Search Results (468)

Background: Acute myeloid leukemia (AML) with CBFB::MYH11 fusion and myeloid/lymphoid neoplasms with eosinophilia and tyrosine kinase gene fusions (MLN-TK) are genetically defined and typically mutually exclusive entities. Case Presentation: We report a unique case of de novo AML harboring two clonal, transcriptionally active class-defining fusions: CBFB::MYH11 and GOLGA4::PDGFRB. A 61-year-old woman presented with leukocytosis with neutrophilia, eosinophilia, and monocytosis; circulating blasts; and a markedly hypercellular marrow. Cytogenetic analysis revealed inv(16)(p13.1q22) and t(3;5)(p21;q32) in all 20 metaphases, and RNA sequencing confirmed expression of both CBFB::MYH11 and GOLGA4::PDGFRB fusions. In addition, an oncogenic WT1 frameshift variant was identified. Hematopathologic findings were largely consistent with AML with CBFB::MYH11 fusion but exhibited features reminiscent of PDGFRB-rearranged MLN-TK. The patient achieved complete remission following the standard 7 + 3 induction chemotherapy regimen for AML with gemtuzumab ozogamicin. Conclusions: This case illustrates the diagnostic challenges posed by concomitant class-defining alterations in hematologic neoplasms and underscores the importance of integrated genomic assessment. Full article

Here we perform a detailed information-theoretic (IT) analysis of atomic electron densities in the periodic table, from hydrogen (Z = 1) to lawrencium (Z = 103). By use of the Shannon entropy, the Fisher information and the disequilibrium functionals in both position and momentum spaces as fundamental descriptors of the atomic densities, the periodic table can be represented in a three-dimensional information space as a continuous, highly ordered manifold. The analysis shows that chemical periodicity naturally emerges as a helicoidal manifold (reminiscent of a helix) at the coordinates of a 3D theoretic-information space (Shannon, Fisher, Disequilibrium), with each period forming one segment within the continuous global trajectory. We find information-theoretic signatures of shell structure, sub-shell filling, and electron-configuration anomalies, such as the familiar irregularities seen in chromium and copper. Therefore, the helicoidal character emerges naturally and is not imposed a priori. Further, through the uncertainty principle of the complementary analysis in momentum space, more insights are gained by exposing maximal information-theoretic differentiation for lighter atoms and compression among heavy elements. Notably, momentum-space analysis reveals that hydrogen occupies a natural intermediate position between helium and lithium based on kinetic energy distribution—contrasting with IT position-space results that emphasize hydrogen’s unique delocalized electron density. Indeed, the 3D IT representation of the elements in position space aligns with the view that H does not belong to either the alkali metals or the halogens, but rather stands as a unique, standalone element. This complementary perspective provides new quantitative support for understanding hydrogen’s dual chemical nature, providing new quantitative insight into ongoing debates about hydrogen’s optimal periodic table position. Furthermore, by considering triadic relationships and complexity properties in relation to the López–Mancini–Ruiz (LMC) and Fisher–Shannon (FS) functionals, we show that atomic complexity increases monotonically along with nuclear charge, and we provide a quantitative measure of how organized atomic electron densities are distributed throughout the periodic system. Based on our IT analyses, the fundamental character of periodicity could be addressed by employing helicoidal representations that highlight the characteristics of hydrogen, while simultaneously preserving the autonomy of the blocks of elements. Full article

Psychological problems such as depression, anxiety, stress, loneliness, and reduced quality of life are prevalent in older adults, yet the effectiveness of psychological interventions remains heterogeneous. This systematic review with meta-analysis evaluated the impact of psychological and psychoeducational interventions on emotional symptoms and quality-of-life outcomes in adults aged 60 years and older. Following PRISMA 2020 guidelines, a comprehensive search was conducted in PubMed, Scopus, CINAHL, and Web of Science. Randomized controlled trials published in the last five years were included if they assessed interventions such as mindfulness, cognitive behavioral therapy, reminiscence therapy, or behavioral activation. Twenty-eight trials were included in the qualitative synthesis and twenty-two in the meta-analysis. Standardized mean differences (Hedges’ g) were pooled under fixed- and random-effects models. Heterogeneity, subgroup analyses, and publication bias were examined using Q, I², Begg–Mazumdar, Egger, and Trim-and-Fill methods. The global meta-analysis showed a moderate and significant favorable effect of psychological interventions on emotional symptoms under the random-effects model (SMD = −0.623, 95% CI −0.888 to −0.359; p < 0.001), where negative values indicate reductions in symptom severity. Subgroup analyses revealed a moderate effect on depressive symptoms, which remained significant after adjustment for publication bias, and a large effect on perceived stress (SMD = 0.581; p < 0.001); for stress outcomes, positive SMDs indicate reductions in stress (i.e., improvement) after aligning scale directionality. Anxiety showed a significant effect only under the fixed-effects model, while loneliness showed a small but significant effect (SMD = −0.110; p = 0.018). Mindfulness-specific outcomes and quality of life did not show significant pooled effects. No substantial publication bias was detected. Psychological interventions significantly improve emotional well-being in older adults, particularly by reducing depression and stress. Effects on anxiety, loneliness, mindfulness, and quality of life are more variable, emphasizing the need for methodological consistency and longer follow-up in future studies. Full article

Background/Objectives: Older adults with neurocognitive and psychological disorders are often institutionalized in nursing homes, which negatively affects well-being and mood, and may accelerate cognitive decline. Immersive virtual reality (VR) is a promising non-pharmacological countermeasure, but VR-headset discomfort limits its usability in this population. Therefore, this study examined the tolerability and feasibility of an immersive VR room, which provides customizable interactive environments projected across four walls at 360° and enables shared experiences, to enhance positive affect and engagement in nursing home residents. Methods: Twenty nursing home residents were initially enrolled, and nineteen completed five 10 min sessions in the immersive VR room accompanied by a caregiver. State positive and negative effects were assessed using the visual analogue scale (VAS) and the Observed Emotion Rating Scale (OERS), and participants’ verbal feedback was collected during and after the sessions. Results: VAS scores indicated that VR room immersion was feasible and well-tolerated, with most participants feeling secure and experiencing increased positive affect during and just after the sessions. OERS scores and observations revealed frequent expressions of pleasure, interest, and active engagement with both the VR environments and the caregiver. Participants’ reports valued the enjoyable and relaxing experience provided by immersion in the VR room, noting the realism and aesthetics of the environments and nature-related elements, which allowed them to travel virtually and evoke personal memories. Conclusions: Immersive VR room sessions were well tolerated, enhanced positive affect, and may support cognitive functioning by fostering active engagement and social interaction. Given that this is a feasibility study with a small cohort and short follow-up, the present findings should be considered preliminary and confirmed in larger, controlled, longer-term studies. Full article

Objectives: Dementia prevalence continues to rise, predicted to reach 150 million by 2050, making development of effective, person-centred, non-pharmacological interventions an urgent healthcare priority. Music therapy and music (MTAM) are increasingly recognised as low-cost options to alleviate behavioural and psychological symptoms of dementia (BPSD), particularly in acute hospital environments. This scoping review evaluates national dementia strategies and clinical practice guidelines (CPGs) to determine how far MTAM are acknowledged as formal components of dementia care. Methods: A scoping review of databases identified the most recent national clinical strategies or CPGs for people with dementia (PWD), published between 2015 and 2025. Using the PRISMA guidelines in June 2025, with pre-determined inclusion and exclusion criteria we examined four databases, supplemented with an internet search and reference snowballing. National strategies and CPGs that included MTAM were examined in more detail. Results: Of the 37 national strategies or CPGs, 19 were eligible for inclusion, identified from 16 countries. Although non-pharmacological interventions were widely endorsed, only seven guidelines referenced MTAM, and fewer acknowledged its potential value in hospital. In contrast, interventions such as occupational therapy, reminiscence therapy and cognitive behavioural therapy appeared far more frequently. Further analysis was not in the scope of this review. Conclusions: Our findings underscore the gap between emerging evidence supporting music-based interventions and its inclusion in national policy. Clinical Implications: These findings highlight the need for further robust research demonstrating the benefit of MTAM for PWD to strengthen future policy recommendations and promote integration of music-based approaches in dementia care. Full article

Background: Due to communication problems, people with primary progressive aphasia (PwPPA) are often affected in their self-image and experience a reduced quality of life (QoL). Biographic-narrative therapy is an effective approach to improve QoL in post-stroke aphasia. This study describes how PwPPA experienced their participation in the biographic-narrative intervention called Cope PPA. Methods: The intervention comprised a combination of five individual and seven group therapy sessions as well as the use of music and art therapy elements. Inclusion criteria were a capacity to give consent and sufficient visual/auditory abilities of PwPPA. Exclusion criteria were the presence of severe depression (MADRS > 35) or severe cognitive deficits (MMST < 10). After the therapy, PwPPA and their family members took part in half-hour semi-structured interviews. Interviews were analysed according to the reflexive thematic analysis by Braun and Clarke. Results: The qualitative analysis was based on a data set of 34 interviews. A total of six themes were identified: (1) Participation required adherence; (2) Materials were considered remarkable; (3) Storytelling was conducted in an aphasia-free area; (4) Group participation created a sense of belonging; (5) Experiences encouraged self-reflection and (6) Coping is lengthy and ongoing. Conclusions: The findings of our reflexive thematic analysis suggest that PwPPA experienced the intervention as meaningful. Some PwPPA described the effects of our intervention on their self-image. Others emphasised that coping with their condition was an ongoing process requiring continuous support. Full article

We present a conceptual and computational investigation of vacuum memory within a discrete toy-model framework. In this phenomenological approach, we introduce an effective memory field that records virtual events and nonlocal couplings on a lattice, without claiming to derive a fundamental new field of nature. Using a discrete toy model, we simulate memory formation via virtual events, nonlocal links, and black-hole-like information sinks. The resulting dynamics exhibit long-range spatial correlations, curvature-induced accumulation, high-entropy retention zones, and distinct spectral features, indicating that the modeled memory field can store and organize information in a vacuum-like medium. Building on this foundation, we incorporate curvature-modulated vacuum memory fields into Bohmian particle dynamics. By varying the memory coupling strength λ, we demonstrate that memory gradients systematically bend particle trajectories toward curvature centers, illustrating an active role for structured memory in guiding quantum-like motion. We further show that when vacuum memory encodes the full quantum phase S(x, t) and particles are guided by the Bohmian relation $\dot{x}=m^{-1}{\partial }_{x}S$, the trajectories collapse onto a single path with machine-level precision, providing a numerical consistency check that our implementation reproduces exact pilot-wave guidance and minimal-action dynamics. Through a minimal two-site entangled-memory model, we demonstrate that coupled memory fields—without explicit particle dynamics—can spontaneously synchronize via weak informational coupling, generating robust nonlocal correlations reminiscent of entanglement. Finally, we simulate two-slit interference under vacuum memory perturbations. While random, unstructured memory preserves quantum coherence and fringe visibility, structured, phase-sensitive memory induces dephasing and suppresses interference, functioning as a phenomenological decoherence mechanism. Together, these results situate our toy model within emerging information-based views of quantum dynamics and spacetime, offering a computational platform and conceptual lens for exploring the informational dynamics of a vacuum-like medium. Full article

Pressure-controlled intermittent coronary sinus occlusion (PICSO) was initially developed to salvage ischemic myocardium. However, recent evidence suggests a more profound role: reawakening embryonic molecular pathways that facilitate myocardial regeneration. This review examines the paradigm shift in PICSO’s mechanism—from its traditional focus on infarct size reduction to its emerging role as a catalyst for myocardial repair through the reactivation of embryonic signaling. Findings suggested that myocardial decay could be ameliorated beyond salvage, revealing that PICSO enhances vascular activation in the coronary venous system, thereby influencing the fate of endothelial and myocardial cells. The theorem “embryonic recall” posits that PICSO induces molecular signals reminiscent of early cardiac development, offering a novel approach to cardiac repair in myocardial jeopardy. Noncoding RNA serves as a universal signaling event, thereby supporting the hypothesis. Yet, conflicting clinical outcomes highlight the need to redefine PICSO’s objectives, optimize device settings, and realize interventional strategies. The evolution of PICSO demands a radical shift in scientific perspective. Beyond ischemic salvage, its true potential may lie in harnessing regenerative mechanisms within the failing heart. Modern cardiology must adopt this dual role, bridging mechanical intervention with molecular rejuvenation to ensure its continued viability as a therapeutic option. PICSO, like the phoenix, may yet rise anew as a transformative force in cardiovascular medicine. Full article

Background: International policy increasingly recognises the importance of inclusive, community-based support for people living with dementia. Football, as a culturally significant sport, has the potential to reach older adults and communities disproportionately affected by health inequalities. The objectives of this review were to collate evidence on football-based dementia initiatives, including intervention format, delivery approaches, and reported outcomes. Methods: Seven databases (Sportdiscus, MEDLINE, Embase, Scopus, PsycINFO, CINAHL, and Web of Science) were searched for relevant peer-reviewed and grey literature from their inception to June 2025. The PICO framework was used to define eligibility criteria. Eligible studies described community-based football-themed or football-based programmes involving people living with dementia. Data were extracted on participant sample, intervention characteristics, and reported outcomes, and iteratively charted. Results: In total, 11 of the 1059 identified articles were included within this review. Initiatives were often delivered through professional football clubs and charitable foundations, with formats ranging from reminiscence therapy sessions to walking football. Common outcomes for participants included increased sociability, improved mood, enhanced communication, and a strengthened sense of identity and belonging. Some interventions also reported physical benefits, such as improved mobility. Carers highlighted respite opportunities, peer support, and enjoyment from seeing relatives more engaged. Despite positive reports, outcome measurement was inconsistent, and most studies were small-scale or descriptive pilot projects. Conclusions: Football-based dementia initiatives provide meaningful, culturally grounded opportunities for social inclusion and support. Their delivery through community clubs/organisations positions them well to address inequities in dementia care, particularly in areas of disadvantage. However, stronger evaluation methods are required to build a robust evidence base and guide sustainable implementation at scale. Full article

Background: Care homes are complex care environments where supporting residents’ identity, wellbeing, and sense of personhood is central to person-centred care. Reminiscence is widely recognised as a psychosocial approach that can support these outcomes. However, existing evidence has largely focused on group-based interventions, with comparatively limited attention given to how individual reminiscence is implemented and sustained within care home practice. Methods: This study was an implementation-focused qualitative exploration of staff experiences of introducing and embedding individualised reminiscence in care home practice. Care home staff participated in four monthly workshops that introduced principles of individualised reminiscence and supported them to plan and implement reminiscence with at least one resident. Participants used either the InspireD digital reminiscence app (n = 19) or non-digital approaches such as life story books (n = 2), depending on local preferences and perceived suitability. Three focus groups were conducted with 21 care home staff to explore experiences of implementing individualised reminiscence and perceptions of its impact on residents, staff, and families. Data were analysed using reflexive thematic analysis. Results: Four interrelated themes were identified: (1) reminiscence within pressured systems; (2) resident experience and identity; (3) adapting and sustaining practice; and (4) families as partners in reminiscence. Participants described challenges associated with workload pressures, role expectations, and variability in family involvement, which influenced how reminiscence was adopted in practice. Despite these constraints, participants described perceived benefits for residents, including perceived improvements in mood, engagement, and expressions of identity. Participants also discussed perceived increased staff confidence, strengthened staff–resident relationships, and enhanced awareness of person-centred care practices. Conclusions: Findings highlight the perceived potential of individualised reminiscence to support person-centred and relational care in care homes, while identifying key contextual influences on implementation. Further research is needed to examine sustainability and effectiveness using comparative and mixed-method designs. Full article

This paper argues that the challenge managers face today when trying to justify investments in sustainability is reminiscent of the challenge of investing in quality management in the 1980s. Quality managers relied on evidence rather than ideology to select investment projects in quality and defined optimal investment budgets with cost of quality reports. In the first part of the paper, a quality–sustainability analogy is used to adapt lessons learned from Total Quality Management into a Total Sustainability Management framework. In the second part of the paper, the focus shifts to the adaptation of the cost of quality report into a cost of sustainability report. The credibility of the cost of the sustainability model is compared to extant knowledge from the sustainability literature. The discussion shows how many topical questions about sustainability—which can only be answered today through a recourse to ideology—could be answered more factually if we applied quality management knowledge and techniques. Full article

This study investigates the impact of eddy viscosity on equatorially trapped waves and the instability of the background shear in a simple barotropic–baroclinic model. It is the first study to include eddy viscosity in the study of tropical wave dynamics. This study also unifies the study of baroclinic and barotropic instabilities by using a coupled barotopic and baroclinic model of the tropical atmosphere. Linear wave theory is combined with a systematic Galerkin projection of the baroclinic dynamical fields onto parabolic cylinder functions. This study investigates varying shear strengths, eddy viscosities, and their combined effects. In the absence of shear, baroclinic and barotropic waves decouple. The baroclinic waves themselves separate into triads, forming the equatorially trapped wave modes known as Matsuno waves. However, when a strong eddy viscosity is included, the structure and propagation characteristics of these equatorial waves are significantly altered. Different wave types interact, leading to strong mixing in the meridional direction and coupling between meridional modes. This coupling destroys the Matsuno mode separation and offers pathways for these waves to couple and interact with one another. These results suggest that viscosity does not simply suppress growth; it may also reshape the propagation characteristics of unstable modes. In the presence of a background shear, some wave modes become unstable, and barotropic and baroclinic waves are coupled. Without eddy viscosity, instability begins with small scale and slowly propagating modes, at arbitrary small shear strengths. This instability manifests as an ultra-violet catastrophe. As the shear strength increases, the catastrophic instability at small scales expands to high-frequency waves. Meanwhile, instability peaks emerge at synoptic and planetary scales along several Rossby mode branches. When a small eddy viscosity is reintroduced, the catastrophic small-scale instabilities disappear, while the large-scale Rossby wave instabilities persist. These westward-moving modes exhibit a mixed barotropic–baroclinic structure with signature vortices straddling the equator. Some vortices are centered close to the equator, while others are far away. Some waves resemble synoptic-scale monsoon depressions and tropical easterly waves, while others operate on the planetary scale and present elongated shapes reminiscent of atmospheric-river flow patterns. Full article

Cold-active lipolytic enzymes enable low-temperature biocatalysis, but remain underexplored in Antarctic actinomycetes. Here, we report the discovery and first-step characterization of a CALB-like cold-active lipolytic enzyme (PanLip) from Pseudonocardia antarctica. Sequence and structure analyses revealed a canonical α/β-hydrolase fold with a conserved Ser–Asp–His triad and short helical elements around the pocket reminiscent of CALB’s α5/α10 lid. Mature PanLip was expressed primarily as inclusion bodies in E. coli; an N-terminally truncation (PanLipΔN) improved solubility and PanLipΔN was purified by Ni–NTA. Far-UV CD confirmed a folded α/β architecture. PanLipΔN favored short-chain substrates (p-NPA, k_cat/K_M = 2.4 × 10⁵ M⁻¹·s⁻¹) but also showed measurable hydrolytic activity toward natural triglycerides, consistently with a lipase-family esterase. The enzyme showed an activity optimum near 25 °C and pH 8.0. The enzyme tolerated low salt (maximal at 0.1 M NaCl), mild glycerol, and selected organic solvents (notably n-hexane), but was inhibited by high salt, Triton X-100, and SDS. AlphaFold predicted high local confidence for the catalytic core; DALI placed PanLip closest to fungal lipases (AFLB/CALB). Temperature-series MD and CABS-flex indicated enhanced surface breathing and flexible segments adjacent to the active site—including a region topologically matching CALB α10—supporting a flexibility-assisted access mechanism at low temperature. Structure-based MSAs did not support a cold adaptation role for the reported VDLPGRS motif. Taken together, these findings position PanLip as a promising cold-active catalyst with CALB-like access control and potential for low-temperature biocatalysis. Full article

Presented here are additional explanations for five key points offered by Rojero et al. in their 2025 publication in this journal, regarding characteristics of hyper-aggressive phage 0524phi7-1. These are (i) that the “bypassing of the evolution of host resistance” has been seen in other phages, especially dual-receptor generalist phages; (ii) that the “clearing of semi-turbid plaques” could be due to a phenomenon known as lysis inhibition collapse, (iii) that the “formation of satellite plaques” is reminiscent of the morphology of plaques generated by phage T4 star mutants, (iv) that “multi-day plaque enlargement” has been seen in other phages such as phage T7 but may also be explained by other phenomena including endolysin release, (v) that suggestions of phage “swimming” could be explained by virion diffusion within empty volumes found within maturing bacterial lawns. In particular, phage plaques that display lysis inhibition can influence the surrounding bacterial lawn well beyond their visible region. This presumably occurs via a reaction–diffusion mechanism whose leading edge of virion diffusion fails to display lysis inhibition, but which leaves in its wake lysis-inhibited bacterial infections that may not lyse in a timely manner. Phage-infected bacteria thus may be found well beyond a plaque’s visible boundaries, along with diffusing endolysin. Full article

This study investigates the dynamic magneto-optical properties of ferrofluid thin films, focusing on how magnetic fields induce light–matter interactions using a device known as Ferrocell. Our findings reveal that incident light interacts with self-assembled, anisotropic nanoparticle structures, transforming the ferrofluid into a highly responsive optical medium. Monochromatic laser experiments confirmed the direct correlation between laser color and diffracted light color offering direct insights into particle orientation and aggregate morphology. We observed significant chromatic shifts, especially in regions under strong perpendicular magnetic fields, which provide compelling evidence of structural colors. This phenomenon stems from wavelength-selective interference and diffraction, reminiscent of photonic crystal behavior, yet characterized by short-range order, classifying the material as a photonic glass. Full article