistently higher than the loss modulus. Particle size ranged from 4143 to 9570 nm, while PDI values remained below 0.3, reflecting uniform particle distribution. Zeta potential values were strongly negative, supporting physical stability. XRD studies indicated reduced crystallinity of nystatin within the formulations, while FTIR confirmed drug-excipient compatibility. SEM images showed spherical particles within the micrometer range. In vitro release studies demonstrated sustained drug release over 12 h, with F6 releasing the highest amount. The novasomal gel formulations-maintained stability for 30 days, with no notable alterations in pH, viscosity, or entrapment efficiency. Antifungal evaluation showed a larger inhibition zone (23 ± 2 mm) compared with the plain drug solution (15 ± 1.6 mm), while the MIC value was reduced (4.57 µg/mL), indicating greater potency. Skin irritation assessment in rats revealed only minor, temporary erythema, and the calculated Primary Irritation Index (0.22) confirmed a non-irritant profile. These findings suggest that the developed novasomal gel offers a promising approach for enhancing the treatment of fungal infections by enabling prolonged drug release, minimizing dosing frequency, and improving patient compliance. Full article

Background/Objectives: Vaccination uptake in Ethiopia is deeply shaped by gender norms, with women serving as primary caregivers but often limited by low autonomy, while men typically control household decisions but remain less engaged in child health. This study examines gendered influences on vaccine hesitancy and acceptance to inform future strategies. Methods: A community-based cross-sectional mixed-methods study was conducted in four regions of Ethiopia (Amhara, Oromia, Afar, and Tigray). Quantitative data were collected from 992 caregivers through multistage stratified sampling procedure, whereas qualitative data were collected from 26 in-depth interviews, 24 exit interviews and 11 key informant interviews and were analyzed thematically guided by the WHO Behavioural and Social Drivers framework. Multivariable logistic regression was conducted to determine the associations. Results: The result highlighted that the proportion of caregivers who reported willingness to vaccinate their child with all recommended vaccines was high (93.5%) and more likely among those with higher education, family support, religious support, and frequency of health worker contact. However, 51.1% of caregivers displayed some degree of vaccine hesitancy, with higher prevalence among males. Hesitancy was linked to traditional beliefs and norms that assign vaccination responsibility to mothers, urban residence, and being employed, while secondary education, family support, and religious support were protective. While acceptance is high, hesitancy persists. Gender roles, education, social support, and health worker engagement influence immunization outcomes. Conclusions: The study highlighted that expanding immunization across all age groups and reducing persistent hesitancy requires a shift toward gender-responsive strategies including integrating a gender perspective into the immunization programs that address traditional norms and misinformation. Full article

Brushless DC (BLDC) motors are commonly used in electric vehicles (EVs) because of their efficiency, small size and great torque-speed performance. These motors have a few benefits such as low maintenance, increased reliability and power density. Nevertheless, BLDC motors are highly nonlinear and their dynamics are very complicated, in particular, under changing load and supply conditions. The above features require the design of strong and adaptable control methods that can ensure performance over a broad spectrum of disturbances and uncertainties. In order to overcome these issues, this paper uses a Fractional-Order Proportional-Integral-Derivative (FOPID) controller that offers better control precision, better frequency response, and an extra degree of freedom in tuning by using non-integer order terms. Although it has the benefits, there are three primary drawbacks: (i) it is not real-time adaptable, (ii) it is hard to choose appropriate initial gain values, and (iii) it is sensitive to big disturbances and parameter changes. A new control framework is suggested to address these problems. First, a Reinforcement Learning (RL) approach based on Deep Deterministic Policy Gradient (DDPG) is presented to optimize the FOPID gains online so that the controller can adjust itself continuously to the variations in the system. Second, Snake Optimization (SO) algorithm is used in fine-tuning of the FOPID parameters at the initial stages to guarantee stable convergence. Lastly, cascade control structure is adopted, where FOPID controllers are used in the inner (current) and outer (speed) loops. This construction adds robustness to the system as a whole and minimizes the effect of disturbances on the performance. In addition, the cascade design also allows more coordinated and smooth control actions thus reducing stress on the power electronic switches, which reduces switching losses and the overall efficiency of the drive system. The suggested RL-enhanced cascade FOPID controller is verified by Hardware-in-the-Loop (HIL) testing, which shows better performance in the aspects of speed regulation, robustness, and adaptability to realistic conditions of operation in EV applications. Full article

Osteoarthritis is a prevalent and disabling condition in companion dogs, yet existing treatments are primarily symptomatic and limited by safety concerns. EF-M2, a defined derivative of vitamin D-binding protein, selectively biases macrophages toward an anti-inflammatory phenotype in vitro. We conducted a randomised, double-blind, placebo-controlled trial (IMPAWS-OA-1) in 60 client-owned dogs with naturally occurring hip or elbow osteoarthritis. Animals were allocated to subcutaneous EF-M2 (0.1 µg/kg) given thrice weekly or twice weekly, or to saline placebo for four weeks, followed by four weeks off-drug. The primary endpoint was change in Canine Brief Pain Inventory–Pain Severity Score (CBPI-PSS) at Day 28. EF-M2 produced dose–frequency-dependent benefits: LS-mean ΔPSS was −2.11 for thrice weekly, −1.42 for twice weekly, and −0.54 for placebo (arm effect p < 0.001). Objective measures showed parallel improvements in peak vertical force and accelerometery. Serum biomarkers confirmed macrophage repolarisation (ARG1/iNOS ratio, IL-10 increase, TNF-α decrease), correlating with clinical response. Adverse events were infrequent and mild, with no excess over placebo. In conclusion, EF-M2 achieved clinically meaningful pain relief, functional gains, and biomarker shifts without safety signals, establishing first-in-species proof that targeted macrophage modulation may be a viable disease-modifying approach for canine osteoarthritis. Full article