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Search Results (345)

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Keywords = sexual awareness

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16 pages, 580 KiB  
Review
Disabling Norms, Affirming Desires: A Scoping Review on Disabled Women’s Sexual Practices
by Inês Silva, Ana Cristina Santos and Alexandra Oliveira
Societies 2025, 15(6), 154; https://doi.org/10.3390/soc15060154 - 2 Jun 2025
Viewed by 241
Abstract
Disabled women have historically been marginalized from sexuality education and discussions due to harmful stereotypes that portray them as asexual or incompatible with cis-heteroreproductive sexual norms. To assess whether these assumptions are supported by empirical evidence, a scoping review was conducted following Arksey [...] Read more.
Disabled women have historically been marginalized from sexuality education and discussions due to harmful stereotypes that portray them as asexual or incompatible with cis-heteroreproductive sexual norms. To assess whether these assumptions are supported by empirical evidence, a scoping review was conducted following Arksey and O’Malley’s proposal and the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for scoping reviews (PRISMA-ScR). The protocol is registered with the Open Science Framework. EBSCOhost, SCOPUS, and Web of Science databases were searched to map peer-reviewed scientific articles published between 2013 and 2023 on disabled women’s sexual practices. Seven qualitative studies were selected and analyzed through reflexive thematic analysis. Four key themes were identified: Reclaiming Sexuality, Navigating Constraints, Barriers to Awareness, and Building Inclusive Futures. The findings illustrate the diversity of sexual experiences among disabled women and highlight their active role in overcoming the barriers imposed by their bodies and environments. This review contributes to a broader discourse on sexuality and disability, challenges oversimplified narratives of de-sexualization, and provides evidence supporting a paradigm shift towards inclusive, affirmative sexual health education. Further research and policy reforms are essential to ensure recognition of their sexual citizenship, desires, and lived realities. Full article
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21 pages, 535 KiB  
Article
Preventing Sexual Violence and Strengthening Post-Victimization Support Among Adolescents and Young People in Kenya: An INSPIRE-Aligned Analysis of the 2019 Violence Against Children Survey (VACS)
by Denis Okova, Akim Tafadzwa Lukwa and Olufunke A. Alaba
Int. J. Environ. Res. Public Health 2025, 22(6), 863; https://doi.org/10.3390/ijerph22060863 - 30 May 2025
Viewed by 110
Abstract
Background: Sexual violence against adolescents and young people (AYP) remains a public health concern. This study explores patterns of sexual violence and help-seeking behaviour as well as their associated risk/protective factors with guidance of a technical package (INSPIRE) designed to reduce sexual violence [...] Read more.
Background: Sexual violence against adolescents and young people (AYP) remains a public health concern. This study explores patterns of sexual violence and help-seeking behaviour as well as their associated risk/protective factors with guidance of a technical package (INSPIRE) designed to reduce sexual violence in low-resource settings. Methods: The 2019 Violence Against Children Survey (VACS) dataset comprises 788 males and 1344 females. After describing the prevalence and patterns of sexual violence and help-seeking behaviour (informal disclosure, knowledge of where to seek formal help, seeking formal help, and receipt of formal help) among 13- to 24-year-old AYP, logistic regression models were then fitted to predict past-year sexual violence and informal disclosure among adolescent girls and young women (AGYW). Results: More young women than young men informally disclosed sexual violence experience (46% versus 23%). Gender inequitable attitudes [AOR 3.07 (1.10–8.56); p = 0.03], experiencing emotional violence at home [AOR 2.11 (1.17–3.81); p = 0.01] and cyberbullying [AOR 5.90 (2.83–12.29); p = 0.00] were identified as risk factors for sexual violence among AGYW. Life skills training [AOR 0.22 (0.07–0.73); p = 0.01] and positive parental monitoring [AOR 0.31 (0.10–0.99); p = 0.05] were found to be protective against sexual violence among AGYW. Positive parental monitoring [AOR 3.85 (1.56–9.46); p = 0.00] was associated with an increased likelihood of informal disclosure among AGYW. Conclusions: As Kenya intensifies efforts towards sexual violence prevention, this study underscores the need to develop and strengthen policies and programs on life skills training, cultural norms, and positive parenting, as well as improve awareness and access to post-violence response and support services. Full article
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20 pages, 300 KiB  
Article
An Exploration of Predictors of Psychological Help-Seeking Attitudes in a Transgender Population in a Non-Western Context
by Shakir Adam, Kiran Bashir Ahmad, Yusra Khan and David L. Rowland
Sexes 2025, 6(2), 25; https://doi.org/10.3390/sexes6020025 - 30 May 2025
Viewed by 267
Abstract
Barriers to help-seeking behaviors in transgender populations in non-Western contexts are both understudied and poorly understood. Using a quantitative cross-sectional design, this study examined the psychological help-seeking attitudes of 109 transgender persons from Pakistan in relation to their psychological distress and attitudes toward [...] Read more.
Barriers to help-seeking behaviors in transgender populations in non-Western contexts are both understudied and poorly understood. Using a quantitative cross-sectional design, this study examined the psychological help-seeking attitudes of 109 transgender persons from Pakistan in relation to their psychological distress and attitudes toward sexuality. This research further identified which components of distress (stress, anxiety, or depression) were stronger predictors and assessed the role of particular demographic/behavioral factors in help-seeking attitudes. Participants completed three validated assessment tools translated into Urdu: Beliefs about Psychological Services Scale, the Depression, Anxiety, and Stress Scale (DASS-21), and the Sexual Attitude Scale. The results indicated that psychological distress predicted expertness and intent but not stigma tolerance. Post hoc analysis using DASS-21 subscales revealed that stress and anxiety were the stronger predictors of attitudes related to expertness and intent. The Sexual Attitude Scale marginally predicted stigma tolerance directly and also moderated the relationship between psychological distress and help-seeking attitudes for stigma tolerance. Finally, a role for demographic/behavioral factors—possibly serving as a proxy for mental health literacy—was identified for stigma tolerance. These findings reiterate the importance of tailored mental health awareness initiatives within the transgender community in non-Western settings and highlight the need for qualitative research to further understand the dynamics of psychological distress along with other linked factors. Full article
23 pages, 2542 KiB  
Article
HPV Infection Prevalence, Vaccination-Related Knowledge, Attitudes, and Barriers Among Women Aged 30–64 in Shenzhen, China: A Cross-Sectional Study
by Zhongai Ouyang, Minting Zhu, Zhijian Chen, Weigui Ni, Lijuan Lai, Bingyi Lin, Long Jiang, Yi Jing and Jingjie Fan
Vaccines 2025, 13(6), 561; https://doi.org/10.3390/vaccines13060561 - 25 May 2025
Viewed by 338
Abstract
Background: the distribution of human papillomavirus (HPV) infection, vaccination rates, and awareness levels varies across China. Methods: this study examined HPV infection prevalence, vaccine uptake, and barriers among 2440 women aged 30–64 in Shenzhen, China, using partial least squares structural equation [...] Read more.
Background: the distribution of human papillomavirus (HPV) infection, vaccination rates, and awareness levels varies across China. Methods: this study examined HPV infection prevalence, vaccine uptake, and barriers among 2440 women aged 30–64 in Shenzhen, China, using partial least squares structural equation modeling (PLS-SEM) to analyze associated factors. Results: The overall HPV prevalence was 14.2% (347/2440), with HPV52 being the most common type, followed by HPV58 and HPV53. Factors significantly associated with HPV infection included more sexual partners, genital tract infections, manual labor, and single marital status (p < 0.05), whereas higher education demonstrated a protective association (p < 0.05). The HPV vaccination rate was 41.8% in ages 30–45. There were direct effect indicators of younger age, fewer pregnancies, and premenopausal status (p < 0.05) on HPV vaccine uptake, whereas inversely associated factors included divorce/widowed, lower household income, irregular menstruation, more deliveries, no contraception, and lack of HPV knowledge. Among 828 unvaccinated individuals, 47.9% of those aged 46–64 were willing if the age restrictions were expanded, with the main barrier being a lack of vaccine knowledge (40.7%). Willingness was significantly associated with younger age and healthcare occupation (p < 0.05), but negatively with eastern Shenzhen residence, lower household income, no HPV disease awareness, abnormal leucorrhea, lack of HPV knowledge, and belief against post-vaccination screening (p < 0.05). Conclusions: Socioeconomic disparities in HPV infection and vaccination rates in Shenzhen highlight intervention priorities. The impact of HPV knowledge underscores the need for effective health communication. The vaccination willingness and infection status among women aged 45+ provide supporting evidence for expanding HPV vaccination to older age groups. Full article
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18 pages, 261 KiB  
Article
Gender-Sensitive Sex Education for Boys*
by Gottfried Schweiger
Sexes 2025, 6(2), 24; https://doi.org/10.3390/sexes6020024 - 24 May 2025
Viewed by 251
Abstract
Sex education goes far beyond merely conveying biological facts; it encompasses the psychological, social, and cultural aspects of sexuality. A gender-sensitive approach to sex education for boys* aims to address their specific needs and challenges, critically reflect on hegemonic norms of masculinity, and [...] Read more.
Sex education goes far beyond merely conveying biological facts; it encompasses the psychological, social, and cultural aspects of sexuality. A gender-sensitive approach to sex education for boys* aims to address their specific needs and challenges, critically reflect on hegemonic norms of masculinity, and develop alternative, non-toxic models of masculinity. This article explores the foundations and core elements of such a gender-sensitive sex education for boys*, considering theoretical concepts such as sexual socialization, hegemonic masculinity, and sexual scripts, as well as sexual health and rights for boys*. An intersectional perspective enables a nuanced analysis of the diverse social inequalities that shape boys’* sexual development. This paper argues for four key elements of gender-sensitive sex education for boys*: (1) empowerment and self-determination to strengthen boys* in their formation of sexual identity; (2) the development of alternative masculinities to challenge stereotypical gender constraints; (3) the promotion of gender justice by raising boys’* awareness of their societal responsibility; and (4) fostering critical competencies in dealing with media and social norms. These approaches contribute to establishing a holistic and inclusive form of sex education that acknowledges boys* in their diversity and helps create a more just society. Full article
(This article belongs to the Section Gender Studies)
24 pages, 641 KiB  
Article
Partner-Inflicted Brain Injury: Intentional, Concurrent, and Repeated Traumatic and Hypoxic Neurologic Insults
by Julianna M. Nemeth, Clarice Decker, Rachel Ramirez, Luke Montgomery, Alice Hinton, Sharefa Duhaney, Raya Smith, Allison Glasser, Abigail (Abby) Bowman, Emily Kulow and Amy Wermert
Brain Sci. 2025, 15(5), 524; https://doi.org/10.3390/brainsci15050524 - 19 May 2025
Viewed by 492
Abstract
(1) Background: Traumatic brain injury (TBI) is caused from rapid head acceleration/deceleration, focal blows, blasts, penetrating forces, and/or shearing forces, whereas hypoxic–anoxic injury (HAI) is caused through oxygen deprivation events, including strangulation. Most service-seeking domestic violence (DV) survivors have prior mechanistic exposures that [...] Read more.
(1) Background: Traumatic brain injury (TBI) is caused from rapid head acceleration/deceleration, focal blows, blasts, penetrating forces, and/or shearing forces, whereas hypoxic–anoxic injury (HAI) is caused through oxygen deprivation events, including strangulation. Most service-seeking domestic violence (DV) survivors have prior mechanistic exposures that can lead to both injuries. At the time of our study, some evidence existed about the exposure to both injuries over the course of a survivor’s lifetime from abuse sources, yet little was known about their co-occurrence to the same survivor within the same episode of physical intimate partner violence (IPV). To better understand the lived experience of service-seeking DV survivors and the context in which partner-inflicted brain injury (PIBI) is sustained, we sought to understand intentional brain injury (BI) exposures that may need to be addressed and accommodated in services. Our aims were to 1. characterize the lifetime co-occurrence of strangulation and intentional head trauma exposures from all abuse sources to the same survivor and within select physical episodes of IPV and 2. establish the lifetime prevalence of PIBI. (2) Methods: Survivors seeking DV services in the state of Ohio in the United States of America (U.S.) completed interview-administered surveys in 2019 (n = 47). Community-based participatory action approaches guided all aspects of the study development, implementation, and interpretation. (3) Results: The sample was primarily women. Over 40% reported having Medicaid, the government-provided health insurance for the poor. Half had less than a postsecondary education. Over 80% of participants presented to DV services with both intentional head trauma and strangulation exposures across their lifetime from intimate partners and other abuse sources (i.e., child abuse, family violence, peer violence, sexual assault, etc.), though not always experienced at the same time. Nearly 50% reported an experience of concurrent head trauma and strangulation in either the first or last physical IPV episode. Following a partner’s attack, just over 60% reported ever having blacked out or lost consciousness—44% experienced a loss of consciousness (LOC) more than once—indicating a conservative estimate of a probable brain injury by an intimate partner. Over 80% of service-seeking DV survivors reported either a LOC or two or more alterations in consciousness (AICs) following an IPV attack and were classified as ever having a partner-inflicted brain injury. (4) Conclusions: Most service-seeking IPV survivors experience repetitive and concurrent exposures to abusive strangulation and head trauma through the life course and by intimate partners within the same violent event resulting in brain injury. We propose the use of the term partner-inflicted brain injury (PIBI) to describe the physiological disruption of normal brain functions caused by intentional, often concurrent and repeated, traumatic and hypoxic neurologic insults by an intimate partner within the context of ongoing psychological trauma, coercive control, and often past abuse exposures that could also result in chronic brain injury. We discuss CARE (Connect, Acknowledge, Respond, Evaluate), a brain-injury-aware enhancement to service delivery. CARE improved trauma-informed practices at organizations serving DV survivors because staff felt knowledgeable to address and accommodate brain injuries. Survivor behavior was then interpreted by staff as a “can’t” not a “won’t”, and social and functional supports were offered. Full article
(This article belongs to the Special Issue Shedding Light on the Hidden Epidemic of Violence and Brain Injury)
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13 pages, 544 KiB  
Systematic Review
The Impact of Methylphenidate on Sexual Functions: A Systematic Review of Benefits and Risks
by Rafał Bieś, Zuzanna Szewczyk, Anna Warchala, Ewa Martyniak and Marek Krzystanek
Pharmaceuticals 2025, 18(5), 718; https://doi.org/10.3390/ph18050718 - 14 May 2025
Viewed by 1151
Abstract
Background: Methylphenidate is a psychostimulant that enhances dopamine and norepinephrine neurotransmission through the mechanism of reuptake inhibition at the synaptic cleft. Studies indicate that sexual dysfunction is prevalent among psychiatric patients. The objective of our study was to assess the impact of methylphenidate [...] Read more.
Background: Methylphenidate is a psychostimulant that enhances dopamine and norepinephrine neurotransmission through the mechanism of reuptake inhibition at the synaptic cleft. Studies indicate that sexual dysfunction is prevalent among psychiatric patients. The objective of our study was to assess the impact of methylphenidate on patients’ sexual health, identify specific types of sexual dysfunction, and analyse the correlations between psychiatric disorders, treatment dosages and durations, and the presence of sexual dysfunction. Additionally, we aimed to evaluate the prevalence of improved sexual function resulting from methylphenidate use. Methods: A systematic literature review was performed using the PubMed database in accordance with PRISMA guidelines. The initial search yielded 186 articles, of which 14 met the inclusion criteria and were analyzed. Clinical studies involving changes in libido, erectile function, ejaculation, semen quality, and sexual behavior due to methylphenidate were reviewed. Results: The findings indicate that methylphenidate can have both negative and positive effects on sexual function. In some patients, particularly those with psychiatric comorbidities, methylphenidate was associated with decreased libido and ejaculation disorders. In other cases, especially in individuals with preexisting dysfunctions or on low doses, it appeared to enhance sexual arousal and performance. Conclusions: Methylphenidate may influence sexual function in complex ways depending on individual patient profiles and treatment variables. Clinicians should be aware of these potential outcomes and consider sexual health as part of the therapeutic discussion when prescribing methylphenidate. Full article
(This article belongs to the Special Issue Toxicological Effects of Drug Abuse and Its Consequences on Health)
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16 pages, 1170 KiB  
Article
Knowledge, Awareness and Vaccination Attitude Towards HPV in Sex and Gender Minorities: A Cross-Sectional Study
by Antonio Di Lorenzo, Paola Berardi, Andrea Martinelli, Francesco Paolo Bianchi, Giovanni Migliore, Silvio Tafuri and Pasquale Stefanizzi
Vaccines 2025, 13(5), 508; https://doi.org/10.3390/vaccines13050508 - 12 May 2025
Viewed by 363
Abstract
Background/Objectives: Sex and gender minorities (SGMs) include individuals who do not comply with sexual binarism and heteronormative standards. They represent a high-risk population for Human Papillomavirus (HPV) infection and potential target of an HPV vaccine offer. This study investigates SGMs’ knowledge, awareness [...] Read more.
Background/Objectives: Sex and gender minorities (SGMs) include individuals who do not comply with sexual binarism and heteronormative standards. They represent a high-risk population for Human Papillomavirus (HPV) infection and potential target of an HPV vaccine offer. This study investigates SGMs’ knowledge, awareness and vaccination attitude regarding HPV. Methods: This is a cross-sectional, questionnaire-based study. The target population was represented by SGMs living in Italy and using social media platforms of SGM rights associations. The study questionnaire was based on the literature and disseminated via said associations’ social media. It included items regarding knowledge and awareness, expressed as seven-point Likert scales, and questions about personal information, sexual anamnesis and vaccination attitude. Data collection started on 1 November 2023 and ended on 8 December 2023. Results: The questionnaire was answered by 177 people. Knowledge and awareness scores were generally high (45.98 ± 6.14 and 34.21 ± 4.62, respectively). Regarding attitude, 31.64% of participants reported being hesitant or refusing HPV vaccination, mainly due to prohibitive costs or low perception of the vaccine’s utility. Higher education was associated with a higher knowledge score (coeff.: 2.25; 95%CI: 0.69–3.82); likewise, a history of HPV-related lesions positively influenced the score (coeff.: 2.47; 95%CI: 0.20–4.75). The awareness score was only increased by a greater number of sexual partners (coeff.: 0.06; 95%CI: 0.01–0.11). Older age was proven to significantly increase the odd of vaccine hesitancy (OR: 1.07; 95%CI: 1.02–1.12). Conclusions: Despite a good level of knowledge and awareness, the study population manifested significant barriers to vaccination. The main ones were related to the vaccine’s cost and lack of medical information. Future efforts should focus on reinforcing vaccine offers to SGMs. Full article
(This article belongs to the Special Issue Promoting HPV Vaccination in Diverse Populations)
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15 pages, 274 KiB  
Article
Social Service Providers’ Understanding of the Consequences of Human Trafficking on Women Survivors—A South African Perspective
by Sipho Sibanda, Juliet Sambo and Sanjeev Dahal
Soc. Sci. 2025, 14(5), 298; https://doi.org/10.3390/socsci14050298 - 12 May 2025
Viewed by 316
Abstract
Human trafficking for forced labour or sexual exploitation often takes the form of forced migration. It is the third-largest crime industry in the world and has severe consequences on the women survivors. Trafficking violates the safety, welfare, and human rights of the victims [...] Read more.
Human trafficking for forced labour or sexual exploitation often takes the form of forced migration. It is the third-largest crime industry in the world and has severe consequences on the women survivors. Trafficking violates the safety, welfare, and human rights of the victims and forces physical and psychological imprisonment on them. Despite the significant number of women being trafficked, little is known about the best ways to address their needs. This article highlights the understanding developed by social service providers in South Africa regarding the consequences of human trafficking on women survivors. Being aware of the complex challenges faced by women survivors of human trafficking enables social service providers to respond to their needs effectively through appropriate interventions and services. Data for this qualitative study were collected through one-on-one interviews and analysed using thematic analysis. Social service providers understand the following to be related to women survivors of trafficking: involvement in drugs and sex work, dependency on the perpetrator, lack of self-esteem, self-blame and shame, being disoriented, psychological challenges, lack of financial support, health issues, isolation, and loneliness. To be relevant and effective, services should be packaged in a manner that addresses all the challenges faced by women survivors of human trafficking. Full article
(This article belongs to the Special Issue Health and Migration Challenges for Forced Migrants)
19 pages, 948 KiB  
Article
Knowledge, Attitudes, and Behaviors Regarding Sexually Transmitted Infections Among Romanian Medical Students: A Cross-Sectional Study
by Roxana-Denisa Capraș, Teodora Telecan, Răzvan Crețeanu, Carmen-Bianca Crivii, Alexandru-Florin Badea, Ariana-Anamaria Cordoș, Diana Roman-Pepine and Carmen-Maria Micu
Healthcare 2025, 13(10), 1120; https://doi.org/10.3390/healthcare13101120 - 12 May 2025
Viewed by 355
Abstract
Introduction: Sexual and reproductive health is a critical aspect of medical education, yet significant knowledge gaps persist even among future healthcare professionals. This study aimed to evaluate the knowledge, behaviors, and attitudes of Romanian medical students regarding sexually transmitted infections (STIs) and contraceptive [...] Read more.
Introduction: Sexual and reproductive health is a critical aspect of medical education, yet significant knowledge gaps persist even among future healthcare professionals. This study aimed to evaluate the knowledge, behaviors, and attitudes of Romanian medical students regarding sexually transmitted infections (STIs) and contraceptive practices. Materials and Methods: A cross-sectional observational study was conducted on 510 undergraduate medical students, using a validated 30-item online questionnaire assessing socio-demographic data, sexual behaviors, STI knowledge, and attitudes towards sexual health. Descriptive statistics, chi-square, and Spearman correlation tests were used to analyze the data. Results: Participants demonstrated a good understanding of common STI pathogens and transmission routes, with 99.02% identifying unprotected vaginal intercourse as a risk factor. However, only 58.82% correctly identified Chlamydia trachomatis, and awareness of less common pathogens remained low. Long-term complications such as infertility (85.29%) and cervical cancer (87.25%) were well recognized, although misconceptions about STI severity persisted, with over 40% believing that STIs are not dangerous because they are treatable. Male students reported earlier sexual debut and more frequent high-risk behaviors, while females were more likely to consult specialist doctors and receive HPV vaccination. The level of knowledge correlated positively with parental education and faculty program. Conclusions: Despite generally high awareness of STI-related topics, considerable gaps and misconceptions persist among Romanian medical students. These findings highlight the need for comprehensive, structured sexual health education integrated into medical curricula to ensure future healthcare providers are well-equipped to promote public health. Full article
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15 pages, 4697 KiB  
Article
Demographic and Life-History Responses of Rhinella arenarum to Road-Associated Environments
by Mariana Baraquet, Favio Pollo, Manuel Otero, Adolfo Martino and Pablo Grenat
Animals 2025, 15(9), 1343; https://doi.org/10.3390/ani15091343 - 6 May 2025
Viewed by 194
Abstract
The global decline of amphibians is linked to habitat loss, with urbanization and roads as major threats. Roads fragment habitats and introduce stressors like pollution, temperature changes, and non-native predators. Despite growing awareness, studies in Latin America are scarce. In this study, we [...] Read more.
The global decline of amphibians is linked to habitat loss, with urbanization and roads as major threats. Roads fragment habitats and introduce stressors like pollution, temperature changes, and non-native predators. Despite growing awareness, studies in Latin America are scarce. In this study, we examined life-history traits of Rhinella arenarum from four sites in central Argentina that differ in urbanization intensity near roads. We analyzed snout–vent length (SVL), age, growth, size at maturity, and longevity in reproductive individuals. Sexual size dimorphism was present across sites, with females consistently larger than males. Moderate variation in SVL and age structure was observed among populations, with smaller and generally younger individuals in sites with medium-to-high urbanization. In contrast, individuals from the least disturbed site tended to show broader age ranges and greater longevity. Growth rates were also slower in the most urbanized site. While differences were moderate and sample sizes limited, these patterns suggest that urban-associated factors may influence demographic traits in R. arenarum. These findings contribute to our understanding of how human-altered environments might affect amphibian populations and highlight the need to distinguish between natural geographic variation and anthropogenic impacts on amphibian populations. Full article
(This article belongs to the Special Issue Age Determination, Growth and Longevity of Amphibians and Reptiles)
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17 pages, 254 KiB  
Article
Displacement and Disease: HIV Risks and Healthcare Gaps Among Refugee Populations
by AKM Ahsan Ullah
Venereology 2025, 4(2), 7; https://doi.org/10.3390/venereology4020007 - 6 May 2025
Viewed by 324
Abstract
Forced displacement exacerbates health vulnerabilities, particularly regarding HIV prevention, diagnosis, and treatment. Refugees often experience heightened exposure to HIV due to precarious living conditions, sexual violence, and healthcare access barriers. Background: Structural inequalities, legal precarity, and stigma hinder HIV care for refugees, especially [...] Read more.
Forced displacement exacerbates health vulnerabilities, particularly regarding HIV prevention, diagnosis, and treatment. Refugees often experience heightened exposure to HIV due to precarious living conditions, sexual violence, and healthcare access barriers. Background: Structural inequalities, legal precarity, and stigma hinder HIV care for refugees, especially in resource-limited settings. Excluded from national health programs, refugees often depend on underfunded humanitarian aid. Cultural stigma, limited awareness, and mobility constraints further heighten their vulnerability. Methods: This study draws on a review of peer-reviewed articles, policy documents, and case studies from refugee-hosting countries. It examines healthcare access, service provision gaps, and policy responses to HIV among displaced populations. Results: The article highlights systemic barriers to HIV services, including inadequate testing, inconsistent treatment availability, and cultural barriers to care. Policy frameworks often fail to integrate refugees into national HIV programs, exacerbating health disparities. Conclusions: The exclusion of refugees from national healthcare, compounded by stigma and mobility constraints, deepens health disparities and heightens HIV transmission risks. Without targeted interventions and inclusive health systems, refugees face disproportionate HIV-related morbidity, endangering broader public health in host communities. Full article
40 pages, 1230 KiB  
Review
Human T-Lymphotropic Virus (HTLV): Epidemiology, Genetic, Pathogenesis, and Future Challenges
by Francesco Branda, Chiara Romano, Grazia Pavia, Viola Bilotta, Chiara Locci, Ilenia Azzena, Ilaria Deplano, Noemi Pascale, Maria Perra, Marta Giovanetti, Alessandra Ciccozzi, Andrea De Vito, Angela Quirino, Nadia Marascio, Giovanni Matera, Giordano Madeddu, Marco Casu, Daria Sanna, Giancarlo Ceccarelli, Massimo Ciccozzi and Fabio Scarpaadd Show full author list remove Hide full author list
Viruses 2025, 17(5), 664; https://doi.org/10.3390/v17050664 - 1 May 2025
Viewed by 687
Abstract
Human T-lymphotropic viruses (HTLVs) are deltaretroviruses infecting millions of individuals worldwide, with HTLV-1 and HTLV-2 being the most widespread and clinically relevant types. HTLV-1 is associated with severe diseases such as adult T-cell leukemia/lymphoma (ATL) and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP), while HTLV-2 [...] Read more.
Human T-lymphotropic viruses (HTLVs) are deltaretroviruses infecting millions of individuals worldwide, with HTLV-1 and HTLV-2 being the most widespread and clinically relevant types. HTLV-1 is associated with severe diseases such as adult T-cell leukemia/lymphoma (ATL) and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP), while HTLV-2 shows a lower pathogenic potential, with occasional links to neurological disorders. HTLV-3 and HTLV-4, identified in Central Africa, remain poorly characterized but are genetically close to their simian counterparts, indicating recent zoonotic transmission events. HTLVs replicate through a complex cycle involving cell-to-cell transmission and clonal expansion of infected lymphocytes. Viral persistence is mediated by regulatory and accessory proteins, notably Tax and HBZ in HTLV-1, which alter host cell signaling, immune responses, and genomic stability. Integration of proviral DNA into transcriptionally active regions of the host genome may contribute to oncogenesis and long-term viral latency. Differences in viral protein function and intracellular localization contribute to the distinct pathogenesis observed between HTLV-1 and HTLV-2. Geographically, HTLV-1 shows endemic clusters in southwestern Japan, sub-Saharan Africa, the Caribbean, South America, and parts of the Middle East and Oceania. HTLV-2 is concentrated among Indigenous populations in the Americas and people who inject drugs in Europe and North America. Transmission occurs primarily via breastfeeding, sexual contact, contaminated blood products, and, in some regions, zoonotic spillover. Diagnostic approaches include serological screening (ELISA, Western blot, LIA) and molecular assays (PCR, qPCR), with novel biosensor and AI-based methods under development. Despite advances in understanding viral biology, therapeutic options remain limited, and preventive strategies focus on transmission control. The long latency period, lack of effective treatments, and global neglect complicate public health responses, underscoring the need for increased awareness, research investment, and targeted interventions. Full article
(This article belongs to the Section Human Virology and Viral Diseases)
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19 pages, 9253 KiB  
Systematic Review
Prevalence of Trichomonas vaginalis Among Women in the Chinese Population: A Systematic Review and Meta-Analysis
by Shuang Li, Jiahui Xu, Sisi Ru, Changjun Hu, Chongyang Liu, Xingquan Sun, Heteng Guo and Xi Zhang
Trop. Med. Infect. Dis. 2025, 10(4), 113; https://doi.org/10.3390/tropicalmed10040113 - 19 Apr 2025
Viewed by 465
Abstract
Trichomonas vaginalis (TV) is the most common non-viral sexually transmitted infection (STI) among women worldwide. However, there is little information available regarding the burden of trichomoniasis infection among Chinese women. The aim of the present study is to assess the status of trichomoniasis [...] Read more.
Trichomonas vaginalis (TV) is the most common non-viral sexually transmitted infection (STI) among women worldwide. However, there is little information available regarding the burden of trichomoniasis infection among Chinese women. The aim of the present study is to assess the status of trichomoniasis in China. To address this gap, we searched seven databases for relevant studies published from their inception to June 2024. The overall prevalence of T. vaginalis in China was determined to be 6.31% with a high level of heterogeneity (I2 = 99.68%). Subgroup analysis also demonstrated a statistically significant association between the T. vaginalis prevalence in the type of population, age range, year, residential status, and province. Among these, sex workers are the most prominent with 12.16%. Meta-regression analysis indicated that the infection rate of T. vaginalis among Chinese women had not shown a significant decline over time (p = 0.2919). Therefore, it continues to be a public health issue that should not be overlooked. Sex workers and rural women have a relatively higher infection rate of trichomoniasis, and this is largely associated with sexual safety awareness and hygiene conditions. Our findings provide crucial information for healthcare authorities and can shed light on the prevention strategies for trichomoniasis in China. Full article
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20 pages, 3237 KiB  
Article
To Intervene or Not to Intervene: An Experimental Methodology Measuring Actual Bystander Behaviour
by Danielle Labhardt, Nadine McKillop, Emma Holdsworth, Sarah Brown, Douglas Howat and Christian Jones
Behav. Sci. 2025, 15(4), 550; https://doi.org/10.3390/bs15040550 - 18 Apr 2025
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Abstract
Bystander intervention and sexual assault research typically rely on self-reported intent to intervene. However, predicted behaviour can be considerably different from actual behaviour. Hypothetical scenarios are often utilised to remove extenuating circumstances, limiting insight into actual behaviour where those circumstances impact intervention. This [...] Read more.
Bystander intervention and sexual assault research typically rely on self-reported intent to intervene. However, predicted behaviour can be considerably different from actual behaviour. Hypothetical scenarios are often utilised to remove extenuating circumstances, limiting insight into actual behaviour where those circumstances impact intervention. This paper discusses the development and evaluation of an innovative methodology to measure actual bystander behaviour when witnessing signs of an impending sexual assault. With careful attention paid to ethical considerations and participant safety, 13 participants were directly deceived about the true aim of the research. Utilising observational data and a funnelling debrief, the findings demonstrated varied reactions to sexual assault cues, from not noticing and therefore not intervening, to noticing and (in)directly intervening. Participants’ responses indicated they remained unaware of the deception until it was formally revealed, suggesting the methodology effectively realised the study’s aims. The funnelling debrief mitigated the adverse effects of the deception, with some participants reporting more confidence and motivation to intervene in the future. Further development of this methodology could create more interactive bystander intervention programmes that teach people to identify signs of a sexual assault, develop skills to safely intervene, and raise awareness about sexual violence. Full article
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