Search Results (41,308)

The anisotropic mechanical properties of selective laser melting (SLM)-processed Ti-6Al-4V (TC4) alloy hinder its deployment in polar marine equipment. This study systematically probes the relationships between laser scanning strategies (unidirectional vs. 67°-rotated scanning between layers), notch orientation (governing loading direction), and cryogenic impact energy of SLM-TC4. Charpy impact tests from −60 °C to 20 °C were performed on V-notched specimens fabricated with distinct scanning strategies and notch orientations (top/side surfaces). The analysis of impact energy data and macro/micro-fractography demonstrates that impact energy declines markedly with decreasing temperature, showing a 25–35% reduction at −60 °C versus 20 °C while exhibiting enhanced data consistency under cryogenic conditions. Notably, specimens fabricated with 67°-rotated scanning between layers achieve higher impact toughness than unidirectionally scanned equivalents. Moreover, for identical scanning strategies, side-notched specimens consistently outperform top-notched specimens, evidencing superior interfacial bonding strength between deposited layers relative to bonding within individual layers. Within individual layers, toughness normal to the laser scan path exceeds that parallel to the path. However, controlling ductile-to-brittle transition behavior and precluding brittle failure are imperative for SLM-TC4 components in polar cryogenic service. This work delivers essential quantitative benchmarks and experimental validation for optimizing SLM processing in critical polar vessel components. Full article

Metabolic syndrome is characterized by a group of metabolic disorders that can lead to the development of cardiovascular diseases, obesity and type 2 diabetes mellitus (T2DM). Nowadays, there are several groups of drugs for the treatment of T2DM, but there is no one that would not have significant side effects and suitable for most patients. In our previous study, it was shown that the (S)-2-ethoxy-3-phenylpropanoic acid derivative containing isopimaric acid moiety exhibited pronounced antidiabetic activity. In the present study, a series of (S)-2-ethoxy-3-phenylpropanoic acid derivatives containing an isopimaric acid moiety with various aromatic substituents at position 16 were synthesized. The synthesized compounds were tested for their ability to improve glycemic control and to counter lipid abnormalities in C57BL/6^Ay mice placed on a high-fat/high-cholesterol diet. Of all tested compounds, the 2-NO₂-phenyl derivative (16d) had the most pronounced effect in decreasing blood glucose and serum triglyceride levels. All the compounds displayed a relatively safe profile in the animal studies carried out in this work. Therefore, it can be concluded that chemical modification of isopimaric acid may enhance its efficacy as an antidiabetic agent as part of the potential glitazar. Full article

Neuropathic pain presents a persistent therapeutic challenge, arising from diverse etiologies such as trigeminal neuralgia, postherpetic neuralgia, post-amputation pain, painful polyneuropathy, peripheral nerve injury pain, and painful radiculopathy. Given the limitations and side effects associated with pharmacologic treatments, interest in interventional therapies has surged. Herein, ultrasound guidance provides real-time, radiation-free visualization that enhances procedural accuracy and safety. This narrative review synthesizes current evidence on ultrasound-guided techniques—including nerve blocks, pulsed radiofrequency, hydrodissection, and peripheral nerve stimulation—in the management of neuropathic pain. These minimally invasive approaches demonstrate potential in providing significant and durable pain relief, enhancing functional outcomes, and reducing reliance on systemic medications. Notably, much of the existing literature comprises small-scale or observational studies and larger randomized controlled trials are therefore essential to confirm efficacy, define optimal treatment parameters, and inform clinical guidelines for broader adoption. Full article

One of the most common issues encountered in the rehabilitation of timber-structured buildings is the crushing of elements subjected to compression perpendicular to the grain. This crushing results in differential settlements that decrease comfort and, in some cases, compromise the habitability of the building. This study analyzed a reinforcement method involving the lateral confinement of timber members using two metallic side plates. Experimental tests were conducted with various configurations of the bolts used to fix the plates. In addition, several finite element models were developed and validated to extend the scope of the analysis virtually. An initial reinforcement proposal was examined, in which the metal plates were allowed to move vertically with the wood’s deformation. This setup achieved only a 26% reduction in deformation. Subsequently, an enhanced reinforcement system was tested, wherein the plates were anchored to the lower vertical stud, preventing their vertical movement. This configuration significantly enhanced performance, achieving maximum deformation reductions of up to 53%. Finally, in the improved reinforcement system, the load distribution among the bolts was analyzed to support their structural design. Full article

Traumatic injuries to the brain and spinal cord remain among the most challenging conditions in clinical neuroscience due to the complexity of repair mechanisms and the limited regenerative capacity of neural tissues. Nanotechnology has emerged as a transformative field, offering precise diagnostic tools, targeted therapeutic delivery systems, and advanced scaffolding platforms that are capable of overcoming the biological barriers to regeneration. This review summarizes the recent advances in nanoscale diagnostic markers, functionalized nanoparticles for drug delivery, and nanostructured scaffolds designed to modulate the injured microenvironment and support axonal regrowth and remyelination. Emerging evidence indicates that nanotechnology enables real-time, minimally invasive detection of inflammation, oxidative stress, and cellular damage, while improving therapeutic efficacy and reducing systemic side effects through targeted delivery. Electroconductive scaffolds and hybrid strategies that integrate electrical stimulation, gene therapy, and artificial intelligence further expand opportunities for personalized neuroregeneration. Despite these advances, significant challenges remain, including long-term safety, immune compatibility, the scalability of large-scale production, and translational barriers, such as small sample sizes, heterogeneous preclinical models, and limited follow-up in existing studies. Addressing these issues will be critical to realize the full potential of nanotechnology in traumatic brain and spinal cord injury and to accelerate the transition from promising preclinical findings to effective clinical therapies. Full article

Today’s linear nutrient flows are rooted in a long history of agronomic and wastewater engineering strategies that have created cascading environmental, social, and economic side effects, signaling the need for more holistic and circular approaches. Our examination of the regulatory pathways that enable and constrain urine recycling—an underutilized approach to repurposing human waste as fertilizer—addresses a persistent research gap related to the mainstreaming of transformative technologies. Framed around policy process theories—Street Level Bureaucracy and Multiple Streams Theory—our methods include a review and mapping of 54 regulatory documents; action research where we reflect on our own efforts to expand urine recycling; and interviews with 16 practitioners and regulators in four states which, to our knowledge, are the only places in the US with efforts to scale up urine recycling in community settings. Given its circular nature, a key challenge we find is a lack of clarity around which sectors, or what scales of government, “own” the decision to allow the collection and use of urine as a fertilizer. Working around these challenges, we show how practitioners use many practical strategies to simplify the approval process and reduce the risk aversion regulators face when confronted with ambiguous rulemaking. Full article

This study examines the upper-ocean response to Typhoon Khanun, which traversed the northern South China Sea in October 2017, by integrating multi-satellite observations with numerical simulations from the Regional Ocean Modeling System (ROMS). For the ROMS simulations, an Arakawa C-grid was adopted with a 4-km horizontal resolution and 40 vertical terrain-following $\sigma$-layers, covering the domain of 105° E to 119° E and 15° N to 23° N. Typhoons significantly influence ocean dynamics, altering sea surface temperature (SST), sea surface salinity (SSS), and ocean currents, thereby modulating air–sea exchange processes and marine ecosystem dynamics. High-resolution satellite datasets, including GHRSSST for SST, SMAP for SSS, GPM IMERG for precipitation, and GLORYS12 for sea surface height, were combined with ROMS simulations configured at a 4-km horizontal resolution with 40 vertical layers to analyze ocean changes from 11 to 18 October 2017. The results show that Typhoon Khanun induced substantial SST cooling, with ROMS simulations indicating a maximum decrease of 1.94 °C and satellite data confirming up to 1.5 °C, primarily on the right side of the storm track due to wind-driven upwelling and vertical mixing. SSS exhibited a complex response: nearshore regions, such as the Beibu Gulf, experienced freshening of up to 0.1 psu driven by intense rainfall, while the right side of the storm track showed a salinity increase of 0.6 psu due to upwelling of saltier deep water. Ocean currents intensified significantly, reaching speeds of 0.5–1 m/s near coastal areas, with pronounced vertical mixing in the upper 70 m driven by Ekman pumping and wave-current interactions. By effectively capturing typhoon-induced oceanic responses, the integration of satellite data and the ROMS model enhances understanding of typhoon–ocean interaction mechanisms, providing a scientific basis for risk assessment and disaster management in typhoon-prone regions. Future research should focus on refining model parameterizations and advancing data assimilation techniques to improve predictions of typhoon–ocean interactions, providing valuable insights for disaster preparedness and environmental management in typhoon-prone regions. Full article

The integration of essential oils (EOs) with biological control agents offers a promising alternative to synthetic pesticides, though compatibility remains unclear. This study evaluated nutmeg (Myristica fragrans, NM), cinnamon (Cinnamomum verum, CIN), and clove (Syzygium aromaticum, CL) specifically on S. oryzae and L. distinguendus. Olfactory and behavioral responses to whole EOs and major constituents (myristicin, cinnamaldehyde, eugenol) were analyzed using the area preference method (APM) and two-choice behavioral bioassay (TCB), with confirmation by gas chromatography–mass spectrometry (GC-MS). In S. oryzae, APM showed attraction to all three EOs (PI = 0.14 to 0.56). A paradox emerged, however, as single constituents were mostly repellent (eugenol: PI = −0.58 to −0.70; cinnamaldehyde: PI shifted from 0.16 to −0.20), underscoring the complexity of EO mixtures where multiple compounds act jointly rather than individually. In contrast, L. distinguendus strongly avoided CL and CIN in TCB, with fewer than 30% of parasitoids choosing the EO-treated side (χ² test, p < 0.05). CIN therefore demonstrated selective potential, simultaneously attracting S. oryzae while repelling L. distinguendus. These findings highlight the dual role of EOs as botanical pest control tools, while stressing the need to consider non-target effects before practical application. Full article

Background/Objectives: This study aims to evaluate the quality of life (QoL) and oncological outcomes in premenopausal women diagnosed with hormone receptor-positive breast cancer who are receiving either bilateral oophorectomy (BO) or gonadotropin-releasing hormone agonist (GnRH) therapy. Both methods serve to inhibit ovarian function, which is essential for the management of estrogen-dependent tumors; however, their effects on QoL have yet to be fully clarified. Methods: Data were analyzed from the Mayo Clinic Breast Disease Registry, focusing on women under 55 diagnosed with estrogen receptor-positive breast cancer who received either BO or GnRH within one year of diagnosis. QoL was assessed using the Patient-Reported Outcomes Measurement Information System Global-10 (PROMIS-10) at baseline and annually for five years. Results: A total of 181 patients were enrolled in the study; 40 into the BO group and 141 to the GnRH group. Both groups exhibited similar levels of sexual dysfunction after a one-year period; however, the BO group stated a higher frequency of hot flashes. PROMIS-10 scores improved in both mental and physical health over time, with no significant differences between the groups. Within the BO group, one recurrence was observed, in contrast to the GnRH group, which had six events. Nonetheless, the difference in recurrence rates did not reach statistical significance. Conclusions: The long-term QoL and oncologic outcomes for premenopausal women with hormone receptor-positive breast cancer were similar for BO and GnRH therapy. These findings emphasize the need for individualized treatment decisions, considering patient preferences and side effects. Full article

Irvine–Gass syndrome (IGS) is a macular edema that is mostly observed after cataract surgery, also known as pseudophakic cystoid macular edema (PCME). To date, there are still no standardized guidelines for its treatment. Background/Objectives: This study aimed to compare the efficacy of local and systemic treatments on the resolution of Irvine–Gass Syndrome as well as the therapeutic outcomes of patients with known risk factors such as diabetes and arterial hypertension in order to be able to personalize treatment regimens for each patient. Methods: A total of 136 eyes were followed for a mean of 9.7 ± 15.2 months, with patients divided as follows: those who received only local treatment (LT), those who received systemic treatment (ST), those with cardiovascular diseases (CV), and those without cardiovascular diseases (NCV). We compared the time from the diagnosis of IGS to fully recovered edema (no sub- or intraretinal fluid), central subfield thickness (CST, as evaluated using optical coherence tomography), visual acuity (VA), and intraocular pressure (IOD) in each group. The time from diagnosis to resolution was measured from the initiation of therapy to the full resolution of edema. Results: A total of 136 eyes were examined. The mean CST significantly decreased in the LT (n = 75) (458.3 ± 96.5 µm to 320 ± 39.5 µm (p < 0.01)) and ST (n = 61) groups (519.3 ± 121.6 µm to 337.2 ± 70.6 µm (p < 0.01)) from baseline to 12 months, with no significant difference (p = 0.92). The mean VA significantly increased in both groups from baseline to 12 months (LT: 69.1 ± 11.9 to 80.4 ± 6.6 letters (p < 0.01); ST: 65.1 ± 11.8 to 78.5 ± 6.8 letters (p < 0.01)). The mean time to the resolution of edema was significantly shorter in the LT group (p < 0.05). There were no significant differences in the CST decrease, VA gain, or time to edema resolution between the CV and NCV patients. Conclusions: In regard to the non-inferiority of local treatment, a personalized approach for each patient should be considered, and systemic treatment must be critically evaluated to determine possible side effects. Full article

Despite advances in cancer treatment, head and neck squamous cell carcinoma (HNSCC) remains a serious clinical problem due to tumor aggressiveness, tumor resistance to therapy, and treatment toxicity. The combination of photodynamic therapy (PDT) with chemotherapy is a promising approach to improve efficacy while reducing side effects. For the first time, the possibility and antitumor effect of the combined use of PDT and chemotherapy with intra-arterial administration of chlorin e6 (Ce6) and cisplatin in patients with HNSCC were assessed. Two patients with locally advanced HNSCC received intra-arterial administration of Ce6 (at a dose of 0.5 mg/kg) and cisplatin (at a dose of 50 mg/m²) via a catheter into the tumor-feeding artery followed by laser irradiation. Ce6 distribution, tumor response, and treatment efficacy were assessed by fluorescence diagnostics, confocal microscopy, and histopathological analysis. Intra-arterial administration of the photosensitizer (PS) and chemotherapeutic agent ensured high selectivity of their tumor accumulation. Fluorescence diagnostics showed rapid and selective Ce6 accumulation in the tumor and PS photobleaching after PDT. For a patient with three PDT sessions, there is a significant acceleration of the Ce6 spread from the tumor-feeding artery throughout the tumor bed with each therapy session. This is a good sign of a tumor stroma density decrease. The combined use of PDT and chemotherapy with intra-arterial administration of Ce6 and cisplatin is safe and feasible, with preliminary evidence of local cytotoxicity treatment for HNSCC, allowing targeted drug delivery to the tumor. This is the first report of the combined use of PDT and chemotherapy with selective intra-arterial administration of a PS and a chemotherapeutic drug for the treatment of cancer. Full article

The aim of this pilot study was to evaluate the relaxation, stress reduction and behavioral changes observed after manual therapy applied to horses exposed to racing and physical training stimulus. This descriptive approach is aimed at veterinary clinicians to evaluate the therapy process more effectively with behavioral feedback. For this purpose, the study was conducted in two different equestrian clubs in Adana (Adana Mediterranean and Suvari Equestrian Clubs) between 2023 and 2024. A total of 32 racehorses (16 Thoroughbred, 16 Arabian; 16 female, 16 male) of different ages, genders and breeds were included in the study. Five minutes of manual therapy was applied for each of 7 different muscle groups. After the massage, behavioral observations were made for 10 min by moving 2 m away from the animals, and no separate baseline assessment was performed prior to the intervention. The application was carried out by a veterinarian with 15 years of experience. Importantly, no separate baseline assessment or control group was performed, and only behavioral responses were evaluated, which represents a major limitation of this pilot study. Among the observed behaviors in all horses, blinking, muscle twitching, respiratory changes, lip relaxation, licking and chewing were recorded for all horses. Relaxation signs such as head dropping (78.1%), yawning (34.4%), and ears falling to the side (62.5%) were frequently observed. Behaviors such as the appearance of the third eyelid (3.1%), grunting (12.5%) and sneezing (15.6%) were observed at a low percentage. Individual variables such as gender and breed did not have a statistically significant effect on the percentage of behavior (Chi-square test, p > 0.05). In conclusion, these preliminary findings suggest that manual therapy applications might be effective in reducing stress by triggering relaxation behaviors in riding horses, as these behaviors have been previously reported in the literature as reliable indicators of relaxation. Evaluation of behavioral responses after massage could be an important tool in determining physiotherapeutic effects. The fact that the application is performed by experienced people is an important factor that increases the success of the therapy and shows that manual therapy provides relaxation regardless of individual differences. Future controlled studies integrating physiological stress biomarkers are warranted to confirm these observations. Full article

Over the past decade, the application of Tunnel Boring Machines (TBMs) in tunnel construction has increased significantly. During the construction process, numerous unfavorable geological structures, especially water-conducting structures, are encountered. The commonly used Tunnel Seismic Prediction (TSP) method often cannot accurately interpret water-conducting features, while resistivity methods are sensitive to low-resistivity bodies, which are frequently associated with water channels. Due to the limited space and the surrounding pipe lining near the tunnel face, as well as the difficulty in drilling boreholes under TBM construction conditions, this paper proposes a novel electrode arrangement method that replaces rigid electrodes with flexible electrodes installed on the sidewalls. This approach overcomes the difficulty of deploying traditional electrodes downward in TBM tunnels. A simple direct current resistivity configuration was employed for field testing during the construction of the Guiyang Metro Line 3 TBM tunnel, and the results were compared with those from the Tunnel Seismic Prediction (TSP) method. The experimental results demonstrate that the improved DC resistivity method achieves high detection accuracy for water-conducting structures within a range of 30 m, showing strong consistency with the TSP detection results. This validates the feasibility and accuracy of the method, effectively addressing the challenges associated with traditional electrode deployment in TBM tunnels while compensating for the limited response of seismic methods to water-bearing structures. However, the effectiveness near the tunnel face remains suboptimal, with insufficient current distribution—an area requiring improvement, potentially by increasing forward current supply or further optimizing the electrode layout. Additionally, the study highlights the limitations of relying solely on a single advanced prospecting method. It suggests adopting an integrated approach, primarily based on seismic methods supplemented by electrical methods, to enable joint detection and interpretation, thereby minimizing the risk of accidents during construction. Full article

Background and Objectives: Stroke and hemiplegia disrupts symmetrical activation of skeletal and abdominal muscles, impairing trunk control and functional movement. Although asymmetry is also present in healthy adults, its magnitude and patterns differ with neurological impairment. Understanding trunk muscle symmetry across functional tasks in healthy individuals and patients with stroke is essential for targeted rehabilitation strategies. Materials and Methods: A comparative cross-sectional study was conducted including healthy adults and patients with stroke. Muscle activation symmetry of the rectus abdominis, external oblique, internal oblique, and multifidus was analyzed across four trunk movements: flexion, extension, and lateral flexion to the dominant or non-dominant side. A two-way repeated measures ANOVA examined main and interaction effects of condition, muscle, and group. Results: Trunk muscle symmetry was significantly influenced by the movement conditions, and patterns of change differed between groups. While no consistent differences were observed across muscles, specific interactions revealed condition-dependent variations, particularly between abdominal and deep spinal muscles. Lateral flexion elicited the greatest asymmetry, with distinct response patterns in healthy individuals compared with patients with stroke. Conclusions: This study highlights the importance of addressing movement-specific demands in trunk rehabilitation. Rather than focusing on isolated muscles, interventions should consider the dynamic and condition-dependent nature of symmetry to optimize functional recovery in patients with stroke. Full article

As the deployment of wind energy systems continues to rise globally, ensuring the reliability and efficiency of grid-connected Doubly Fed Induction Generator (DFIG) wind turbines has become increasingly critical. Two core challenges faced by these systems include fault diagnosis in power electronic converters and accurate prediction of wind conditions for adaptive power control. Recent advancements in artificial intelligence (AI) have introduced powerful tools for addressing these challenges. This study presents the first unified comparative performance analysis of two deep learning-based models: (i) a Convolutional Neural Network-Long Short-Term Memory CNN-LSTM with Variational Mode Decomposition for real-time Grid Side Converter (GSC) fault diagnosis, and (ii) an Incremental Generative Adversarial Network (IGAN) for wind attribute prediction and adaptive droop gain control, applied to grid-integrated DFIG wind turbines. Unlike prior studies that address fault diagnosis and wind forecasting separately, both models are evaluated within a common MATLAB/Simulink framework using identical wind profiles, disturbances, and system parameters, ensuring fair and reproducible benchmarking. Beyond accuracy, the analysis incorporates multi-dimensional performance metrics such as inference latency, robustness to disturbances, scalability, and computational efficiency, offering a more holistic assessment than prior work. The results reveal complementary strengths: the CNN-LSTM achieves 88% accuracy with 15 ms detection latency for converter faults, while the IGAN delivers more than 95% prediction accuracy and enhances frequency stability by 18%. Comparative analysis shows that while the CNN-LSTM model is highly suitable for rapid fault localization and maintenance planning, the IGAN model excels in predictive control and grid performance optimization. Unlike prior studies, this work establishes the first direct comparative framework for diagnostic and predictive AI models in DFIG systems, providing novel insights into their complementary strengths and practical deployment trade-offs. This dual evaluation lays the groundwork for hybrid two-tier AI frameworks in smart wind energy systems. By establishing a reproducible methodology and highlighting practical deployment trade-offs, this study offers valuable guidance for researchers and practitioners seeking explainable, adaptive, and computationally efficient AI solutions for next-generation renewable energy integration. Full article