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Search Results (216)

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Keywords = stiffness gradient

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32 pages, 3156 KB  
Article
Magneto-Hygrothermal Deformation of FG Nanocomposite Annular Sandwich Nanoplates with Porous Core Using the DQM
by Fatemah H. H. Al Mukahal, Mohammed Sobhy and Aamna H. K. Al-Ali
Crystals 2025, 15(9), 827; https://doi.org/10.3390/cryst15090827 - 20 Sep 2025
Viewed by 230
Abstract
This study introduces a novel numerical approach to analyze the axisymmetric bending behavior of functionally graded (FG) graphene platelet (GPL)-reinforced annular sandwich nanoplates featuring a porous core. The nanostructures are exposed to coupled magnetic and hygrothermal environments. The porosity distribution and GPL weight [...] Read more.
This study introduces a novel numerical approach to analyze the axisymmetric bending behavior of functionally graded (FG) graphene platelet (GPL)-reinforced annular sandwich nanoplates featuring a porous core. The nanostructures are exposed to coupled magnetic and hygrothermal environments. The porosity distribution and GPL weight fraction are modeled as nonlinear functions through the thickness, capturing realistic gradation effects. The governing equations are derived using the virtual displacement principle, taking into account the Lorentz force and the interaction with an elastic foundation. To address the size-dependent behavior and thickness-stretching effects, the model employs the nonlocal strain gradient theory (NSGT) integrated with a modified version of Shimpi’s quasi-3D higher-order shear deformation theory (Q3HSDT). The differential quadrature method (DQM) is applied to obtain numerical solutions for the displacement and stress fields. A detailed parametric study is conducted to investigate the influence of various physical and geometric parameters, including the nonlocal parameter, strain gradient length scale, magnetic field strength, thermal effects, foundation stiffness, core thickness, and radius-to-thickness ratio. The findings support the development of smart, lightweight, and thermally adaptive nano-electromechanical systems (NEMS) and provide valuable insights into the mechanical performance of FG-GPL sandwich nanoplates. These findings have potential applications in transducers, nanosensors, and stealth technologies designed for ultrasound and radar detection. Full article
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21 pages, 3628 KB  
Article
Uncertainty Propagation for Power-Law, Bingham, and Casson Fluids: A Comparative Stochastic Analysis of a Class of Non-Newtonian Fluids in Rectangular Ducts
by Eman Alruwaili and Osama Hussein Galal
Mathematics 2025, 13(18), 3030; https://doi.org/10.3390/math13183030 - 19 Sep 2025
Viewed by 149
Abstract
This study presents a novel framework for uncertainty propagation in power-law, Bingham, and Casson fluids through rectangular ducts under stochastic viscosity (Case I) and pressure gradient conditions (Case II). Using the computationally efficient Stochastic Finite Difference Method with Homogeneous Chaos (SFDHC), validated via [...] Read more.
This study presents a novel framework for uncertainty propagation in power-law, Bingham, and Casson fluids through rectangular ducts under stochastic viscosity (Case I) and pressure gradient conditions (Case II). Using the computationally efficient Stochastic Finite Difference Method with Homogeneous Chaos (SFDHC), validated via comparison with quasi-Monte Carlo simulations, we demonstrate significantly lower computational costs across varying Coefficients of Variation (COVs). For viscosity uncertainty (Case I), results show a 0.54–2.8% increase in mean maximum velocity with standard deviations reaching 75.3–82.5% of the COV, where the power-law model exhibits the greatest sensitivity (velocity variations spanning 71.2–177.3% of the mean at COV = 20%). Pressure gradient uncertainty (Case II) preserves mean velocities but produces narrower and symmetric distributions. We systematically evaluate the effects of aspect ratio, yield stress, and flow behavior index on the stochastic velocity response of each fluid. Moreover, our analysis pioneers a performance hierarchy: Herschel–Bulkley fluids show the highest mean and standard deviation of maximum velocity, followed by power-law, Robertson–Stiff, Bingham, and Casson models. A key finding is the extreme fluctuation of the Robertson–Stiff model, which exhibits the most drastic deviations, reaching up to 177% of the average velocity. The significance of fluid-specific stochastic analysis in duct system design is underscored by these results. This is especially critical for non-Newtonian flows, where system performance and reliability are greatly impacted by uncertainties in viscosity and pressure gradient, which reflect actual operational variations. Full article
(This article belongs to the Section E: Applied Mathematics)
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32 pages, 1551 KB  
Article
Free Vibration Analysis of Porous FGM Plates on Elastic Foundations with Temperature-Dependent Material Properties
by Aleksandar Radaković, Dragan Čukanović, Aleksandar Nešović, Petar Knežević, Milan T. Djordjević and Gordana Bogdanović
Mathematics 2025, 13(18), 2957; https://doi.org/10.3390/math13182957 - 12 Sep 2025
Viewed by 283
Abstract
This study investigates the free vibration behaviors of functionally graded (FGM) plates with a porous structure, resting on a Kerr-type elastic foundation, while accounting for thermal effects and complex material property distributions. Within the framework of higher-order shear deformation theory (HSDT), two novel [...] Read more.
This study investigates the free vibration behaviors of functionally graded (FGM) plates with a porous structure, resting on a Kerr-type elastic foundation, while accounting for thermal effects and complex material property distributions. Within the framework of higher-order shear deformation theory (HSDT), two novel shape functions are introduced to accurately model transverse shear deformation across the plate thickness without employing shear correction factors. These functions are constructed to satisfy shear stress boundary conditions and capture nonlinear effects induced by material gradation and porosity. A variational formulation is developed to describe the dynamic response of FGM plates in a thermo-mechanical environment, incorporating temperature-dependent material properties and three porosity distributions: uniform, linear, and trigonometric. Numerical solutions are obtained using in-house MATLAB codes, allowing complete control over the formulation and interpretation of the results. The model is validated through detailed comparisons with existing literature, demonstrating high accuracy. The findings reveal that the porosity distribution pattern and gradient intensity significantly influence natural frequencies and mode shapes. The trigonometric porosity distribution exhibits favorable dynamic performance due to preserved stiffness in the surface regions. Additionally, the Kerr-type elastic foundation enables fine tuning of the dynamic response, depending on its specific parameters. The proposed approach provides a reliable and efficient tool for analyzing FGM structures under complex loading conditions and lays the groundwork for future extensions involving nonlinear, time-dependent, and multiphysics analyses. Full article
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23 pages, 6464 KB  
Article
Mechanistic Analysis of Textured IEL and Meshing ASLBC Synergy in Heavy Loads: Characterizing Predefined Micro-Element Configurations
by Jiafu Ruan, Xigui Wang, Yongmei Wang and Weiqiang Zou
Machines 2025, 13(9), 842; https://doi.org/10.3390/machines13090842 - 11 Sep 2025
Viewed by 225
Abstract
Friction contact regulation has been widely acknowledged, yet research on micro-textured meshing interfaces appears to have reached an impasse. Conventional wisdom holds that the similarity of micro-element configurations is the key factor contributing to textured interface issues. The traditional perception is transcended, and [...] Read more.
Friction contact regulation has been widely acknowledged, yet research on micro-textured meshing interfaces appears to have reached an impasse. Conventional wisdom holds that the similarity of micro-element configurations is the key factor contributing to textured interface issues. The traditional perception is transcended, and a novel method for presetting the optimal parameters of gradientized micro-textured interface elements is proposed. The study has analyzed the Interface Enriched Lubrication (IEL) performance and meshing Anti-Scuffing Load-Bearing Capacity (ASLBC) of periodic symmetrical and continuously gradient micro-elements. By actively regulating IEL behavior through geometric constraint effects, dynamic micro-cavity lubrication storage units are formed, thereby extending the retention time of medium film layers. The textured edges induce micro-vortices, delaying scuffing failures induced by load-bearing. Validation analyses demonstrate that optimal micro-element configurations can distribute contact stress to achieve stress homogenization, with the maximum contact stress reduced by 21%. The localized hydrodynamic effect of micro-textured elements increases interfacial meshing stiffness by 5.32% while decreasing friction torque by 27.3%. This investigation reveals a synergistic mechanism between IEL performance and meshing ASLBC under heavy loads conditions. The findings confirm that gradient-based micro-textured element configuration presetting offers an effective solution to reconcile the inherent trade-off between lubrication and load-bearing performance in heavy loads applications. Full article
(This article belongs to the Section Friction and Tribology)
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22 pages, 7255 KB  
Article
Multi-Objective Optimization and ML-Driven Sustainability Mechanical Performance Enhancement of Trenchless Spiral Wound Lining Rehabilitation
by Siying Zhang, Kangfu Sun, Shaoqing Peng, Zongyuan Zhang and Jingguo Cao
Sustainability 2025, 17(18), 8109; https://doi.org/10.3390/su17188109 - 9 Sep 2025
Viewed by 356
Abstract
Addressing safety, environmental, and economic challenges associated with aging urban underground pipeline infrastructure, this study develops an integrated multi-objective optimization framework for sustainable trenchless spiral wound lining (SWL) rehabilitation. The framework integrates machine learning (ML)-driven predictive modeling with structural performance enhancement technologies to [...] Read more.
Addressing safety, environmental, and economic challenges associated with aging urban underground pipeline infrastructure, this study develops an integrated multi-objective optimization framework for sustainable trenchless spiral wound lining (SWL) rehabilitation. The framework integrates machine learning (ML)-driven predictive modeling with structural performance enhancement technologies to advance urban infrastructure management. To enhance the mechanical performance of SWL liners, a multi-objective structural optimization was conducted to systematically examine the impact of strip profile cross-sectional parameters on ring stiffness (Sp), material consumption (V), and total strip profile height (H). ANSYS finite element analysis was employed to conduct numerical simulations of ring stiffness tests for various liner structures, and Sp was calculated based on the resultant loading force (F). Random Forest (RF), Support Vector Regression (SVR), and Extreme Gradient Boosting (XGBoost) were evaluated for predicting F and V. The results demonstrated that the SVR model achieved high accuracy in predicting F (R2 = 0.9873), while the XGBoost model exhibited excellent performance in predicting V (R2 = 0.97). Using the Non-dominated Sorting Genetic Algorithm II (NSGA-II), multi-objective optimization of the SWL liner was performed, yielding an optimized liner that showed a 24.46% improvement in Sp with only a 1.82% increase in V. The established predictive formula for SWL liner Sp increments (R2 = 0.9874) provides an efficient tool for structural optimization, offering important technical support and a theoretical foundation for sustainable urban pipeline infrastructure management. Full article
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11 pages, 692 KB  
Article
High-Intensity Physical Activity During Late Adolescence Predicts Young Adult CT-Based Finite Element Bone Strength in Emerging Adulthood: Iowa Bone Development Study
by Soyang Kwon, Kathleen F. Janz, Indranil Guha, Alex V. Rowlands, Oscar Rysavy, Punam K. Saha, Chandler Pendleton, Euisung D. Shin and Steven M. Levy
Children 2025, 12(9), 1204; https://doi.org/10.3390/children12091204 - 9 Sep 2025
Viewed by 373
Abstract
Objective: This study investigated associations between physical activity (PA) during late adolescence and emerging adulthood and bone strength in emerging adulthood by utilizing advanced finite element analysis of computed tomography (CT/FEA) technology beyond the traditional dual-energy X-ray absorptiometry (DXA) method. Methods: This study [...] Read more.
Objective: This study investigated associations between physical activity (PA) during late adolescence and emerging adulthood and bone strength in emerging adulthood by utilizing advanced finite element analysis of computed tomography (CT/FEA) technology beyond the traditional dual-energy X-ray absorptiometry (DXA) method. Methods: This study included 266 participants (152 females) from the Iowa Bone Development Study. PA volume (average acceleration) and intensity (intensity gradient) metrics were calculated from ActiGraph accelerometer data collected at ages 17, 19, 21, and 23 years. Compressive modulus and compressive stiffness of the tibia were estimated at age 23 via CT/FEA of the tibia. Sex-specific linear regression models were used to evaluate associations between PA metrics and bone outcomes, adjusting for age, height, weight, musculoskeletal fitness, and calcium intake. Results: Intensity gradient averaged over 17–23 years of age was positively associated with compressive stiffness at age 23 years in both females and males (p < 0.01). Intensity gradient was positively associated with compressive modulus in females (p < 0.01), but not in males. No significant associations were found between average acceleration and either compressive stiffness or modulus in either sex (p > 0.05). Conclusions: Using a state-of-the-art CT/FEA method, this study suggests that high-intensity PA during late adolescence and emerging adulthood improves bone strength. Full article
(This article belongs to the Special Issue Physical Fitness and Health in Adolescents)
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23 pages, 6823 KB  
Article
A Thermo-Mechanical Coupled Gradient Damage Model for Heterogeneous Rocks Based on the Weibull Distribution
by Juan Jin, Ying Zhou, Hua Long, Shijun Chen, Hanwei Huang, Jiandong Liu and Wei Cheng
Energies 2025, 18(17), 4699; https://doi.org/10.3390/en18174699 - 4 Sep 2025
Viewed by 664
Abstract
This study develops a thermo-mechanical damage (TMD) model for predicting damage evolution in heterogeneous rock materials after heat treatment. The TMD model employs a Weibull distribution to characterize the spatial heterogeneity of the mechanical properties of rock materials and develops a framework that [...] Read more.
This study develops a thermo-mechanical damage (TMD) model for predicting damage evolution in heterogeneous rock materials after heat treatment. The TMD model employs a Weibull distribution to characterize the spatial heterogeneity of the mechanical properties of rock materials and develops a framework that incorporates thermal effects into a nonlocal gradient damage model, thereby overcoming the mesh dependency issue inherent in homogeneous local damage models. The model is validated by numerical simulations of a notched cruciform specimen subjected to combined mechanical and thermal loading, confirming its capability in thermo-mechanical coupled scenarios. Sensitivity analysis shows increased material heterogeneity promotes localized, X-shaped shear-dominated failure patterns, while lower heterogeneity produces more diffuse, network-like damage distributions. Furthermore, the results demonstrate that thermal loading induces micro-damage that progressively spreads throughout the specimen, resulting in a significant reduction in both overall stiffness and critical strength; this effect becomes increasingly pronounced at higher heating temperatures. These findings demonstrate the model’s ability to predict the mechanical behavior of heterogeneous rock materials under thermal loading, offering valuable insights for safety assessments in high-temperature geotechnical engineering applications. Full article
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26 pages, 12355 KB  
Review
Nature-Inspired Gradient Material Structure with Exceptional Properties for Automotive Parts
by Xunchen Liu, Wenxuan Wang, Yingchao Zhao, Haibo Wu, Si Chen and Lanxin Wang
Materials 2025, 18(17), 4069; https://doi.org/10.3390/ma18174069 - 30 Aug 2025
Viewed by 460
Abstract
Inspired by natural gradient structures observed in biological systems such as lobster exoskeletons and bamboo, this study proposes a biomimetic strategy for developing advanced automotive materials that achieve an optimal balance between strength and ductility. Against this backdrop, the present work systematically reviews [...] Read more.
Inspired by natural gradient structures observed in biological systems such as lobster exoskeletons and bamboo, this study proposes a biomimetic strategy for developing advanced automotive materials that achieve an optimal balance between strength and ductility. Against this backdrop, the present work systematically reviews the design principles underlying natural gradient structures and examines the advantages and limitations of current additive manufacturing—specifically selective laser melting (AM-SLM)—as well as conventional forming and machining processes, in fabricating nature-inspired architectures. The research systematically explores hierarchical gradient designs which endow materials with superior mechanical properties, including enhanced strength, stiffness, and energy absorption capabilities. Two primary strengthening mechanisms—hetero-deformation-induced (HDI) hardening and precipitation hardening—were employed to overcome the conventional strength–ductility trade-off. Gradient-structured materials were fabricated using selective laser melting, and microstructural analyses demonstrated that controlled interface zones and tailored precipitation distribution critically influence property improvements. Based on these findings, an integrated material design strategy combining nature-inspired gradient architectures with post-processing treatments is presented, providing a versatile methodology to meet the specific performance requirements of automotive components. Overall, this work offers new insights for developing next-generation lightweight structural materials with exceptional ductility and damage tolerance and establishes a framework for translating bioinspired concepts into practical engineering solutions. Full article
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22 pages, 10237 KB  
Article
Mechanical Properties and Energy Absorption Characteristics of the Fractal Structure of the Royal Water Lily Leaf Under Quasi-Static Axial Loading
by Zhanhong Guo, Zhaoyang Wang, Weiguang Fan, Hailong Yu and Meng Zou
Fractal Fract. 2025, 9(9), 566; https://doi.org/10.3390/fractalfract9090566 - 28 Aug 2025
Viewed by 481
Abstract
Inspired by the self-organizing optimization mechanisms in nature, the leaf venation of the royal water lily exhibits a hierarchically branched fractal network that combines excellent mechanical performance with lightweight characteristics. In this study, a structural bionic approach was adopted to systematically investigate the [...] Read more.
Inspired by the self-organizing optimization mechanisms in nature, the leaf venation of the royal water lily exhibits a hierarchically branched fractal network that combines excellent mechanical performance with lightweight characteristics. In this study, a structural bionic approach was adopted to systematically investigate the venation architecture through macroscopic morphological observation, experimental testing, 3D scanning-based reverse reconstruction, and finite element simulation. The influence of key fractal geometric parameters under vertical loading on the mechanical behavior and energy absorption capacity was analyzed. The results demonstrate that the leaf venation of the royal water lily exhibits a core-to-margin gradient fractal pattern, with vein thickness linearly decreasing along the radial direction. At each hierarchical bifurcation, the vein width is reduced to 65–75% of the preceding level, while the bifurcation angle progressively increases with branching order. During leaf development, the fractal dimension initially decreases and then increases, indicating a coordinated functional adaptation between the stiff central trunk and the compliant peripheral branches. The veins primarily follow curved trajectories and form a multidirectional interwoven network, effectively extending the energy dissipation path. Finite element simulations reveal that the fractal venation structure of the royal water lily exhibits pronounced nonlinear stiffness behavior. A smaller bifurcation angle and higher fractal branching level contribute to enhanced specific energy absorption and average load-bearing capacity. Moreover, a moderate branching length ratio enables a favorable balance between yield stiffness, ultimate strength, and energy dissipation. These findings highlight the synergistic optimization between energy absorption characteristics and fractal geometry, offering both theoretical insights and bioinspired strategies for the design of impact-resistant structures. Full article
(This article belongs to the Special Issue Fractal Mechanics of Engineering Materials, 2nd Edition)
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28 pages, 44995 KB  
Article
Constitutive Modeling of Coal Gangue Concrete with Integrated Global–Local Explainable AI and Finite Element Validation
by Xuehong Dong, Guanghong Xiong, Xiao Guan and Chenghua Zhang
Buildings 2025, 15(17), 3007; https://doi.org/10.3390/buildings15173007 - 24 Aug 2025
Viewed by 510
Abstract
Coal gangue concrete (CGC), a recycled cementitious material derived from industrial solid waste, presents both opportunities and challenges for structural applications due to its heterogeneous composition and variable mechanical behavior. This study develops an ensemble learning framework—incorporating XGBoost, LightGBM, and CatBoost—to predict four [...] Read more.
Coal gangue concrete (CGC), a recycled cementitious material derived from industrial solid waste, presents both opportunities and challenges for structural applications due to its heterogeneous composition and variable mechanical behavior. This study develops an ensemble learning framework—incorporating XGBoost, LightGBM, and CatBoost—to predict four key constitutive parameters based on experimental data. The predicted parameters are subsequently incorporated into an ABAQUS finite element model to simulate the compressive–bending response of CGC columns, with simulation results aligning well with experimental observations in terms of failure mode, load development, and deformation characteristics. To enhance model interpretability, a hybrid approach is adopted, combining permutation-based global feature importance analysis with SHAP (SHapley Additive exPlanations)-derived local explanations. This joint framework captures both the overall influence of each feature and its context-dependent effects, revealing a three-stage stiffness evolution pattern—brittle, quasi-ductile, and re-brittle—governed by gangue replacement levels and consistent with micromechanical mechanisms and numerical responses. Coupled feature interactions, such as between gangue content and crush index, are shown to exacerbate stiffness loss through interfacial weakening and pore development. This integrated approach delivers both predictive accuracy and mechanistic transparency, providing a reference for developing physically interpretable, data-driven constitutive models and offering guidance for tailoring CGC toward ductile, energy-absorbing structural materials in seismic and sustainability-focused engineering. Full article
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17 pages, 5836 KB  
Article
Mechanical Performance of Square Box-Type Core Mold Hollow Floor Slabs Based on Field Tests and Numerical Simulation
by Ziguang Zhang, Fengyu Chen, Wenjun Yu, Jie Sheng, Lin Wei and Ankang Hu
Buildings 2025, 15(16), 2948; https://doi.org/10.3390/buildings15162948 - 20 Aug 2025
Viewed by 416
Abstract
This study investigates the mechanical performance and failure mechanisms of large-span, cast-in situ hollow-core floor slabs with square-box core molds under vertical loading. A combination of in situ tests and refined numerical simulations was used to investigate the slab’s behavior. An 8 m [...] Read more.
This study investigates the mechanical performance and failure mechanisms of large-span, cast-in situ hollow-core floor slabs with square-box core molds under vertical loading. A combination of in situ tests and refined numerical simulations was used to investigate the slab’s behavior. An 8 m × 8 m hollow slab from the Xinluzhou Industrial Park in Hefei, China, was subjected to five-stage cyclic loading up to 9.0 kN/m2 using a distributed water tank system. Real-time strain monitoring showed that the slab remained within the elastic range, exhibiting a linear strain-load relationship and bidirectional bending stiffness, with less than 5% deviation between the X and Y directions. Finite element analysis, incorporating a concrete plastic damage model and a bilinear steel model, replicated the experimental stress distribution, with errors of less than 6.9% for reinforcement and 8.8% for concrete. The simulation predicted an ultimate load-bearing capacity of 27.2 kN/m2, with initial failure indicated by diagonal cracks at the column capital edges, followed by flexural cracks at the slab mid-span. These findings clarify the bidirectional bending behavior and stress redistribution, characterized by “banded gradient” and “island-shaped” stress zones. This study provides valuable insights and design optimization strategies to improve the structural performance and safety of hollow-core floor slabs in high-rise buildings. Full article
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22 pages, 2608 KB  
Article
Fast Buckling Analysis of Stiffened Composite Structures for Preliminary Aerospace Design
by Dimitrios G. Stamatelos and George N. Labeas
Aerospace 2025, 12(8), 726; https://doi.org/10.3390/aerospace12080726 - 14 Aug 2025
Viewed by 755
Abstract
Predicting buckling in large-scale composite structures is hindered by the need for highly detailed Finite Element (FE) models, which are computationally expensive and impractical for early-stage design iterations. This study introduces a macromodelling buckling framework that reduces those models to plate-level size without [...] Read more.
Predicting buckling in large-scale composite structures is hindered by the need for highly detailed Finite Element (FE) models, which are computationally expensive and impractical for early-stage design iterations. This study introduces a macromodelling buckling framework that reduces those models to plate-level size without sacrificing accuracy. An equivalent bending stiffness matrix is derived from strain–energy equivalence, rigorously retaining orthotropic in-plane terms, bending–extensional coupling, and—crucially—the eccentricity of compressive loads about an unsymmetrically stiffened mid-plane, effects overlooked by conventional Parallel-Axis smearing. These stiffness terms contribute to closed-form analytical solutions for homogeneous orthotropic plates, providing millisecond-level evaluations ideal for gradient-based design optimisation. The method is benchmarked against detailed FE simulations of panels with three to ten stringers under longitudinal and transverse compression, showing less than 5% deviation in critical load prediction. Its utility is demonstrated in the sizing optimisation of the upper cover of a scaled Airbus A330 composite wing-box, where the proposed model explores the design space in minutes on a standard workstation, orders of magnitude faster than full FE analyses. By combining analytical plate theory, enhanced smearing, and rapid optimisation capability, the framework provides an accurate, ultra-fast tool for buckling analysis and the preliminary design of large-scale stiffened composite structures. Full article
(This article belongs to the Section Aeronautics)
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14 pages, 3088 KB  
Article
CAF-Driven Mechanotransduction via Collagen Remodeling Accelerates Tumor Cell Cycle Progression
by Yating Xiao, Yingying Jiang, Ting Bao, Xin Hu, Xiang Wang, Xiaoning Han and Linhong Deng
Gels 2025, 11(8), 642; https://doi.org/10.3390/gels11080642 - 13 Aug 2025
Viewed by 624
Abstract
Cancer-associated fibroblasts (CAFs) restructure collagen hydrogels via actomyosin-driven fibril bundling and crosslinking, increasing polymer density to generate mechanical stress that accelerates tumor proliferation. Conventional hydrogel models lack spatial heterogeneity, thus obscuring how localized stiffness gradients regulate cell cycle progression. To address this, we [...] Read more.
Cancer-associated fibroblasts (CAFs) restructure collagen hydrogels via actomyosin-driven fibril bundling and crosslinking, increasing polymer density to generate mechanical stress that accelerates tumor proliferation. Conventional hydrogel models lack spatial heterogeneity, thus obscuring how localized stiffness gradients regulate cell cycle progression. To address this, we developed a collagen hydrogel-based microtissue platform integrated with programmable microstrings (single/double tethering), enabling real-time quantification of gel densification mechanics and force transmission efficiency. Using this system combined with FUCCI cell cycle biosensors and molecular perturbations, we demonstrate that CAF-polarized contraction increases hydrogel stiffness (350 → 775 Pa) and reduces pore diameter (5.0 → 1.9 μm), activating YAP/TAZ nuclear translocation via collagen–integrin–actomyosin cascades. This drives a 2.4-fold proliferation increase and accelerates G1/S transition in breast cancer cells. Pharmacological inhibition of YAP (verteporfin), actomyosin (blebbistatin), or collagen disruption (collagenase) reversed mechanotransduction and proliferation. Partial rescue upon CYR61 knockdown revealed compensatory effector networks. Our work establishes CAF-remodeled hydrogels as biomechanical regulators of tumor growth and positions gel-based mechanotherapeutics as promising anti-cancer strategies. Full article
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20 pages, 4095 KB  
Article
Integrated Explainable Diagnosis of Gear Wear Faults Based on Dynamic Modeling and Data-Driven Representation
by Zemin Zhao, Tianci Zhang, Kang Xu, Jinyuan Tang and Yudian Yang
Sensors 2025, 25(15), 4805; https://doi.org/10.3390/s25154805 - 5 Aug 2025
Viewed by 511
Abstract
Gear wear degrades transmission performance, necessitating highly reliable fault diagnosis methods. To address the limitations of existing approaches—where dynamic models rely heavily on prior knowledge, while data-driven methods lack interpretability—this study proposes an integrated bidirectional verification framework combining dynamic modeling and deep learning [...] Read more.
Gear wear degrades transmission performance, necessitating highly reliable fault diagnosis methods. To address the limitations of existing approaches—where dynamic models rely heavily on prior knowledge, while data-driven methods lack interpretability—this study proposes an integrated bidirectional verification framework combining dynamic modeling and deep learning for interpretable gear wear diagnosis. First, a dynamic gear wear model is established to quantitatively reveal wear-induced modulation effects on meshing stiffness and vibration responses. Then, a deep network incorporating Gradient-weighted Class Activation Mapping (Grad-CAM) enables visualized extraction of frequency-domain sensitive features. Bidirectional verification between the dynamic model and deep learning demonstrates enhanced meshing harmonics in wear faults, leading to a quantitative diagnostic index that achieves 0.9560 recognition accuracy for gear wear across four speed conditions, significantly outperforming comparative indicators. This research provides a novel approach for gear wear diagnosis that ensures both high accuracy and interpretability. Full article
(This article belongs to the Section Fault Diagnosis & Sensors)
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16 pages, 4328 KB  
Article
High-Throughput Study on Nanoindentation Deformation of Al-Mg-Si Alloys
by Tong Shen, Guanglong Xu, Fuwen Chen, Shuaishuai Zhu and Yuwen Cui
Materials 2025, 18(15), 3663; https://doi.org/10.3390/ma18153663 - 4 Aug 2025
Viewed by 513
Abstract
Al-Mg-Si (6XXX) series aluminum alloys are widely applied in aerospace and transportation industries. However, exploring how varying compositions affect alloy properties and deformation mechanisms is often time-consuming and labor-intensive due to the complexity of the multicomponent composition space and the diversity of processing [...] Read more.
Al-Mg-Si (6XXX) series aluminum alloys are widely applied in aerospace and transportation industries. However, exploring how varying compositions affect alloy properties and deformation mechanisms is often time-consuming and labor-intensive due to the complexity of the multicomponent composition space and the diversity of processing and heat treatments. This study, inspired by the Materials Genome Initiative, employs high-throughput experimentation—specifically the kinetic diffusion multiple (KDM) method—to systematically investigate how the pop-in effect, indentation size effect (ISE), and creep behavior vary with the composition of Al-Mg-Si alloys at room temperature. To this end, a 6016/Al-3Si/Al-1.2Mg/Al KDM material was designed and fabricated. After diffusion annealing at 530 °C for 72 h, two junction areas were formed with compositional and microstructural gradients extending over more than one thousand micrometers. Subsequent solution treatment (530 °C for 30 min) and artificial aging (185 °C for 20 min) were applied to simulate industrial processing conditions. Comprehensive characterization using electron probe microanalysis (EPMA), nanoindentation with continuous stiffness measurement (CSM), and nanoindentation creep tests across these gradient regions revealed key insights. The results show that increasing Mg and Si content progressively suppresses the pop-in effect. When the alloy composition exceeds 1.0 wt.%, the pop-in events are nearly eliminated due to strong interactions between solute atoms and mobile dislocations. In addition, adjustments in the ISE enabled rapid evaluation of the strengthening contributions from Mg and Si in the microscale compositional array, demonstrating that the optimum strengthening occurs when the Mg-to-Si atomic ratio is approximately 1 under a fixed total alloy content. Furthermore, analysis of the creep stress exponent and activation volume indicated that dislocation motion is the dominant creep mechanism. Overall, this enhanced KDM method proves to be an effective conceptual tool for accelerating the study of composition–deformation relationships in Al-Mg-Si alloys. Full article
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