Search Results (578)

This study empirically verified the effect of solar radiation on the building envelope, with particular emphasis on the generated surface temperature. A model of a cellular concrete block wall with ETICS (External Thermal Insulation Composite System) was constructed with varying insulation-plaster configurations, followed by tests in a “sun chamber” aging chamber and numerical analyses. The measurement results were compared with those from the numerical simulations, taking into account the thermal properties of the materials used and the radiation exposure conditions. The purpose of the study was to determine to what extent different types of plasters and insulation materials affect the heating of the façades. Computer simulations confirmed the direction of energy flow and the gradual heating of successive layers. Furthermore, the differences between the material variants were consistent with the experimental observations. By modeling perfectly uniform conditions, the numerical analysis allowed us to limit the impact of radiation variability, resulting in results with reduced error. Full article

Introduction: Adequate maternal vitamin D status during pregnancy is essential for fetal skeletal development and neonatal vitamin D reserves. Evidence from Central and Eastern Europe on maternal deficiency, its determinants, and supplementation effectiveness in late pregnancy is limited. This study assessed the impact of 2000 IU/day and 4000 IU/day maternal vitamin D supplementation during the third trimester, compared to no supplementation, on maternal and neonatal 25-hydroxyvitamin D [25(OH)₂D] levels at birth, and explored sociodemographic, obstetric, dietary, and lifestyle factors affecting vitamin D status. Methods: In a cross-sectional study at Târgu Mureș County Clinical Hospital, Romania, 322 term mother–newborn pairs (37–41 weeks) from January 2021 to July 2023 were evaluated. The maternal and umbilical cord 25(OH)₂D was measured via electrochemiluminescence immunoassay. Data on socioeconomic status, parity, sun exposure, diet, and supplementation were collected through questionnaires and records. Statistical analysis included chi-square, linear regression, and multivariate modeling. Results: Vitamin D insufficiency and deficiency affected 32.3% and 18.9% of mothers, respectively. Supplementation was the strongest predictor of sufficiency (p < 0.01), showing a dose–response effect (r = 0.84, p < 0.01). Maternal and neonatal 25(OH)₂D levels were strongly correlated (r = 0.99, p < 0.01). Although several factors correlated with deficiency in univariate analyses, only supplementation remained significant in multivariate models. No link was found between 25(OH)₂D status and neonatal anthropometrics or early complications. Conclusions: A high prevalence of vitamin D deficiency has been documented among pregnant women in Romania. High-dose supplementation during late pregnancy is critical to ensure sufficient maternal and neonatal vitamin D, highlighting the need for standardized antenatal supplementation protocols, especially in disadvantaged groups. Full article

Background/Objectives: Intrinsic biomarkers, such as serum vitamin D levels and the conjunctival ultraviolet autofluorescence (CUVAF) area, have been proposed to quantify sunlight exposure. Evidence suggests that reduced outdoor activity during the SARS-CoV-2 pandemic accelerated the progression of myopia; however, there is little information on the impact of such restrictions on vitamin D levels and CUVAF area in populations with myopia. This study aims to assess the association between serum vitamin D levels and conjunctival ultraviolet autofluorescence area (CUVAF) in young adults with myopia during and after the pandemic, as well as its relationship with sun exposure habits and the use of skin protection measures. Methods: A prospective observational study was carried out. A total of 59 students participated, 32 with a diagnosis of myopia and 27 controls, during SARS-CoV-2 pandemic. Two serological tests for total 25-hydroxy vitamin D (D2 + D3) (Calciferol) were taken, activity habits and sun exposure were identified using the Intermountain Live Well Institute tool, and CUVAF images were taken post-pandemic. Results: In the 59 participants, we observed similar vitamin D concentrations between the myopic and control groups during and after the pandemic. However, analysis of CUVAF areas after the pandemic revealed that myopes had significantly smaller areas compared to controls (p < 0.05). Conclusions: The study demonstrated that using vitamin D as a biomarker for outdoor activity requires additional investigation; the CUVAF biomarker showed a significant association with myopia. Full article

Gongolaria usneoides is a native brown alga in Europa, known for its high release of phenolics into the water. Rugulopteryx okamurae is a native brown macroalga from Asia but invasive in Europe, causing significant environmental and socioeconomic impacts. It has been observed that in some regions where Gongolaria is present, there is less biomass of Rugulopteryx, and they are often epiphytized by red filamentous algae. The present study aimed to analyze whether phenolics released in the seawater by G. usneoides affect the photosynthetic and biochemical responses in R. okamurae. To analyze the resilience of R. okamurae, algae were cultivated for 5 days in water with different percentages of phenolics released by G. usneoides (exposure phase) (0, 75, 150, 225 and 300 µg mL⁻¹) in laboratory (20 °C, a 12:12 photoperiod, and PAR 190 µmol photons m⁻² s⁻¹ for a period of 115 h) and a period in the sun (4 h), followed 2 days cultured under phenolic-free water (recovery phase). Photosynthetic characteristics (Fv/Fm and ETR) and biochemical composition (phenolic, antioxidant activity, C, N and S) were measured (R. okamurae showed considerable photosynthetic declines without recovery when exposed to high concentrations of phenolics (225 and 300 µg mL⁻¹). It can be inferred that the presence of G. usneoides in nature and the release of phenolic compounds by this alga may be affecting the invasive alga R. okamurae, potentially serving as a natural means to decrease or weaken the invasive species. Full article

Background: The relationship between occupational sun exposure and melanoma risk is complex and multifaceted, with existing evidence yielding contradictory findings. Unlike Non-Melanoma Skin Cancer (NMSC), for which occupational sun exposure is a well-established risk factor, the link with cutaneous melanoma remains contentious. Objectives: This study aimed to evaluate whether, in a cohort of patients with cutaneous melanoma, an association existed between occupational sun exposure and melanoma, specifically with histotype, site of occurrence, and Breslow index. Methods: This is a retrospective cohort analysis conducted to evaluate whether occupational sun exposure constitutes a risk factor for the development of cutaneous melanoma in patients diagnosed between January 2005 and October 2023 at the Dermatology Unit, Azienda USL Toscana Centro, Florence. Occupational ultraviolet (UV) exposure was examined by classifying each participant’s job into categories based on solar UV exposure levels—outdoor (e.g., agriculture and construction roles), mixed indoor/outdoor (e.g., trades and public safety professions), and indoor settings (e.g., office-based work). Results: A final total of 1417 patients were analyzed. Occupational categorization revealed that 1171 patients (82.64%) were classified as non-occupationally exposed (indoor), while 246 (17.36%) were occupationally exposed to solar UV radiation (including 14.82% mixed indoor/outdoor and 2.54% outdoor workers). A significant association was observed between occupational sun exposure and lentigo maligna, which was more prevalent among exposed workers and even more so in the outdoor subgroup. Anatomical site distribution exhibited a significant association with occupational sun exposure. Indeed occupationally exposed individuals showed a higher prevalence of melanomas in the head and neck region, a distribution pattern particularly evident among outdoor workers, suggesting that these sites may be more susceptible to chronic sun exposure in outdoor and mixed occupations. Moreover, a significant association was found between occupational exposure and Breslow thickness, with exposed workers presenting with thicker melanomas at diagnosis, suggesting more advanced disease. Conclusions: The finding of this study may reflect variations in occupational sun exposure patterns and warrants further investigation into protective measures and early-detection strategies tailored to occupational groups. Full article

Monocular depth estimation (MDE) is a cornerstone of computer vision and is applied to diverse practical areas such as autonomous vehicles, robotics, etc., yet even the latest methods suffer substantial errors in high-dynamic-range (HDR) scenes where over- or under-exposure erases critical texture. To address this challenge in real-world autonomous driving scenarios, we propose the Exposure-Aware Single-Step Diffusion Framework for Monocular Depth Estimation (EASD). EASD leverages a pre-trained Stable Diffusion variational auto-encoder, freezing its encoder to extract exposure-robust latent RGB and depth representations. A single-step diffusion process then predicts the clean depth latent vector, eliminating iterative error accumulation and enabling real-time inference suitable for autonomous vehicle perception pipelines. To further enhance robustness under extreme lighting conditions, EASD introduces an Exposure-Aware Feature Fusion (EAF) module—an attention-based pyramid that dynamically modulates multi-scale features according to global brightness statistics. This mechanism suppresses bias in saturated regions while restoring detail in under-exposed areas. Furthermore, an Exposure-Balanced Loss (EBL) jointly optimises global depth accuracy, local gradient coherence and reliability in exposure-extreme regions—key metrics for safety-critical perception tasks such as obstacle detection and path planning. Experimental results on NYU-v2, KITTI, and related benchmarks demonstrate that EASD reduces absolute relative error by an average of 20% under extreme illumination, using only 60,000 labelled images. The framework achieves real-time performance (<50 ms per frame) and strikes a superior balance between accuracy, computational efficiency, and data efficiency, offering a promising solution for robust monocular depth estimation in challenging automotive lighting conditions such as tunnel transitions, night driving and sun glare. Full article

Background: Patients diagnosed with melanoma are at increased risk of developing multiple primary melanomas (MPMs). Identifying clinical and genetic factors associated with MPM is critical for implementing personalized surveillance strategies. This study aims to describe the clinical, histopathological, and genetic characteristics of patients with MPM managed in a tertiary hospital and to contextualize findings within the current literature. Methods: We conducted a retrospective review of patients diagnosed with two or more primary melanomas between 2010 and 2023 at a tertiary dermatology unit. Demographic data, personal and family cancer history, phototype, melanoma characteristics, genetic testing, staging, treatments, and outcomes were collected. These data were compared with findings from the recent literature. Results: Thirteen patients (ten males, three females; median age: 59 years) were found to have a total of 33 melanomas. Most patients had Fitzpatrick phototype II and no immunosuppression. The number of melanomas per patient ranged from two to five. Synchronous lesions were observed in two patients. Common locations included the trunk and extremities. Histologically, 57% were in situ melanomas, and subsequent melanomas were generally thinner than the index lesion. Two patients showed progression to advanced disease. One patient was positive for MC1R mutation; the rest were negative or inconclusive. Additional phenotypic and environmental risk factors were extracted from patient records and are summarized as follows: Ten patients (76.9%) had Fitzpatrick skin phototype II, and three (23.1%) had phototype III. Chronic occupational sun exposure was reported in four patients (30.8%), while five (38.5%) recalled having suffered multiple sunburns during childhood or adolescence. Eight patients (61.5%) presented with a total nevus count exceeding 50, and five (38.5%) exhibited clinically atypical nevi. None of the patients reported use of tanning beds. Conclusions: Our findings are consistent with the existing literature indicating that patients with MPM often present with thinner subsequent melanomas and require long-term dermatologic follow-up. The inclusion of genetic testing and phenotypic risk factors enables stratified surveillance and supports the application of personalized medicine in melanoma management. Full article

Resettlement communities in Qinghai are located in cold, high-altitude regions with dry climates and strong solar radiation. Although not extremely cold, the moderate heating demand aligns well with high solar availability, making passive design highly effective for reducing energy use. This study investigates solar-optimized spatial configurations that enhance passive energy performance while addressing functional settlement needs. Through parametric modeling and climate-responsive simulations, four key spatial parameters are examined: building spacing, courtyard depth, density, and volumetric ratio. The findings highlight the dominant role of front–rear spacing in solar access, with optimal values at 3–4 m for single-story and 5–10 m for two-story buildings, balancing radiation gain and land use efficiency. Courtyard depths under 2.7 m significantly limit south façade exposure due to shading from the opposite courtyard wall under low-angle winter sun. This reduction results in the south façade attaining only 55.7–79.6% of the solar radiation acquisition by an unobstructed south façade (the baseline). Meanwhile, clustered orientations reduce inter-building shading losses by 38–42% compared to dispersed layouts. A three-tiered design framework is proposed: (1) macro-scale solar orientation zoning, (2) meso-scale spacing tailored to building height, and (3) micro-scale courtyard modulation for low-angle winter radiation. Together, these strategies provide practical, scalable guidelines for energy-efficient, climate-responsive settlement design in the alpine regions of Qinghai. Full article

Background: Connubial melanoma, the occurrence of melanoma in non-consanguineous spouses, is rarely described in the literature. This study aimed to evaluate the prevalence of shared risk factors, preventive behaviors, and the influence of couple dynamics on the early diagnosis of cutaneous melanoma (CM). Methods: We conducted a retrospective observational study at the San Gallicano Dermatological Institute IRCCS, Rome, enrolling 52 heterosexual couples diagnosed with CM between 2010 and 2023. Clinical and anamnestic data, including phototype, history of sun exposure, use of tanning devices, and reason for dermatological evaluation, were collected. Dermatological assessments included dermoscopy, total body photography, and histological examination of excised lesions. Statistical analyses were performed using chi-square and Student’s t-tests. Results: Women reported significantly higher use of artificial ultraviolet sources (51.9% vs. 19.2%, p < 0.001) and more frequent histories of sunburn. Phototype II was associated with higher use of tanning devices and a greater prevalence of sunburns. Although the CM stage did not significantly differ between sexes, husbands exhibited a greater Breslow thickness. Melanoma localization differed by sex, with lower limbs more often affected in women and the trunk in men (p < 0.001). In 86.5% of cases, wives initiated their husband’s dermatological evaluation, leading to earlier diagnosis. Conclusions: Despite shared environmental exposures, men and women differ in preventive behaviors and risk profiles. Women play a crucial role in promoting early detection among couples. Couple-based preventive strategies may be instrumental in improving early melanoma diagnosis and outcomes. Full article

Urban residential design influences local microclimates and human thermal comfort. This study combines empirical microclimate data with remotely sensed data on tree canopy cover, housing lot size, surface permeability, and roof colour to examine thermal differences between three newly built and three established residential suburbs in Western Sydney, Australia. Established areas featured larger housing lots and mature street trees, while newly developed suburbs had smaller lots and limited vegetation cover. Microclimate data were collected during summer 2021 under both heatwave and non-heatwave conditions in full sun, measuring air temperature, relative humidity, wind speed, and wet-bulb globe temperature (WBGT) as an index of heat stress. Daily maximum air temperatures reached 42.7 °C in new suburbs, compared to 39.3 °C in established ones (p < 0.001). WBGT levels during heatwaves were in the “extreme caution” category in new suburbs, while remaining in the “caution” range in established ones. These findings highlight the benefits of larger green spaces, permeable surfaces, and lighter roof colours in the context of urban heat exposure. Maintaining mature trees and avoiding dark roofs can significantly reduce summer heat and improve outdoor thermal comfort across a range of conditions. Results of this work can inform bottom-up approaches to climate-responsive urban design where informed homeowners can influence development outcomes. Full article

Juglans neotropica Diels, an Andean native species classified as endangered by the IUCN, holds significant potential for reforestation and sustainable forest management programs. This study evaluated seed quality, phenotypic variability, and early establishment under nursery and field conditions in southern Ecuador. Three provenance sites—The Tundo, The Victoria, and The Argelia—were evaluated during the nursery phase, and two (The Tundo and The Victoria) in plantations, applying four pre-germination treatments: control, mechanical scarification, hot water, and water-sun exposure. Parameters assessed included seed weight, size, viability, germination, survival, and growth across three planting environments: secondary forest, riparian forest, and pasture. Significant differences in seed morphometry were observed among localities, while germination was influenced by treatment but not provenance. Seed viability remained high for up to six months, decreasing with a 2% loss of moisture. Survival reached 100% with urea application, and 96% of individuals exhibited straight stems after one year. No significant differences in growth were found between localities; however, basal diameter was highest in the pasture (13.2 mm/year⁻¹), and total height was greatest in the secondary forest (54.8 cm/year⁻¹). These findings provide key technical evidence to optimize the propagation and establishment of J. neotropica in ecological restoration and forest production contexts. Full article

Background and Objectives: Maternal vitamin D (25-hydroxyvitamin D, 25(OH)D) deficiency during pregnancy is associated with adverse outcomes for both mother and fetus. While vitamin D supplementation is commonly recommended, dietary and lifestyle factors influencing maternal 25(OH)D levels at term remain underexplored, particularly in Southern Europe. Aim: This study aimed to investigate prenatal determinants of maternal 25(OH)D levels at the time of delivery, focusing on dietary intake, supplement use, and seasonal variation. Materials and Methods: We conducted a cross-sectional study on 248 pregnant women admitted for delivery at the General Hospital of Piraeus “Tzaneio” between September 2019 and January 2022. A structured questionnaire was used to assess prenatal intake of vitamin D-rich foods (such as fatty fish, eggs, dairy, and fortified products), supplement use (dose, frequency), sun exposure habits, and lifestyle factors. Maternal serum 25(OH)D concentrations were measured from blood samples collected at the time of admission for delivery. Statistical analysis included descriptive statistics and multivariate linear regression to identify independent dietary and supplemental predictors of maternal vitamin D status. Results: A high prevalence of maternal vitamin D deficiency (VDD) was observed, particularly during the autumn and winter months. Women who reported regular intake of vitamin D supplements (400–800 IU daily) had significantly higher 25(OH)D levels compared to those who did not. Dietary intake of vitamin D-rich foods was positively associated with maternal 25(OH)D status, although the effect size was smaller compared to supplementation. Seasonal variation, BMI, and limited sun exposure were also independent predictors. Conclusions: Both vitamin D supplementation and increased dietary intake were positively associated with maternal 25(OH)D concentrations at delivery. These findings underscore the importance of prenatal nutritional assessment and targeted supplementation strategies to prevent maternal VDD in Mediterranean populations. Full article

Background and Aims: Vitamin D is currently well regarded for its pleiotropic effects on the immune system, stimulating an anti-inflammatory response and enhancing immune tolerance. Vitamin D deficiency is an established risk factor for multiple sclerosis (MS). Additionally, lower vitamin D serum levels are associated with worse disease outcomes. However, current randomized clinical trials provide conflicting evidence about the beneficial role of vitamin D on disease progression. Most studies have evaluated the effect of vitamin D supplementation on clinical and radiological activity, yet very few have examined the impact on brain atrophy. Methods: A 4-year observational, non-interventional study design was applied to evaluate the association between vitamin D supplementation and disease progression. Altogether, 132 relapsing–remitting multiple sclerosis patients were enrolled in the study (97 subjects in the group with vitamin D supplementation and 35 subjects in the group without supplementation). The analyzed groups were similar in terms of age, body mass index, sun exposure, comorbidities, nicotinism, duration of the disease, and current treatment. The number of relapses, Expanded Disability Status Scale assessments, and the number of new/enlarged T2-weighted lesions and gadolinium-enhancing lesions in magnetic resonance imagining analyses, as well as 25-hydroxyvitamin D serum levels, were assessed every 12 months of a 4-year follow-up, whereas brain atrophy was assessed at the baseline and after 36 months using two-dimensional measurements. Results: After 36 months, a significant increase in atrophy was observed in both groups; however, patients without vitamin D supplementation had a significantly higher increase in intercaudate distance, third ventricle width, and bicaudate ratio after 36 months of observation (p < 0.05). Vitamin D supplementation among the studied group did not affect other disease activity outcomes. Conclusions: Our study revealed an observed association between vitamin D supplementation and reduced brain atrophy in patients with MS. Randomized controlled trials are required to establish the impact of vitamin D supplementation on brain atrophy progression. Full article

Tropical montane cloud forests (TMCFs) are biodiversity hotspots that have been increasingly cleared to cultivate coffee under full sun exposure, replacing traditional shaded agroforestry systems. This study evaluated the impact of TMCF clearing on soil quality by analyzing 108 samples from undisturbed primary and secondary forests and deforested coffee plantations in the Dominican Republic and Haiti. Our findings indicate that forest clearing has a substantial adverse impact on soil nutrient status. Soils from undisturbed plots had total organic carbon (TOC) concentrations 4.83 units higher than those from cleared plots. Nitrogen levels were reduced by 28–61%, and available potassium declined by 23–51% in soils that had been cleared. Conversely, the available phosphorus levels exhibited a modest increase (ranging from 23% to 27%) following the clearing process, presumably attributable to diminished plant uptake and augmented mineralization in conditions characterized by diminished organic matter. However, given that phosphorus is not a limiting factor for coffee growth, this marginal gain does not compensate for the broader degradation of soil fertility. The study emphasizes that allowing TMCFs to be used for sun-grown coffee results in long-term nutrient depletion through erosion and leaching, which poses a threat to both the productivity of the soil and the ecological integrity of these valuable forest systems. Full article

The role of vitamin D in reducing cardiovascular disease (CVD) risk remains debated despite growing evidence. Prospective observational studies consistently show that low serum 25-hydroxyvitamin D [25(OH)D] concentrations (below 40–50 nmol/L [16–20 ng/mL]) are associated with the highest risk of CVD incidence. In addition, a large prospective observational study found that serum 25(OH)D concentration was inversely correlated with CVD mortality rate to over 100 nmol/L. Randomized controlled trials have not generally demonstrated benefit due to faulty study designs, such as enrolling participants with baseline 25(OH)D levels > 50 nmol/L. However, a major trial found that 60,000 IU/month of vitamin D₃ supplementation reduced the risk of major cardiovascular events for participants with predicted 25(OH)D concentrations ≥ 50 nmol/L or taking statins or CV drugs by ~13 to ~17%. In addition, vitamin D supplementation studies have found modest reductions in several CVD risk factors. Other observational studies of vitamin D supplementation have reported reduced CVD risks (e.g., ischemic heart disease, hypertension, and myocardial infarction). Temporal ecological studies further support this relationship, revealing that CVD incidence rates are lowest in summer and CVD mortality rates are significantly higher in late winter—when 25(OH)D concentrations are lowest—compared to late summer. A previously reported analysis using eight of Hill’s criteria for causality in a biological system further strengthens the biological plausibility of vitamin D’s role in CVD risk reduction. Its role in modulating inflammation and oxidative stress, improving endothelial function, and reducing several cardiometabolic risk factors supports its inclusion as part of a comprehensive, multi-modal approach to cardiovascular health. Therefore, vitamin D should be considered an integral component in the prevention and management of CVD. Preferably, it should be used in combination with other nutritional supplements, a heart-healthy diet, and prescription medications to reduce the risk of CVD incidence. People should consider vitamin D₃ supplementation with at least 2000 IU/day (50 mcg/day) (more for those who are obese) when sun exposure is insufficient to maintain serum 25(OH)D concentrations above 75 nmol/L. To reduce CVD mortality rates, higher doses to achieve higher 25(OH)D concentrations might be warranted. Full article