Search Results (2,482)

Aging is accompanied by profound alterations in immune function, termed immunosenescence, and by a chronic, low-grade inflammatory state known as inflammaging. These processes are increasingly recognized as central drivers of age-related neurodegenerative diseases, including Alzheimer’s Disease, Parkinson’s Disease, Amyotrophic Lateral Sclerosis and Multiple Sclerosis. In the central nervous system, senescent microglia and astrocytes lose their homeostatic and neuroprotective functions, while systemic immune aging and blood–brain barrier dysfunction further amplify neuroinflammation and impair protein aggregate clearance. This sustained pro-inflammatory environment promotes synaptic dysfunction, neuronal loss and cognitive decline. Here, we synthesize current knowledge of the mechanistic links among immunosenescence, inflammaging, and neurodegeneration, highlighting innate and adaptive immune dysregulation, mitochondrial impairment, and failed resolution pathways. We further discuss emerging therapeutic strategies, including senolytics, immunoceuticals, microbiome-based interventions and advanced drug delivery systems, aimed at restoring immune homeostasis and enhancing brain resilience. By integrating mechanistic and translational insights, this review provides a framework for developing novel interventions to target immune aging in neurodegenerative diseases. Full article

Global poultry production continues to expand rapidly to meet the growing demand for affordable and high-quality animal protein. However, this growth raises pressing concerns about environmental sustainability, natural resource use, and public health. Although current initiatives, such as improved housing systems, optimized feeding practices, and partial soybean meal substitution, have helped mitigate some impacts, comprehensive integrated solutions remain underexplored. This review synthesizes emerging nutritional and management innovations that enhance the sustainability of poultry production while maintaining profitability. It addresses three central research questions: (1) Which alternative feed ingredients most effectively preserve animal performance while minimizing environmental burdens? (2) How can environmental management practices enhance resource efficiency and waste valorization? (3) What roles do life cycle assessment methodologies and policy frameworks play in advancing sustainable poultry systems? Evidence from 100 peer-reviewed studies, industrial data, and field analyses reveals that incorporating insect meals, algae, and agro-industrial by-products can reduce dependence on soybean meal by 20–40% and improve feed efficiency by 5–12% across various poultry production systems. Furthermore, integrating environmental management strategies, such as manure valorization, efficient water and energy use, and the adoption of renewable energy, substantially reduces greenhouse gas emissions and promotes circular economic principles. Life cycle assessment studies confirm that combined dietary and management interventions yield greater reductions in carbon footprint than isolated measures. Future research should focus on optimizing interactions among feed strategies, environmental management, and policy frameworks through digital technologies, nanomaterial-based feed additives, and region-specific sustainability plans to accelerate the transition toward resilient, climate-smart poultry production systems. Full article

Rapid expansion of electric vehicle adoption has led to increased dependence on a charging infrastructure that is tightly integrated with energy distribution systems and digital communication networks. As electric vehicle charging stations evolve into complex cyber–physical systems, cybersecurity risks pose a growing threat to grid reliability and user trust. This paper presents a hybrid decision-support framework for cybersecurity risk assessment in EV charging infrastructure that advances beyond prior multi-criteria decision-making approaches by combining interpretability with data-driven validation. Specifically, the framework integrates the Analytic Hierarchy Process (AHP) for expert-driven weighting of cybersecurity attributes with PROMETHEE for flexible threat prioritization, enabling transparent and auditable risk rankings. The framework categorizes cybersecurity criteria across four infrastructure layers—transmission, distribution, consumer, and electric vehicle charging stations—and assigns relative weights through expert-driven pairwise comparisons. PROMETHEE is then applied to rank potential cyber threats based on these weights, allowing for flexible prioritization of cybersecurity interventions. The methodology is validated using the real-world WUSTL-IIoT-2018 SCADA dataset, which includes simulated reconnaissance (network scanning), device identification, and exploitation attacks. While this dataset does not natively include OCPP 2.0 or ISO 15118 protocols, the experimental results demonstrate strong discrimination power (AUC = 0.99, recall = 95%) and provide a basis for extension to modern EVSE communication standards. The results identify critical metrics such as anomalous source packet behavior and encryption reliability as key vulnerability markers, aligning with documented EV charging attack scenarios. By bridging expert judgment with empirical traffic data, the proposed framework offers both technical robustness and explainability, supporting grid operators, SOC teams, and infrastructure planners in systematically assessing risks, allocating resources, and enhancing the resilience of EV charging ecosystems against evolving cyber threats. Full article

Alzheimer’s disease (AD) is an age-related neurodegenerative disorder characterized by progressive synaptic dysfunction, axonal pathology, and cognitive decline, with the hippocampal circuits showing particular vulnerability during disease progression. However, early-life nutritional interventions may influence long-term synaptic resilience. In this study, we investigated the long-term effects of prenatal and lactational supplementation with choline, UMP, and fish oil in the 5XFAD mouse model. To this end, hippocampal synaptic and axonal pathology was assessed at 3, 6, and 9 months using Western blotting and immunofluorescence to measure synaptophysin, PSD-95, and neurofilament medium chain (NF-M), alongside a multidimensional behavioral battery that evaluated cognitive, affective, motor, and sensory outcomes. Results showed that early-life supplementation did not significantly improve the learning performance decline, increase nociception, or reverse changes in anxiety behavior in transgenic mice. However, it attenuated synaptic decline in transgenic animals by partially preserving synaptophysin and PSD-95 levels and reducing NF-M elevations. These molecular effects were accompanied by selective behavioral modulation, including preserved learning dynamics, altered anxiety-like behavior, and delayed nociceptive hypersensitivity, while late-stage motor impairments remained largely unaffected. Overall, prenatal and lactational supplementation produced modest, age-dependent effects on synaptic markers and partially prevented neurodegenerative progression in the 5XFAD model. Full article

Digital transformation has profoundly reshaped caregiving practices, yet its influence on family cohesion within disability contexts remains underexplored, particularly in Arab societies. This qualitative phenomenological study examines how digital technologies shape family cohesion among Jordanian caregivers of children with disabilities. In-depth, semi-structured interviews were conducted with 22 primary caregivers, and data were analyzed using reflexive thematic analysis. The findings reveal a central tension of being “between connectivity and care,” articulated through four interrelated themes: (1) a digital double-bind in which online support networks function as a vital “virtual village” while simultaneously contributing to intra-familial fragmentation; (2) the reconfiguration of care labor, whereby digital management emerges as an invisible and gendered form of caregiving work, often positioning mothers as primary digital coordinators; (3) the translation of traditional social capital (wasta) into digital spaces to navigate systemic resource constraints, producing new moral and emotional burdens; and (4) the strategic use of digital platforms to preserve cultural, religious, and familial identity in the face of stigma, thereby reinforcing internal cohesion. These findings suggest that digital technologies do not merely facilitate connection but actively reconfigure family dynamics through ongoing negotiation between support and strain. The study underscores the need for family-centered digital inclusion policies and support interventions that mitigate digital burdens while harnessing technology’s potential to strengthen culturally grounded resilience among families of children with disabilities. Full article

Background/Objectives: Patients with breast cancer show substantial heterogeneity in terms of psychological adjustment following diagnosis. We aimed to characterize longitudinal trajectories of quality of life (QoL) and depressive symptoms during the first 18 months post-diagnosis and to identify robust clinical, psychosocial, and behavioral predictors associated with distinct adjustment pathways. Methods: Women (N = 538; mean age 55.4 years; range 40–70) with operable breast cancer (stages I–III) were drawn from the multicenter BOUNCE cohort. QoL (Global Health Status/QoL scale of the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire Core 30) and depressive symptoms (depression subscale of the Hospital Anxiety and Depression Scale) were assessed at baseline and months 3, 6, 9, 12, 15 and 18. Latent class growth analysis and growth mixture modeling identified distinct trajectory classes. Associations between early predictors and trajectory membership were examined using logistic regression combined with elastic net regularization. Results: Depression trajectories demonstrated heterogeneity, with groups characterized by persistent resilience (59.7%), stable moderate/high (25.3%), delayed onset (5.0%), and recovery (10.0%). QoL trajectories ranged from stable excellent (13.2%) and stable high (40.7%) to moderate (31.4%) and persistent low/deteriorating (6.9%), as well as a distinct recovering trajectory (7.8%). Trajectory differentiation was primarily driven by psychological resources, symptom burden, functional status, and coping processes, alongside specific contributions from clinical factors. Conclusions: Distinct subgroups of women with breast cancer follow divergent adjustment pathways. These findings highlight the multidimensional nature of resilience and support the need for tailored interventions that promote long-term well-being beyond simple risk reduction. Full article

Heatwaves, intensified by climate change and urbanization, pose increasing threats to human health, with occupational populations facing disproportionate risks due to prolonged exposure and high metabolic demands. Existing evidence remains fragmented, particularly regarding the integration of acute and chronic health effects in workplace settings. This narrative review synthesizes current knowledge on occupational heat exposure, highlighting emerging risks such as cumulative physiological strain, heat-related chronic diseases, and mental health impacts. We identify key occupational-specific pathways that amplify vulnerability beyond that of the general population. Despite growing awareness, substantial gaps persist in the implementation of effective adaptation strategies, especially in low- and middle-income countries, where regulatory, economic, and structural barriers limit intervention uptake. To address these challenges, we emphasize the need for adaptive work–rest scheduling, dynamic early warning systems, and cross-sectoral collaboration to enhance occupational heat resilience under a changing climate. Full article

The study examines the adoption of drought-tolerant maize (DTM) as a climate adaptation measure among smallholder farmers in northern Ghana, using data from 500 households and probit model analysis to determine key adoption drivers. The findings reveal that only 28% of the sampled farmers have adopted DTM, with maize yield, awareness of DTM, access to extension services, and geographical location being significant influencing factors. Among these, maize yield and awareness of DTM have the strongest association with adoption decisions. Additionally, 29% of smallholder farmers employ early planting as a climate adaptation measure. Seed sourcing patterns show that 66% rely on saved seeds, while 33% obtain seeds from input dealers. Encouragingly, 96% of farmers expressed willingness to adopt improved maize varieties. Despite the relatively low adoption rate, targeted policy interventions, such as strengthening agricultural extension services, promoting climate-smart practices, and ensuring continuous research on DTM varieties, can enhance adoption and improve farmers’ resilience to climate change. These findings provide crucial insights for policymakers and agricultural stakeholders aiming to promote sustainable maize production in northern Ghana. Full article

Constructing resilient Ecological Security Patterns (ESPs) in polycentric urban agglomerations is computationally challenging due to persistent scale mismatches between local planning and regional strategies. To address this, we developed a novel Proactive Integration Mechanism (PIM), a computational framework that dynamically optimizes ESPs by algorithmically fusing multi-source geospatial data. The PIM integrates three innovative components: (1) a Function–Structure–Policy data fusion approach that couples Self-Organizing Map clustering of ecosystem services with Morphological Spatial Pattern Analysis and policy data to identify ecological sources; (2) a Dual-Feedback Mechanism that hybridizes circuit theory with an Improved Ant Colony Optimization algorithm for dynamic corridor delineation; and (3) complex network analysis to derive targeted interventions from topological properties. Applied to a node city of the Chengdu-Chongqing Economic Circle, the PIM identified 22 integrated ecological sources and 37 corridors. The optimized network showed enhanced resilience: a deterministic 20.5% increase in circuit redundancy (α-index) and an 8.6% improvement in overall connectivity (γ-index), achieved through minimal topological modifications. Temporal validation (2000–2020) confirmed the high stability of the identified patterns. This study provides a potentially replicable and computationally robust framework that bridges spatial ecology with optimization algorithms, offering a promising paradigm for constructing ESPs in node cities within subtropical urban agglomerations. Full article

Acute heat stress frequently causes mass mortality in farmed red swamp crayfish (Procambarus clarkii), yet the mechanisms underlying immune collapse remain poorly understood. We established an acute heat stress model (37 °C, 6 h) and performed an integrative analysis combining hemocyte profiling, redox and immune assays, RNA-seq, and qRT-PCR. Heat stress significantly increased mortality and disrupted the hemocyte system, with a ~25% reduction in total hemocyte count and a selective decline in granular cells. This was associated with severe redox imbalance, evidenced by ROS/H₂O₂ accumulation, suppressed SOD and CAT activities, and lipid peroxidation damage. Transcriptomic analysis revealed 1446 differentially expressed genes, indicating concurrent activation of ER stress and autophagy alongside suppression of energy metabolism. Key gene validation confirmed upregulation of pro-apoptotic factors (CASP3, P53) and ER stress markers (GRP78, XBP1), consistent with hemocyte depletion. These findings provide multi-level evidence that acute heat stress triggers a redox crisis (“oxidative burst–defense suppression”), which in turn activates ER stress and apoptosis, leading to selective loss of granular cells and systemic immune compromise. This study establishes a mechanistic framework for understanding heat-induced mortality in crustaceans and offers a theoretical basis for developing targeted interventions to enhance thermal resilience in crayfish aquaculture. Full article

High-density cities face dual challenges of aging populations and climate change, driving widespread renewal of aging residential communities. Current practices, however, often treat sustainability goals (e.g., energy efficiency, carbon reduction) and age-friendly design objectives (e.g., accessibility, social inclusion), often guided by frameworks like the World Health Organization’s (WHO) age-friendly cities initiative, as separate or conflicting agendas, leading to fragmented policies and suboptimal outcomes. This study addresses this gap by proposing and testing a framework for “Sustainable-Age-friendly Coordinated Renewal” (SACR). Through a mixed-methods case study of a typical old community in the humid subtropical city of Guangzhou, China, we investigate how green infrastructure and low-carbon interventions can be synergistically designed to enhance both environmental performance and the well-being of elderly residents. A “Coordinated Renewal Strategy Package” was developed, incorporating ecological shading, sponge city facilities, energy retrofits, and accessible slow-traffic systems. Post-intervention simulation and evaluation indicated significant improvements in microclimate (e.g., reduced mean radiant temperature and Physiological Equivalent Temperature (PET)) and marked increases in outdoor activity duration and social interaction frequency among elderly residents. This study concludes that a human-centric, needs-based design approach is key to unlocking synergistic benefits. The proposed SACR framework and evaluation matrix offer a practical tool for urban planners, architects, and policymakers to holistically assess and implement community renewal projects, contributing to more resilient, inclusive, and sustainable urban futures by addressing localized challenges like the Urban Heat Island (UHI) effect. Full article

This study bridges the existing gaps in quantifying risk and enhancing community defences by applying a cohesive five-pillar risk and resilience framework developed within the C2IMPRESS project. We assessed the anticipated impacts of various C2IMPRESS tools on community resilience across four European case study areas (CSAs): Egaleo (Greece), Mallorca (Spain), Ordu (Turkey), and the Centro Region (Portugal). Methodologically, a targeted survey asked CSA representatives to estimate the expected changes across 42 resilience indicators—encompassing social, institutional, economic, infrastructural, and environmental dimensions—following tool implementation. A public–private-civil partnership (PPCP) framework was also assessed across all sites to enable a comparative analysis. The results indicate that individual vulnerability and emergency preparedness are the most responsive dimensions, exhibiting significant projected improvements alongside institutional capacities and community trust. Conversely, the community economy emerged as the least flexible dimension, exhibiting minimal anticipated change. In conclusion, the C2IMPRESS framework effectively bridges disaster risk reduction and climate adaptation by integrating local knowledge into actionable interventions. However, while social and institutional resilience can be actively enhanced, improving economic resilience requires long-term structural adjustments beyond the scope of these localised tools. Full article

Although urban resilience is a complex concept, several initiatives have made it more tangible. Urban public authorities and policymakers are of utmost importance, as they influence multiple neighbourhoods, stakeholders and aspects of urban resilience. Nevertheless, the role of individual facilities—such as sports fields—should not be overlooked. While their impacts are smaller in scale, they can significantly enhance local resilience and serve as inspirational pilots for broader initiatives. To assess resilience at the facility scale, an existing assessment framework was adapted, aligned with ESG (environmental, social and governance) criteria and climate action pillars and valuing ecosystem services. In the sports field case study, stormwater was reframed from a burden into a resource and integrated with other scheduled resilience-enhancing interventions: water conservation, installation of photovoltaic panels, enhanced tree shading, and circularity through sports equipment reuse. Together, these interventions strengthen urban sustainability, resilience, and climate adaptation while delivering ecological and social benefits. The stormwater drainage system was modelled to simulate naturalization actions. The assessment framework is described, and its application at both neighbourhood and facility scales is discussed. Comparisons between the existing and improved situations show clear resilience gains, and opportunities for extending these measures to the city scale are explored. Full article

This study addresses the challenge of designing low-carbon supply chain pathways in the global seaborne metallurgical coal sector by developing an enhanced Ant Colony Optimisation (ACO) algorithm. This quantitative approach bridges operations research and sustainability science by identifying optimal supply pathways to minimise transportation-related carbon emissions. The enhanced framework incorporates coal-specific maritime logistical constraints and maintains Pareto efficiency across a comprehensive global dataset encompassing 201 mines, 11 exporting nations, and 72 destination ports in 26 importing countries. Computational analysis demonstrates that the proposed algorithm achieves a 25% reduction in transportation carbon intensity (from 38.2 to 28.6 kg CO₂eq/t) relative to the 2022 baseline. To evaluate supply chain resilience, scenario analyses incorporating geopolitical disruptions, such as the Russian coal sanctions, provide quantitative insights into the trade-offs between policy interventions and emission reduction objectives. Extending projections to 2050 under various demand trajectories yields cumulative emission reductions of 35–70 Mt CO₂eq (an average of 53 Mt), representing additional mitigation beyond the 230 Mt of reductions identified in prior research. These findings demonstrate that mathematical optimisation can deliver near-term environmental benefits without requiring capital-intensive technological breakthroughs, thereby supporting global climate mitigation targets. Full article

Background: A paediatric cancer diagnosis is a profound stressor for the entire family system. Although coping strategies are well-studied, their link to the quality of the parent–child attachment relationship remains less explored. In this study, we investigated whether dyadic attachment dynamics—specifically closeness and conflict between parent and child—are associated with the use of adaptive or maladaptive coping strategies in caregivers of children undergoing active treatment for oncohaematological diseases. Methods: We conducted a multicentre, cross-sectional study across three Italian paediatric oncohaematology centres. A total of 165 caregivers of 91 paediatric patients aged 3–17 years completed self-report measures assessing parent–child relationship quality (Child–Parent Relationship Scale-CPRS), coping strategies (COPE-NVI), perceived social support (MSPSS), and resilience (RS-14). We tested whether the quality of the parent–child attachment relationship is associated with caregivers’ coping strategies. We hypothesised that Attachment Closeness would be associated with adaptive coping (Positive Attitude, Social Support, Problem Orientation), whereas Attachment Conflict would be associated with maladaptive coping (Avoidance). We conducted multiple linear regression models, adjusted for key covariates and with robust standard errors clustered at the family level, to test these hypotheses. Results: Higher levels of emotional closeness (CPRS) were significantly associated with greater use of adaptive coping strategies, specifically Positive Attitude (β = 0.20, p = 0.049) and Problem Orientation (β = 0.26, p = 0.002), even after controlling for sociodemographic factors, social support, and resilience. Conversely, higher levels of relational conflict were significantly associated with greater use of the maladaptive Avoidance strategy (β = 0.14, p = 0.015). The hypothesis linking closeness to Social Support seeking was not supported. Conclusions: The findings suggest that the parent–child attachment relationship is a significant correlate of caregiver coping strategies in caregivers of children with cancer. Interventions aimed at supporting the caregiver–child dyad by fostering emotional closeness and reducing conflict may promote more adaptive parental coping mechanisms, thereby enhancing family resilience and psychological adjustment throughout the treatment journey. Full article