Search Results (19,263)

Background and Clinical Significance: Spina bifida in the cervical region is closely associated with Chiari malformation, which is an amalgamation of terminology for separate conditions with similar pathophysiological mechanisms and progression from one another. Chiari malformations are associated with varying degrees of dilation of the foramen magnum or lack of fusion of the occipital bone with syringomyelia, herniation of the cerebellum, occipitocele and occipitomyelocele; Case Presentation: A previously healthy 23-year-old primigravida presented to our institution due to fetal demise in the third lunar month, established on routine outpatient maternal consultation. Point-of-care ultrasound revealed an amniotic sac measuring 3 cm in diameter and containing a single fetus, without cardiac function. Due to these, the patient was scheduled for pregnancy termination, during which the cervix was noted to be spontaneously dilated and abrasion accomplished complete evacuation of the amniotic sac, without its rupture. Upon sectioning of the amniotic sac, a fetus, measuring 2.5 cm in length, was noted, with a significant cuffing of the occipital and cervical paraspinal region. Histology revealed fetal structures with an adequate maturation index for its gestational age, but it presented with a pronounced meningoencephalomyelocele in the cervical and thoracic regions, characterized by the complete absence of vertebral arches and spinous processes from the atlanto-occipital to the sacral region; Conclusions: In the present case, not only is a significant and complex form of Chiari type III reported, but the condition is also associated with spina bifida aperta in all spinal regions, leading to meningoencephalomyelocele, incompatible with life. Full article

In the context of China’s increasingly competitive agricultural product branding, authenticity has become a pivotal mechanism for shaping consumer trust and willingness to pay. This study takes Perceived Brand Authenticity (PBA) as its focal construct and builds a chained mediation framework incorporating experiential quality (EQ) and consumer trust. Employing a dual-evidence strategy that combines structural discovery and causal validation, the study integrates Jaccard similarity clustering and PLS-SEM to examine both behavioral patterns and psychological mechanisms. Drawing on 636 valid survey responses from across China, the results reveal clear segmentation in channel choice, certification concern, and premium acceptance by gender, age, income, and education. Younger and highly educated consumers rely more on e-commerce and digital traceability, while middle-aged, older, and higher-income groups emphasize geographical indications and organic certification. The empirical analysis confirms that PBA has a significant positive effect on EQ and consumer trust, and that the chained mediation pathway “PBA → EQ → Trust → Purchase Intention” robustly captures the transmission mechanism of authenticity. The findings demonstrate that verifiable and consistent authenticity signals not only shape cross-group consumption structures but also strengthen trust and repurchase intentions through enhanced experiential quality. The core contribution of this study lies in advancing an evidence-based framework for sustainable agricultural branding. Theoretically, it reconceptualizes authenticity as a measurable governance mechanism rather than a rhetorical construct. Methodologically, it introduces a dual-evidence approach integrating Jaccard clustering and PLS-SEM to bridge structural and causal analyses. Practically, it proposes two governance tools—“evidence density” and “experiential variance”—which translate authenticity into actionable levers for precision marketing, trust management, and policy regulation. Together, these insights offer a replicable model for authenticity governance and consumer trust building in sustainable agri-food systems. Full article

Background/Objectives: Transcatheter aortic valve implantation (TAVI) is a standard treatment for severe aortic stenosis, especially in older adults and high-risk patients. However, many TAVI candidates have osteopenia or osteoporosis, indicated by low bone mineral density (BMD), which is linked to frailty and adverse outcomes. Although prior research suggests an association with poor clinical outcomes, data remain limited. We investigated the impact of osteopenia on TAVI outcomes, hypothesizing that a lower BMD is associated with poor perioperative outcomes and decreased long-term survival. Methods: In this single-center retrospective study, we analyzed data from 411 patients who underwent TAVI at Yamaguchi University Hospital from 2014 to 2024. Clinical and survival data were collected, and Cox regression analysis was used to identify independent predictors of mortality. Preoperative BMD was measured using computed tomography, defining osteopenia as <135 Hounsfield units at L1. Patients were categorized as having mild, moderate, or severe osteopenia. Results: Early clinical outcomes and procedural success were similar; however, patients with osteopenia had longer intensive care unit stays (p = 0.04) and higher late cardiac mortality (p < 0.001). Six-year survival was 36.2% and 88.1% in patients with and without osteopenia, respectively (p < 0.0001). Cox regression analysis revealed osteopenia as a mortality risk factor (hazard ratio: 6.75, 95% confidence interval: 2.96–15.38, p < 0.0001). Severe osteopenia was associated with the poorest outcomes. Conclusions: Osteopenia is an independent predictor of poor long-term survival after TAVI. These findings underscore the importance of comprehensive risk assessment, suggesting that targeted interventions may improve outcomes. Full article

The prevention and control of coupled disasters caused by strong mining pressure and high gas is currently the main challenge during coal seam deep mining in the southeastern mining areas of Shanxi Province. This paper takes the 1310 working face of Hudi Coal Mine as the engineering background, analyzing its on-site strong mining pressure event and triggering factors. A reasonable hydraulic fracturing scheme (including layer selection, drilling parameter design, etc.) is proposed based on theoretical analysis of the principles and advantages of hydraulic fracturing technology. Then, the physical analog modeling (PAM) method was used to study the movement law and fracture development of the overlying strata during coal seam mining after hydraulic fracturing. The weakening effect of mining pressure was analyzed through the evolution law of roof stress. The deformation of the surrounding rock in the roadway, coal drilling cuttings, support working resistance, and roof fracture development of the in situ measurement results show that hydraulic fracturing has a good effect on weakening mining pressure. It has achieved safe and efficient mining of coal seams while providing a reference for coal mines with similar conditions. Full article

We investigate the quantum dynamics of entanglement and fidelity in the hyperfine structure of hydrogen atoms under dephasing noise, modeled via the Lindblad master equation. The effective Hamiltonian captures the spin–spin interaction between the electron and proton, with dephasing incorporated through local Lindblad operators. Analytical solutions for the time-dependent density matrix are derived for various initial states, including separable, partially entangled, and maximally entangled configurations. Entanglement is quantified using the concurrence, while fidelity measures the similarity between the evolving state and the initial state. Numerical results demonstrate that entanglement exhibits oscillatory decay modulated by the dephasing rate, with anti-parallel spin states displaying greater robustness compared to parallel configurations, often leading to entanglement sudden death. Fidelity dynamics reveal similar damped oscillations, underscoring the interplay between coherent hyperfine evolution and environmental dephasing. These insights elucidate strategies for preserving quantum correlations in atomic systems, with implications for quantum information processing and metrology. Full article

Mean flow velocities and the corresponding turbulence fluctuation velocities were measured within the suction port of a standard twin-screw compressor using LDV and PIV optical techniques. Time-resolved velocity measurements were carried out over a time window of 1° at a rotor speed of 1000 rpm, a pressure ratio of 1, and an air temperature of 55 °C. Detailed LDV measurements revealed a very stable and slow inflow, with almost no influence from rotor movements except near the rotors, where a more complex flow formed in the suction port. The axial velocity near the rotors exhibited wavy profiles, while the horizontal velocity showed a rotational flow motion around the centre of the port. The turbulence results showed uniform distributions and were independent of the rotors’ motion, even near the rotors. PIV measurements confirmed that there is no rotor movement influence on the inflow structure and revealed complex flow structures, with a crossflow dominated by a main flow stream and two counter-rotating vortices in the X-Y plane; in the Y-Z plane, the presence of a strong horizonal stream was observed away from the suction port, which turned downward vertically near the entrance of the port. The corresponding turbulence results in both planes showed uniform distributions independent of rotor motions that were similar in all directions. Full article

This paper develops a Natural Language Processing (NLP) pipeline to quantify the hawkish–dovish stance in the Federal Reserve’s semiannual Monetary Policy Reports (MPRs). The goal is to transform long-form central-bank text into reproducible stance scores and interpretable policy signals for research and monitoring. The corpus comprises 26 MPRs (26 February 2013 to 20 June 2025). PDFs are parsed and segmented and chunks are embedded, indexed with FAISS, retrieved via LangChain, and scored by GPT-4o on a continuous scale from −2 (dovish) to +2 (hawkish). Reliability is assessed with a four-dimension validation suite: (i) semantic consistency using cosine-similarity separation, (ii) numerical consistency against theory-implied correlation ranges (e.g., Taylor-rule logic), (iii) bootstrap stability of reported metrics, and (iv) content-quality diagnostics. Results show a predominant Neutral distribution (50.0%), with Dovish (26.9%) and Hawkish (23.1%). The average stance is near zero (≈0.019) with volatility σ ≈ 0.866, and the latest window exhibits a hawkish drift of ~+0.8 points. The Numerical Consistency Score is 0.800, and the integrated validation score is 0.796, indicating publication-grade robustness. We conclude that an embedding-based, agentic RAG approach with GPT-4o yields a scalable, auditable measure of FED communication; limitations include biannual frequency and prompt/model sensitivity, but the framework is suitable for policy tracking and empirical applications. Full article

Background: Preliminary evidence supports high-intensity functional training (HIFT) for improving various health outcomes in non-disabled adults with overweight/obesity. It remains unknown whether HIFT produces similar benefits in individuals who are overweight/obese and also have a mobility disability (e.g., spinal cord injury, multiple sclerosis)—a population disproportionately affected by obesity-related health conditions and systemic barriers to exercise. This pilot study aimed to evaluate the feasibility and preliminary effects of a 24-week HIFT intervention, delivered at community sites by certified trainers, for adults with mobility disabilities (MDs) who were overweight/obese. Methods: Twenty adults with MD and overweight/obesity (self-reported BMI 25–46 kg/m²) enrolled in a 24-week HIFT intervention (3 days/wk, 60 min sessions) delivered at four community-based facilities by certified trainers. Feasibility indicators included recruitment, retention, and attendance; adverse events were tracked. Effect sizes (Cohen’s d) were calculated for changes in obesity-related measures, physical function, work capacity, and psychological measures from baseline to post-intervention. Results: Feasibility targets were met, with a recruitment rate of 72.2%, 76.9% retention, and 80.7% attendance. Thirteen adverse events occurred. Effects on obesity-related measures ranged from negligible to moderate, with stable weight/BMI, reduced waist circumference (45% ≥ 3 cm decrease), decreased body fat, and increased lean mass. Functional outcome effects ranged from small to large and included grip strength, balance, and walking speed. Large improvements were observed for the endurance, speed, work capacity, and self-reported physical function. Conclusions: A community-based HIFT program is feasible and may improve health outcomes in adults with MD and overweight/obesity. Full article

This study aims to evaluate the shrinkage, degree of conversion, water sorption and solubility, and mechanical properties of a newly developed one-shade universal composite and compare it with five other commercially available universal composites with one or multiple shades. Our proprietary resin and filler technologies developed the experimental one-shade universal composite (Experimental). Volumetric shrinkage was determined using the AcuVol video imaging method (n = 5). Degree of conversion was measured using FTIR (n = 5). Water sorption and solubility (15 × 1 mm, n = 5) and flexural strength and modulus (2 × 2 × 25 mm, n = 5) were measured according to ISO-4049. Diametral tensile strength (6 × 3 mm, n = 8) was tested according to ANSI/ADA-Specification #27. The data were analyzed using one-way ANOVA and post hoc Tukey tests (p ≤ 0.05). Like Clearfil Majesty ES-2, Experimental showed lower or significantly lower volumetric shrinkage than other composites. Experimental exhibited a considerably higher degree of conversion and high flexural modulus compared to the others. However, there are no significant differences in flexural strength among these universal composites except for Omnichroma. Experimental also displayed significantly higher diametral tensile strength than the others, except similar to Filtek Supreme Ultra. Experimental has the lowest values of water sorption and solubility among the composites tested. The experimental universal composite demonstrated improved or comparable physical and mechanical properties compared to commercially available one-shade universal composites or multi-shade conventional universal composites, which is of significance for the clinical performance of dental restorations. Full article

The deployment of autonomous vehicles (AVs) depends on the readiness of both physical and digital infrastructure. However, existing national and city-level indices often overlook deficiencies along specific routes, particularly in developing contexts such as Thailand, where infrastructure conditions vary widely. This study develops and applies a corridor-level framework to assess AV readiness on five controlled-access roads in western Bangkok. The framework evaluates key infrastructure dimensions beyond conventional vehicle requirements. In this study, infrastructure readiness means the extent to which essential physical (EV charging capacity, traffic sign visibility, and lane marking retroreflectivity) and digital (5G speed and coverage) subsystems meet minimum operational thresholds required for AV deployment. Data were collected through field measurements and secondary sources, utilizing tools such as a retroreflectometer, a handheld spectrum analyzer, and the Ookla Speedtest application. The results reveal significant contrasts for physical infrastructure, showing that traffic signage is generally satisfactory, but EV charging capacity and road marking retroreflectivity are insufficient on most routes. On the digital side, 5G coverage was generally adequate, but network speeds remained less than half of the global benchmark. Kanchanaphisek Road demonstrated comparatively higher digital readiness, whereas Ratchaphruek Road exhibited the weakest road marking conditions. These findings point out the need for stepwise enhancements to EV charging infrastructure, lane marking maintenance, and digital connectivity to support safe and reliable AV operations. The proposed framework not only provides policymakers in Thailand with a practical tool for prioritizing corridor-level investments but also offers transferability to other rapidly developing urban regions experiencing similar infrastructure challenges for AV deployment. Full article

Localization of a semi-humanoid mobile robot Pepper is proposed based on the particle swarm optimization algorithm (PSO) that is robust to the disturbance perturbations of LIDAR-measured distances from the mobile robot to the walls of the robot real laboratory workspace. The novel PSO, with the avoiding local minima algorithm (PSO-ALM), uses a novel fitness function that can prevent the PSO search from trapping into the local minima and thus prevent the mobile robot from misidentifying the actual location. The fitness function penalizes nonsense solutions by introducing continuous integrity checks of solutions between two different consecutive locations. The proposed methodology enables accurate and real-time global localization of a mobile robot, given the underlying a priori map, with a consistent and predictable time complexity. Numerical simulations and real-world laboratory experiments with different a priori map accuracies have been conducted to prove the proper functioning of the method. The results have been compared with the benchmarks, i.e., the plain vanilla PSO and the built-in robot’s odometrical method, a genetic algorithm with included elitism and adaptive mutation rate (GA), the same GA algorithm with the included ALM algorithm (GA-ALM), the state-of-the-art plain vanilla golden eagle optimization (GEO) algorithm, and the same GEO algorithm with the added ALM algorithm (GEO-ALM). The results showed similar performance with the odometrical method right after recalibration and significantly better performance after some traveled distance. The GA and GEO algorithms with or without the ALM extension gave us similar results according to the accuracy of localization. The optimization algorithms’ performance with added ALM algorithms was much better at not getting caught in the local minimum, while the PSO-ALM algorithm gave us the overall best results. Full article

Objective: To evaluate the measurements made on digital scans of maxillary plaster models in comparison with those obtained directly with a digital caliper on plaster models obtained from individuals with unilateral cleft lip and palate. Methods: This study included 42 unilateral cleft lip and palate cases and a control group of 43 Angle Class I cases. The research material consisted of maxillary orthodontic plaster models obtained from these individuals and three-dimensional digital models obtained by scanning these models with a 3 Shape Trios scanner. A total of 12 anatomic reference points were used and six transverse dimension parameters were measured. The differences between the two groups were examined with a Student’s t-test. Intraclass correlation coefficients were calculated for repeatability and similarity evaluations. Results: Significant differences were found between the CLP and control groups for all parameters, with smaller values obtained in the CLP group. In the CLP group, when comparing the asymmetry of the right and left regions in the 3 Shape model, significant differences were observed regarding all parameters (p < 0.05); furthermore, there was a significant difference between the CLP and control groups (p < 0.05) in the asymmetry comparison. In both groups, there was no statistically significant difference in the measured parameters between the 3 Shape and digital caliper measurements. Conclusions: The measurements obtained after scanning plaster models from CLP individuals with the 3 Shape digital scanner are acceptable and reliable. It can be concluded that the transfer of CLP patients’ archived plaster models to the digital environment is reliable regarding scientific research and clinical measurements. Full article

The study of fractals has a long history in mathematics and signal analysis, providing formal tools to describe self-similar structures and scale-invariant phenomena. In recent years, cognitive science has developed a set of powerful theoretical and experimental tools capable of probing the representations that enable humans to extend hierarchical structures beyond given input and to generate fractal-like patterns across multiple domains, including language, music, vision, and action. These paradigms target recursive hierarchical embedding (RHE), a generative capacity that supports the production and recognition of self-similar structures at multiple scales. This article reviews the theoretical framework of RHE, surveys empirical methods for measuring it across behavioral and neural domains, and highlights their potential for cross-domain comparisons and developmental research. It also examines applications in linguistic, musical, visual, and motor domains, summarizing key findings and their theoretical implications. Despite these advances, the computational and biological mechanisms underlying RHE remain poorly understood. Addressing this gap will require linking cognitive models with algorithmic architectures and leveraging the large-scale behavioral and neuroimaging datasets generated by these paradigms for fractal analyses. Integrating theory, empirical tools, and computational modelling offers a roadmap for uncovering the mechanisms that give rise to recursive generativity in the human mind. Full article

Background/Objectives: Peritonsillar abscess (PTA) and cellulitis (PTC) often present with similar clinical features, making differentiation challenging despite imaging. This study evaluates the diagnostic performance of serum HMGB1 and kallistatin levels as potential independent biomarkers to distinguish PTA from PTC. Methods: In this single-center prospective cohort study, 97 patients aged 18 to 65 years who met the inclusion criteria and presented with peritonsillar infection (39 PTA; 58 PTC) between February and July 2025 were enrolled. Serum levels of HMGB1, kallistatin, and routine inflammatory markers were measured and compared. Univariate and multivariate logistic regression analyses identified independent predictors for distinguishing PTA from PTC. Receiver operating characteristic (ROC) curve analysis assessed the diagnostic accuracy of biomarkers. Decision curve analysis (DCA) was performed to evaluate the clinical net benefit of individual biomarkers and their combinations across a range of threshold probabilities. Results: Compared to controls, patients with peritonsillar infection had significantly higher WBC, neutrophil, CRP, procalcitonin, and HMGB1 levels and significantly lower kallistatin levels (all p < 0.05). Within the infection group, PTA patients showed significantly higher CRP (p = 0.036) and HMGB1 (p = 0.003) levels and lower kallistatin (p < 0.001) levels compared to PTC patients. In univariate analysis, CRP, HMGB1, and kallistatin were significantly associated with PTA; however, in multivariate analysis, only elevated HMGB1 (OR: 1.21; 95% CI: 1.09–1.35; p < 0.001) and reduced kallistatin (OR: 0.395; 95% CI: 0.24–0.648; p < 0.001) remained independent predictors. ROC analysis showed that both HMGB1 and kallistatin demonstrated good discriminative ability in distinguishing PTA from PTC. DCA revealed that the three-biomarker combination (kallistatin + HMGB1 + CRP) achieved the highest mean net benefit (0.183) across all threshold probabilities, outperforming individual biomarkers (kallistatin: 0.131, HMGB1: 0.111, CRP: 0.099) and the two-biomarker model (0.176). The combined model maintained superior net benefit across threshold probabilities of 25–75%, indicating optimal clinical utility within this decision range. Conclusions: Serum HMGB1 and kallistatin may be effective adjunctive biomarkers for differentiating PTA from PTC. Full article

Work–family conflicts (WFCs) and family–work conflicts (FWCs) have been found to be important to worker morale and retention as well as family (as defined by the respondents) well-being, with particular importance within the military, as indicated by a number of studies in the United States, Canada, and European countries. However, few studies have focused on the impact of WFC and FWC for high ranking officers and their families. This study involved two samples of officers attending an advanced leadership course at Fort Leavenworth, Kansas, in 2007, featuring a total of 262 Army officers and another 45 officers from other services and countries. The sample of Army officers included 239 men (85.4% of whom were a parent) and 22 women (63.6% of whom were a parent; Fisher’s Exact Test, p < 0.02), with one missing case for sex. Of the men and women, respectively, most were married for the first time (190/11), with some never married (14/5), married but divorced (10/1), married/divorced/remarried (20/4), married/spouse died/remarried (1/0), married/divorced/remarried/divorced/remarried (4/0), and married/divorced/remarried/divorced/remarried (0/1). Measures for cohabitation or same-sex partnerships were not used. Two modified measures of WFC and FWC of four items each were tested and found to represent different factors and to have high internal consistency reliability. In general we found few sex differences, but female officers seemed to be more influenced by family–work conflict than male officers. One of our most substantial findings was that work–family conflict was more prevalent than family–work conflict within our sample. Also, we found that marital satisfaction tended to be higher than parental satisfaction and that officers usually found their own retention intentions to be higher than their perception of that of their spouses. Satisfaction with the military was consistently and strongly related to lower levels of work–family conflict while similar but weaker trends were found for family–work conflict. Most of our results were found to cross-validate with a subsample of non-Army officers in our sample. We found bias from marital social desirability to be lower for our marital process scale and for FWC than for marital satisfaction and WFC. In sum, our results confirm adverse effects of deployments and other stressors on military families and a continuing need for military support for families, even among higher ranking officer families. Full article