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17 pages, 1569 KB  
Article
The Role of Automated Diagnostics in the Identification of Learning Disabilities: Bayesian Probability Models in the Diagnostic Assessment
by Gergő Vida, Kálmán Sántha, Márta Trembulyák, Petra Pongrácz and Regina Balogh
Educ. Sci. 2025, 15(10), 1385; https://doi.org/10.3390/educsci15101385 - 16 Oct 2025
Abstract
This study investigates the application of Bayesian probability models in the diagnostic assessment of learning disabilities. The objective of this study was to determine whether specific conditions identified in expert reports could predict subsequent diagnoses. The sample consisted of 201 expert reports on [...] Read more.
This study investigates the application of Bayesian probability models in the diagnostic assessment of learning disabilities. The objective of this study was to determine whether specific conditions identified in expert reports could predict subsequent diagnoses. The sample consisted of 201 expert reports on children diagnosed with learning disabilities, which were analysed using qualitative content analysis, fuzzy set qualitative comparative analysis (fsQCA), and Bayesian conditional probability models. Variables such as vocabulary, working memory index, processing speed, and visuomotor coordination were examined as potential predictors. The analysis demonstrated that Bayesian networks captured conditional links, such as the strong association between working memory and perceptual inference, as well as an unexpected negative link between vocabulary and verbal comprehension. The study concludes that Bayesian networks provide a transparent and data-driven framework for pre-screening and risk assessment in special education settings. The limitations of this study include the absence of a control group and exclusive reliance on SNI cases. Future research should explore the integration of abductive reasoning into automated diagnostic software to enhance inclusivity and support decision-making. Full article
(This article belongs to the Special Issue Building Resilient Education in a Changing World)
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27 pages, 1191 KB  
Article
Elevational Patterns of Plant Species Richness: Insights from Western Himalayas
by Abhishek Kumar, Meenu Patil, Pardeep Kumar and Anand Narain Singh
Forests 2025, 16(10), 1591; https://doi.org/10.3390/f16101591 - 16 Oct 2025
Abstract
Understanding the patterns and drivers of species distribution has remained a central theme for biogeographical, conservation, and ecological research. This study aims to investigate the elevational patterns of plant species richness and compare the observed species richness with the predictions of the mid-domain [...] Read more.
Understanding the patterns and drivers of species distribution has remained a central theme for biogeographical, conservation, and ecological research. This study aims to investigate the elevational patterns of plant species richness and compare the observed species richness with the predictions of the mid-domain effect (MDE) null model. By combining information from field observations and the published literature, we compiled a comprehensive database of the elevational distribution of plant species for three protected areas in the Western Himalayas. We used generalised linear model (GLM) and null model simulations to explore the elevational patterns of plant species richness. Our study revealed simple linear to complex non-linear patterns depending on the location and range of the elevational gradient. While non-linear unimodal patterns were common, a linear decreasing pattern was also observed. The observed species richness showed consistent deviations from the predictions of the mid-domain effect null model, suggesting that factors beyond the range constraints shape species richness patterns. These observations indicate that richness patterns are not solely generated by random processes, rather climatic gradients, ecological interactions, and topographic heterogeneity can shape these patterns. Understanding these factors can aid in predicting and managing the impacts of ongoing environmental changes on Himalayan biodiversity. Full article
(This article belongs to the Section Forest Biodiversity)
28 pages, 4794 KB  
Article
Aircraft Propeller Design Technology Based on CST Parameterization, Deep Learning Models, and Genetic Algorithm
by Evgenii I. Kurkin, Jose Gabriel Quijada Pioquinto, Oleg E. Lukyanov, Vladislava O. Chertykovtseva and Artem V. Nikonorov
Technologies 2025, 13(10), 469; https://doi.org/10.3390/technologies13100469 (registering DOI) - 16 Oct 2025
Abstract
This article presents aircraft propeller optimal design technology; including an algorithm and OpenVINT 5 code. To achieve greater geometric flexibility, the proposed technique implements Class-Shape Transformation (CST) parameterization combined with Bézier curves, replacing the previous fully Bézier-based system. Performance improvements in the optimization [...] Read more.
This article presents aircraft propeller optimal design technology; including an algorithm and OpenVINT 5 code. To achieve greater geometric flexibility, the proposed technique implements Class-Shape Transformation (CST) parameterization combined with Bézier curves, replacing the previous fully Bézier-based system. Performance improvements in the optimization process are accomplished through deep learning models and a genetic algorithm, which substitute XFOIL and Differential Evolution-based approaches, respectively. The scientific novelty of the article lies in the application of a neural network to predict the aerodynamic characteristics of profiles in the form of contour diagrams, rather than scalar values, which execute the neural network repeatedly per ISM algorithm iteration and speed up the design time of propeller blades by 32 times as much. A propeller for an aircraft-type UAV was designed using the proposed methodology and OpenVINT 5. A comparison was made with the results to solve a similar problem using numerical mathematical models and experimental studies in a wind tunnel. Full article
(This article belongs to the Special Issue Aviation Science and Technology Applications)
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25 pages, 7428 KB  
Article
In Silico Analysis of MiRNA Regulatory Networks to Identify Potential Biomarkers for the Clinical Course of Viral Infections
by Elena V. Mikheeva, Kseniya S. Aulova, Georgy A. Nevinsky and Anna M. Timofeeva
Int. J. Mol. Sci. 2025, 26(20), 10100; https://doi.org/10.3390/ijms262010100 - 16 Oct 2025
Abstract
MiRNA expression profiles exhibit notable alterations in numerous diseases, particularly viral infections. Consequently, miRNAs may be regarded as both therapeutic targets and markers for the development of complications. MiRNAs can significantly influence the modulation of immune responses, offering an extra layer of regulation [...] Read more.
MiRNA expression profiles exhibit notable alterations in numerous diseases, particularly viral infections. Consequently, miRNAs may be regarded as both therapeutic targets and markers for the development of complications. MiRNAs can significantly influence the modulation of immune responses, offering an extra layer of regulation during viral infections. In this study, miRNAs associated with viral infections were analyzed using an in silico approach. Computer modeling predicted a number of miRNAs capable of influencing the functionality of specific components of the immune system. As a result, 242 miRNAs common to the three types of infections were identified. A network of miRNA-gene regulatory interactions, encompassing 502 nodes (224 miRNAs and 278 genes) and 2236 interactions, was developed. Within this network, subnetworks were identified that are involved in the operation of specific connections in the immune response to viruses. For each step of the immune response, the miRNAs involved in governing these processes were examined. These predicted miRNAs are of particular interest for further analysis aimed at establishing the relationship between their differential expression and disease symptom severity. The obtained data lay the foundation for identifying the most promising molecules as predictive biomarkers and the subsequent development of a diagnostic system. Full article
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73 pages, 2702 KB  
Review
Towards an End-to-End Digital Framework for Precision Crop Disease Diagnosis and Management Based on Emerging Sensing and Computing Technologies: State over Past Decade and Prospects
by Chijioke Leonard Nkwocha and Abhilash Kumar Chandel
Computers 2025, 14(10), 443; https://doi.org/10.3390/computers14100443 (registering DOI) - 16 Oct 2025
Abstract
Early detection and diagnosis of plant diseases is critical for ensuring global food security and sustainable agricultural practices. This review comprehensively examines latest advancements in crop disease risk prediction, onset detection through imaging techniques, machine learning (ML), deep learning (DL), and edge computing [...] Read more.
Early detection and diagnosis of plant diseases is critical for ensuring global food security and sustainable agricultural practices. This review comprehensively examines latest advancements in crop disease risk prediction, onset detection through imaging techniques, machine learning (ML), deep learning (DL), and edge computing technologies. Traditional disease detection methods, which rely on visual inspections, are time-consuming, and often inaccurate. While chemical analyses are accurate, they can be time consuming and leave less flexibility to promptly implement remedial actions. In contrast, modern techniques such as hyperspectral and multispectral imaging, thermal imaging, and fluorescence imaging, among others can provide non-invasive and highly accurate solutions for identifying plant diseases at early stages. The integration of ML and DL models, including convolutional neural networks (CNNs) and transfer learning, has significantly improved disease classification and severity assessment. Furthermore, edge computing and the Internet of Things (IoT) facilitate real-time disease monitoring by processing and communicating data directly in/from the field, reducing latency and reliance on in-house as well as centralized cloud computing. Despite these advancements, challenges remain in terms of multimodal dataset standardization, integration of individual technologies of sensing, data processing, communication, and decision-making to provide a complete end-to-end solution for practical implementations. In addition, robustness of such technologies in varying field conditions, and affordability has also not been reviewed. To this end, this review paper focuses on broad areas of sensing, computing, and communication systems to outline the transformative potential of end-to-end solutions for effective implementations towards crop disease management in modern agricultural systems. Foundation of this review also highlights critical potential for integrating AI-driven disease detection and predictive models capable of analyzing multimodal data of environmental factors such as temperature and humidity, as well as visible-range and thermal imagery information for early disease diagnosis and timely management. Future research should focus on developing autonomous end-to-end disease monitoring systems that incorporate these technologies, fostering comprehensive precision agriculture and sustainable crop production. Full article
32 pages, 2613 KB  
Article
Recognition of Stages of Endogenous Fire Outbreak and Development in Coal Mines
by Nurlan Suleimenov, Gulmira Sattarova, Nursultan Sarsenbekov, Nurzhamal Ermukhanova, Vasiliy Portnov, Nail Zamaliyev, Firuza Batessova, Sveta Imanbayeva, Alexandr Zakharov and Assylbek Abdirashit
Appl. Sci. 2025, 15(20), 11114; https://doi.org/10.3390/app152011114 - 16 Oct 2025
Abstract
This article reveals the nature, causes, and main stages of occurrence and development of endogenous fires in coal mines. It is emphasized that one of the key tasks of fire protection specialists is the most accurate determination of the stage of oxidation and [...] Read more.
This article reveals the nature, causes, and main stages of occurrence and development of endogenous fires in coal mines. It is emphasized that one of the key tasks of fire protection specialists is the most accurate determination of the stage of oxidation and self-heating of coal. A review of existing gas analysis methods for identifying the initial and subsequent stages of endogenous fire development is conducted. Particular attention is focused on the importance of obtaining prompt reliable information on the self-heating temperature of coal and the dynamics of its change in the early stages of the process. Since self-heating zones are usually inaccessible for direct instrumental control, the main source of information is the gas analysis of air samples. The authors present the results of research on the dependence of the indicator gas content on the coal self-heating temperature. Based on the Graham criterion, the stages of thermal development of the process are predicted. Correlation dependencies between temperature and integral parameters of indicator gas concentrations are developed, allowing for a sufficient degree of reliability in determining the stages of coal self-heating and spontaneous combustion. Based on the results of the work, methodological recommendations for the prevention and warning of endogenous fires in coal mines and opencasts are proposed. They are based on the most informative and accessible signs suitable for quantitative assessment. The implementation of these recommendations will improve the level of industrial safety and reduce the risks of fires and explosions during mining operations. Full article
24 pages, 8189 KB  
Article
Research on Safety Evaluation Methods for Interchange Diverting Zones Based on Operating Speed
by Haochen Bai, Shengyu Xi, Chi Zhang, Bo Wang, Zhuxuan Cai, Yi Lin and Tingyu Guo
Sustainability 2025, 17(20), 9194; https://doi.org/10.3390/su17209194 (registering DOI) - 16 Oct 2025
Abstract
In response to the growing safety challenges posed by large-scale and specialized freight transportation on China’s rapidly expanding highway network, this study investigates the operational characteristics of trucks in interchange diverging areas—a critical segment with elevated accident risks. Leveraging high-frequency trajectory data collected [...] Read more.
In response to the growing safety challenges posed by large-scale and specialized freight transportation on China’s rapidly expanding highway network, this study investigates the operational characteristics of trucks in interchange diverging areas—a critical segment with elevated accident risks. Leveraging high-frequency trajectory data collected from 16 interchanges, we analyze speed profiles and acceleration behavior of heavy trucks across key sections: the diversion influence zone, preparation zone, transition segment, and deceleration lane. A key contribution of this work is the development of a continuous speed prediction model based on Partial Least Squares Regression, which integrates road geometric parameters and driving behavior features to estimate speeds at four critical cross-sections of the diverging process. Furthermore, we propose a comprehensive safety evaluation framework incorporating three novel indicators: longitudinal speed consistency, lateral stability, and deceleration comfort. The model demonstrates strong performance, with all mean absolute percentage errors below 10% during validation using data from four independent interchanges. Comparative analysis with existing safety standards confirms the practical applicability and accuracy of the proposed methodology. This research offers three major contributions: (1) a systematic approach for processing large-scale trajectory data and predicting truck speeds in diverging areas; (2) a safety assessment framework tailored for geometric design consistency evaluation; and (3) empirical support for optimizing traffic safety facilities in interchange design and operation. The findings address a significant gap in current highway design guidelines and provide actionable insights for enhancing safety in truck-dominated transportation environments. Full article
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14 pages, 866 KB  
Review
Genetic Prediction of Eye, Hair, and Skin Color: Forensic Applications and Challenges in Latin American Populations
by Beatriz Armida Flores-López, Anna Guadalupe López-Ceballos, Cristal Azucena López-Aguilar, Manuel Alejandro Rico-Méndez, Kesia Lyvier Acosta-Ramírez, Alan Cano-Ravell, Gildardo Gembe-Olivarez, Andres López-Quintero, José Alonso Aguilar-Velázquez, Jorge Adrian Ramírez-de-Arellano Sánchez and José Miguel Moreno-Ortiz
Genes 2025, 16(10), 1227; https://doi.org/10.3390/genes16101227 - 16 Oct 2025
Abstract
Forensic DNA phenotyping (FDP) is an important innovation approach in forensics sciences, especially when traditional DNA profiling results are limited, mostly due to the absence of reference samples. FDP is based on the detection of genetic variants in specific genes whose function is [...] Read more.
Forensic DNA phenotyping (FDP) is an important innovation approach in forensics sciences, especially when traditional DNA profiling results are limited, mostly due to the absence of reference samples. FDP is based on the detection of genetic variants in specific genes whose function is related to pigmentation mechanisms and uses the genotypes found in the sample to determine the externally visible traits (EVT) such as the iris, hair, and skin tone or color of the individual; this prediction would help and expedite human identification processes and solve criminal cases. Several technologies have been developed to facilitate EVT prediction; however, most of them have been validated only in European populations. Implementing techniques for FDP in Latin American countries is essential given the problems of disappearance and human identification that have persisted for years. Nonetheless, scientists have a great challenge due to the admixed genetic structure of the population. This review explores the current application of FDP, emphasizing its significance, practical uses, and limitations within Latin American populations. Full article
(This article belongs to the Special Issue Advances in Forensic Genetics and DNA)
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13 pages, 767 KB  
Article
Reinterpretation of Fermi Acceleration of Cosmic Rays in Terms of Ballistic Surfing Acceleration in Supernova Shocks
by Krzysztof Stasiewicz
Physics 2025, 7(4), 51; https://doi.org/10.3390/physics7040051 (registering DOI) - 16 Oct 2025
Abstract
The applicability of the first-order Fermi mechanism—a cornerstone of the diffusive shock acceleration (DSA) model—in explaining the cosmic ray spectrum is reexamined in light of recent observations from the Magnetospheric Multiscale (MMS) mission at Earth’s bow shock. It is demonstrated that the Fermi [...] Read more.
The applicability of the first-order Fermi mechanism—a cornerstone of the diffusive shock acceleration (DSA) model—in explaining the cosmic ray spectrum is reexamined in light of recent observations from the Magnetospheric Multiscale (MMS) mission at Earth’s bow shock. It is demonstrated that the Fermi and DSA mechanisms lack physical justification and should be replaced by the physically correct ballistic surfing acceleration (BSA) mechanism. The results show that cosmic rays are energized by the convection electric field during ballistic surfing upstream of quasi-perpendicular shocks, independently of internal shock processes. The spectral index of cosmic rays is determined by the magnetic field compression and shock geometry: the acceleration is strongest in perpendicular shocks and vanishes in parallel shocks. The BSA mechanism reproduces the observed spectral indices, with s=2.7 below the knee at 1016 eV and s=3 above it. It is suggested that the spectral knee may correspond to particles whose gyroradii are comparable to the characteristic size of shocks in supernova remnants. The acceleration time to reach the knee energy, as predicted by the BSA, is in the order of 500 years. Full article
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26 pages, 2009 KB  
Article
Tool Wear Prediction Using Machine-Learning Models for Bone Drilling in Robotic Surgery
by Shilpa Pusuluri, Hemanth Satya Veer Damineni and Poolan Vivekananda Shanmuganathan
Automation 2025, 6(4), 59; https://doi.org/10.3390/automation6040059 (registering DOI) - 16 Oct 2025
Abstract
Bone drilling is a widely encountered process in orthopedic surgeries and keyhole neuro surgeries. We are developing a sensor-integrated smart end-effector for drilling for robotic surgical applications. In manual surgeries, surgeons assess tool wear based on experience and force perception. In this work, [...] Read more.
Bone drilling is a widely encountered process in orthopedic surgeries and keyhole neuro surgeries. We are developing a sensor-integrated smart end-effector for drilling for robotic surgical applications. In manual surgeries, surgeons assess tool wear based on experience and force perception. In this work, we propose a machine-learning (ML)-based tool condition monitoring system based on multi-sensor data to preempt excessive tool wear during drilling in robotic surgery. Real-time data is acquired from the six-component force sensor of a collaborative arm along with the data from the temperature and multi-axis vibration sensor mounted on the bone specimen being drilled upon. Raw data from the sensors may have noises and outliers. Signal processing in the time- and frequency-domain are used for denoising as well as to obtain additional features to be derived from the raw sensory data. This paper addresses the challenging problem of identification of the most suitable ML algorithm and the most suitable features to be used as inputs to the algorithm. While dozens of features and innumerable machine learning and deep learning models are available, this paper addresses the problem of selecting the most relevant features, the most relevant AI models, and the optimal hyperparameters to be used in the AI model to provide accurate prediction on the tool condition. A unique framework is proposed for classifying tool wear that combines machine learning-based modeling with multi-sensor data. From the raw sensory data that contains only a handful of features, a number of additional features are derived using frequency-domain techniques and statistical measures. Using feature engineering, we arrived at a total of 60 features from time-domain, frequency-domain, and interaction-based metrics. Such additional features help in improving its predictive capabilities but make the training and prediction complicated and time-consuming. Using a sequence of techniques such as variance thresholding, correlation filtering, ANOVA F-test, and SHAP analysis, the number of features was reduced from 60 to the 4 features that will be most effective in real-time tool condition prediction. In contrast to previous studies that only examine a small number of machine learning models, our approach systematically evaluates a wide range of machine learning and deep learning architectures. The performances of 47 classical ML models and 6 deep learning (DL) architectures were analyzed using the set of the four features identified as most suitable. The Extra Trees Classifier (an ML model) and the one-dimensional Convolutional Neural Network (1D CNN) exhibited the best prediction accuracy among the models studied. Using real-time data, these models monitored the drilling tool condition in real-time to classify the tool wear into three categories of slight, moderate, and severe. Full article
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27 pages, 3065 KB  
Article
Chinese Financial News Analysis for Sentiment and Stock Prediction: A Comparative Framework with Language Models
by Hsiu-Min Chuang, Hsiang-Chih He and Ming-Che Hu
Big Data Cogn. Comput. 2025, 9(10), 263; https://doi.org/10.3390/bdcc9100263 - 16 Oct 2025
Abstract
Financial news has a significant impact on investor sentiment and short-term stock price trends. While many studies have applied natural language processing (NLP) techniques to financial forecasting, most have focused on single tasks or English corpora, with limited research in non-English language contexts [...] Read more.
Financial news has a significant impact on investor sentiment and short-term stock price trends. While many studies have applied natural language processing (NLP) techniques to financial forecasting, most have focused on single tasks or English corpora, with limited research in non-English language contexts such as Taiwan. This study develops a joint framework to perform sentiment classification and short-term stock price prediction using Chinese financial news from Taiwan’s top 50 listed companies. Five types of word embeddings—one-hot, TF-IDF, CBOW, skip-gram, and BERT—are systematically compared across 17 traditional, deep, and Transformer models, as well as a large language model (LLaMA3) fully fine-tuned on the Chinese financial texts. To ensure annotation quality, sentiment labels were manually assigned by annotators with finance backgrounds and validated through a double-checking process. Experimental results show that a CNN using skip-gram embeddings achieves the strongest performance among deep learning models, while LLaMA3 yields the highest overall F1-score for sentiment classification. For regression, LSTM consistently provides the most reliable predictive power across different volatility groups, with Bayesian Linear Regression remaining competitive for low-volatility firms. LLaMA3 is the only Transformer-based model to achieve a positive R2 under high-volatility conditions. Furthermore, forecasting accuracy is higher for the five-day horizon than for the fifteen-day horizon, underscoring the increasing difficulty of medium-term forecasting. These findings confirm that financial news provides valuable predictive signals for emerging markets and that short-term sentiment-informed forecasts enhance real-time investment decisions. Full article
(This article belongs to the Special Issue Natural Language Processing Applications in Big Data)
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17 pages, 4052 KB  
Article
Melting Behavior of Direct Reduced Iron Pellets with Different Carbon Content in Molten Steel and Molten Slag
by Fabian Andres Calderon Hurtado, Joseph Govro, Arezoo Emdadi and Ronald J. O’Malley
Materials 2025, 18(20), 4749; https://doi.org/10.3390/ma18204749 (registering DOI) - 16 Oct 2025
Abstract
This study investigates the melting behavior of direct reduced iron (DRI) pellets in molten slag and steel baths, focusing on how the carbon content influences the melting rate through the stirring effects of gas evolution on heat transfer. A computational model using COMSOL [...] Read more.
This study investigates the melting behavior of direct reduced iron (DRI) pellets in molten slag and steel baths, focusing on how the carbon content influences the melting rate through the stirring effects of gas evolution on heat transfer. A computational model using COMSOL Multiphysics 6.1 is developed to simulate the temperature profile at the pellet’s core and the gas evolution resulting from the reaction between FeO and carbon within the pellet. The model is validated using experimental data from this study as well as literature on the DRI pellet–molten slag system. Results indicate that, despite the increased enthalpy demand associated with the gas-generating reactions, higher carbon content enhances heat transfer within the pellet, leading to an increased melting rate. The computational model accurately predicts gas generation and temperature profiles, aligning well with experimental observations. Overall, the findings demonstrate that increasing the carbon content in DRI pellets accelerates the melting process. Full article
(This article belongs to the Section Green Materials)
23 pages, 1412 KB  
Article
Probabilistic 4D Trajectory Prediction for UAVs Based on Brownian Bridge Motion
by Pengda Zhu, Minghua Hu, Zexi Dong and Jianan Yin
Appl. Sci. 2025, 15(20), 11105; https://doi.org/10.3390/app152011105 - 16 Oct 2025
Abstract
Unmanned aerial vehicle (UAV) flight trajectories in complex environments are often affected by multiple uncertainties, making accurate prediction challenging. To address this issue, this study proposes a probabilistic four-dimensional (4D) trajectory prediction model based on Brownian bridge motion. The UAV’s flight from mission [...] Read more.
Unmanned aerial vehicle (UAV) flight trajectories in complex environments are often affected by multiple uncertainties, making accurate prediction challenging. To address this issue, this study proposes a probabilistic four-dimensional (4D) trajectory prediction model based on Brownian bridge motion. The UAV’s flight from mission start to endpoint is modeled as a Brownian bridge stochastic process with endpoint constraints, where the mean function sequence is constructed from path planning results and UAV performance parameters. To incorporate operational feasibility, the concept of the spatiotemporal reachable domain from time geography is introduced to dynamically constrain reachable positions, while a truncated Brownian bridge distribution is used to model probabilistic positions in three-dimensional space. A simulation platform in a realistic 3D geographical environment is developed to validate the model. Case studies show that the proposed method achieves dynamic probabilistic trajectory prediction under mission constraints with strong adaptability and practicality. The results provide theoretical support and technical reference for trajectory planning, conflict detection, and flight risk assessment in the pre-tactical phase. Full article
21 pages, 3443 KB  
Review
Artificial Intelligence in the Management of Infectious Diseases in Older Adults: Diagnostic, Prognostic, and Therapeutic Applications
by Antonio Pinto, Flavia Pennisi, Stefano Odelli, Emanuele De Ponti, Nicola Veronese, Carlo Signorelli, Vincenzo Baldo and Vincenza Gianfredi
Biomedicines 2025, 13(10), 2525; https://doi.org/10.3390/biomedicines13102525 - 16 Oct 2025
Abstract
Background: Older adults are highly vulnerable to infectious diseases due to immunosenescence, multimorbidity, and atypical presentations. Artificial intelligence (AI) offers promising opportunities to improve diagnosis, prognosis, treatment, and continuity of care in this population. This review summarizes current applications of AI in [...] Read more.
Background: Older adults are highly vulnerable to infectious diseases due to immunosenescence, multimorbidity, and atypical presentations. Artificial intelligence (AI) offers promising opportunities to improve diagnosis, prognosis, treatment, and continuity of care in this population. This review summarizes current applications of AI in the management of infections in older adults across diagnostic, prognostic, therapeutic, and preventive domains. Methods: We conducted a narrative review of peer-reviewed studies retrieved from PubMed, Scopus, and Web of Science, focusing on AI-based tools for infection diagnosis, risk prediction, antimicrobial stewardship, prevention of healthcare-associated infections, and post-discharge care in individuals aged ≥65 years. Results: AI models, including machine learning, deep learning, and natural language processing techniques, have demonstrated high performance in detecting infections such as sepsis, pneumonia, and healthcare-associated infections (Area Under the Curve AUC up to 0.98). Prognostic algorithms integrating frailty and functional status enhance the prediction of mortality, complications, and readmission. AI-driven clinical decision support systems contribute to optimized antimicrobial therapy and timely interventions, while remote monitoring and telemedicine applications support safer hospital-to-home transitions and reduced 30-day readmissions. However, the implementation of these technologies is limited by the underrepresentation of frail older adults in training datasets, lack of real-world validation in geriatric settings, and the insufficient explainability of many models. Additional barriers include system interoperability issues and variable digital infrastructure, particularly in long-term care and community settings. Conclusions: AI has strong potential to support predictive and personalized infection management in older adults. Future research should focus on developing geriatric-specific, interpretable models, improving system integration, and fostering interdisciplinary collaboration to ensure safe and equitable implementation. Full article
(This article belongs to the Special Issue Feature Reviews in Infection and Immunity)
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22 pages, 2322 KB  
Article
Adsorption of Methylene Blue (MB) Using Novel Synthesized Phosphogypsum Flotation Tailings-Derived Zeolite (PGTZ): Experimental and Modeling Approaches
by Changxin Li, Jinyu Yang, Shanpei Liu, Nan Liu, Lili Zhang and Lu Ren
Separations 2025, 12(10), 286; https://doi.org/10.3390/separations12100286 - 16 Oct 2025
Abstract
A phosphogypsum flotation tailings-derived zeolite (PGTZ) was synthesized from the tailings produced during the reverse flotation of phosphogypsum through alkaline fusion and hydrothermal treatment. The response surface methodology (RSM) utilizing a three-level Box–Behnken design (BBD) was used to assess the adsorption of MB [...] Read more.
A phosphogypsum flotation tailings-derived zeolite (PGTZ) was synthesized from the tailings produced during the reverse flotation of phosphogypsum through alkaline fusion and hydrothermal treatment. The response surface methodology (RSM) utilizing a three-level Box–Behnken design (BBD) was used to assess the adsorption of MB by PGTZ. Polynomial regression models were developed to analyze the effects of process parameters on adsorption capacity (qe). The maximum MB adsorption occurred under the following optimized conditions: PGTZ dosage = 5.31 g·L−1; initial MB concentration = 294.59 mg·L−1; pH = 7.42; and adsorption time = 187.89 min. Additionally, adsorption isotherm and kinetic models were fitted to the experimental data to determine model parameters. The Langmuir isotherm model and pseudo-second-order kinetic model incorporating intraparticle diffusion were able to effectively predict MB adsorption onto PGTZ. Thermodynamic analyses indicated that the adsorption process was spontaneous, with strong chemical interactions between MB and PGTZ. Full article
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