Search Results (3,071)

As the process of agricultural modernization accelerates, exploring the impact of agricultural mechanization services on production technology efficiency has become a key issue for enhancing agricultural productivity and promoting sustainable agricultural development. The study focuses on cotton growers in the Tarim River Basin and systematically explores the impact and driving mechanisms of agricultural mechanization services (AMSs) on cotton production’s technical efficiency within the framework of the social–ecological system (SES). By employing a combination of stochastic frontier analysis (SFA) and propensity score matching (PSM), the research indicates that the adoption of AMSs significantly enhances the production technical efficiency of cotton farmers. Among the sample that adopted this service, as much as 53.04% of the farmers have their production efficiency within the range of [0.8, 0.9], demonstrating a high production capability. In contrast, the production efficiency values of the farmers who did not adopt such services are more dispersed, with inefficient samples accounting for 11.48%. Furthermore, while the technical efficiency levels across different regions are similar, there are significant efficiency differences within regions. A further analysis indicates that the age of the household head, their education level, the number of agricultural laborers in the family, the proportion of income from planting, and irrigation convenience have a positive impact on farmers’ adoption of AMSs, while the degree of land fragmentation has a negative impact. Therefore, AMSs are not only a core pathway to enhance cotton production’s technical efficiency but also an important support for promoting agricultural modernization in arid areas and strengthening farmers’ risk-resistance capabilities. Future policies should focus on optimizing service delivery, enhancing technical adaptability, and promoting regional collaboration to drive the high-quality development of the cotton industry and support sustainable rural revitalization. Full article

Using additives in sugarcane silage can reduce dry matter losses and enhance animal performance by preserving nutritional value. This study evaluated the performance, nutrient digestibility, and blood parameters of sheep fed sugarcane silage with or without cottonseed cake. Twenty-six uncastrated, mixed-breed male lambs (approximately 6 months of age; 26 ± 1.3 kg) were allocated to two dietary treatments based on sugarcane silage (SS) and cottonseed cake (CSC), which differed in the form of feed presentation: (1) the control, consisting of SS and fresh CSC provided simultaneously but offered separately, without physical mixing; and (2) the Partial Mixed Ration silage (S + CSC), in which SS and CSC were pre-mixed and ensiled together at a proportion of 80:20 (natural matter basis). Dry matter intake (1620 g/kg) was similar between diets, but dry matter digestibility (64.75%) and average daily gain (202.88 g/day) were higher in the cottonseed cake group, leading to greater total weight gain (8.11 kg). These animals also had a lower acetate/propionate ratio (4.2 vs. 2.0 mmol/L) and higher blood glucose (44 vs. 35 mg/dL). Higher N intake, urinary N, and retained N were observed in the cottonseed cake diet, which also improved the diet’s mineral balance. In conclusion, adding cottonseed cake to sugarcane silage enhances fermentation, preserves nutritional value, and improves sheep performance. Full article

Surface charge accumulation is considered one of the key factors that lead to unexpected insulator flashover failures in gas-insulated switchgear (GIS). With the existence of metal particles, charge accumulation characteristics on insulator surfaces become intricate in eco-friendly gases under AC voltage. In this study, the surface charge behavior on a down-scaled 252 kV AC GIS basin insulator model with a linear metal particle adhered to the HV electrode on the convex surface in compressed air (80%N₂/20%O₂) and C₄F₇N/CO₂ mixtures was investigated. After applying an AC voltage of 40 kV for 5 min, the charge densities on both surfaces were measured, and the effect of the metal particle and gas parameters was discussed. The results showed that charge spots were induced by metal particles on the insulator surfaces, and the polarities of which varied with the gas atmosphere. A decrease in maximum charge density was detected with an increase in C₄F₇N proportion at 0.1 MPa, and soar of which was observed at 0.5 MPa. With an increase in gas pressure, the maximum charge density increased in both atmospheres. The total quantity of charges showed similar behavior to the charge densities. It is indicated that the high electronegativity of C₄F₇N molecules presents a competing relationship in charge accumulation as the pressure increases. Full article

In this study, the feasibility of using three-dimensional (3D) printing technology to investigate the impact of macrotexture and microtexture on the skid resistance of asphalt pavement was verified. The macrotexture characteristics of the five types of real asphalt mixtures were captured, reconstructed, and printed. The comparison analysis of the skid resistance between the pavement and printed specimens was conducted, and the correlations and contribution proportions of the macrotexture and microtexture on skid resistance were also calculated. Results show that five printed asphalt mixtures present good consistency in the microtexture with a roughness of about 100 nm. The impact of thin water film on the skid resistance is insignificant for real asphalt mixtures, while it is significant for printed mixtures. The printed specimens under dry conditions show a similar British pendulum number (BPN) with the real pavement specimens under wet conditions, while the BPN under wet conditions for printed specimens are much smaller than the real ones but follows a similar variation trend. Mean profile depth (MPD) values of four printed asphalt concrete (AC) mixtures are well linearly correlated with their BPN under dry and wet conditions, especially for wet conditions with the R² of 0.91. The contribution proportion of macrotexture to the skid resistance is nearly 90% for the dry condition and about 50% for the wet condition. Full article

Patent licensing is essential for sustainable technological diffusion, fostering innovation and strengthening industrial resilience. However, the determinants influencing patent licensing decisions remain underexplored. This study investigates these factors at both the enterprise and patent levels, emphasizing their role in promoting sustainable industrial innovation and knowledge transfer. Given the low proportion of licensed patents, this research proposes a measurement framework to identify thematically similar but unlicensed patents and applies a conditional logistic regression model to analyze the factors affecting licensing decisions. Using patent abstracts from the intelligent connected vehicles (ICVs) sector, topic modeling is conducted to classify technological themes, and Kullback–Leibler divergence is applied to measure differences between licensed and unlicensed patents. The results indicate that technological prestige and depth negatively influence licensing, whereas technological breadth, advancement, and stability have a positive effect. From a sustainability perspective, enterprises should optimize technology management to support responsible knowledge transfer and green innovation. Universities should enhance patent quality and innovation impact to contribute more effectively to sustainable development. Policymakers should refine patent licensing frameworks to foster an efficient, inclusive, and sustainable intellectual property ecosystem, thereby facilitating cross-sectoral technology diffusion, advancing eco-friendly industrial transformation, and promoting sustainable economic growth. Full article

Investigating the coupling coordination between urban scale and vitality is critical for enhancing holistic urban development quality and advancing sustainability. Taking the Changsha-Zhuzhou-Xiangtan (ChangZhuTtan) metropolitan area as a case study, this research integrates multi-source raster and vector data to: (1) analyze spatial patterns of urban scale and virtual–substantive vitality; (2) delineate a “scale-vitality” hierarchical zonal structure; (3) quantify coupling relationships across subzones; and (4) propose synergistic spatial optimization strategies. Key findings reveal that, distinct core-periphery structure characterizes urban scale and vitality, with Changsha’s central districts dominating population, land use, and economic metrics, while Zhuzhou and Xiangtan exhibit moderate concentrations. Significant positive correlations exist between urban scale and dual vitality types, with scale-driven vitality enhancement being most pronounced in core agglomeration zones. Furthermore, in the metropolitan core, where both urban scale and vitality values are high, they exhibit a high-value coupling state. As they expanded outward, both metrics gradually decreased, resulting in a low-value coupling state. However, zonal comparisons (core agglomeration circle–peripheral expansion circle) reveal that the proportion of spatially coupled units progressively increases. By elucidating scale-vitality coupling in the ChangZhuTtan metropolitan area, this study provides actionable insights for spatial planning and sustainable urban transition. The methodology framework is replicable for similar metropolitan regions globally. Full article

Glycerol can effectively replace corn as an energy source in lamb diets without negatively impacting productive performance. This study evaluated the effects of substituting ground corn with different glycerol levels on the productive performance, ruminal fermentation, carcass characteristics, and meat quality at 24 h, 7, 14, and 21 d post-slaughter. A total of 40 male Suffolk × Hampshire crossbred lambs (25 ± 5 kg live weight) were used in a completely randomized design with four treatment groups (n = 10 each): 0% glycerol (GLY₀), 5% glycerol (GLY0₅), 10% glycerol (GLY₁₀), and 15% glycerol (GLY₁₅). Including glycerol in the diet did not affect growth performance (p > 0.05). However, it did lead to an increase (p < 0.05) in the concentrations of NH₃-N and the proportions of propionic and butyric acids, while the acetic acid levels decreased (p < 0.05). The backfat thickness, loin eye area (LEA), and carcass yield were not significantly affected (p > 0.05) by the addition of glycerol. Additionally, pH and color were also unaffected (p > 0.05), although the water-holding capacity showed a decrease (p < 0.05) over the shelf life of the meat. The chemical composition of the meat remained similar across all treatments, time points, and interactions (p > 0.05). In contrast, the protein content was significantly affected (p < 0.05) by the glycerol inclusion, time, and interactions between treatment and time. The results indicate that substituting up to 15% of ground corn with glycerol in lamb diets does not negatively impact productive performance, backfat thickness, LEA, carcass traits, or meat quality during shelf life. Throughout the shelf life, the crude protein concentrations and water-holding capacity decreased, while the propionic acid and NH₃-N concentrations increased. Full article

Background: When missing data are present in clinical outcomes studies, complete-case analysis (CCA) is often performed, whereby patients with missing data are excluded. While simple, CCA analysis may impart selection bias and reduce statistical power, leading to erroneous statistical results in some cases. However, there exist more rigorous statistical approaches, such as single and multiple imputation, which approximate the associations that would have been present in a full dataset and preserve the study’s power. The purpose of this study is to evaluate how statistical results differ when performed after CCA analysis versus imputation methods. Methods: This simulation study analyzed a sample dataset consisting of 2204 shoulders, with complete datapoints from a larger multicenter total shoulder arthroplasty database. From the sampled dataset of demographics, surgical characteristics, and clinical outcomes, we created five test datasets, ranging from 100 to 2000 shoulders, and simulated 10–50% missingness in the postoperative American Shoulder and Elbow Surgeons (ASES) score and range of motion in four planes in missing completely at random (MCAR), missing at random (MAR), and not missing at random (NMAR) patterns. Missingness in outcomes was remedied using CCA, three single imputation techniques, and two multiple imputation techniques. The imputation performance was evaluated relative to the native complete dataset using the root mean squared error (RMSE) and the mean absolute percentage error (MAPE). We also compared the mean and standard deviation (SD) of the postoperative ASES score and the results of multivariable linear and logistic regression to understand the effects of imputation on the study results. Results: The average overall RMSE and MAPE were similar for MCAR (22.6 and 27.2%) and MAR (19.2 and 17.7%) missingness patterns, but were substantially poorer for NMAR (37.5 and 79.2%); the sample size and the percentage of data missingness minimally affected RMSE and MAPE. Aggregated mean postoperative ASES scores were within 5% of the true value when missing data were remedied with CCA, and all candidate imputation methods for nearly all ranges of sample size and data missingness when data were MCAR or MAR, but not when data were NMAR. When data were MAR, CCA resulted in overestimates of the SD. When data were MCAR or MAR, the accuracy of the regression estimate (β or OR) and its corresponding 95% CI varied substantially based on the sample size and proportion of missing data for multivariable linear regression, but not logistic regression. When data were MAR, the width of the 95% CI was up to 300% larger when CCA was used, whereas most imputation methods maintained the width of the 95% CI within 50% of the true value. Single imputation with k-nearest neighbor (kNN) method and multiple imputation with predictive mean matching (MICE-PMM) best-reproduced point estimates and intervariable relationships resembling the native dataset. Availability of correlated outcome scores improved the RMSE, MAPE, accuracy of the mean postoperative ASES score, and multivariable linear regression model estimates. Conclusions: Complete-case analysis can introduce selection bias when data are MAR, and it results in loss of statistical power, resulting in loss of precision (i.e., expansion of the 95% CI) and predisposition to false-negative findings. Our data demonstrate that imputation can reliably reproduce missing clinical data and generate accurate population estimates that closely resemble results derived from native primary shoulder arthroplasty datasets (i.e., prior to simulated data missingness). Further study of the use of imputation in clinical database research is critical, as the use of CCA may lead to different conclusions in comparison to more rigorous imputation approaches. Full article

Background: This study aimed to analyze the clinical features and prognosis of cervical esophageal squamous cell carcinoma (ESCC) compared to ESCC more inferiorly in the esophagus. Methods: Medical records of patients with ESCC between December 2008 and December 2024 were retrospectively reviewed. A total of 497 patients with ESCC were included and divided into cervical (n = 32) and non-cervical (n = 465) groups. Clinical features and survival according to treatment were compared between the two groups. Results: Patients with cervical ESCC were older (median age 73 years vs. 67 years, p = 0.047) with a higher proportion of females (18.7% vs. 10.1%, p = 0.133) than patients with non-cervical ESCC. Cervical ESCC had worse differentiation (34.4% vs. 19.6%, p = 0.049 in the rate of poorly differentiated carcinoma) and higher T stage (6.2% vs. 37.2%, p = 0.003 in T1; 28.1% vs. 4.7%, p < 0.001 in T4) than non-cervical ESCC. There was no difference in lymph node metastasis (65.6% vs. 54.6%, p = 0.229) or distant metastasis (15.6% vs. 15.5%, p = 0.983) between the two groups. Overall survival was lower in the cervical group (hazard ratio [HR], 1.51; 95% confidence interval [CI], 0.96–2.40; p = 0.076). When comparing outcomes of patients who underwent definitive chemoradiotherapy, the complete response rate (63.6% vs. 53.4%, p = 0.340) and survival (HR, 1.01; 95% CI, 0.51–1.99; p = 0.973) were similar between the two groups. Conclusions: Although cervical ESCC had a poor prognosis due to its higher T-stage and worse differentiation compared to other locations, outcomes were similar when treated with definitive chemoradiotherapy. Full article

Objective: This study aimed to evaluate the characteristics, clinical outcomes, and resource use of patients with unresectable hepatocellular carcinoma (uHCC) treated with first-line (1L) atezolizumab plus bevacizumab (A+B) at five United States (US) institutions: the Mayo Clinic, Houston Methodist, Moffitt Cancer Center, Mays Cancer Center, and University of Arizona. Methods: Treating oncologists extracted data from medical charts of patients with uHCC who were treated with A+B after 1 January 2019. Real-world progression-free survival (rwPFS) and overall survival (OS) were assessed using the Kaplan–Meier method for the overall cohort and for a “trial-like” subgroup with characteristics similar to those in the IMbrave150 trial (Eastern Cooperative Oncology Group Performance Status [ECOG PS] 0–1, Child–Pugh [CP] class A, albumin–bilirubin grade 1–2). Results: Of the 300 patients in the overall cohort (median age of 68 years; 12% ECOG PS ≥ 2; 73% CP A; 26% CP B; median follow-up of 8.7 months), the median rwPFS was 6.8 (95% confidence interval [CI]: 5.8, 8.4) months, and the median OS was 14.4 (95% CI: 12.3, 18.2) months. In the trial-like subgroup (n = 194), the median rwPFS was 8.8 (95% CI: 7.6, 12.1) months and the median OS was 19.5 (95% CI: 14.6, 24.7) months. A significantly lower proportion of patients with CP A compared with CP B (39.7% vs. 73.4%) experienced hospitalization within one year of A+B initiation, whereas hospitalizations due to treatment-related adverse events were similar. Conclusions: This study provides insights into the real-world effectiveness of 1L A+B in a diverse US patient cohort, with results from trial-like patients supporting the reproducible efficacy of A+B in clinical practice. Full article

A significant proportion of children with Autism spectrum disorder (ASD) experience sleep issues, such as insomnia and other disorders, as assessed by the Sleep Disturbance Scale for Children. Our study investigated the link between six single nucleotide polymorphisms (SNPs) in the melatonin receptor genes MT1 and MT2 and ASD susceptibility, clinical severity and associated sleep problems. A total of 139 ASD children, 82 siblings, and 53 unrelated healthy controls, all of Sardinian ancestry, were studied; among them, 38 children with co-occurring sleep issues were assessed for the outcomes of a rehabilitative program, including behavioral therapy and sleep hygiene. The MT2 rs10830963 G allele is more prevalent in ASD children and their siblings compared to the healthy controls, while rs2119882 (MT1) and rs1562444 (MT2) are associated with DIMS, DA, and SHY. ASD Children carrying the rs2119882 T allele have higher scores for DIMS and DA compared to C allele carriers, and those carrying rs1562444 A allele have higher scores for SHY than G allele carriers. After rehabilitative treatment, homozygous TT carriers of rs2119882 showed less improvement in DIMS symptoms compared to CT and CC carriers. A similar result was observed for AA carriers of SNP rs1562444 about SHY. We may suggest that the MT1 and MT2 variants may serve as useful predictive genetic markers for the severity of sleep disorders in children with ASD, potentially informing the design of more targeted rehabilitative treatments. Full article

This study examined spontaneous activity in children aged 3–11 years with specific language impairment (SLI) using an electroencephalogram (EEG). We compared SLI-diagnosed children with a normo-development group (ND). The signal complexity, multiscale entropy (MSE) and parameterized power spectral density (FOOOF) were analyzed, decomposing the PSD into its aperiodic (AP, proportional to 1/fx) and periodic (P) components. The results showed increases in complexity across scales in both groups. Although the topographic distributions were similar, children with SLI exhibited an increased AP component over a broad frequency range (13–45 Hz) in the medial regions. The P component showed differences in brain activity according to the frequency and region. At 9–12 Hz, ND presented greater central–anterior activity, whereas, in SLI, this was seen for posterior–central. At 33–36 Hz, anterior activity was greater in SLI than in ND. At 37–45 Hz, SLI showed greater activity than ND, with a specific increase in the left, medial and right regions at 41–45 Hz. These findings suggest alterations in the excitatory–inhibitory balance and impaired intra- and interhemispheric connectivity, indicating difficulties in neuronal modulation possibly associated with the cognitive and linguistic characteristics of SLI. Full article

Background and Objectives: Medical residency programs play a crucial role in emergency departments (EDs). However, clinical processes may differ between EDs staffed with medical residents and those staffed only by attending physicians. This study aims to compare clinical process times and clinical outcomes between these two types of EDs. Materials and Methods: A retrospective observational study was conducted, analyzing patients aged ≥ 18 years who visited an ED with a medical residency program and an ED staffed only by attending physicians. Time variables, including the time to first physician encounter, first order, CT order, consultation request, consulted specialist arrival, disposition decision, ED length of stay (LOS), and ED dispositions were compared between the two ED settings. Results: A total of 24,942 patients in an ED with a medical residency program and 19,867 patients in an ED staffed only by attending physicians were included in the final analysis. The ED with a medical residency program exhibited significantly longer times in all time variables including time to first physician encounter (7.0 [4.0–12.0] vs. 3.0 [1.0–5.0] min), first order (15.0 [9.0–23.0] vs. 9.0 [5.0–13.0] min), consultation request (95.0 [42.0–146.0] vs. 72.0 [27.0–124.0] min), consulted specialist arrival (156.0 [90.0–238.0] vs. 117.0 [63.0–176.0] min), and disposition decision (134.0 [70.0–208.0] vs. 92.0 [32.0–139.0] min). However, the proportion of discharges, admissions, and deaths were similar between the two EDs. Conclusions: The ED with a medical residency program may contribute to delays in clinical processing times; however, it appears to have no significant impact on clinical outcomes. Full article

Background/Objectives: As the regulatory center for basal ganglia, the substantia nigra is involved in the pathophysiology of dopaminergic dysregulation in Parkinson’s disease (PD). Increasing neuronal excitability of dopaminergic neurons by different therapeutic methods could reverse the locomotor disturbances of PD. The purpose of this study was the comparative assessment of effects induced by excitatory output from the motor cortex to the substantia nigra (SN) and to investigate the pattern of neuronal responses in an experimental rat model of rotenone-induced (intracerebral infusion) neurodegeneration and treated with bacterial melanin (BM). Methods: Thirty-three rats were divided into three groups: control or intact animals (n = 12), animals with the rotenone-induced model of PD (n = 10), and animals with the PD model and treated with BM in 48 h following the infusion (n = 11). Registration of neuronal activity from SN neurons was conducted at four weeks following the rotenone administration. High-frequency stimulation of brain cortical area M1 was performed and the background and evoked activity patterns of 622 neurons were recorded. The difference between the groups was analyzed using one-way ANOVA followed by Tukey’s test. Results: A statistically significant difference was observed between the similar proportions of post-stimulus effects registered in different groups, showing the predominance of excitatory responses in the neurons of the melanin-treated group. A comparison of the firing pattern between the SNc and SNr neurons did not reveal significant differences. Conclusions: BM treatment has the potential to enhance motor recovery after neurodegeneration in the SN. Deep brain stimulation via the cortico-nigral pathway, with the application of BM, enhances electrical activity in dopaminergic neurons of the substantia nigra and could be a potential therapeutic model for PD. Full article

This study aims to develop fluid–solid coupled similar materials to enhance the reliability of geotechnical model tests simulating reservoir slope stability under water-level fluctuations. Using an orthogonal experimental method, materials were prepared with quartz sand and barite as aggregates, cement and gypsum as binders, and water as the regulator. Tests on density, uniaxial and triaxial compressive strength, and flow properties determined the relationships between material properties and raw components. Uniaxial compressive strength tests under dry–wet cycles revealed that cement-to-binder ratio primarily influenced density, uniaxial compressive strength, cohesion, and hydraulic conductivity, while the binder-to-aggregate ratio affected elastic modulus and internal friction angle. Uniaxial compressive strength continuously degraded with cycles but at a decreasing rate. A water-damage resistance coefficient was defined to quantify degradation. Multiple linear regression analysis established a robust model for uniaxial compressive strength prediction, providing a theoretical basis for material proportioning. These findings improve the simulation accuracy in hydrologically active zones, with applications in designing stable reservoir slopes. Full article