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19 pages, 673 KB  
Article
Solving a Multi-Period Dynamic Pricing Problem Using Learning-Augmented Exact Methods and Learnheuristics
by Angel A. Juan, Yangchongyi Men, Veronica Medina and Marc Escoto
Algorithms 2026, 19(4), 284; https://doi.org/10.3390/a19040284 - 7 Apr 2026
Abstract
This paper addresses a dynamic multi-period pricing problem that incorporates time-varying contextual information and inventory constraints. Sales are modeled as a function of both price and a multidimensional context vector, which may include factors such as customer location, income, loyalty, competitor prices, and [...] Read more.
This paper addresses a dynamic multi-period pricing problem that incorporates time-varying contextual information and inventory constraints. Sales are modeled as a function of both price and a multidimensional context vector, which may include factors such as customer location, income, loyalty, competitor prices, and promotional activity. This formulation captures complex market dynamics over a finite selling horizon. The problem is formulated as a quadratic programming model, and two alternative solution approaches are proposed. The first uses a multivariate regression model to approximate the sales function linearly, allowing an exact quadratic programming solution that serves as a benchmark. The second is a ‘learnheuristic’ algorithm that combines a nonlinear sales learning model with metaheuristic optimization to generate high-quality pricing strategies under realistic operational constraints. Computational experiments demonstrate the effectiveness of the proposed learnheuristic approach. Full article
(This article belongs to the Special Issue Hybrid Intelligent Algorithms (2nd Edition))
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24 pages, 4461 KB  
Article
Approximated Adaptive Dynamic Programming Control of Axial-Piston Pump
by Jordan Kralev, Alexander Mitov and Tsonyo Slavov
Mathematics 2026, 14(7), 1127; https://doi.org/10.3390/math14071127 - 27 Mar 2026
Viewed by 250
Abstract
This article presents the synthesis, real-time implementation, and experimental validation of an approximated adaptive dynamic programming (AADP) actor–critic controller for precise flow rate regulation of a variable-displacement axial-piston pump designed for open-circuit hydraulic systems. Replacing the conventional hydro-mechanical regulator with an electrohydraulic proportional [...] Read more.
This article presents the synthesis, real-time implementation, and experimental validation of an approximated adaptive dynamic programming (AADP) actor–critic controller for precise flow rate regulation of a variable-displacement axial-piston pump designed for open-circuit hydraulic systems. Replacing the conventional hydro-mechanical regulator with an electrohydraulic proportional spool valve, the model-free controller employs two compact two-layer neural networks: the actor generates valve PWM signals from the flow tracking error, its integral, and measured discharge pressure, while the critic approximates the infinite-horizon quadratic cost-to-go via the online solution of the Bellman equation through gradient descent on Bellman residuals. Lyapunov analysis establishes closed-loop stability under bounded learning rates, with initial weights tuned via nominal plant simulation to ensure convergence from feasible starting policies. After extensive laboratory testing across four fixed loading conditions and dynamic load variations, the adaptive controller demonstrated superior performance compared with a proportional-integral (PI) controller, a Lyapunov model-reference adaptive controller (LMRAC), and an H controller (Hinf). Real-time metrics confirm bounded critic signals and near-zero Bellman errors, validating optimal policy convergence amid unmodeled hydraulic nonlinearities. Full article
(This article belongs to the Special Issue Advances in Robust Control Theory and Its Applications)
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24 pages, 4739 KB  
Article
Hierarchical Cooperative Control of Trajectory Tracking and Stability for Distributed Drive Electric Vehicles Under Extreme Conditions
by Guosheng Wang, Jian Liu and Gang Liu
Actuators 2026, 15(4), 182; https://doi.org/10.3390/act15040182 - 26 Mar 2026
Viewed by 282
Abstract
To enhance the trajectory tracking accuracy and lateral stability of distributed-drive electric vehicles, a hierarchical cooperative control strategy optimized by the Genetic–Firefly Algorithm (G-FA) is proposed. First, bottom-level controllers for trajectory tracking utilizing a Linear Quadratic Regulator (LQR) and stability relying on Sliding [...] Read more.
To enhance the trajectory tracking accuracy and lateral stability of distributed-drive electric vehicles, a hierarchical cooperative control strategy optimized by the Genetic–Firefly Algorithm (G-FA) is proposed. First, bottom-level controllers for trajectory tracking utilizing a Linear Quadratic Regulator (LQR) and stability relying on Sliding Mode Control (SMC) are jointly optimized offline using the G-FA to address the limitations of empirical parameter tuning and effectively mitigate chattering. Compared to traditional Nonlinear Model Predictive Control (NMPC), which relies on computationally demanding dynamic programming, the proposed G-FA acts as an efficient approximate optimization method that significantly reduces the online computational burden while maintaining high control accuracy. Second, an adaptive cooperative mechanism based on desired yaw rate correction is introduced. By constructing two reference benchmarks—“tracking-oriented” and “stability-oriented”—a cooperative weighting coefficient adapts the fusion of control objectives based on the vehicle’s stability state. Hardware-in-the-loop (HIL) simulation results demonstrate that, under high-adhesion double lane change maneuvers, the proposed strategy reduces peak lateral error and sideslip angle by 31.53% and 28.08%, respectively, compared to traditional LQR. In low-adhesion S-curve limit maneuvers, where traditional LQR fails, the proposed strategy outperforms the NMPC benchmark, further reducing these indices by 61.98% and 8.33%, respectively, significantly improving control performance under extreme conditions. Full article
(This article belongs to the Section Actuators for Surface Vehicles)
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19 pages, 2182 KB  
Article
End Effector Driven Whole Body Trajectory Tracking for Mobile Manipulator Based on Linear and Angular Motion Decomposition
by Ji-Wook Kwon, Taeyoung Uhm, Ji-Hyun Park, Jongdeuk Lee and Jeong Hwan Hwang
Electronics 2026, 15(7), 1384; https://doi.org/10.3390/electronics15071384 - 26 Mar 2026
Viewed by 257
Abstract
This paper proposes an end-effector (EE) driven whole-body trajectory tracking control algorithm for wheeled mobile manipulators based on linear and angular motion decomposition. Instead of solving a high-dimensional optimization problem across all degrees of freedom, the proposed method formulates the control objective directly [...] Read more.
This paper proposes an end-effector (EE) driven whole-body trajectory tracking control algorithm for wheeled mobile manipulators based on linear and angular motion decomposition. Instead of solving a high-dimensional optimization problem across all degrees of freedom, the proposed method formulates the control objective directly in the EE space and decomposes the required motion into planar linear, vertical, and angular components. To address redundancy between the mobile base and the manipulator under non-holonomic constraints, a control authority switching strategy with a radial blending function is introduced. This approach eliminates ambiguity in control allocation while preventing abrupt switching near workspace boundaries. The kinematic controller guarantees exponential convergence of position and orientation errors without requiring a full dynamic model. Numerical simulations demonstrate stable tracking performance in three-dimensional space. Compared with a quadratic programming-based whole-body controller, the proposed method achieves comparable or faster error convergence while reducing computational burden by more than 13 times on average. These results indicate that the proposed EE-driven framework provides a computationally efficient and practically deployable solution for real-time mobile manipulator control. Full article
(This article belongs to the Special Issue Stability and Control of Nonlinear Systems)
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26 pages, 3386 KB  
Article
A Two-Level Optimal Water Allocation Model for Canal-Drip Irrigation Systems Based on Decomposition–Coordination Theory
by Jingzheng Li, Chunfang Yue and Shengjiang Zhang
Sustainability 2026, 18(7), 3217; https://doi.org/10.3390/su18073217 - 25 Mar 2026
Viewed by 333
Abstract
Agriculture in Xinjiang, a region in arid northwest China, is almost entirely dependent on irrigation, leading to significant supply–demand contradictions. This study addresses the spatial and temporal mismatches between water supply and demand, and the resulting conflicts in crop water supply. Using the [...] Read more.
Agriculture in Xinjiang, a region in arid northwest China, is almost entirely dependent on irrigation, leading to significant supply–demand contradictions. This study addresses the spatial and temporal mismatches between water supply and demand, and the resulting conflicts in crop water supply. Using the primary irrigation cycle of Wutai branch canal as a case study, we developed a two-level optimal water allocation model based on large-scale system optimization. For the lateral canal water distribution, a model minimizing the sum of squares of the water shortage rate was solved using the Sequential Quadratic Programming (SQP) algorithm. For the drip irrigation systems, water distribution time was incorporated as a second objective, and the resulting bi-objective model was solved using the Non-dominated Sorting Genetic Algorithm II (NSGA-II). Compared to actual distribution processes, our results show that (1) 74% of the distribution canals and pipelines achieved over 90% of their design flow rate, fully utilizing flow capacity and reducing the overall distribution time of the branch canal by 4.68 h. (2) The overall water shortage rate was reduced by 1.59% compared to the actual rate, with a more balanced water allocation among users. These results demonstrate that the model can effectively coordinate water distribution in a multi-level canal system, enhance the fairness of water use, and provide a valuable reference for single-event water distribution in water-scarce areas. Full article
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21 pages, 3115 KB  
Article
Low-Carbon Economic Dispatch and Settable Incentive-Based Demand Response for Integrated Electro–Heat–Hydrogen Energy Systems Based on Safety Transformer–PPO
by Jia Zhengjian, Yang Wanchun, Huang Xin, Liang Nan, Liu Yupeng, Wang Xiaojun and Song Yu
Energies 2026, 19(6), 1578; https://doi.org/10.3390/en19061578 - 23 Mar 2026
Viewed by 235
Abstract
This paper proposes a safety-constrained Transformer–PPO framework for low-carbon economic dispatch with settable incentive-based demand response (DR) in wind–PV integrated electro–thermal–hydrogen industrial-park energy systems. Hydrogen is modeled as exogenous hydrogen-domain demand and is satisfied through electrolyzer production and hydrogen inventory dynamics. A causal [...] Read more.
This paper proposes a safety-constrained Transformer–PPO framework for low-carbon economic dispatch with settable incentive-based demand response (DR) in wind–PV integrated electro–thermal–hydrogen industrial-park energy systems. Hydrogen is modeled as exogenous hydrogen-domain demand and is satisfied through electrolyzer production and hydrogen inventory dynamics. A causal Transformer captures long-horizon multi-energy coupling and intertemporal constraints and is trained with PPO under uncertainty. A dual-layer safety mechanism combines dual-variable (Lagrange multiplier) updates for statistical constraints with an execution-layer quadratic-programming action projection to enforce hard physical constraints, including operating limits, ramping, battery SOC, hydrogen inventory bounds, and energy balance. Baseline–verification–settlement rules and budget-ledger states are embedded to ensure verifiable response quantities and settlement outcomes that are traceable and independently recompilable. Case studies on a real industrial-park scenario in Inner Mongolia show reduced peak-hour maximum grid purchase demand and constraint violations, together with lower total cost, carbon cost, and curtailment penalties versus MILP, PPO-MLP, and Transformer–PPO without safety mechanisms. Full article
(This article belongs to the Special Issue Energy Systems: Optimization, Modeling, and Simulation)
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31 pages, 13358 KB  
Article
The Lateral Control of Unmanned Vehicles Based on Neural Network Identification and a Fast Tube Model Predictive Control Algorithm
by Yong Dai and Zhichen Zhou
Sensors 2026, 26(6), 1973; https://doi.org/10.3390/s26061973 - 21 Mar 2026
Viewed by 351
Abstract
In traditional vehicle trajectory tracking processes, the dynamic model of the vehicle may not accurately represent complex and nonlinear vehicle behaviors. Moreover, conventional control methods may perform poorly when dealing with system uncertainties and disturbances, facing challenges in real-time computation. To address these [...] Read more.
In traditional vehicle trajectory tracking processes, the dynamic model of the vehicle may not accurately represent complex and nonlinear vehicle behaviors. Moreover, conventional control methods may perform poorly when dealing with system uncertainties and disturbances, facing challenges in real-time computation. To address these issues, this paper proposes an autonomous driving control method based on control-affine feedforward neural network (CAFNN) and fast tube model predictive control (tube-MPC). This method utilizes CAFNN for system dynamic identification, replacing traditional mathematical modeling with data-driven neural network pattern recognition to more accurately describe the vehicle’s nonlinear dynamic characteristics. On this basis, the proposed tube-MPC structure is divided into two parts: nominal MPC and sliding mode control (SMC). The nominal MPC controller associates the MPC problem with a linear complementarity problem (LCP) using a ramp function, enabling rapid computation of the quadratic programming (QP) solution through piecewise affine (PWA) functions; the auxiliary SMC controller employs multi-power sliding mode reaching laws to enhance the system’s robustness against external disturbances and model uncertainties. This control strategy demonstrates high accuracy and stability in vehicle trajectory tracking under complex road conditions, providing strong support for the advancement of autonomous driving technology. Full article
(This article belongs to the Section Vehicular Sensing)
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28 pages, 2201 KB  
Article
Addressing Mixed-Integer Nonlinear Energy Management in Hybrid Vehicles: Comparing Genetic Algorithm and Sequential Quadratic Programming Within Model Predictive Control
by Ferris Herkenrath, Silas Koßler, Marco Günther and Stefan Pischinger
Energies 2026, 19(6), 1535; https://doi.org/10.3390/en19061535 - 20 Mar 2026
Viewed by 229
Abstract
Model Predictive Control (MPC) has emerged as a promising approach for energy management in hybrid electric vehicles, enabling predictive optimization of powertrain operation. The energy management problem in parallel hybrid powertrains constitutes a Mixed-Integer Nonlinear Programming (MINLP) problem, combining continuous decision variables such [...] Read more.
Model Predictive Control (MPC) has emerged as a promising approach for energy management in hybrid electric vehicles, enabling predictive optimization of powertrain operation. The energy management problem in parallel hybrid powertrains constitutes a Mixed-Integer Nonlinear Programming (MINLP) problem, combining continuous decision variables such as torque distribution with discrete decisions including engine on/off states and clutch engagement. This problem structure presents distinct challenges for different optimization approaches. Gradient-based methods such as Sequential Quadratic Programming (SQP) solve continuous, differentiable optimization problems and require auxiliary methods to handle integer variables, while metaheuristic approaches such as Genetic Algorithms (GA) can handle the mixed-integer structure directly at the cost of increased computational effort. This study presents a systematic comparison between GA and SQP as optimization solvers within an MPC framework for a P1P3 parallel hybrid powertrain. A multi-objective cost function is formulated to simultaneously optimize system efficiency, battery state of charge management, and noise emissions. Both approaches are evaluated across the WLTC as well as a real-world RDE scenario. On the WLTC, both MPC approaches reduce fuel consumption by 0.5–1.0% and improve system efficiency by 3.7–4.6% compared to a state-of-the-art deterministic reference strategy optimized for fuel consumption. At the same time, both approaches additionally achieve substantial reductions in noise emissions compared to the deterministic reference, which was not optimized for acoustic behavior. On both cycles, the GA-based MPC achieves favorable performance compared to SQP, with the performance gap widening from the WLTC to the RDE cycle. Both methods achieve real-time capability, yet SQP reduces computational time by a factor of four compared to GA. As long as computational resources in automotive ECUs remain constrained, this efficiency advantage positions gradient-based optimization for series production applications, whereas metaheuristic methods offer greater flexibility for concept development stages with relaxed real-time requirements. The findings contribute to the understanding of optimization algorithm selection for MINLP energy management problems in hybrid electric vehicles. Full article
(This article belongs to the Special Issue Challenges and Research Trends of Energy Management)
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20 pages, 8853 KB  
Article
Graph Burning: An Overview of Compact Mathematical Programs
by Lourdes Beatriz Cajica-Maceda, Freddy Alejandro Chaurra-Gutiérrez, Julio César Pérez-Sansalvador and Jesús García-Díaz
Mathematics 2026, 14(6), 1011; https://doi.org/10.3390/math14061011 - 17 Mar 2026
Viewed by 439
Abstract
The Graph Burning Problem (GBP) is a combinatorial optimization problem that has gained relevance as a tool for quantifying a graph’s vulnerability to contagion. Although it is based on a very simple propagation model, its decision version is NP-complete and its optimization version [...] Read more.
The Graph Burning Problem (GBP) is a combinatorial optimization problem that has gained relevance as a tool for quantifying a graph’s vulnerability to contagion. Although it is based on a very simple propagation model, its decision version is NP-complete and its optimization version is NP-hard. This paper introduces novel mathematical programs for the GBP. Among the introduced programs are a Mixed-Integer Linear Program (MILP), a Constraint Satisfaction Problem (CSP), two Integer Linear Programs (ILPs), and two Quadratic Unconstrained Binary Optimization (QUBO) problems. Most optimization solvers can handle these, with QUBO problems being of capital interest in quantum computing. Nonetheless, the primary objective of this paper is not to solve instances of the GBP, but rather to deepen our understanding of it by identifying and examining what we believe to be its simplest mathematical formulations, that is, models that use as few variables and constraints as possible (compact mathematical programs). We believe that this collection of programs can provide ideas for modeling variants and related problems. As a marginal result, one of the proposed ILPs, equipped with a row generation technique, allowed a commercial solver to find optimal solutions for some of the largest and most challenging instances for the GBP. Full article
(This article belongs to the Special Issue Graph Theory and Network Theory)
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22 pages, 2596 KB  
Article
Active Earth Pressure in Unsaturated Retaining Walls Influenced by Vegetation Root
by Renxing Wu, Chaoguang Wu, Long Xia, Guihua Long and Liwei Ren
Mathematics 2026, 14(6), 995; https://doi.org/10.3390/math14060995 - 15 Mar 2026
Viewed by 192
Abstract
This study proposes a comprehensive framework, based on an upper-bound approach, for assessing how vegetation enhances wall stability through two primary mechanisms. The two mechanisms are reinforcement from root systems and hydrological reinforcement through transpiration-induced soil suction. Both contributions are integrated as additional [...] Read more.
This study proposes a comprehensive framework, based on an upper-bound approach, for assessing how vegetation enhances wall stability through two primary mechanisms. The two mechanisms are reinforcement from root systems and hydrological reinforcement through transpiration-induced soil suction. Both contributions are integrated as additional internal energy dissipation terms within a logarithmic-spiral failure model. New expressions of earth pressure in unsaturated soil are derived, considering the influence of vegetation. The active earth pressure acting on the retaining wall is obtained using sequential quadratic programming. The proposed method is validated against classical non-vegetated solutions, confirming its accuracy. The results show that vegetation significantly reduces active earth pressure, with the extent of reduction depending on soil type, root distribution, and transpiration rate. In clay soils, both mechanical and hydrological effects are important, while in sandy soils, mechanical root reinforcement plays the dominant role. The effectiveness of vegetation is influenced by root depth, density, and diameter, with practical design insights provided through parametric charts. This work offers a theoretically consistent and design-oriented tool for evaluating vegetated retaining walls, emphasizing the coupled hydro-mechanical interactions between plants and soil. Full article
(This article belongs to the Special Issue Multiscale Modeling in Engineering and Mechanics, 2nd Edition)
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40 pages, 608 KB  
Article
A Θ(m9) Ternary Minimum-Cost Network Flow LP Model of the Assignment Problem Polytope, with Applications to Hard Combinatorial Optimization Problems
by Moustapha Diaby
Logistics 2026, 10(3), 63; https://doi.org/10.3390/logistics10030063 - 12 Mar 2026
Viewed by 388
Abstract
Background: Combinatorial optimization problems (COPs) are central to Logistics and Supply Chain decision making, yet their NP-hardness prevents exact optimal solutions in reasonable time. Methods: This work addresses that limitation by developing a novel ternary network flow linear programming (LP) model of the [...] Read more.
Background: Combinatorial optimization problems (COPs) are central to Logistics and Supply Chain decision making, yet their NP-hardness prevents exact optimal solutions in reasonable time. Methods: This work addresses that limitation by developing a novel ternary network flow linear programming (LP) model of the assignment problem (AP) polytope. The model is very large scale (with Θ(m9) variables and Θ(m8) constraints, where m is the number of assignments). Although not intended to compete with conventional two-dimensional formulations of the AP with respect to solution procedures, it enables hard COPs to be solved exactly as “strict” (integrality requirements-free) LPs through simple transformations of their cost functions. Illustrations are given for the quadratic assignment problem (QAP) and the traveling salesman problem (TSP). Results: Because the proposed LP model is polynomial-sized and there exist polynomial-time algorithms for solving LPs, it affirms “P=NP.” A separable substructure of the model shows promise for practical-scale instances due to its suitability for large-scale optimization techniques such as Dantzig–Wolfe Decomposition, Column Generation, and Lagrangian Relaxation. The formulation also has greater robustness relative to standard network flow models. Conclusions: Overall, the approach provides a systematic, modeling-barrier-free framework for representing NP-complete problems as polynomial-sized LPs, with clear theoretical interest and practical potential for medium to large-scale Logistics and other COP-intensive applications. Full article
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37 pages, 41641 KB  
Article
Bumpless Multi-Mode Control Allocation for Over-Actuated AUV Docking
by Peiyan Gao, Yiping Li, Gaopeng Xu, Yuexing Zhang, Junbao Zeng, Yiqun Wang and Shuo Li
J. Mar. Sci. Eng. 2026, 14(5), 516; https://doi.org/10.3390/jmse14050516 - 9 Mar 2026
Viewed by 287
Abstract
This paper addresses the multi-phase homing and docking missions of over-actuated autonomous underwater vehicles (AUVs), where switching among forward cruising, reverse braking, and hovering can induce actuator saturation, rate limit violations, and undesirable transients. We propose a unified framework that couples supervisory mode [...] Read more.
This paper addresses the multi-phase homing and docking missions of over-actuated autonomous underwater vehicles (AUVs), where switching among forward cruising, reverse braking, and hovering can induce actuator saturation, rate limit violations, and undesirable transients. We propose a unified framework that couples supervisory mode management with mode-driven constrained control allocation solved by a warm-started sequential quadratic programming (SQP) routine. The controllable wrench is modeled by a mode-dependent differentiable map constructed from the actuator models, and the allocator enforces amplitude bounds and per-cycle increment limits while trading off wrench tracking and actuator usage through mode-scheduled weights. To mitigate switching transients, a continuous transition factor is introduced to interpolate the desired wrench and dominant cost weights, and an integrator alignment reset is applied at switching instants to keep the outer-loop proportional–integral–derivative (PID) output continuous. The allocator is further warm-started by projecting the previous solution onto the post-switch constraint box. The framework is integrated into the Mission-Oriented Operating Suite–Interval Programming (MOOS-IvP) autonomy middleware with adaptive line-of-sight (ALOS) guidance and adaptive PID motion control and is validated on the TS-100 AUV in water tank experiments. Comparative results against a PID-only baseline without control allocation and a variant without bumpless switching show reduced roll transients during the reverse-to-hover transition and improved hover-mode depth station keeping while maintaining feasible actuator commands under constraints. Full article
(This article belongs to the Section Ocean Engineering)
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27 pages, 4102 KB  
Article
Constraint-Aware Payload Layer Fusion Control for Dual-Quadrotor Cooperative Slung-Load Transportation
by Xi Wang, Pengliang Zhao, Xing Wang, Weihua Tan, Hongqiang Zhang, Jiwen Zeng and Shasha Tang
Aerospace 2026, 13(3), 250; https://doi.org/10.3390/aerospace13030250 - 8 Mar 2026
Viewed by 224
Abstract
Low altitude logistics and aerial transport increasingly rely on multirotor unmanned aerial vehicles (UAVs) carrying slung payloads, where cable flexibility and load swing can degrade safety and delivery accuracy. This paper studies payload trajectory tracking for a dual-quadrotor cooperative slung-load system, targeting accurate [...] Read more.
Low altitude logistics and aerial transport increasingly rely on multirotor unmanned aerial vehicles (UAVs) carrying slung payloads, where cable flexibility and load swing can degrade safety and delivery accuracy. This paper studies payload trajectory tracking for a dual-quadrotor cooperative slung-load system, targeting accurate tracking with swing suppression under thrust, attitude, and cable-tension limits. First, a payload-layer dynamic model is derived from d’Alembert’s principle with geometric cable constraints, and explicit tension reconstruction formulas are provided to enable direct enforcement of tension bounds. Building on this model, a payload-layer DEA nominal tracking controller is designed by applying dynamic extension to the tension-scalar channels and enforcing output-level linear error dynamics. To ensure real-time feasibility, a convex quadratic-programming (QP) projection layer minimally corrects the nominal command to satisfy thrust saturation, attitude-cone constraints, and cable-tension bounds. Moreover, an adaptive tuning control layer updates the DEA feedback gain and the projection weighting matrix within preset constraint limits based on energy residual and constraint-activation information, improving robustness and reducing manual tuning. Input-to-state stability is established under bounded disturbances and constraint-activation switching via a composite Lyapunov analysis. ROS–PX4–Gazebo simulations show low tracking error, suppressed swing, and sustained tension-limit compliance, validating the fusion controller. Full article
(This article belongs to the Section Aeronautics)
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19 pages, 2404 KB  
Article
Metabolic Flux Analysis of Escherichia coli Based on Kinetic Model and Genome-Scale Metabolic Network Model
by Zhiren Gan, Jingyan Jiang, Mengxuan Zhou, Qihang Tao, Jinpeng Yang, Renquan Guo, Xueliang Li, Jian Ding and Zhenggang Xie
Fermentation 2026, 12(3), 134; https://doi.org/10.3390/fermentation12030134 - 4 Mar 2026
Viewed by 693
Abstract
The application of Genome-Scale Metabolic Network Models (GSMM) in fermentation optimization is hampered by challenges in differentiating viable from dead cells and parameter distortion induced by conventional detection methods. Using E. coli BL21(DE3) as the model organism, this study developed a flux analysis [...] Read more.
The application of Genome-Scale Metabolic Network Models (GSMM) in fermentation optimization is hampered by challenges in differentiating viable from dead cells and parameter distortion induced by conventional detection methods. Using E. coli BL21(DE3) as the model organism, this study developed a flux analysis strategy that couples cell kinetics with GSMM. Key parameters were estimated using the gradient descent algorithm, thereby enabling precise prediction of viable cell concentration and glucose consumption dynamics. Integrating this with the Quadratic Programming-based parsimonious Flux Balance Analysis (QP-pFBA) algorithm, intracellular metabolic reaction fluxes were quantified. Results demonstrated that the model can effectively differentiate viable from dead cells; Batch D, adopting the gradient-increasing feeding strategy, achieved the maximum specific growth rate (μmax) of 0.6457, the highest among the four batches. Moreover, key metabolic reaction fluxes were highly correlated with the feeding strategy. This framework forgoes specialized, high-cost equipment and offers robust cross-strain/process adaptability, thereby greatly advancing GSMM utility. It provides a powerful tool for precise fermentation control and accelerates the shift toward data-driven biomanufacturing. Full article
(This article belongs to the Special Issue Applied Microorganisms and Industrial/Food Enzymes, 3rd Edition)
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17 pages, 3614 KB  
Article
Adaptive Cooperative Control of Dual-Arm Robots Using RBF-ADP with Event-Triggering Mechanism
by Yuanwei Dai
Symmetry 2026, 18(3), 437; https://doi.org/10.3390/sym18030437 - 3 Mar 2026
Viewed by 273
Abstract
High-precision cooperative control of dual-arm manipulators faces significant challenges arising from complex dynamic coupling, parametric uncertainties, and external disturbances. Furthermore, in networked control scenarios, communication bandwidth and computational resources are inevitably constrained. To address these issues, this paper proposes a novel composite control [...] Read more.
High-precision cooperative control of dual-arm manipulators faces significant challenges arising from complex dynamic coupling, parametric uncertainties, and external disturbances. Furthermore, in networked control scenarios, communication bandwidth and computational resources are inevitably constrained. To address these issues, this paper proposes a novel composite control framework that integrates adaptive dynamic programming (ADP) with active disturbance rejection control (ADRC) under a static event-triggering mechanism (SETM). First, to handle model uncertainties and external perturbations, a smooth nonlinear extended state observer (ESO) based on continuous fractional-power functions is developed. This observer guarantees finite-time convergence of the disturbance estimation without inducing the high-frequency chattering inherent in conventional sliding-mode observers. Second, leveraging the disturbance-compensated dynamics, a radial basis function (RBF) neural network-based ADP controller is designed to learn the optimal control policy online, thereby minimizing a quadratic performance index without requiring accurate model knowledge. Third, to improve resource utilization, a static event-triggering strategy is introduced to schedule control updates based on the system state and tracking error. Extensive simulation studies on a 3-DoF dual-arm system demonstrate that the proposed scheme achieves superior trajectory tracking accuracy and disturbance robustness while significantly reducing the communication frequency compared to time-triggered approaches. Full article
(This article belongs to the Special Issue Symmetry/Asymmetry and Autonomous Robotics)
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