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Keywords = pyrrole-2-carboxaldehyde (Py-2-C)

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28 pages, 3079 KB  
Review
Pyrrole-2-carboxaldehydes: Origins and Physiological Activities
by Seiichi Matsugo and Yutaka Nakamura
Molecules 2023, 28(6), 2599; https://doi.org/10.3390/molecules28062599 - 13 Mar 2023
Cited by 16 | Viewed by 5634
Abstract
Pyrrole-2-carboxaldehyde (Py-2-C) derivatives have been isolated from many natural sources, including fungi, plants (roots, leaves, and seeds), and microorganisms. The well-known diabetes molecular marker, pyrraline, which is produced after sequential reactions in vivo, has a Py-2-C skeleton. Py-2-Cs can be chemically produced by [...] Read more.
Pyrrole-2-carboxaldehyde (Py-2-C) derivatives have been isolated from many natural sources, including fungi, plants (roots, leaves, and seeds), and microorganisms. The well-known diabetes molecular marker, pyrraline, which is produced after sequential reactions in vivo, has a Py-2-C skeleton. Py-2-Cs can be chemically produced by the strong acid-catalyzed condensation of glucose and amino acid derivatives in vitro. These observations indicate the importance of the Py-2-C skeleton in vivo and suggest that molecules containing this skeleton have various biological functions. In this review, we have summarized Py-2-C derivatives based on their origins. We also discuss the structural characteristics, natural sources, and physiological activities of isolated compounds containing the Py-2-C group. Full article
(This article belongs to the Special Issue Research Progress and Applications of Natural Products)
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