Search Results (4,789)

This study proposes an integrated control–optimization framework for harmonic mitigation in two-level, grid-connected inverters with battery energy storage operating under unbalanced grid conditions. A proportional–resonant controller in the stationary $\alpha \beta$ frame and a proportional–integral controller in the synchronous $dq$ frame are compared, with controller gains optimized using PSO, GA, and a hybrid PSO–GA approach. The hybrid method achieves superior trade-offs among THD, convergence speed, and computational effort. For the PR controller, hybrid PSO–GA reduces THD to 1.07%, satisfying IEEE 1547 and IEC 61727 standards, while for the PI controller it achieves 2.70%, outperforming standalone PSO (4.12%) and GA (3.38%). The hybrid-optimized gains further minimize tracking error indices (IAE, ISE, ITAE, ITSE), ensuring precise steady-state current regulation. Convergence analysis shows that hybrid PSO–GA attains optimal solutions within three iterations for both controllers, faster than GA and comparable to PSO for the PR case. Simulation studies on the IEEE 13-bus unbalanced feeder in DIgSILENT PowerFactory validate the proposed framework. Results confirm that the PR controller delivers a 60.36% THD reduction and tenfold ISE improvement over the optimized PI design, establishing a robust and scalable solution for harmonic suppression in unbalanced grid-tied energy systems. Full article

Background/Objectives: Metabolic dysfunction-associated steatotic liver disease (MASLD) is becoming more common among adolescents, but non-invasive biomarkers for early detection are still limited. Liver-expressed antimicrobial peptide-2 (LEAP-2), a ghrelin receptor antagonist, has been connected to obesity and liver fat buildup in adults, but pediatric data are limited. This study investigates the hypothesis that higher levels of LEAP-2 are associated with hepatic steatosis and the role of LEAP-2 serum levels in the earlier and easier diagnosis of MASLD in children. Methods: In this cross-sectional study, 51 adolescents aged 12–18 were divided into three groups: one with MASLD and obesity (MASLD-Ob) (confirmed hepatosteatosis by imaging studies such as magnetic resonance or ultrasound, along with at least one cardiometabolic criterion and a body mass index (BMI) > 2 SD) (n = 19), another with obesity without any liver pathology or MASLD (BMI > 2 SD) (n = 14), and healthy controls (n = 18). The controlled attenuation parameter (CAP) was measured using FibroScan^® Mini + 430 (Echosens SA, Créteil, France), and serum ghrelin and LEAP-2 levels were determined via ELISA. Correlations between LEAP-2, ghrelin, CAP, BMI z-score, and metabolic parameters were analyzed. Results: LEAP-2 and ghrelin levels among the three groups were similar (p = 0.148, p = 0.515). A positive correlation was observed between LEAP-2 levels and CAP values in the obese group (both the MASLD-Ob and obesity groups) (r = 0.379, p = 0.030). When a cutoff of 240 dB/m was used, the median LEAP-2 level in cases above this value was 2.20 ng/mL, compared to 1.37 ng/mL in cases below it (p = 0.021), which was significantly different. When analyzing the obese group (both the MASLD-Ob and obese groups) a statistically significant correlation was found between serum LEAP-2 levels and CAP, AST, GGT, and total bilirubin values (r = 0.379, p = 0.030; r = 0.369, p = 0.035; r = 0.369, p = 0.035; r = 0.357, p = 0.049, respectively). Conclusions: Interventional imaging methods and biomarkers for diagnosing and monitoring hepatosteatosis have become well-established in the literature. However, since these tests are not available at all centers and can be costly, there is an increasing search for other easily accessible diagnostic and follow-up parameters. LEAP-2 could be a promising non-invasive biomarker for pediatric MASLD, especially when used alongside CAP measurements. The application of this biomarker in pediatric MASLD provides valuable data to help identify and monitor the condition in adolescents. We believe our study offers strong evidence to support further research and the development of drug treatments for MASLD that aim to reduce plasma LEAP-2. Full article

Background: This retrospective cross-sectional study evaluated the association of the global wall thickness index (GTI), derived from cardiovascular magnetic resonance (CMR), with demographic, clinical, and imaging findings, as well as heart failure history in transfusion-dependent thalassemia (TDT) patients. Methods: We analyzed 1154 TDT patients (52.9% female, 37.46 ± 10.67 years) from the Extension-Myocardial Iron Overload in Thalassemia project and 167 healthy controls (54.5% female, 36.33 ± 15.78 years). The CMR protocol included the T2* technique for the assessment of iron overload, cine imaging for the assessment of left ventricular (LV) function and size, and late gadolinium enhancement (LGE) imaging for the detection of replacement myocardial fibrosis (in the subset of 366 patients who underwent contrast administration). GTI (in mm/m²) was calculated from LV mass and end-diastolic volume. Results: GTI discriminated TDT patients from controls better than the LV end-diastolic volume index. Among TDT patients, GTI was higher in males, in those with diabetes, and in those with severe myocardial iron overload (cardiac T2* < 10 ms), but was unrelated to age, hemoglobin and ferritin levels, splenectomy, hepatic and pancreatic T2* values, LV ejection fraction, and fibrosis. GTI showed a diagnostic performance comparable to global heart T2* and superior to LV ejection fraction in identifying patients with prior heart failure. Conclusions: GTI is elevated in TDT patients compared with healthy controls. Male sex and severe myocardial iron overload are key determinants of GTI in TDT. Increased GTI is linked to a history of heart failure, supporting its role as a complementary tool to conventional CMR indices. Full article

Parahydrogen-induced hyperpolarization (PHIP), introduced nearly four decades ago, provides an elegant solution to one of the fundamental limitations of nuclear magnetic resonance (NMR)—its notoriously low sensitivity. By converting the spin order of parahydrogen into nuclear spin polarization, NMR signals can be boosted by several orders of magnitude. Here we present a portable, compact, and cost-effective setup that brings PHIP and Signal Amplification by Reversible Exchange (SABRE) experiments within easy reach, operating seamlessly across ultra-low-field (0–10 μT) and high-field (>1 T) conditions at 50% parahydrogen enrichment. The system provides precise control over bubbling pressure, temperature, and gas flow, enabling systematic studies of how these parameters shape hyperpolarization performance. Using the benchmark Chloro(1,5-cyclooctadiene)[1,3-bis(2,4,6-trimethylphenyl)imidazole-2-ylidene]iridium(I) (Ir–IMes) catalyst, we explore the catalyst activation time and response to parahydrogen flow and pressure. Polarization transfer experiments from hydrides to [1-¹³C]pyruvate leading to the estimation of heteronuclear J-couplings are also presented. We further demonstrate the use of Chloro(1,5-cyclooctadiene)[1,3-bis(2,6-diisopropylphenyl)imidazolidin-2-ylidene]iridium(I) (Ir–SIPr), a recently introduced catalyst that can also be used for pyruvate hyperpolarization. The proposed design is robust, reproducible, and easy to implement in any laboratory, widening the route to explore and expand the capabilities of parahydrogen-based hyperpolarization. Full article

Parkinson’s disease (PD) is a multisystem disorder, with early changes extending beyond basal ganglia circuitries and involving non-dopaminergic pathways, including cerebellar networks. Whether cerebellar dysfunction reflects a compensatory mechanism or an intrinsic hallmark of disease progression remains unresolved. In this cross-sectional study, we examined how cerebellar γ-aminobutyric acid (GABA) and glutamate/glutamine (Glx) systems, as well as their excitatory/inhibitory (E/I) balance, are modulated along the disease course. As to ascertain how these mechanisms contribute to motor and non-motor features in the premotor and early stages of PD, 18 individuals with isolated REM sleep behavior disorder (iRBD), 20 de novo, drug-naïve PD (dnPD), and 18 matched healthy controls underwent clinical, cognitive, and neuropsychiatric assessments alongside cerebellar magnetic resonance spectroscopy (MRS, MEGA-PRESS, 3T). While cerebellar neurotransmitter levels did not differ significantly across groups, dnPD patients exhibited a shift toward hyperexcitability in the E/I ratio, without correlation to clinical or cognitive measures. In contrast, in iRBD, an inverse relationship between heightened GABAergic activity and neuropsychiatric symptoms emerged. These findings suggest an early, dynamic cerebellar involvement, potentially reflecting compensatory modulation of altered basal ganglia output. Our results support cerebellar GABA MRS as a promising biomarker and open perspectives for targeting non-dopaminergic pathways in PD. Full article

This paper provides a comprehensive review of recent advancements in radio-frequency (RF) multifunctional components with integrated filtering characteristics, including tunable filtering attenuators, filtering power dividers, filtering couplers, and filtering Butler matrices, all of which play critical roles in wireless communication systems. With the increasing demand for miniaturization, integration, and low-loss performance in RF front-ends, multifunctional components with filtering characteristics have become essential. This review first introduces tunable attenuators and filtering attenuators based on various technologies such as PIN diodes, graphene-based structures, and RF-MEMS switches, and also analyzes their advantages, limitations, and performance. Then, we discuss filtering power dividers developed from Wilkinson structures, three-line coupled structures, resonator-based coupling matrix methods, and SSPP-waveguide hybrids. Furthermore, filtering couplers and filtering Butler matrices are reviewed, highlighting their capability to simultaneously achieve amplitude and phase control, making them suitable for multi-beam antenna feeding networks. Finally, a brief conclusion is summarized. Future research directions, such as hybrid technologies, novel materials, broadband and multi-band designs, and antenna-matrix co-design, are suggested to further enhance the performance and practicality of multifunctional RF components for next-generation wireless communication systems. Full article

Generation of idler pulses via the four-wave mixing (FWM) effect in a nonlinear optical ring resonator (NORR) was investigated numerically. It was found that the relative delay $\tau$ between input pump pulses significantly affects both the energy and temporal–spectral characteristics of generated idler pulses. Specifically, idler pulse energy decreases with increasing $\tau$ due to phase-matching conditions in FWM. Maximum energy transfer occurs for $\tau$ = 0, where optimal phase alignment among pump, signal, and idler waves is achieved. Temporal and spectral analysis at different relative delays reveals a change from a symmetric, multi-subpulse structure with a comb-like spectrum (for $\tau$ = 0) to a near-single-pulse form with a single-comb-line spectrum (for $\tau$ = 9 ps). These findings demonstrate the critical dependence of FWM efficiency on pump pulse synchronization. Therefore, precise control of the relative delay is essential for optimizing idler pulse generation in NORRs. Full article

Familial Hypercholesterolemia (FH) is a common genetic disorder characterized by elevated LDL-cholesterol levels and an increased risk of premature cardiovascular disease. While pathogenic variants in LDLR, APOB, and PCSK9 are well-established causes, a substantial proportion of clinically suspected FH cases do not carry either pathogenic variants or rare variants of uncertain significance in these genes (FH/V−/USV−). This study aimed to characterize the metabolome/lipidome of genetically confirmed heterozygous FH (HeFH) patients compared to FH/V−/USV−, seeking to identify specific alterations associated with genetic status and phenotypic variability. Untargeted high-resolution mass spectrometry (UHPLC-Q-Exactive-MS)-based lipidomics and nuclear magnetic resonance-based metabolomics were performed on plasma samples of FH patients (n = 20 HeFH and n = 19 FH/V−/USV−) towards healthy controls (n = 22). PLS-DA analysis revealed group-level separation, suggesting differences in the circulating metabolome/lipidome. As expected, most of identified lipid classes were higher in both FH groups compared to normolipidemic controls. Notably, significant lipids (VIP > 1, p < 0.05) showed potential in distinguishing HeFH and FH/V−/USV− patients, particularly sphingomyelins. These data were confirmed by multivariable regression analysis controlling for age, sex, and lipid-lowering therapy as well as by ROC analysis. The evidence of a distinct lipidome signature in the HeFH subgroup may relate to the increased cardiovascular risk of HeFH patients compared to patients without pathogenic variants. Full article

Structural dynamics analysis is essential for predicting the behavior of engineering systems under dynamic forces. This study presents a hybrid framework that combines analytical modeling, machine learning, and optimization techniques to enhance the accuracy and efficiency of dynamic response predictions for Single-Degree-of-Freedom (SDOF) systems subjected to harmonic excitation. Utilizing a classical spring–mass–damper model, Fourier decomposition is applied to derive transient and steady-state responses, highlighting the effects of damping, resonance, and excitation frequency. To overcome the uncertainties and limitations of traditional models, Extended Kalman Filters (EKFs) and Physics-Informed Neural Networks (PINNs) are incorporated, enabling precise parameter estimation even with sparse and noisy measurements. This paper uses Adam followed by LBFGS to improve accuracy while limiting runtime. Numerical experiments using 1000 time samples with a 0.01 s sampling interval demonstrate that the proposed PINN model achieves a displacement MSE of 0.0328, while the Eurocode 8 response-spectrum estimation yields 0.047, illustrating improved predictive performance under noisy conditions and biased initial guesses. Although the present study focuses on a linear SDOF system under harmonic excitation, it establishes a conceptual foundation for adaptive dynamic modeling that can be extended to performance-based seismic design and to future calibration of Eurocode 8. The harmonic framework isolates the fundamental mechanisms of amplitude modulation and damping adaptation, providing a controlled environment for validating the proposed PINN–EKF approach before its application to transient seismic inputs. Controlled-variable analyses further demonstrate that key dynamic parameters can be estimated with relative errors below 1%—specifically 0.985% for damping, 0.391% for excitation amplitude, and 0.692% for excitation frequency—highlighting suitability for real-time diagnostics, vibration-sensitive infrastructure, and data-driven design optimization. This research deepens our understanding of vibratory behavior and supports future developments in smart monitoring, adaptive control, resilient design, and structural code modernization. Full article

Controlling low-frequency noise and achieving multi-band sound insulation remain significant challenges and have long been hot topics in industrial research. This study introduces a novel multifunctional device based on the principles of acoustic metamaterials, which not only offers high-performance sound insulation but also converts low-frequency acoustic energy into electrical energy. Through an innovative design featuring multiple local resonance design, the proposed device effectively mitigates the impact of pre-tension on the membrane, while enabling efficient multi-band sound insulation that can be finely tuned by adjusting structural parameters. Experimental results demonstrate that the device achieves a maximum sound insulation of 40 dB and an average sound insulation exceeding 25 dB within the 1000 Hz frequency range. Moreover, by utilizing its local resonance property, a triboelectric nanogenerator (TENG) is specifically designed for low-frequency acoustic–electric conversion, maintaining high performance low-frequency sound insulation while simultaneously powering small scale electronic devices. This work provides a promising approach for multi-band sound insulation and low-frequency acoustic–electric conversion, offering broad potential for industrial applications. Full article

The central purpose of this study is to develop and validate an advanced numerical model capable of simulating the vibrational behavior of the operator’s seat in a tractor-type agricultural vehicle designed for operation in protected horticultural environments, such as vegetable greenhouses. The three-dimensional (3D) model of the seat was created using SolidWorks 2023, while its dynamic response was investigated through Finite Element Analysis (FEA) in Altair SimSolid, enabling a detailed evaluation of the natural vibration modes within the 0–80 Hz frequency range. Within this interval, eight significant natural frequencies were identified and correlated with the real structural behavior of the seat assembly. For experimental validation, direct time-domain measurements were performed at a constant speed of 5 km/h on an uneven, grass-covered dirt track within the research infrastructure of INMA Bucharest, using the TE-0 self-propelled electric tractor prototype. At the operator’s seat level, vibration data were collected considering the average anthropometric characteristics of a homogeneous group of subjects representative of typical tractor operators. The sample of participating operators, consisting exclusively of males aged between 27 and 50 years, was selected to ensure representative anthropometric characteristics and ergonomic consistency for typical agricultural tractor operators. Triaxial accelerometer sensors (NexGen Ergonomics, Pointe-Claire, Canada, and Biometrics Ltd., Gwent, UK) were strategically positioned on the seat cushion and backrest to record accelerations along the X, Y, and Z spatial axes. The recorded acceleration data were processed and converted into the frequency domain using Fast Fourier Transform (FFT), allowing the assessment of vibration transmissibility and resonance amplification between the floor and seat. The combined numerical–experimental approach provided high-fidelity validation of the seat’s dynamic model, confirming the structural modes most responsible for vibration transmission in the 4–8 Hz range—a critical sensitivity band for human comfort and health as established in previous studies on whole-body vibration exposure. Beyond validating the model, this integrated methodology offers a predictive framework for assessing different seat suspension configurations under controlled conditions, reducing experimental costs and enabling optimization of ergonomic design before physical prototyping. The correlation between FEA-based modal results and field measurements allows a deeper understanding of vibration propagation mechanisms within the operator–seat system, supporting efforts to mitigate whole-body vibration exposure and improve long-term operator safety in horticultural mechanization. Full article

Background: Prostate cancer is one of the most common malignancies in men and a leading cause of cancer-related mortality. Early detection is essential to ensure curative treatment and favorable outcomes, but traditional diagnostic approaches—such as serum prostate-specific antigen (PSA) testing, digital rectal examination (DRE), and histopathological confirmation following biopsy—are limited by suboptimal accuracy and variability. Multiparametric magnetic resonance imaging (mpMRI) has improved diagnostic performance but remains highly dependent on reader expertise. Artificial intelligence (AI) offers promising opportunities to enhance diagnostic accuracy, reproducibility, and efficiency in prostate cancer detection. Objective: To evaluate the diagnostic accuracy and reporting timeliness of AI-based technologies compared with conventional diagnostic methods in the early detection of prostate cancer. Methods: Following PRISMA 2020 guidelines, PubMed, Scopus, Web of Science, and Cochrane Library were searched for studies published between January 2015 and April 2025. Eligible designs included randomized controlled trials, cohort, case–control, and pilot studies applying AI-based technologies to early prostate cancer diagnosis. Data on AUC-ROC, sensitivity, specificity, predictive values, diagnostic odds ratio (DOR), and time-to-reporting were narratively synthesized due to heterogeneity. Risk of bias was assessed using the QUADAS-AI tool. Results: Twenty-three studies involving 23,270 patients were included. AI-based technologies achieved a median AUC-ROC of 0.88 (range 0.70–0.93), with median sensitivity and specificity of 0.86 and 0.83, respectively. Compared with radiologists, AI or AI-assisted readings improved or matched diagnostic accuracy, reduced inter-reader variability, and decreased reporting time by up to 56%. Conclusions: AI-based technologies show strong diagnostic performance in early prostate cancer detection. However, methodological heterogeneity and limited standardization restrict generalizability. Large-scale prospective trials are required to validate clinical integration. Full article

Vibrations induced by marine environmental loads can compromise the operational performance of offshore platforms and, in severe cases, result in structural instability or overturning. This study proposes a biomimetic nonlinear X-shaped vibration isolation system (NXVIS) to suppress earthquake-induced vibration response in offshore platforms. Compared with traditional passive vibration isolators, the key innovations of the NXVIS include: (1) the proposed NXVIS can be tailored to different load requirements and resonant frequencies to accommodate diverse offshore platforms and environmental loads; (2) By adjusting isolator parameters (e.g., link length and spring stiffness, etc.), the anti-vibration system can achieve different types of nonlinear stiffness and a large-stroke quasi-zero stiffness (QZS) range, enabling ultra-low frequency (ULF) vibration control without compromising load capacity. To evaluate the effectiveness of the designed NXVIS for vibration suppression of jacket offshore platforms under seismic loads, numerical analysis was performed on a real offshore platform subjected to seismic loads. The results show that the proposed nonlinear vibration isolation solution significantly reduces the dynamic response of deck displacement and acceleration under seismic loads, demonstrating effective low-frequency vibration control. This proposed NXVIS provides a novel and effective method for manipulating beneficial nonlinearities to achieve improved anti-vibration performance. Full article

Aiming at the significant challenges faced by active power filters (APFs) in suppressing low-order harmonic currents (such as second and fourth), this paper proposes a rarefaction suppression method based on quasi-proportional resonance (QPR) control. Firstly, the harmonic mathematical model of APFs in a synchronous, rotating coordinate system is established to reveal the inherent defects of traditional proportional–integral (PI) control in low-order harmonic suppression. Theoretical analysis shows that although the proportional resonant (PR) controller can achieve zero-steady-state-error tracking of specific frequency harmonics, its narrow bandwidth and low robustness may easily lead to system oscillation. Therefore, the QPR control strategy is introduced. By superimposing a low-pass filter with an adjustable cut-off frequency on the resonant link, the bandwidth is significantly broadened and the anti-frequency disturbance ability of the system is enhanced. In addition, the stability of QPR control parameters is analyzed. Finally, the verification based on the experimental platform demonstrates that the proposed method reduces the total harmonic distortion (THD) of the 380 V bus current from 82.18% to 3.45%, and the low-order harmonic current suppression performance is significantly better than the traditional scheme. This research provides an effective solution for the synergistic suppression of low-order harmonic currents. Full article

The control of the quantities of multi-tonnage polymers, in particular, making them biodegradable, is an urgent task. This study suggests a new approach in the application of natural rubber (NR) as an initiator of biodegradation of low-density polyethylene (LDPE) in soil. The study examines the structure, properties and rates of biodegradation of thin LDPE films with different content of NR. Such methods as fourier transform infrared spectroscopy (FTIR), electron paramagnetic resonance (EPR), differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), scanning electron microscope (SEM), atomic force microscopy (AFM), gel-permeation chromatography (GPC), and acoustic microscopy were used for the most complete characterization of NR/LDPE composite systems. It was shown for the first time that at concentrations above 30%, NR is able to form an interpenetrating structure with the LDPE matrix, which has a decisive effect on the initiation of biodegradation during exposure in soil. Thus, the composition with 50% natural rubber exhibits the highest mass loss. The sample with 50% natural rubber content lost 70% of its mass, while the one with 40% NR content lost 38%. Furthermore, after soil burial, a significant decrease in crystallinity was observed: from 39.5% to 31.5% for the 90/10 composition and from 39.1% to 24.2% for the 50/50 composition. The results obtained are confirmed by a noticeable decrease in the molecular weight characteristics of LDPE. Full article