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Keywords = space systems

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16 pages, 4475 KB  
Article
A Novel Radar Mainlobe Anti-Jamming Method via Space-Time Coding and Blind Source Separation
by Xinyu Ge, Yu Wang, Yangcheng Zheng, Guodong Jin and Daiyin Zhu
Sensors 2025, 25(19), 6081; https://doi.org/10.3390/s25196081 (registering DOI) - 2 Oct 2025
Abstract
This paper proposes a radar mainlobe anti-jamming method based on Space-Time Coding (STC) and Blind Source Separation (BSS). Addressing the performance degradation issue of traditional BSS methods under low Signal-to-Noise Ratio (SNR) and insufficient spatial resolution, this study first establishes the airborne SAR [...] Read more.
This paper proposes a radar mainlobe anti-jamming method based on Space-Time Coding (STC) and Blind Source Separation (BSS). Addressing the performance degradation issue of traditional BSS methods under low Signal-to-Noise Ratio (SNR) and insufficient spatial resolution, this study first establishes the airborne SAR imaging geometric model and the jamming signal mixing model. Subsequently, STC technology is introduced to construct more equivalent phase centers and increase the system’s spatial Degrees of Freedom (DOF). Leveraging the increased DOFs, a JADE-based blind source separation algorithm is then employed to separate the mixed jamming signals. The separation of these signals significantly enhances the anti-jamming capability of the radar system. Simulation results demonstrate that the proposed method effectively improves BSS performance. As compared to traditional BSS schemes, this method provides an additional jamming suppression gain of approximately 10 dB in point target scenarios and about 3 dB in distributed target scenarios, significantly enhancing the radar system’s mainlobe anti-jamming capability in complex jamming environments. This method provides a new insight into radar mainlobe anti-jamming by combining the STC scheme and BSS technology. Full article
(This article belongs to the Special Issue SAR Imaging Technologies and Applications)
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26 pages, 4563 KB  
Article
Personalized Smart Home Automation Using Machine Learning: Predicting User Activities
by Mark M. Gad, Walaa Gad, Tamer Abdelkader and Kshirasagar Naik
Sensors 2025, 25(19), 6082; https://doi.org/10.3390/s25196082 - 2 Oct 2025
Abstract
A personalized framework for smart home automation is introduced, utilizing machine learning to predict user activities and allow for the context-aware control of living spaces. Predicting user activities, such as ‘Watch_TV’, ‘Sleep’, ‘Work_On_Computer’, and ‘Cook_Dinner’, is essential for improving occupant comfort, optimizing energy [...] Read more.
A personalized framework for smart home automation is introduced, utilizing machine learning to predict user activities and allow for the context-aware control of living spaces. Predicting user activities, such as ‘Watch_TV’, ‘Sleep’, ‘Work_On_Computer’, and ‘Cook_Dinner’, is essential for improving occupant comfort, optimizing energy consumption, and offering proactive support in smart home settings. The Edge Light Human Activity Recognition Predictor, or EL-HARP, is the main prediction model used in this framework to predict user behavior. The system combines open-source software for real-time sensing, facial recognition, and appliance control with affordable hardware, including the Raspberry Pi 5, ESP32-CAM, Tuya smart switches, NFC (Near Field Communication), and ultrasonic sensors. In order to predict daily user activities, three gradient-boosting models—XGBoost, CatBoost, and LightGBM (Gradient Boosting Models)—are trained for each household using engineered features and past behaviour patterns. Using extended temporal features, LightGBM in particular achieves strong predictive performance within EL-HARP. The framework is optimized for edge deployment with efficient training, regularization, and class imbalance handling. A fully functional prototype demonstrates real-time performance and adaptability to individual behavior patterns. This work contributes a scalable, privacy-preserving, and user-centric approach to intelligent home automation. Full article
(This article belongs to the Special Issue Sensor-Based Human Activity Recognition)
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24 pages, 5544 KB  
Article
Novel Model Predictive Control Strategies for PMSM Drives: Reducing Computational Burden and Enhancing Real-Time Implementation
by Mohamed Salah, Kotb B. Tawfiq, Arafa S. Mansour and Ahmed Farhan
Machines 2025, 13(10), 908; https://doi.org/10.3390/machines13100908 - 2 Oct 2025
Abstract
Model predictive control (MPC) has emerged as a favorable control approach for PMSM drives, though its practical deployment is frequently hindered by superior computational complexity and execution burden. This paper presents four finite control set MPC (FCS-MPC) techniques applied to a two-level inverter-fed [...] Read more.
Model predictive control (MPC) has emerged as a favorable control approach for PMSM drives, though its practical deployment is frequently hindered by superior computational complexity and execution burden. This paper presents four finite control set MPC (FCS-MPC) techniques applied to a two-level inverter-fed PMSM drive. Two of the approaches are conventional methods, while the other two are novel developed strategies proposed in this paper. The novel techniques focus on significantly decreasing computational burdens by employing an efficient space-vector selection mechanism that quickly selects the optimum switching vector without exhaustive evaluation. A comprehensive comparative assessment of all four control methods is conducted under various operating conditions, evaluating their dynamic and steady-state performance, computational requirements, and real-time feasibility. Simulation results demonstrate that the proposed techniques achieve a significant reduction in computational effort and faster processing, up to 39.65% faster than conventional full-state evaluation, while maintaining control performances comparable to conventional techniques. These results highlight the potential of the proposed MPC approaches to bridge the gap between advanced control theory and practical implementation in real-time PMSM drive systems, providing effective solutions for installing high-performance PMSM drives on hardware with limited resources. Full article
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10 pages, 1464 KB  
Communication
A Signal Detection Method Based on BiGRU for FSO Communications with Atmospheric Turbulence
by Zhenning Yi, Zhiyong Xu, Jianhua Li, Jingyuan Wang, Jiyong Zhao, Yang Su and Yimin Wang
Photonics 2025, 12(10), 980; https://doi.org/10.3390/photonics12100980 - 2 Oct 2025
Abstract
In free space optical (FSO) communications, signals are affected by turbulence when transmitted through the atmosphere. Fluctuations in intensity caused by atmospheric turbulence lead to an increase in the bit error rate of FSO systems. Deep learning (DL), as a current research hotspot, [...] Read more.
In free space optical (FSO) communications, signals are affected by turbulence when transmitted through the atmosphere. Fluctuations in intensity caused by atmospheric turbulence lead to an increase in the bit error rate of FSO systems. Deep learning (DL), as a current research hotspot, offers a promising approach to improve the accuracy of signal detection. In this paper, we propose a signal detection method based on a bidirectional gated recurrent unit (BiGRU) neural network for FSO communications. The proposed detection method considers the temporal correlation of received signals due to the properties of the BiGRU neural network, which is not available in existing detection methods based on DL. In addition, the proposed detection method does not require channel state information (CSI) for channel estimation, unlike maximum likelihood (ML) detection technology with perfect CSI. Numerical results demonstrate that the proposed BiGRU-based detector achieves significant improvements in bit error rate (BER) performance compared with a multilayer perceptron (MLP)-based detector. Specifically, under weak turbulence conditions, the BiGRU-based detector achieves an approximate 2 dB signal-to-noise ratio (SNR) gain at a target BER of 106 compared to the MLP-based detector. Under moderate turbulence conditions, it achieves an approximate 6 dB SNR gain at the same target BER of 106. Under strong turbulence conditions, the proposed detector obtains a 6 dB SNR gain at a target BER of 104. Additionally, it outperforms conventional methods by more than one order of magnitude in BER under the same turbulence and SNR conditions. Full article
(This article belongs to the Section Optical Communication and Network)
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18 pages, 1699 KB  
Article
A Comparative Analysis of Defense Mechanisms Against Model Inversion Attacks on Tabular Data
by Neethu Vijayan, Raj Gururajan and Ka Ching Chan
J. Cybersecur. Priv. 2025, 5(4), 80; https://doi.org/10.3390/jcp5040080 - 2 Oct 2025
Abstract
As more machine learning models are used in sensitive fields like healthcare, finance, and smart infrastructure, protecting structured tabular data from privacy attacks is a key research challenge. Although several privacy-preserving methods have been proposed for tabular data, a comprehensive comparison of their [...] Read more.
As more machine learning models are used in sensitive fields like healthcare, finance, and smart infrastructure, protecting structured tabular data from privacy attacks is a key research challenge. Although several privacy-preserving methods have been proposed for tabular data, a comprehensive comparison of their performance and trade-offs has yet to be conducted. We introduce and empirically assess a combined defense system that integrates differential privacy, federated learning, adaptive noise injection, hybrid cryptographic encryption, and ensemble-based obfuscation. The given strategies are analyzed on the benchmark tabular datasets (ADULT, GSS, FTE), showing that the suggested methods can mitigate up to 50 percent of model inversion attacks in relation to baseline models without decreasing the model utility (F1 scores are higher than 0.85). Moreover, on these datasets, our results match or exceed the latest state-of-the-art (SOTA) in terms of privacy. We also transform each defense into essential data privacy laws worldwide (GDPR and HIPAA), suggesting the best applicable guidelines for the ethical and regulation-sensitive deployment of privacy-preserving machine learning models in sensitive spaces. Full article
(This article belongs to the Section Privacy)
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14 pages, 4629 KB  
Article
Zak-Phase Dislocations in Trimer Lattices
by Tileubek Uakhitov, Abdybek Urmanov, Serik E. Kumekov and Anton S. Desyatnikov
Symmetry 2025, 17(10), 1631; https://doi.org/10.3390/sym17101631 - 2 Oct 2025
Abstract
Wave propagation in periodic media is governed by energy–momentum relations and geometric phases characterizing band topology, such as Zak phase in one-dimensional lattices. We demonstrate that, in the off-diagonal trimer lattices, Zak phase carries quantized screw-type dislocations winding around degeneracies in parameter space. [...] Read more.
Wave propagation in periodic media is governed by energy–momentum relations and geometric phases characterizing band topology, such as Zak phase in one-dimensional lattices. We demonstrate that, in the off-diagonal trimer lattices, Zak phase carries quantized screw-type dislocations winding around degeneracies in parameter space. If the lattice evolves in time periodically, as in adiabatic Thouless pumps, the corresponding closed trajectory in parameter space is characterized by a Chern number equal to the negative total winding number of Zak phase dislocations enclosed by the trajectory. We discuss the correspondence between bulk Chern numbers and the edge states in a finite system evolving along various pumping cycles. Full article
(This article belongs to the Special Issue Symmetry/Asymmetry in Topological Phases)
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13 pages, 1900 KB  
Article
Simulation-Based Design of a Silicon SPAD with Dead-Space-Aware Avalanche Region for Picosecond-Resolved Detection
by Meng-Jey Youh, Hsin-Liang Chen, Nen-Wen Pu, Mei-Lin Liu, Yu-Pin Chou, Wen-Ken Li and Yi-Ping Chou
Sensors 2025, 25(19), 6054; https://doi.org/10.3390/s25196054 - 2 Oct 2025
Abstract
This study presents a simulation-based design of a silicon single-photon avalanche diode (SPAD) optimized for picosecond-resolved photon detection. Utilizing COMSOL Multiphysics, we implement a dead-space-aware impact ionization model to accurately capture history-dependent avalanche behavior. A guard ring structure and tailored doping profiles are [...] Read more.
This study presents a simulation-based design of a silicon single-photon avalanche diode (SPAD) optimized for picosecond-resolved photon detection. Utilizing COMSOL Multiphysics, we implement a dead-space-aware impact ionization model to accurately capture history-dependent avalanche behavior. A guard ring structure and tailored doping profiles are introduced to improve electric field confinement and suppress edge breakdown. Simulation results show that the optimized device achieves a peak electric field of 7 × 107 V/m, a stable gain slope of −0.414, and consistent avalanche triggering across bias voltages. Transient analysis further confirms sub-20 ps response time under −6.5 V bias, validated by a full-width at half-maximum (FWHM) of ~17.8 ps. Compared to conventional structures without guard rings, the proposed design exhibits enhanced breakdown localization, reduced gain sensitivity, and improved timing response. These results highlight the potential of the proposed SPAD for integration into next-generation quantum imaging, time-of-flight LiDAR, and high-speed optical communication systems. Full article
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28 pages, 6579 KB  
Article
Mathematical Modeling and Optimization of a Two-Layer Metro-Based Underground Logistics System Network: A Case Study of Nanjing
by Jianping Yang, An Shi, Rongwei Hu, Na Xu, Qing Liu, Luxing Qu and Jianbo Yuan
Sustainability 2025, 17(19), 8824; https://doi.org/10.3390/su17198824 - 1 Oct 2025
Abstract
With the surge in urban logistics demand, traditional surface transportation faces challenges, such as traffic congestion and environmental pollution. Leveraging metro systems in metropolitan areas for both passenger commuting and underground logistics presents a promising solution. The metro-based underground logistics system (M-ULS), characterized [...] Read more.
With the surge in urban logistics demand, traditional surface transportation faces challenges, such as traffic congestion and environmental pollution. Leveraging metro systems in metropolitan areas for both passenger commuting and underground logistics presents a promising solution. The metro-based underground logistics system (M-ULS), characterized by extensive coverage and independent right-of-way, has emerged as a potential approach for optimizing urban freight transport. However, existing studies primarily focus on single-line scenarios, lacking in-depth analyses of multi-tier network coordination and dynamic demand responsiveness. This study proposes an optimization framework based on mixed-integer programming and an improved ICSA to address three key challenges in metro freight network planning: balancing passenger and freight demand, optimizing multi-tier node layout, and enhancing computational efficiency for large-scale problem solving. By integrating E-TOPSIS for demand assessment and an adaptive mutation mechanism based on a normal distribution, the solution space is reduced from five to three dimensions, significantly improving algorithm convergence and global search capability. Using the Nanjing metro network as a case study, this research compares the optimization performance of independent line and transshipment-enabled network scenarios. The results indicate that the networked scenario (daily cost: CNY 1.743 million) outperforms the independent line scenario (daily cost: CNY 1.960 million) in terms of freight volume (3.214 million parcels/day) and road traffic alleviation rate (89.19%). However, it also requires a more complex node configuration. This study provides both theoretical and empirical support for planning high-density urban underground logistics systems, demonstrating the potential of multimodal transport networks and intelligent optimization algorithms. Full article
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22 pages, 7838 KB  
Article
Bifurcation Analysis and Solitons Dynamics of the Fractional Biswas–Arshed Equation via Analytical Method
by Asim Zafar, Waseem Razzaq, Abdullah Nazir, Mohammed Ahmed Alomair, Abdulaziz S. Al Naim and Abdulrahman Alomair
Mathematics 2025, 13(19), 3147; https://doi.org/10.3390/math13193147 - 1 Oct 2025
Abstract
This paper investigates soliton solutions of the time-fractional Biswas–Arshed (BA) equation using the Extended Simplest Equation Method (ESEM). The model is analyzed under two distinct fractional derivative operators: the β-derivative and the M-truncated derivative. These approaches yield diverse solution types, including [...] Read more.
This paper investigates soliton solutions of the time-fractional Biswas–Arshed (BA) equation using the Extended Simplest Equation Method (ESEM). The model is analyzed under two distinct fractional derivative operators: the β-derivative and the M-truncated derivative. These approaches yield diverse solution types, including kink, singular, and periodic-singular forms. Also, in this work, a nonlinear second-order differential equation is reconstructed as a planar dynamical system in order to study its bifurcation structure. The stability and nature of equilibrium points are established using a conserved Hamiltonian and phase space analysis. A bifurcation parameter that determines the change from center to saddle-type behaviors is identified in the study. The findings provide insight into the fundamental dynamics of nonlinear wave propagation by showing how changes in model parameters induce qualitative changes in the phase portrait. The derived solutions are depicted via contour plots, along with two-dimensional (2D) and three-dimensional (3D) representations, utilizing Mathematica for computational validation and graphical illustration. This study is motivated by the growing role of fractional calculus in modeling nonlinear wave phenomena where memory and hereditary effects cannot be captured by classical integer-order approaches. The time-fractional Biswas–Arshed (BA) equation is investigated to obtain diverse soliton solutions using the Extended Simplest Equation Method (ESEM) under the β-derivative and M-truncated derivative operators. Beyond solution construction, a nonlinear second-order equation is reformulated as a planar dynamical system to analyze its bifurcation and stability properties. This dual approach highlights how parameter variations affect equilibrium structures and soliton behaviors, offering both theoretical insights and potential applications in physics and engineering. Full article
14 pages, 3885 KB  
Article
A Novel Desired-State-Based Car-Following Model for Describing Asymmetric Acceleration and Deceleration Phenomena
by Han Xing and Gangqiao Wang
Appl. Sci. 2025, 15(19), 10650; https://doi.org/10.3390/app151910650 - 1 Oct 2025
Abstract
This paper addresses the modeling challenge of significant asymmetry between acceleration and deceleration processes in car-following behavior by proposing an Asymmetric Acceleration and Deceleration Car Following (AAD-CF) model. The model characterizes driving decisions using both desired speed and desired spacing, and incorporates an [...] Read more.
This paper addresses the modeling challenge of significant asymmetry between acceleration and deceleration processes in car-following behavior by proposing an Asymmetric Acceleration and Deceleration Car Following (AAD-CF) model. The model characterizes driving decisions using both desired speed and desired spacing, and incorporates an asymmetric correction factor to capture differences in acceleration and deceleration behavior. Based on real vehicle trajectory data from the I-80 dataset, the model was compared at the microscopic level against classical models such as Gipps in terms of trajectory fitting error. The results show that the AAD-CF model consistently achieves lower trajectory fitting errors across different simulation time-steps, with error reduction exceeding 10%. At the macroscopic traffic flow level, the model successfully reproduced three-phase traffic flow states—free flow, synchronized flow, and wide moving jams. By implementing both startup and emergency braking scenarios, it was further revealed that braking waves propagate approximately 40% faster than startup waves, demonstrating asymmetric wave propagation. This study provides quantitative evidence for understanding the intrinsic relationship between microscopic driving behavior and macroscopic traffic phenomena, and the proposed model can support traffic simulation systems and theoretical analysis. Full article
(This article belongs to the Section Transportation and Future Mobility)
21 pages, 4247 KB  
Article
Diverging Carbon Balance and Driving Mechanisms of Expanding and Shrinking Cities in Transitional China
by Jiawei Lei, Keyu Luo, Le Xia and Zhenyu Wang
Atmosphere 2025, 16(10), 1155; https://doi.org/10.3390/atmos16101155 - 1 Oct 2025
Abstract
The synergy between carbon neutrality and urbanization is essential for effective climate governance and socio-ecological intelligent transition. From the perspective of coupled urban dynamic evolution and carbon metabolism systems, this study integrates the Sen-MK trend test and the geographical detector model to explore [...] Read more.
The synergy between carbon neutrality and urbanization is essential for effective climate governance and socio-ecological intelligent transition. From the perspective of coupled urban dynamic evolution and carbon metabolism systems, this study integrates the Sen-MK trend test and the geographical detector model to explore the spatial–temporal differentiation patterns and driving mechanisms of carbon balance across 337 prefecture-level cities in China from 2012 to 2022. The results reveal a spatial–temporal mismatch between carbon emissions and carbon storage, forming an asymmetric carbon metabolism pattern characterized by “expansion-dominated and shrinkage-dissipative” dynamics. Carbon compensation rates exhibit a west–high to east–low gradient distribution, with hotspots of expansionary cities clustered in the southwest, while shrinking cities display a dispersed pattern from the northwest to the northeast. Based on the four-quadrant carbon balance classification, expansionary cities are mainly located in the “high economic–low ecological” quadrant, whereas shrinking cities concentrate in the “low economic–high ecological” quadrant. Industrial structure and population scale serve as the dual-core drivers of carbon compensation. Expansionary cities are positively regulated by urbanization rates, while shrinking cities are negatively constrained by energy intensity. These findings suggest that differentiated regulation strategies can help optimize carbon governance within national territorial space. Full article
(This article belongs to the Section Air Quality)
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27 pages, 2788 KB  
Review
From Trust in Automation to Trust in AI in Healthcare: A 30-Year Longitudinal Review and an Interdisciplinary Framework
by Kelvin K. L. Wong, Yong Han, Yifeng Cai, Wumin Ouyang, Hemin Du and Chao Liu
Bioengineering 2025, 12(10), 1070; https://doi.org/10.3390/bioengineering12101070 - 1 Oct 2025
Abstract
Human–machine trust has shifted over the past three decades from trust in automation to trust in AI, while research paradigms, disciplines, and problem spaces have expanded. Centered on AI in healthcare, this narrative review offers a longitudinal synthesis that traces and compares phase-specific [...] Read more.
Human–machine trust has shifted over the past three decades from trust in automation to trust in AI, while research paradigms, disciplines, and problem spaces have expanded. Centered on AI in healthcare, this narrative review offers a longitudinal synthesis that traces and compares phase-specific changes in theory and method, providing design guidance for human-AI systems at different stages of maturity. From a cross-disciplinary view, we introduce an Interdisciplinary Human-AI Trust Research (I-HATR) framework that aligns explainable AI (XAI) with human–computer interaction/human factors engineering (HCI/HFE). We distill three core categories of determinants of human-AI trust in healthcare, user characteristics, AI system attributes, and contextual factors, and summarize the main measurement families and their evolution from self-report to behavioral and psychophysiological approaches, with growing use of multimodal and dynamic evaluation. Finally, we outline key trends, opportunities, and practical challenges to support the development of human-centered, trustworthy AI in healthcare, emphasizing the need to bridge actual trustworthiness and perceived trust through shared metrics, uncertainty communication, and trust calibration. Full article
32 pages, 9204 KB  
Article
Unveiling Hidden Green Corridors: An Agent-Based Simulation (ABS) of Urban Green Continuity for Ecosystem Services and Climate Resilience
by Tao Dong, Massimo Tadi and Solomon Tamiru Tesfaye
Smart Cities 2025, 8(5), 163; https://doi.org/10.3390/smartcities8050163 - 1 Oct 2025
Abstract
Urban green spaces are essential for mitigating the heat island effect, supporting ecosystem services, and maintaining biodiversity. The distribution, fragmentation, and connection of the green spaces significantly impact the behavior of species in cities, serving as key indicators of environmental resilience and ecological [...] Read more.
Urban green spaces are essential for mitigating the heat island effect, supporting ecosystem services, and maintaining biodiversity. The distribution, fragmentation, and connection of the green spaces significantly impact the behavior of species in cities, serving as key indicators of environmental resilience and ecological benefits. However, current studies, as well as planning standards, often prioritize green spaces independently through their coverage or density, overlooking the importance of continuity and its impact on thermal regulation and accessibility. In this research, urban “hidden green corridors” refer to the unrecognized but functionally significant pathways that link fragmented green spaces through ecological behaviors, which enhance both biological and human habitats. This research focuses on developing an agent-based simulation (ABS) model based on the Physarealm plugin in Rhino, which can assess the effectiveness of these hidden corridors in different urban settings by integrating geographic information systems (GIS) and space syntax. Based on three case studies in Italy (Lambrate District, Bolognina, and Ispra), the simulation results are further interpreted through the AI agentic workflow “SOFIA”, developed by IMM Design Lab, Politecnico di Milano, and compared using manual analysis as well as mainstream large language models (ChatGPT 4.0 Web). The findings indicate that the “hidden green corridors” are essential for urban heat reduction, enhancement of urban biodiversity, and strengthening ecological flows. Full article
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19 pages, 944 KB  
Article
Robust Optimization for IRS-Assisted SAGIN Under Channel Uncertainty
by Xu Zhu, Litian Kang and Ming Zhao
Future Internet 2025, 17(10), 452; https://doi.org/10.3390/fi17100452 - 1 Oct 2025
Abstract
With the widespread adoption of space–air–ground integrated networks (SAGINs) in next-generation wireless communications, intelligent reflecting surfaces (IRSs) have emerged as a key technology for enhancing system performance through passive link reinforcement. This paper addresses the prevalent issue of channel state information (CSI) uncertainty [...] Read more.
With the widespread adoption of space–air–ground integrated networks (SAGINs) in next-generation wireless communications, intelligent reflecting surfaces (IRSs) have emerged as a key technology for enhancing system performance through passive link reinforcement. This paper addresses the prevalent issue of channel state information (CSI) uncertainty in practical systems by constructing an IRS-assisted multi-hop SAGIN communication model. To capture the performance degradation caused by channel estimation errors, a norm-bounded uncertainty model is introduced. A simulated annealing (SA)-based phase optimization algorithm is proposed to enhance system robustness and improve worst-case communication quality. Simulation results demonstrate that the proposed method significantly outperforms traditional multiple access strategies (SDMA and NOMA) under various user densities and perturbation levels, highlighting its stability and scalability in complex environments. Full article
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34 pages, 5208 KB  
Article
Setting Up Our Lab-in-a-Box: Paving the Road Towards Remote Data Collection for Scalable Personalized Biometrics
by Mona Elsayed, Jihye Ryu, Joseph Vero and Elizabeth B. Torres
J. Pers. Med. 2025, 15(10), 463; https://doi.org/10.3390/jpm15100463 - 1 Oct 2025
Abstract
Background: There is an emerging need for new scalable behavioral assays, i.e., assays that are feasible to administer from the comfort of the person’s home, with ease and at higher frequency than clinical visits or visits to laboratory settings can afford us today. [...] Read more.
Background: There is an emerging need for new scalable behavioral assays, i.e., assays that are feasible to administer from the comfort of the person’s home, with ease and at higher frequency than clinical visits or visits to laboratory settings can afford us today. This need poses several challenges which we address in this work along with scalable solutions for behavioral data acquisition and analyses aimed at diversifying various populations under study here and to encourage citizen-driven participatory models of research and clinical practices. Methods: Our methods are centered on the biophysical fluctuations unique to the person and on the characterization of behavioral states using standardized biorhythmic time series data (from kinematic, electrocardiographic, voice, and video-based tools) in naturalistic settings, outside a laboratory environment. The methods are illustrated with three representative studies (58 participants, 8–70 years old, 34 males, 24 females). Data is presented across the nervous systems under a proposed functional taxonomy that permits data organization according to nervous systems’ maturation and decline levels. These methods can be applied to various research programs ranging from clinical trials at home, to remote pedagogical settings. They are aimed at creating new standardized biometric scales to screen and diagnose neurological disorders across the human lifespan. Results: Using this remote data collection system under our new unifying statistical platform for individualized behavioral analysis, we characterize the digital ranges of biophysical signals of neurotypical participants and report departure from normative ranges in neurodevelopmental and neurodegenerative disorders. Each study provides parameter spaces with self-emerging clusters whereby data points corresponding to a cluster are probability distribution parameters automatically classifying participants into different continuous Gamma probability distribution families. Non-parametric analysis reveals significant differences in distributions’ shape and scale (p < 0.01). Data reduction is realizable from full probability distribution families to a single parameter, the Gamma scale, amenable to represent each participant within each subclass, and each cluster of similar participants within each cohort. We report on data integration from stochastic analyses that serve to differentiate participants and propose new ways to highly scale our research, education, and clinical practices. Conclusions: This work highlights important methodological and analytical techniques for developing personalized and scalable biometrics across various populations outside a laboratory setting. Full article
(This article belongs to the Special Issue Personalized Medicine in Neuroscience: Molecular to Systems Approach)
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