Search Results (3,141)

Introduction: Direct pulp capping (DPC) aims to preserve the vitality of the dental pulp by placing a protective biocompatible material over the exposed pulp tissue to facilitate healing. There are several calcium-silicate materials that have been designed to promote mineralization and the regulation of inflammation. These have strong potential for the repair and regeneration of dental pulp. Among them, Biodentine (BD) and EndoSequence RRM Putty (ES) have been found to promote in vitro and in vivo mineralization while minimizing some of the limitations of the first-generation calcium-silicate-based materials. Theracal-LC (TLC), a light-cured, resin-modified calcium-silicate material, is a newer product with potential to improve the clinical outcomes of DPC, but existing studies have reported conflicting findings regarding its biocompatibility and ability to support pulpal healing in direct contact with the pulp. A comprehensive assessment of the biocompatibility and pulpal protection provided by these three capping materials has not yet been performed. Aim: We aimed to quantify the inflammatory response, dentin bridge formation, and material adaptation following DPC using three calcium-silicate materials: ES, BD, and TLC. Materials and Methods: DPC was performed on the maxillary first molar of C57BL/6 female mice. Maxilla were collected and processed at 1 and 21 days post-DPC. The early inflammatory response was measured 24 h post-procedure using confocal imaging of anti-Lys6G6C, which indicates the extent of neutrophil and monocyte infiltration. Reparative mineralized bridge formation was assessed at 21 days post-procedure using high-resolution micro-computed tomography (micro-CT) and histology. Lastly, the homogeneity of the capping materials was evaluated by quantifying voids in calcium-silicate restorations using micro-CT. Results: DPC using TLC induced less infiltration of Lys6G6C⁺ cells at 24 h than BD or ES. BD promoted higher volumes of tertiary dentin than TLC, but TLC and ES showed no significant differences in volume. No differences were observed in material adaptation and void spaces among the three capping materials. Conclusions: All three materials under investigation supported pulp healing and maintained marginal integrity. However, TLC induced a lower inflammatory response on day 1 and induced similar levels of tertiary dentin to ES. These observations challenge the common perception that resin-based capping materials are not suitable for direct pulp capping. Our findings underscore the need to balance biological responses with physical properties when selecting pulp capping materials to improve long-term clinical success. Full article

This study explores the evolving role of architecture centers in the digital age by analyzing the case of Casa da Arquitectura (CdA) in Porto, Portugal, a hybrid institution that functions as both archive and museum. Positioned within the broader context of museum digitization and liminality theory, the research investigates how CdA navigates the spatial, social, and procedural shifts inherent in digital transformation. Drawing on qualitative methods, including in-depth interviews with key personnel and on-site observations, the study examines the institution’s strategies in acquisition, curation, and exhibition design. The findings highlight CdA’s innovative approach to archival visibility, the creation of a multipurpose digital platform (“edifício digital”), and the integration of archival acquisitions with exhibition practices. These practices illustrate a condition of triple liminality of the digital museum concerning its process, position, and place. The study also discusses how digitization reconfigures the museum’s organizational model in terms of accessibility and curatorial complexity. By analyzing CdA’s operational and curatorial choices, the paper discusses how digital museums can act as speculative, process-oriented spaces that challenge traditional boundaries between archive and exhibition, physical and virtual, institutional and public. Full article

Color grading of boiled shrimp is a critical factor influencing market price, yet the process is usually conducted visually by buyers such as middlemen and processing plants. This subjective practice raises concerns about accuracy, impartiality, and fairness, often resulting in disputes with farmers. To address this issue, this study proposes a standardized and automated grading approach based on image processing and artificial intelligence. The method requires only a photograph of boiled shrimp placed alongside a color grading ruler. The grading process involves two stages: segmentation of shrimp and ruler regions in the image, followed by color comparison. For segmentation, deep learning models based on Mask R-CNN with a Feature Pyramid Network backbone were employed. Four model configurations were tested, using ResNet and ResNeXt backbones with and without a Boundary Loss function. Results show that the ResNet + Boundary Loss model achieved the highest segmentation performance, with IoU scores of 91.2% for shrimp and 87.8% for the color ruler. In the grading step, color similarity was evaluated in the CIELAB color space by computing Euclidean distances in the L (lightness) and a (red–green) channels, which align closely with human perception of shrimp coloration. The system achieved grading accuracy comparable to human experts, with a mean absolute error of 1.2, demonstrating its potential to provide consistent, objective, and transparent shrimp quality assessment. Full article

The growing demand for micro-launchers capable of placing payloads between 1 and 100 kg into low Earth orbit stems from rapid advances in electronics and the resulting increase in nanosatellite capabilities. Simultaneously, space programs are prioritizing the use of alternative propellants, those that are more sustainable, cost-effective, and readily available. As a result, modern launcher development emphasizes versatility, reliability, reusability, and adaptability to various working fluids. This paper presents the experimental validation of a supersonic turbine design methodology tailored for such adaptable systems. The focus is on a turbine class intended for a turbopump in micro-launchers with payload capacities around 100 kg. The experimental campaign employed two working fluids (air and methane) to assess the method’s robustness. The validation was performed on a stator only planar model, and the experimental data was compared with the analytical result obtained through the Mach number similarity criterion. The results confirm that the approach accurately identifies flow similarity through Mach number matching, even when the working fluid changes. Comparative analysis between experimental data and predictions demonstrates the method’s reliability, with measurement uncertainties also addressed. These findings support the methodology’s applicability in practical engine design and adaptation. Future work will explore enhancements to improve predictive capability and flexibility. The method may be extended to other systems where fluid substitution offers design or operational advantages. Full article

The objective of this article is to provide a critical analysis of maritime heterotopia as a category for reinterpreting ships, shipwrecks and maritime landscapes between the 16th and 18th centuries. Through an interdisciplinary approach combining history, underwater archaeology, heritage theory and literary analysis, it explores the ways in which maritime spaces, especially ships and shipwrecks, functioned as ‘other spaces’–following Foucault’s concept of heterotopia–in the articulation of imperial projects, power relations, experiences of transit and narratives of memory. A particular focus has been placed on the examination of shipwreck accounts, which are regarded as microhistories of human behaviour in contexts of crisis. These accounts have been shown to offer insights into alternative social structures, dynamics of authority, and manifestations of violence or solidarity. A review of the legal framework and practices related to shipwrecks in the Spanish Carrera de Indias is also undertaken, with particular emphasis on their impact on maritime legislation and international law. This article proposes a reading of maritime heritage as a symbolic and political device in constant dispute, where material remains and associated narratives shape collective memories, geopolitical tensions and new forms of cultural appropriation. Shipwrecks thus become sites of rupture and origin, charged with utopian, dystopian and heterotopic potential. Full article

Manuscript 50 (46) from the library of the monastery of Putna contains a text entitled “Discourse on the appropriate manner of standing in the church.” The first part explains the Eucharistic liturgy, from the vesting of the priest to the moment before the epiclesis. The service is dramatized as an interaction between the priest and an angel of God, who later enters a battle with a demon that distracts the congregation. The second part of the text consists of the vision of the monk who lost his faith in the Eucharist. At the prayers of the community, he receives a revelation of the reality of the liturgical mystery, in which he is shown a child slaughtered on the altar table. The visionary text in the first section is part of a tradition attested in the Slavonic environment of the Balkans, which later became popular in the Russian world. These Slavonic versions are based on a similar visionary text attested in Greek manuscripts, but the similarities are only partial. The present study places the text from the Putna manuscript in relation to the iconography of the liturgical space and highlights the relevance of this type of literature for understanding the local monastic culture. Full article

Evidence of possible cerebellar involvement in spatial processing, place learning and other types of higher order functions comes mainly from clinical observations, as well as from mutant mice and lesion studies. The latter, in particular, have reported deficits in spatial learning and memory following surgical or neurotoxic cerebellar ablation. However, the low specificity of such manipulations has often made it difficult to precisely dissect the cognitive components of the observed behaviors. Likewise, due to conflicting data coming from lesion studies, it has not been possible so far to conclusively address whether a cerebellar dysfunction is sufficient per se to induce learning deficits, or whether concurrent damage to other regulatory structure(s) is necessary to significantly interfere with cognitive processing. In the present study, the immunotoxin 192 IgG-saporin, selectively targeting cholinergic neurons in the basal forebrain and a subpopulation of cerebellar Purkinje cells, was administered to adult rats bilaterally into the basal forebrain nuclei, the cerebellar cortices or both areas combined. Additional animals underwent injections of the toxin into the lateral ventricles. Starting from two–three weeks post-lesion, the animals were tested on paradigms of motor ability as well as spatial learning and memory and then sacrificed for post-mortem morphological analyses. All lesioned rats showed no signs of ataxia and no motor deficits that could impair their performance in the water maze task. The rats with discrete cerebellar lesions exhibited fairly normal performance and did not differ from controls in any aspect of the task. By contrast, animals with double lesions, as well as those with 192 IgG-saporin given intraventricularly did manifest severe impairments in both reference and working memory. Histo- and immunohistochemical analyses confirmed the effects of the toxin conjugate on target neurons and fairly similar patterns of Purkinje cell loss in the animals with cerebellar lesion only, basal forebrain-cerebellar double lesions and bilateral intraventricular injections of the toxin. No such loss was by contrast seen in the basal forebrain-lesioned animals, whose Purkinje cells were largely spared and exhibited a normal distribution pattern. The results suggest important functional interactions between the ascending regulatory inputs from the cerebellum and those arising in the basal forebrain nuclei that would act together to modulate the complex sensory–motor and cognitive processes required to control whole body movement in space. Full article

Palm trees, referred to here as vegetation cover (VC), provide essential ecosystem services in an arid Oasis. However, because of socioeconomic transformation, the rapid urban expansion of major cities and villages at the expense of agricultural lands of the Al-Ahsa Oasis, Saudi Arabia, has placed enormous pressure on the palm-growing area and led to the loss of productive land. These challenges highlight the need for robust, integrative methods to assess their impact on the agroecosystem. Here, we analyze spatiotemporal fluctuations in vegetation cover and its effect on the agroecosystem to determine the potential influencing factors. Data from Landsat satellites, including TM (Thematic mapper of Landsat 5), ETM+ (Enhanced Thematic mapper plus of Landsat 7), and OIL (Landsat 8) and Sentinel-2A imageries were used for analysis, while GeoEye-1 satellite images as well as socioeconomic data were applied for result validation. Principal Component Analysis (PCA) was applied to extract pure endmembers, facilitating Spectral Mixture Analysis (SMA) for mapping vegetation and urban fractions. The spatiotemporal change patterns were analyzed using time- and space-oriented detection algorithms. Results indicated that vegetation fraction patterns differed significantly; pixels with high fraction values declined significantly from 1990 to 2020. The mean vegetation fraction value varied from 0.79 to 0.37. This indicates that a reduction in palm trees was quickly occurring at a decreasing rate of −14.24%. Results also suggest that vegetation fractions decreased significantly between 1990 and 2020, and this decrease had the greatest effect on the agroecosystem situation of the Oasis. We assessed urban sprawl, and our results indicated substantial variability in average urban fractions: 0.208%, 0.247%, 0.699%, and 0.807% in 1990, 2000, 2010, and 2020, respectively. Overall, the data revealed an association between changes in palm tree fractions and urban ones, supporting strategic vegetation and/or agricultural management to enhance the agroecosystem in an arid Oasis. Full article

Prophylactic measures and treatment strategies of implant-related bone and joint infections frequently involve the local delivery of high doses of antimicrobial drugs into the affected bone tissue or articular space in addition to the use of systemic antibiotics. Antibiotic-loaded biomaterials, such as Polymethyl Methacrylate (PMMA) cement, calcium sulfate, calcium phosphate, bioglass, and others, have proven to be clinically effective. However, they suffer from important limitations regarding elution and freedom of choice of admixable antimicrobial drugs. In order to overcome these shortcomings, the techniques of direct intraosseous or intra-articular injection/infusion of antibiotics via needles/cannulas or catheters are gaining popularity. Their attractiveness is based on the potential to achieve extremely high drug concentrations in situ, which can be maintained for as long as the catheters are left in place without increased risks of systemic toxicity. Although these methods are still in an experimental stage, reports on their clinical outcomes look promising. This articles summarizes the knowledge of when, how, and in which clinical settings the different modes and philosophies of local antibiotic delivery work best, with the aim to provide surgeons and infectious disease physicians guidance in clinical practice. This will help to optimize the use for the sake of the patients. Full article

Chrysin (5,7-dihydroxyflavone) is a flavonoid widely distributed in propolis, honey, and various plant sources. It exhibits a wide range of pharmacological activities, including anti-inflammatory, antioxidant, anticancer, antimicrobial, and anti-diabetic effects. However, its clinical translation is hampered by poor aqueous solubility, low bioavailability, and rapid metabolic clearance. To address these limitations and expand the chemical space of this natural scaffold, extensive synthetic efforts have focused on generating structurally diverse chrysin derivatives that possess improved drug-like properties. This review systematically categorizes synthetic methodologies—such as etherification, esterification, transition-metal-mediated couplings, sigmatropic rearrangements, and electrophilic substitutions—and integrates them with corresponding biological outcomes. Particular emphasis is placed on recent (2020–present) advances that directly link structural modifications with pharmacological enhancements, thereby offering comparative structure–activity relationship (SAR) insights. In addition, transition-metal-catalyzed C–C bond-forming reactions are highlighted in a dedicated section, underscoring their growing role in accessing bioactive chrysin analogs previously unattainable by conventional chemistry. Unlike prior reviews that mainly summarized biological activities or broadly covered flavonoid scaffolds, this article bridges synthetic diversification with pharmacological evaluation. It provides both critical synthesis and mechanistic interpretation. Overall, this work consolidates current knowledge and suggests future directions that integrate synthetic innovation with pharmacological validation and address pharmacokinetic challenges in chrysin derivatives. Full article

Border surveillance, as a critical component of national security, places increasingly stringent demands on the target perception capabilities of video monitoring systems, especially in wide-area and complex environments. To address the limitations of existing systems in low-confidence target detection and multi-camera collaboration, this paper proposes a novel visual enhancement method for cooperative control of multiple PTZ (Pan–Tilt–Zoom) cameras based on hierarchical reinforcement learning. The proposed approach establishes a hierarchical framework composed of a Global Planner Agent (GPA) and multiple Local Executor Agents (LEAs). The GPA is responsible for global target assignment, while the LEAs perform fine-grained visual enhancement operations based on the assigned targets. To effectively model the spatial relationships among multiple targets and the perceptual topology of the cameras, a graph-based joint state space is constructed. Furthermore, a graph neural network is employed to extract high-level features, enabling efficient information sharing and collaborative decision-making among cameras. Experimental results in simulation environments demonstrate the superiority of the proposed method in terms of target coverage and visual enhancement performance. Hardware experiments further validate the feasibility and robustness of the approach in real-world scenarios. This study provides an effective solution for multi-camera cooperative surveillance in complex environments. Full article

Resource efficiency is essential in today’s approach to horticulture. The global problems of water scarcity, soil pollution, biodiversity loss, and rapid growth of the global population require increased food production with fewer resources. Resource efficiency is an indicator that allows defining how much biomass an agri-food system can produce per unit of the resource used. Closed hydroponic systems, such as vertical hydroponic towers (VHTs), exhibit high resource efficiency. In these systems, the water use efficiency (WUE) and the nutrient use efficiency (NUE) can be calculated in terms of the water loss through transpiration and the ion concentration in the nutrient solution. The research aimed to determine the WUE and NUE for chard crops in VHT under greenhouse conditions and to evaluate its feasibility as an urban and peri-urban system for leafy vegetable production. Trials were carried out with chard in the fall 2024 in a tunnel-type greenhouse at the facilities of the Autonomous University of San Luis Potosi. The VHTs were built with a 20 L square lower deposit on which a cylindrical pipeline of 11.5 cm in diameter and 1.6 m in height was vertically placed. Each pipe had 45 growing containers distributed on 15 levels of three containers spaced vertically 9 cm and a density of 25 plants·m⁻². The experimental design was completely randomized with three treatments (75, 100, and 125% of Steiner’s nutrient solution) and three replications. The transpiration (Tr) of the crop (recording weight loss in the deposit) and the shoot fresh weight (SFW) of the plants were measured daily using a scale. An ANOVA and Tukey’s test for mean differentiation were performed with p < 0.05. Significant differences were found between treatments for SFW, WUE and NUE obtaining the best results at 75% of Steiner’s nutrient solution. Results show that WUE increased between 3 and 6 times, and NUE between 3 and 12 times compared to chard grown in soil. These results were equal and even higher than horizontal hydroponic systems or vertical farms. Vertical hydroponic closed towers installed in greenhouses are an optimal horticultural production system with high resources use efficiency. The implementation of VHT is feasible in areas where there is water scarcity or have a high population density. Full article

In his 1926 “Criteria of Negro Art,” W.E.B. Du Bois advocates for art’s role in the quest for liberation while acknowledging the challenges facing the creation of Black art, observing, “We can go on the stage; we can be just as funny as white Americans wish us to be; we can play all the sordid parts that America likes to assign to Negroes; but for anything else there is still small place for us.” He elaborates, “As it is now we are handing everything over to a white jury.” Almost 100 years later, the issues Du Bois raises about Black art, the quest for Black freedom, and the structures of white supremacy that stymie this striving remain troublingly relevant for contemporary Shakespearean performance. As scholars have noted, complex challenges (the Shakespeare system, capitalist pressures, etc.) continue to make contemporary American Theater, and Shakespeare within it, “still a small space” for Black artists. In the face of these forces, what can and does resistance look like for Black artists within predominantly white theatrical spaces? Here, I tackle this question, thereby continuing the scholarly interrogation of the relationship between contemporary Shakespeare performance, race, and social justice. I turn to a recent lauded adaptation of Shakespeare that, in its move from local theater to Broadway, inevitably had to engage with the structures of American theater’s (and Shakespeare’s) racial capitalism—James Ijames’s Pulitzer-prize-winning Fat Ham (2021). Fat Ham, I contend, tackles head on the historical racial scripts imposed on Black subjects and, through a range of adaptive moves, exposes and resists them, offering counterscripts that insist on the personal and interpersonal complexity and flourishing of Black subjectivity. Full article

Historic and cultural towns are undergoing spatial restructuring and memory ruptures in the context of urban–rural transformation. Collective memory depends on the continuity of public space, with generational differences playing a key role in its transmission. This study uses Menghe Town in Changzhou, Jiangsu Province, as a case to explore the role of public space in collective memory transmission through interviews, emotional mapping, and intergenerational co-construction analysis. The findings show the following: (1) Interviews and emotional mapping reveal that memories of traditional spaces like farmland have weakened, while emerging public spaces such as squares and walkways have become new memory nodes, reflecting a dynamic “carrying-transformation-reproduction” mechanism. (2) Intergenerational emotional mapping reveals that the transformation of spatial functions has driven the reconstruction of cultural identity, shifting villagers’ sense of place from clan and production-based spaces to modern public spaces. (3) Intergenerational emotional mapping and co-construction analysis reveal significant generational differences in memory perception and spatial use: the older generation relies on ancestral halls and farmland, the middle generation on factories and streets from the “agriculture-to-industry” period, and the younger generation on modern facilities like squares and schools. This study proposes the “Narrate—Preserve—Participate” model, explaining memory transmission across generations and offering insights for intergenerational collaboration and differentiated preservation in public space planning. Full article

In Bayesian analysis, testing for linearity requires placing a prior to the entire space of potential regression functions. This poses a problem for many standard tests, as assigning positive prior probability to such a hypothesis is challenging. The Full Bayesian Significance Test (FBST) sidesteps this issue, standing out for also being logically coherent and offering a measure of evidence against H 0 , although its application to nonparametric settings is still limited. In this work, we use Gaussian process priors to derive FBST procedures that evaluate general linearity assumptions, such as testing the adherence of data and performing variable selection to linear models. We also make use of pragmatic hypotheses to verify if the data might be compatible with a linear model when factors such as measurement errors or utility judgments are accounted for. This contribution extends the theory of the FBST, allowing for its application in nonparametric settings and requiring, at most, simple optimization procedures to reach the desired conclusion. Full article