Search Results (6)

A detailed statistical analysis of the total active reflection coefficient (TARC) is carried out in this paper for three 4-port MIMO antennas featuring different levels of isolation across its ports. This analysis is very useful to determine the most likely performance of a MIMO antenna in a real communications scenario. The TARC parameter is commonly evaluated for only several combinations of the random phase with which a signal reaches every input port of a MIMO antenna. By contrast, we have evaluated a million combinations to obtain the probability density function of the TARC, using frequency as its parameter. In this way, an expected value of the TARC is obtained for each frequency, as well as a confidence interval ($\Delta C{I}_{\mathrm{TARC}}$) where the TARC values occur with 90% probability. Additionally, we have introduced the term “TARC shadow”, a visual representation of the TARC as a function of the frequency where the probability function is projected into this 2D graphic with different colors to identify the most likely values of the TARC. To demonstrate these concepts, a full TARC evaluation was performed for three 4-port MIMO antennas with increasing isolation of 12.9 dB, 25.4 dB, and 37 dB between elements, and different values of the $S_{nn}$ and $S_{nm}$ parameters, with n and $m=$ 1 to 4. From this study, the importance of the isolation among ports and its comparison with the return losses becomes evident in achieving a MIMO antenna array insensitive to random phase variations occurring in the communication channel. Full article

This paper introduces a database-based design methodology aimed at optimizing a 26 GHz MIMO antenna system through machine learning (ML) techniques. The procedure is divided into two primary phases. Initially, a rectangular microstrip patch antenna is designed and enhanced using analytical models alongside ML algorithms that are trained on a detailed dataset of geometric parameters. This yields effective impedance matching (S11 < −45 dB) and a high gain (~6.64 dBi), which serve as the foundation for the MIMO structure. In the second phase, split ring resonator (SRR) configurations are integrated between the antenna elements to reduce mutual coupling. A specialized dataset, featuring varied dimensions of SRR, quantities of unit cells, and spatial placements, is utilized to train Random Forest models that forecast arrangements achieving optimal isolation (S21 < −40 dB) while maintaining low reflection losses. Additionally, a secondary dataset is constructed to investigate the best strategies for SRR placement, ensuring an optimal balance between isolation and return loss. The ultimate MIMO design is validated via comprehensive full-wave electromagnetic simulations and experimental measurements. The proposed system exhibits noteworthy performance enhancements, including an envelope correlation coefficient (ECC) < 0.005, diversity gain (DG) ≈ 9.99 dB, channel capacity loss (CCL) < 0.3 bits/s/Hz, total active reflection coefficient (TARC) < −30 dB, radiation efficiency exceeding 80%, and a maximum gain increase up to 10.22 dB. The close correlation between predicted and measured outcomes validates the effectiveness of the ML-driven approach in expediting antenna optimization for 5G and future applications. Full article

This article presents a symmetrical reduced-size eight-element MIMO antenna array with high electromagnetic isolation among radiators. The array utilizes easy-to-build techniques to cover the n77 and n78 new radio (NR) bands. It is based on an octagonal double-negative metamaterial split-ring resonator (SRR), which enables a size reduction of over 50% for the radiators compared to a conventional disc monopole antenna by increasing the slow-wave factor. Additionally, due to the extreme proximity between the radiating elements in the array, the modal significance (MS) method was employed to identify which propagation modes had the most impact on the electromagnetic coupling among elements. This approach aimed to mitigate their effect by using an electromagnetic barrier, thereby enhancing electromagnetic isolation. The electromagnetic barriers, implemented with strip lines, achieved isolation values exceeding 20 dB for adjacent elements (<0.023 λ) and approaching 40 dB for opposite ones (<0.23 λ) after analyzing the surface current distribution by the MS method. The elements are arranged in axial symmetry, forming an octagon with each antenna port located on a side. The array occupies an area of 0.32 λ² at 3.5 GHz, significantly smaller than previously published works. It exhibits excellent performance for MIMO applications, demonstrating an envelope correlation coefficient (ECC) below 0.0001, a total active reflection coefficient (TARC) lower than −10 dB for various incoming signals with random phases, and a diversity gain (DG) close to 20 dB. Full article

Background: Blood–barrier (BBB) breakdown and active inflammation are hallmarks of relapsing multiple sclerosis (RMS), but the molecular events contributing to the development of new lesions are not well explored. Leaky endothelial junctions are associated with increased production of endothelial-derived extracellular microvesicles (EVs) and result in the entry of circulating immune cells into the brain. MRI with intravenous gadolinium (Gd) can visualize acute blood–barrier disruption as the initial event of the evolution of new lesions. Methods: Here, weekly MRI with Gd was combined with proteomics, multiplex immunoassay, and endothelial stress-optimized EV array to identify early markers related to BBB disruption. Five patients with RMS with no disease-modifying treatment were monitored weekly using high-resolution 3T MRI scanning with intravenous gadolinium (Gd) for 8 weeks. Patients were then divided into three groups (low, medium, or high MRI activity) defined by the number of new, total, and maximally enhancing Gd-enhancing lesions and the number of new FLAIR lesions. Plasma samples taken at each MRI were analyzed for protein biomarkers of inflammation by quantitative proteomics, and cytokines using multiplex immunoassays. EVs were characterized with an optimized endothelial stress EV array based on exosome surface protein markers for the detection of soluble secreted EVs. Results: Proteomics analysis of plasma yielded quantitative information on 208 proteins at each patient time point (n = 40). We observed the highest number of unique dysregulated proteins (DEPs) and the highest functional enrichment in the low vs. high MRI activity comparison. Complement activation and complement/coagulation cascade were also strongly overrepresented in the low vs. high MRI activity comparison. Activation of the alternative complement pathway, pathways of blood coagulation, extracellular matrix organization, and the regulation of TLR and IGF transport were unique for the low vs. high MRI activity comparison as well, with these pathways being overrepresented in the patient with high MRI activity. Principal component analysis indicated the individuality of plasma profiles in patients. IL-17 was upregulated at all time points during 8 weeks in patients with high vs. low MRI activity. Hierarchical clustering of soluble markers in the plasma indicated that all four MRI outcomes clustered together with IL-17, IL-12p70, and IL-1β. MRI outcomes also showed clustering with EV markers CD62E/P, MIC A/B, ICAM-1, and CD42A. The combined cluster of these cytokines, EV markers, and MRI outcomes clustered also with IL-12p40 and IL-7. All four MRI outcomes correlated positively with levels of IL-17 (p < 0.001, respectively), and EV-ICAM-1 (p < 0.0003, respectively). IL-1β levels positively correlated with the number of new Gd-enhancing lesions (p < 0.01), new FLAIR lesions (p < 0.001), and total number of Gd-enhancing lesions (p < 0.05). IL-6 levels positively correlated with the number of new FLAIR lesions (p < 0.05). Random Forests and linear mixed models identified IL-17, CCL17/TARC, CCL3/MIP-1α, and TNF-α as composite biomarkers predicting new lesion evolution. Conclusions: Combination of serial frequent MRI with proteome, neuroinflammation markers, and protein array data of EVs enabled assessment of temporal changes in inflammation and endothelial dysfunction in RMS related to the evolution of new and enhancing lesions. Particularly, the Th17 pathway and IL-1β clustered and correlated with new lesions and Gd enhancement, indicating their importance in BBB disruption and initiating acute brain inflammation in MS. In addition to the Th17 pathway, abundant protein changes between MRI activity groups suggested the role of EVs and the coagulation system along with innate immune responses including acute phase proteins, complement components, and neutrophil degranulation. Full article

The BeiDou Global Satellite Navigation System (BDS-3) broadcast newly developed B1C and B2a signals. To provide a better service for global users, the vertical phase center offset (PCO) and phase center variation (PCV) are estimated for the B1C/B2a ionospheric-free linear combination of the BDS-3 inclined geostationary orbit (IGSO) and medium earth orbit (MEO) satellites in this study. And considering the traditional PCC estimation method needs two Precise orbit determination (POD) processing, based on the correlation between PCO z-offset and PCV, the theoretical analysis and experimental comparison have been made to discuss whether the POD procedure for the PCO estimation can be omitted. The estimated z-offset time series revealed the inadequacy of the solar radiation pressure (SRP) model for the IGSO satellites and the MEO satellites with Pseudo Random Noise code (PRN) C45 and C46. The PCVraws estimated by the traditional method and the PCO estimation omitted method have the same characteristic. The final PCO z-offsets and PCVs calculated by the two schemes agreed very well with differences can be harmlessly ignored, which confirmed that the PCO estimation can be safely omitted to save computation time. The PCC model proposed in this study has been compared with the Test and Assessment Research Center of China Satellite Navigation Office (TARC/CSNO) released model, the qualities of the orbits and BDS-only precise point positioning (PPP) solutions of the new model both show improvements, except for the IGSO orbits. The analysis of the IGSO orbits further verifies the SRP model is not suitable for the IGSO satellites. Full article

Smoking is associated with a moderate increased risk of Hodgkin and follicular lymphoma. To understand why, we examined lymphoma-related biomarker levels among 134 smoking and non-smoking twins (67 pairs) ascertained from the Finnish Twin Cohort. Previously collected frozen serum samples were tested for cotinine to validate self-reported smoking history. In total, 27 immune biomarkers were assayed using the Luminex Multiplex platform (R & D Systems). Current and non-current smokers were defined by a serum cotinine concentration of >3.08 ng/mL and ≤3.08 ng/mL, respectively. Associations between biomarkers and smoking were assessed using linear mixed models to estimate beta coefficients and standard errors, adjusting for age, sex and twin pair as a random effect. There were 55 never smokers, 43 current smokers and 36 former smokers. CCL17/TARC, sgp130, haptoglobin, B-cell activating factor (BAFF) and monocyte chemoattractant protein-1 (MCP1) were significantly (p < 0.05) associated with current smoking and correlated with increasing cotinine concentrations (P_trend < 0.05). The strongest association was observed for CCL17/TARC (P_trend = 0.0001). Immune biomarker levels were similar in former and never smokers. Current smoking is associated with increased levels of lymphoma-associated biomarkers, suggesting a possible mechanism for the link between smoking and risk of these two B-cell lymphomas. Full article