Search Results (5,751)

In the context of national fitness and ecological construction, urban water, as the core carrier of water sports, is increasingly being explored. Through empirical analysis of urban water bodies in Nanjing and Shanghai, the Spearman model and an XGBoost model, based on SHAP, are used to examine the correlation between the subjective perceptions of water-landscape images by various types of water-sports participants and objective evidence of urban water-landscape elements. The results show that amateurs prefer a high green-view index (>20%) + low water visibility (≤30%) + low sky visibility (≤30%) + shallow-water area (≤1.5 m), which enhances their satisfaction with the leisure experience; progressors prefer a moderate green-view index (10–20%) + moderate water visibility (30–40%) + moderate sky visibility (30–40%) + medium water-depth area (1.5–2.5 m), which helps them achieve better perception of skill improvement and training effectiveness; professionals prefer high water visibility (≥40%) + high sky visibility (≥40%) + low green-view index (≤10%) + deep-water area (≥2.5 m), which meets their training requirements for professional competitions. This study provides a scientific basis for urban water landscape planning and design in order to create urban water sports spaces that respond to the needs of various types of water sports participants. Full article

The Corsican pine (Pinus nigra subsp. laricio (Poir.) Maire), a subspecies of black pine endemic to southern Italy, is widely known for the quality of its valuable timber, and the parts of the plant that are not used for this purpose are considered unusable production waste. In this study, we investigated the phytochemical profile and a series of biological activities of extracts from the female and male pine cones. The extracts were prepared by maceration with ethanol and subsequently fractionated using liquid-liquid separation. The total phenolic and flavonoid content, antioxidant potential (DPPH and β-carotene bleaching tests), anti-inflammatory activity (nitric oxide inhibition in RAW 264.7 cells), and enzymatic inhibition against pancreatic lipase and α-amylase were determined. The female cones showed a higher crude extract yield and total phenolic content (76.4 mg GAE/g) than the male cones, while the latter were richer in flavonoids. The extracts from the female cones showed higher antioxidant and pancreatic lipase inhibitory activities. On the contrary, extracts from male cones showed greater activity against α-amylase, with the dichloromethane fraction proving to be the most potent (IC₅₀ = 35.28 ± 3.08 µg/mL). The hexane fraction of female cones also showed significant anti-inflammatory activity (IC₅₀ = 107.50 ± 15.22 µg/mL). Our results reveal that the pine cones of Pinus nigra subsp. laricio (Poir.) Maire are a rich source of bioactive compounds. These results provide the first scientific evidence of the potential of extracts from this still poorly studied part of the plant for further investigation of their antioxidant and anti-inflammatory capabilities. Full article

Numerous ingredients in trichological shampoos are advertised as “active against hair loss”; however, the body of evidence behind such claims seems very limited or, in many cases, nonexistent. The aim of this study was to compile an inventory of substances advertised by shampoo manufacturers as “active” against hair loss and systematically review available evidence from clinical trials that would corroborate such claims. We screened declared compositions of trichological shampoos for ingredients advertised as active against hair loss or promoting hair growth. The second step was a systematic review of clinical trials of these substances used topically in the treatment of hair loss. A query in PubMed, Scopus, and Web of Science followed PRISMA and PICO guidelines with the strength of evidence assessed according to GRADE guidelines. We identified 43 trichological shampoos in which 112 individual ingredients were advertised as “active”. Of these, 36 ingredients were indicated as “active” in at least two shampoos and were subject to further study. In the search for evidence, 103,639 articles were screened for relevant information. Ultimately, we identified 29 clinical trials that tested 16 of the 36 ingredients for efficacy against hair loss. Only four ingredients were tested individually: adenosine (four trials; highest strength of evidence: moderate), caffeine (four trials; moderate), placental protein (two trials; low), and melatonin (one trial; moderate). Another 12 ingredients of interest were only tested as parts of complex preparations: Achillea millefolium extract, arginine, biotin, hydrolyzed wheat protein, hydrolyzed soy protein, Panax ginseng, panthenol, piroctone olamine, Prunus amygdalus dulcis, Rosmarinus officinalis, Serenoa serrulata, and Urtica dioica. Such a study design made it impossible to attribute the observed effects to any specific ingredient. No clinical trials of efficacy could be found for the remaining 20 (55.6%) substances repeatedly cited as “active”. At the present stage, scientific evidence for efficacy against hair loss is available only for caffeine, adenosine, placental proteins, and melatonin, but the overall strength of evidence is low. Moreover, a substantial majority of topical ingredients promoted as “active against hair loss” were never actually tested in clinical trials to verify such claims. While unsubstantiated claims of supposed beneficial properties often refer to alleged scientific evidence, there are major gaps to be filled in the field of non-prescription treatments for hair loss. Full article

This study explores how outdoor environments in cold-region university campuses influence students’ physical and mental health, addressing the lack of research on health-oriented campus design under cold climatic conditions. Drawing on Evidence-Based Design (EBD) theory and the Socio-Ecological Model (SEM), a Multi-Factor Analysis (MFA) framework integrating theoretical analysis, data mining, and empirical validation was developed to reveal the mechanisms linking campus environmental factors and student health. Through a systematic literature review and Latent Dirichlet Allocation (LDA) topic modeling, six key factors—climate adaptability, architectural layout, infrastructure, natural landscape, safety, and transportation accessibility—were identified and further verified through questionnaire data (N = 480) for reliability and validity. The Delphi method was then used to refine the indicator system and determine factor weights, while case studies of representative cold-region universities proposed optimization strategies from the dimensions of built environment, climatic adaptation, and perceived environment. The findings enrich the application of socio-ecological theory in health-oriented campus research and provide scientific and practical guidance for planning and promoting healthy university environments in cold regions. Full article

Nicotinamide adenine dinucleotide (NAD+) is an important coenzyme essential for metabolism, energy production, gene regulation, and cellular communication. With aging, NAD+ levels decrease, which may be partly responsible for age-related disease and impaired function. While certain lifestyle practices may help to maintain NAD+, such as intermittent fasting, exercise, and reduced alcohol consumption, these activities do not appear to support optimal NAD+ levels. For this reason, numerous dietary supplements have emerged, with the claim of increasing NAD+ levels and resulting in improved health and, possibly, increased longevity. Such agents include NAD+, as well as the NAD+ precursors niacin, nicotinamide riboside (NR), and nicotinamide mononucleotide (NMN). This article discusses the scientific rationale and evidence for using such supplements, with a particular emphasis on human oral ingestion and associated health outcomes. The current literature has been reviewed, and practical applications are presented. Full article

The ocular surface is a structure crucial to maintaining eye health and proper vision. Unfortunately, ocular surface diseases functioning as chronic epithelial defects, inflammation, impaired healing, require immediate regenerative repair treatment that can restore tissue integrity and function. Conventional therapies, such as artificial tears and topical anti-inflammatory agents, principally provide symptomatic relief without addressing the underlying biological deficits, thus leading to incomplete or delayed recovery. Therefore, blood derivatives have emerged as a promising bioactive therapy that not only lubricates but also actively promotes regeneration through the delivery of cytokines, growth factors, and vitamins naturally present in blood. Due to their properties mimicking the components of natural tears, autologous origin, biocompatibility and capacity to enhance tissue repair, they have emerged as a cornerstone in regenerative medicine. Therefore, the purpose of this review was to compare the evolution, positive aspects, and drawbacks, in order to demonstrate the molecular mechanism of action and the therapeutic efficacy of different blood derivates at treating ocular surface disease. Over time, these biologic preparations have evolved from the use of simple traditional serum-based derivatives to more advanced platelet-rich products, underscoring the evolving understanding of platelet-driven molecular and cellular mechanisms in tissue regeneration. Despite their widespread use, we would like to highlight the current limitations related to the lack of standardized preparation protocols, variability in composition, and evidence-based integration into clinical practice. Finally, this review highlights contemporary research trends and depicts future directions advancing the field. Key priorities include the establishment of standardized, reproducible preparation protocols; the development of next-generation platelet-derived concentrates and biomaterials; and the integration of multi-omics technologies to achieve comprehensive profiling of their biological and therapeutic activity. Moving toward methodological standardization and the execution of well-designed, high-quality comparative clinical trials will be essential to reinforce the scientific foundation, enhance translational potential, and ensure the clinical reliability of blood-derived therapies in modern regenerative medicine. Full article

Circular RNAs (circRNAs) are small, non-coding RNAs in which the 5′ and 3′ ends are linked covalently by back-splicing of exons from a single pre-mRNA. More and more scientific evidence is gathered for their wide distribution in the animal world, playing the role of regulators for biological processes, being cell- and tissue-specific. They can influence cellular physiology by various molecular mechanisms, finally modulating gene expression. CircRNAs are believed nowadays to be expressed in both receptive and cancerous endometrium. Due to their abundant expression in the endometrial tissue and their small size and stability, they have been considered potential diagnostic markers and treatment targets for endometrial-related diseases. The regulation of proliferation and differentiation is essential for the formation of receptive endometrium and for endometrial cancer emergence and progression. The receptive endometrium can be regarded as the most highly differentiated state of the endometrium. In contrast, the cancerous endometrium is characterized by a high level of proliferation and the lowest degree of differentiation. These endometria could be conditionally considered opposites. We are investigating the circRNA–miRNA–mRNA regulatory networks that can promote or suppress the proliferation and differentiation of endometrial cells by activating specific signaling pathways in both receptive and cancerous endometria. It could be worth knowing whether there are universal endometrial switches responsible for proliferation and differentiation processes that can alter the balance between them. We are interested in their clinical application as biomarkers and therapeutic targets for both endometrial receptivity issues and EC cases, particularly in diagnosis, progression assessment, and outcome prediction. Full article

Misinformation has emerged as a significant threat to both society and public health, with social media acting as a major conduit for its dissemination. This contributes to harmful health outcomes and undermines trust in authoritative institutions. In addition, the dismantling of scientific authority seems to be a symptom of the post-truth era, where “alternative facts” are presented in the public debate as indisputable evidence of the inherent limitations of scientific infallibility. The prevalence of misinformation on social media platforms stems from multiple, interconnected factors, including individual-level influences such as cognitive biases, as well as systemic aspects of social media’s information architecture. Unlike scientific institutions that adhere to the principles of evidence-based knowledge, social media platforms operate under an attention-driven model that favors virality over factuality. Addressing these challenges effectively requires coordinated, multi-level, and multidisciplinary interventions targeting users, content creators, technology companies, health authorities, and governments to restore public trust and safeguard the credibility of medical expertise. Full article

Wounds are disruptions of the dermal layer of the skin caused by physical, chemical, thermal, infectious, or immunological insults. Given the skin’s critical role in maintaining homeostasis and protecting against external threats, prompt and effective wound healing is essential to restore functionality and prevent further complications. Numerous natural products (NPs) have long been employed in wound care due to their antioxidant, anti-inflammatory, antimicrobial, and regenerative properties. Building on this historical and scientific foundation, the present literature review consolidates and critically evaluates recent experimental and clinical evidence on the wound healing potential of marigold (Calendula officinalis L.). By focusing on studies published between 2020 and 2025, this review captures the evolving understanding of the plant’s therapeutic applications, particularly in skin regeneration and wound management. For each selected publication, formulation type, intervention strategy, dosage, and key outcomes (such as healing rate, cell proliferation, and modulation of inflammatory markers) were summarized. This synthesis aims to provide an update on current evaluations involving C. officinalis and how this plant contributes to dermal repair and to identify promising directions for future research and clinical applications. Full article

Background: Mandibular lateral displacement is a common functional occlusal disorder that may occur independently or in conjunction with other types of malocclusion. Substantial evidence indicates that in growing patients, mandibular lateral displacement can have a significant negative impact on the development of both the morphology and function of the stomatognathic system. Early diagnosis and intervention are therefore crucial to preventing a range of developmental abnormalities, including skeletal and soft tissue asymmetries, temporomandibular joint dysfunction, and pathological tooth wear. Aim: The aim of this study is to analyze and systematize current scientific perspectives on the etiopathogenesis of mandibular lateral displacement, as well as approaches to its prevention and early treatment. Methods: A comprehensive review of the literature published between 1980 and 2025 was conducted. Sources were identified through searches in the PubMed, Google Scholar, Elsevier, Web of Science, and SUM Library databases. Results: Mandibular lateral displacement necessitates early diagnosis and timely initiation of orthodontic treatment. The majority of studies addressing the treatment of mandibular lateral displacement are limited to case reports. Conclusions: Further well-designed, longitudinal studies are needed to establish standardized diagnostic criteria and evidence-based treatment protocols for early management of mandibular lateral displacement in growing patients. Full article

Background: Although the micronutrients (vitamins and trace minerals) essential for growth and normal physiological function are obtained from the diet, a substantial fraction of the human population is deficient in one or more micronutrients due to inadequate nutrition and/or malabsorption. Methods: This narrative review examines evidence that airborne micronutrients (‘aeronutrients’) are readily absorbed by the lungs, and preclinical and clinical evidence that inhaled iodine and vitamins A, B12 and D can enter the bloodstream. Results: Inhaled vitamin B12 resolves the symptoms and haematological features of pernicious anaemia with a bioavailability comparable to intramuscular injections and superior to oral formulations. Inhaled nebulised vitamin A restores serum levels in children with retinol deficiency. Randomised controlled trials have reported that inhalation of nebulised preparations of vitamins A, B12, magnesium and zinc are well tolerated and not associated with adverse health effects. Aeronutrient formulations have untapped potential for the therapeutic treatment of nutritional deficits, particularly in individuals with malabsorption or a low tolerance of injections. Aeronutrient therapy should be regarded as a medical intervention and be regulated accordingly, with efficacy and safety supported by scientific evidence, unlike the ‘vitamin vapes’ marketed by the wellness industry. Conclusions: Before this potential can be realised, a regulatory framework will need to be developed for aeronutrients. The high effectiveness of the pulmonary route introduces concerns regarding overdosing and toxicity which can best be addressed by categorising these formulations as prescription drugs that require regular monitoring of nutritional and health status. Full article

Identifying the key drivers behind the spatiotemporal dynamics of ecosystem service functions is essential for clarifying how ecosystems respond to environmental changes. Such insights deepen our understanding of the evolution of complex ecological processes and service functions, and provide critical references for ecological governance, policy-making, and the pursuit of high-quality development pathways. In this study, the Remote Sensing Ecological Index (RSEI) was first constructed for the upstream basin of the Danjiangkou Reservoir using satellite imagery (2015 and 2024). We then employed the InVEST model to quantify six ecosystem service functions and their corresponding services: water purification (total nitrogen and total phosphorus), soil retention (soil erosion), water yield, carbon storage, and habitat provision (habitat quality). Finally, this study analyzes the driving mechanisms as well as the coupling coordination degree between the RSEI and six ecosystem service functions. From 2015 to 2024, the area classified as “excellent” in RSEI significantly expanded from 263.34 km² (3.22%) to 2566.21 km² (31.38%), reflecting a substantial enhancement in ecological quality throughout the upstream basin. There is no serious imbalance in the coupling and coordination relationship between RSEI and the value of various ecosystem service functions. Although improvements in ecosystem quality generally enhanced overall ecosystem service functions, competition among certain services was still evident in localized areas. Future ecological management should, therefore, prioritize not only the protection of ecosystem quality but also the scientific allocation of service supply and demand, the optimization of human–land relationships, and the promotion of a virtuous ecosystem cycle. Full article

The Muji Fault Zone (MJF) in the northeastern Pamir Plateau hosts a well-developed non-volcanic geothermal system, characterized by widespread hot springs and mud volcanoes—where core processes of geothermal fluids, including atmospheric precipitation recharge, shallow crustal circulation, carbonate-driven water–rock interactions, and CO₂-rich fluid discharge, are tightly coupled with regional intense crustal deformation and frequent seismic activity. We collected and analyzed 22 geothermal water samples and 8 bubbling gas samples from the MJF periphery, finding that the geothermal waters are predominantly of the HCO₃-Ca·Mg hydrochemical type, with hydrogen (δD: −103.82‰ to −70.21‰) and oxygen (δ¹⁸O: −14.89‰ to −10.10‰) isotopes indicating atmospheric precipitation as the main recharge source. The Na-K-Mg ternary diagram classified the waters as immature, reflecting low-temperature water–rock interactions in the shallow crust (<3 km), while noble gas isotopes (³He/⁴He: 0.03–0.09 Ra, Ra = 1.43 × 10⁻⁶) and carbon isotopes (δ¹³C-CO₂) confirmed fluid origin from crustal carbonate dissolution; SiO₂ geothermometry estimated thermal reservoir temperatures at 67–155 °C. Long-term monitoring (May 2019–April 2024) of Tahman (THM) and Bulake (BLK) springs revealed significant pre-seismic anomalies: before the 2023 Tajikistan Ms7.2 and 2024 Wushi Ms7.1 earthquakes, Na⁺, Cl⁻, and SO₄²⁻ concentrations showed notable negative anomalies (exceeding 2σ of background values) with synchronous trends between the two springs. Integrating these findings, a “Fault-Spring-Mud Volcano-Earthquake” fluid response model was established, providing direct evidence of deep-shallow fluid coupling in mud volcano–geothermal fluid interactions. This study enhances understanding of the dynamic evolution of non-volcanic geothermal systems under tectonic stress and clarifies the mechanisms of hydrogeochemical variations in fault-controlled geothermal systems, offering a robust scientific basis for advancing research on tectonic–fluid interactions in active fault zones of the northeastern Pamir Plateau. Full article

Digital video surveillance systems are now common in the security infrastructure of modern times, but proprietary file systems provided by large manufacturers are a major challenge to the work of the forensic investigator. This paper proposes a forensic recovery methodology of Hikvision and Dahua surveillance systems by utilizing three major innovations: (1) adaptive temporal sequencing, which dynamically changes gap detection thresholds; (2) dual-signature validation with header–footer matching of DHFS frames; and (3) automatic manufacturer identification. The strategy puts into practice direct binary analysis of proprietary file systems, frame-based parsing and automatic video reconstruction. Testing on 27 surveillance hard drives showed a recovery rate of 91.8, a temporal accuracy of 96.7% and a false positive rate of 2.4%—the lowest of the tools tested with statistically significant improvements over commercial tools (p < 0.01). Better results with fragmented streams (87.2 vs. 82.4% with commercial tools) meet key forensic needs of determining valid evidence chronology. The open methodology offers the necessary algorithmic transparency to be court-admissible, and the automated MP4 conversion with metadata left intact makes the integration of forensic workflow possible. The study provides a scientifically validated approach to proprietary surveillance formats, which evidences technical innovativeness and practical usefulness to digital forensics investigations. Full article

The origin of life remains one of the most profound and enduring enigmas in the biological sciences. Despite substantial advances in prebiotic chemistry, fundamental uncertainties persist regarding the precise mechanisms that enabled the emergence of the first cellular entity and, subsequently, the foundational branches of the tree of life. After examining the core principles that define living systems, we propose that life emerged as a novel property of a prebiotically assembled system—formed through the integration of distinct molecular worlds, defined as sets of structurally and functionally related molecular entities that interact via catalytic, autocatalytic, and/or self-assembly processes. This emergence established a permanent system–process duality, wherein the system’s organization and its dynamic processes became inseparable. Upon acquiring the capacity to replicate and mutate its genetic program, this primordial organism initiated the evolutionary process, ultimately driving the diversification of life under the influence of evolutionary forces and leading to the formation of ecosystems. The challenge of uncovering the origin of life and the emergence of biodiversity is not solely scientific, it requires the integration of empirical evidence, theoretical insight, and critical reflection. This work does not claim certainty but proposes a perspective on how life and biodiversity may have arisen on Earth. Ultimately, time and scientific inquiry will determine the validity of this view. Full article