Search Results (2,732)

Background/Objectives: Therapeutic exercises during hospitalization may provide important benefits for onco-hematological patients. However, the most effective protocols and outcomes for evaluation remain unclear. The objective of this study was to evaluate the effects of a structured exercise program during hospitalization. Methods: We conducted a randomized clinical trial with hospitalized onco-hematological patients. The control group performed conventional exercises, while the intervention group received a combined program of aerobic and resistance training. Outcomes included functional capacity, muscle strength, quality of life, and fatigue, assessed at admission and discharge. The sample size was calculated for a moderate effect size (Cohen’s d = 0.50; α = 0.05; power = 80%), yielding a target of 35 participants per group. Data were analyzed using repeated measures analysis of variance, followed by Bonferroni post hoc tests. The significance level was set at 5%. Results: The intervention group showed significant improvements in dyspnea (p = 0.017) and pain (p = 0.024) compared with the control group. In addition, reductions in insomnia (p = 0.021) and improvements in emotional functioning (p = 0.024) were observed. No significant between-group differences were found for fatigue, muscle strength, or functional capacity. Conclusions: A short-term program of aerobic and resistance exercises was safe and improved pain and dyspnea in hospitalized onco-hematological patients, with additional favorable effects on insomnia and emotional function. However, no significant effects were detected in fatigue, muscle strength, or functional capacity, likely due to the short hospitalization period and limited number of sessions. Future studies should consider longer interventions and post-discharge follow-up to clarify the sustainability of these benefits. Full article

Research Problem and Gap: Live streaming sales rely heavily on streamers, with both genuine and AI-generated virtual streamers gaining popularity. However, these streamer types possess contrasting capabilities. Genuine streamers are superior at building trust and reducing product valuation uncertainty but have limited reach, while virtual streamers excel at broad audience engagement but are less effective at mitigating uncertainty, often leading to higher product return rates. This trade-off creates a critical strategic gap; that is, brand firms lack clear guidance on whether to invest in genuine or virtual streamers or adopt a hybrid approach for their live channels. Objective and Methods: This study addresses this gap by developing a theoretical analytical model to determine a monopolistic brand firm’s optimal streamer strategy among three options: using only a genuine streamer, only a virtual streamer, or a combination of the two (hybrid approach). The researchers model consumer utility, factoring in uncertainty and the streamers’ differential impact on reach, to derive optimal decisions on pricing and streamer selection. Results and Findings: The analysis yields several key findings with direct managerial implications. First, while a hybrid strategy leverages the complementary strengths of both streamer types, its success depends on employing high-quality streamers; in other words, this strategy does not justify settling for inferior talent of either type. Second, employing a virtual streamer requires a moderate price reduction to compensate for higher consumer uncertainty and prevent high profit-eroding return rates. Third, a pure strategy (only genuine or only virtual) is optimal only when that streamer type has a significant cost advantage. Otherwise, the hybrid strategy tends to be the most profitable. Moreover, higher product return costs directly diminish the viability of virtual streamers, making a genuine or hybrid strategy more attractive for products with expensive return processes. Conclusions: The results provide a clear framework for brand firms—that is, the choice of streamer is a strategic decision intertwined with pricing and product return costs. Firms should pursue a hybrid strategy not as a compromise but as a premium approach, use targeted pricing to mitigate the risk of virtual streamers, and avoid virtual options altogether for products with high return costs. Full article

This study investigates the structural optimization of lightweight three-layer panels made from industrial hemp shives (core) and hemp fibers (faces) as a sustainable alternative to wood-based materials in furniture manufacturing. Panels with target densities of 400–600 kg·m⁻³ and face-layer contents of 30%–50%were produced and tested to European standards. The optimal configuration—600 kg·m⁻³ with ~37%–41% face layers—achieved a modulus of elasticity up to 3750 N·mm⁻² and a bending strength (MOR) up to 21.57 N·mm⁻². Across the design space, water absorption ranged from ~83% to 162%, and the minimum thickness swelling was ~29%, indicating that while the mechanical properties meet the requirements for P2 particleboards (EN 312) and in some cases approach MDF benchmarks for dry use, thickness swelling remains above the EN 622-5 limit (12%) and thus precludes MDF classification. These findings demonstrate the technical feasibility of hemp shive–fiber panels and underscore the need to balance density and face-layer ratio to avoid loss of core densification at excessive face contents. From a sustainability perspective, the use of rapidly renewable hemp and agricultural residues highlights the potential of these composites to support resource-efficient, low-carbon furniture production, while future work should target improved water resistance through binder and process modifications. Full article

Global urbanization has led to massive generation of high-water-content waste slurry, creating serious environmental challenges. Conventional treatment methods are costly and unsustainable, while cement-based foamed lightweight soils typically exhibit low strength and limited CO₂ sequestration. To address this issue, this study proposes a novel stabilization pathway by integrating a MgO–mineral powder–carbide slag composite binder with CO₂ foaming–carbonation. The approach enables simultaneous slurry lightweighting, strength enhancement, and CO₂ fixation. A series of laboratory tests were conducted to evaluate flowability, density, compressive strength, and deformation characteristics of the carbonated lightweight stabilized slurry. Microstructural analyses, including SEM and XRD, were used to reveal the formation of carbonate phases and pore structures. The results showed that MgO content strongly promoted carbonation, leading to denser microstructures and higher strength, while mineral powder and carbide slag optimized workability and pore stability. Orthogonal testing indicated that a mix with 25% mineral powder, 12.5% MgO, and 7.5% carbide slag achieved the best performance, with unconfined compressive strength up to 0.48 MPa after carbonation. Compared with conventional cement- or GGBS-based foamed lightweight soils, the proposed system exhibits superior strength development, improved pore stability, and enhanced CO₂ sequestration potential. These findings demonstrate the feasibility of recycling high-water-content waste slurry into value-added construction materials while contributing to carbon reduction targets. This study not only provides a sustainable solution for waste slurry management but also offers new insights into the integration of CO₂ mineralization into geotechnical engineering practice. Full article

The aim of the study was to determine correlations between performance of vertical jumps and dolphin kick sprints, and between the results of a dry-land butterfly arm pull test and butterfly arms-only swimming. The study recruited competitive junior male swimmers (15.9 (0.7) years, 179.3 (5.3) cm body height, 64.6 (4.3) kg body mass). On dry land, we measured jump height, lower-limb work and power, as well as peak velocity, power, and force in the butterfly arm pull test. In swimming tests, time, velocity, power, force, and work were assessed during the dolphin kick and butterfly arms-only trials. Pearson’s correlation coefficients and the coefficients of determination were calculated between measurements. The findings showed correlations between swimming velocity and power recorded during the dolphin kick test with jump height, work and power measured in the jump tests (maximum r = 0.90, r² = 0,81, p < 0.05). The best correlations between the results of the jump tests and swim variables were determined for the CJ30s test. The butterfly arm pull test was not associated with all parameters measured by the butterfly arms-only test. Our study demonstrates that targeted dry-land training programmes using exercises like vertical jumps can enhance competitive swimmers’ performance and offer coaches an accessible means of tracking athlete progress. Moreover, such simple drills may serve as a cost-effective approach for early evaluation of strength and power potential and for preventing musculoskeletal injuries, all without requiring pool access or specialized underwater equipment. However, the small and homogeneous sample (n = 12, junior males only) and the absence of reliability analyses limit the generalizability of the results. Full article

Yield stress and thixotropy are critical rheological properties for enabling successful 3D printing of magnetic colloidal systems. However, conventional magnetic colloids, typically composed of a single dispersed phase, exhibit insufficient rheological tunability for reliable 3D printing. In this study, we developed a novel magnetic colloidal system comprising a carrier liquid, magnetic nanoparticles, and organic modified bentonite. A direct-ink-writing 3D-printing platform was specifically designed and optimized for thixotropic materials, incorporating three distinct extruder head configurations. Through an in-depth rheological investigation and printing trials, quantitative analysis revealed that the printability of magnetic colloids is significantly affected by multiple factors, including magnetic field strength, pre-shear conditions, and printing speed. Furthermore, we successfully fabricated 3D architectures through the precise coordination of deposition paths and magnetic field modulation. This work offers initial support for the material’s future applications in soft robotics, in vivo therapeutic systems, and targeted drug delivery platforms. Full article

This research presents a comprehensive analysis of green development policies in the building industry in New South Wales (NSW), Australia, examining their evolution and development over the past two decades. The research adopts a structured methodology comprising a policy review to identify relevant policy documents, content analysis to trace the policy framework, and SWOT (Strengths, Weaknesses, Opportunities, and Threats) analysis to evaluate the policy development, and then generate evidence-based recommendations. As the first comprehensive assessment of green development policy in the Australian building industry, the study proposes targeted policy recommendations based on analyzing the SWOT factors, including policy for the non-residential sectors and construction phase, education and training, financial support and incentives, and innovation and technology adoption. The insights offer guidance for policymakers to strengthen policy integration and accelerate the transition toward a low-carbon building industry. Full article

Background/Objectives: Polybia-MP1 (MP1) exhibits antimicrobial and anticancer properties. To improve selectivity toward acidic tumor microenvironments, we designed HMP1, a histidine-substituted analog of MP1, aiming to introduce pH-responsive behavior within physiological and pathological pH ranges. Methods: HMP1 was synthesized by replacing all lysine residues in MP1 with histidines. We characterized its surfactant properties and interactions with lipid monolayers composed of DPPC under varying pH and ionic strength conditions. Langmuir monolayer experiments were used to evaluate peptide-induced morphological changes and lipid packing effects at physiologically relevant lateral pressures. Results: HMP1 displayed pH-dependent activity between pH 5.5 and 7.5, inducing significant morphological reorganization of lipid domains without reducing the condensed phase area. Ionic strength modulated these effects, with distinct behaviors observed at low and physiological saline conditions. HMP1 preferentially interacted with cholesterol-enriched membranes, while MP1 did not induce comparable effects under the same conditions, as previously reported, at physiological lateral pressures. HMP1 also exhibited non-hemolytic properties and lower cytotoxicity compared to MP1. Conclusions: The lysine-to-histidine substitution conferred pH sensitivity to HMP1, enabling selective modulation of membrane organization based on lipid composition, packing, pH, and ionic environment. These findings highlight HMP1’s potential in targeted therapeutics and pH-responsive drug delivery systems. Full article

Precast concrete frames integrating ultra-high-performance concrete (UHPC) beams and high-strength concrete (HSC) columns offer exceptional seismic resilience and construction efficiency. However, a performance-based seismic design methodology tailored for this hybrid structural system remains underdeveloped. This study aims to develop and validate a direct displacement-based design (DDBD) procedure specifically for precast UHPC-HSC frames. A novel six-tier performance classification scheme (from no damage to severe damage) was established, with quantitative limit values of interstory drift ratio proposed based on experimental data and code calibration. The DDBD methodology incorporates determining the target displacement profile, converting the multi-degree-of-freedom system to an equivalent single-degree-of-freedom system, and utilizing a displacement response spectrum. A ten-story case study frame was designed using this procedure and rigorously evaluated through pushover analysis. The results demonstrate that the designed frame consistently met the predefined performance objectives under various seismic intensity levels, confirming the effectiveness and reliability of the proposed DDBD method. This work contributes a performance oriented seismic design framework that enhances the applicability and reliability of UHPC-HSC structures in earthquake regions, offering both theoretical insight and procedural guidance for engineering practice. Full article

This study investigates the economic role of wine tourism in Nemea, Greece, a prominent Protected Designation of Origin (PDO) wine-producing region. Employing a mixed-methods approach, the research combines interviews with local stakeholders and a structured post-wine-tasting visitor survey to assess wine tourism’s contribution to local development. A two-step multivariate analysis, incorporating Multiple Correspondence Analysis and Hierarchical Cluster Analysis, reveals five distinct visitor profiles differing in spending behaviour, familiarity with the destination, and engagement patterns. While high-spending visitors support winery revenues, their limited local integration reduces their broader developmental impact. Conversely, younger and repeat domestic visitors offer more dispersed economic benefits through overnight stays, gastronomy, and cultural participation. In addition, local stakeholders highlight the region’s viticultural identity and growing tourism interest as strengths but also note persistent weaknesses such as inadequate infrastructure, limited coordination, and underdeveloped visitor services. The study concludes that visitor segmentation offers actionable insights for enhancing wine tourism’s developmental role. Targeted strategies tailored to specific visitor types are essential for improving integration with the local economy. These findings contribute to ongoing discussions on how wine tourism can act as a lever for inclusive, sustainable rural development in traditional wine regions. Full article

The integration of nanoengineered materials into concrete systems has emerged as a promising strategy for enhancing structural performance and sustainability. This study presents a hybrid experimental-analytical investigation into the use of multilayer graphene as a smart admixture in high-performance concrete. The research combines mechanical testing, microstructural characterization, and a multi-objective optimization model to determine the optimal graphene dosage that maximizes strength gains while minimizing carbon emissions. Concrete specimens incorporating multilayer graphene (ranging from 0.01% to 0.10% by weight of cement) were tested over 7 to 90 days for compressive, tensile, and flexural strengths. Simultaneously, X-ray diffraction, scanning electron microscopy, and energy-dispersive X-ray analyses revealed crystallinity enhancement, pore densification, and favorable elemental redistribution due to graphene inclusion. A normalized composite objective function was formulated to balance three maximization targets—compressive, tensile, and flexural strength—and one minimization goal—carbon emission. The highest objective score (Z = 1.047) was achieved at 0.10% graphene dosage, indicating the optimal balance of strength performance and environmental efficiency. This dual-framework study not only confirms graphene’s reinforcing effects experimentally but also validates the 0.10% dosage through mathematical scoring. The outcomes position of multilayer graphene as a powerful additive for high-strength, low-carbon concrete, especially suited for infrastructure in hot and arid environments. The proposed optimization approach provides a scalable pathway for performance-based graphene dosing in future innovative concrete formulations. Full article

To improve the applicability of tetragonal zirconia (TZP) in the high-vacuum friction drive field, a strategy combining Cr ion implantation-modified layer and hydrogen-containing amorphous carbon coating was proposed in this study. The designed coating (WC/a-C:H) consists of a Cr bonding layer, a WC-rich load-bearing layer and an a-C:H target layer. The effects of implantation voltage on the adhesion strength of WC/a-C:H coatings were investigated. The tribological behaviors of WC/a-C:H against TZP and TZP self-mated pairs at various loads in high vacuum were comparatively explored. The results indicated that when the TZP substrate was modified by a Cr ion implantation layer, the WC/a-C:H coating showed obviously better adhesion strength. Therein, at the implantation voltage of 30 kV, the coating exhibited the optimal adhesion of 88 N, which was 112% higher than that of the coating on original TZP. Surprisingly, the WC/a-C:H coating featuring maximum adhesion strength also achieved a high friction coefficient (>0.22) and exceptional wear resistance across a wide load range of 0.5~15 N in high vacuum. Compared with the TZP self-mated wear pairs, the wear rates of both the WC/a-C:H coating and its counterparts decreased by 1~2 orders of magnitude. Unlike the severe abrasive wear and plastic deformation of the TZP self-mated pairs, even at 15 N, the WC/a-C:H coating exhibited mild abrasive wear and adhesive wear mechanisms. Full article

Background: Obesity is a well-established risk factor for numerous chronic diseases, including heart disease and type 2 diabetes, and its impact is particularly acute among Black/African American men. According to the Centers for Disease Control and Prevention (CDC), 70.9% of Black men aged 20 and older are overweight or obese. Despite this alarming prevalence, there remains a limited number of studies that specifically investigate the root causes of obesity in this population. Addressing this gap is critical to developing culturally relevant interventions that promote health equity. The purpose of this study was to assess dietary patterns, that are associated with overweight/obesity, in Black men aged 18–65 across the United States of America, to gain an in-depth understanding of variables influencing BMI in Black men. Methods: This study utilized a quantitative approach to collect information from participants. A survey questionnaire was developed and administered via Qualtrics to participants using a web link. The survey collected information across 18 dietary variables. Data was exported to Microsoft Excel for statistical analysis. A simple linear regression was used to determine dietary variables correlation strength and significance with BMI. A significance level of p < 0.05 was used to determine if a variable was statistically significant. Variables were then organized based on significance vs. non significance and correlation strength. Result: The study sample consisted of 466 Black men aged 18 to 65 years. The mean BMI was 30.21. Approximately 19% (n = 87) had a BMI within the healthy range (18.5–24.9), 41% (n = 190) were categorized as overweight (BMI 25.0–29.9), and another 41% (n = 189) were classified as obese (BMI ≥ 30.0). The findings revealed that fruit and vegetable consumption and whole grain cereal consumption were significantly and positively correlated with BMI. Other variables, such as fried foods, processed foods, and sugary drinks, though historically associated with obesity, did not show statistical significance in this population. Conclusions: Results suggest that while multiple dietary factors influence BMI, fruit, vegetable, and whole grain consumption are significantly correlated with BMI in Black men living in America. The findings from this study serve as a foundational step for designing targeted, culturally sensitive interventions aimed at reducing obesity-related health disparities. Future research should further explore how tailored public health messaging and community-based programming can address the specific needs of this population. Full article

This preliminary study investigates the optimization of the mechanical properties of the zinc wrought alloy ZEP1510 with the objective of assessing its potential to approach the hardness, strength, and toughness of the brass alloy, CuZn21Si3P. Enhancing both toughness and hardness was targeted to improve the durability of potential replacement components. Heat treatment was the primary method, applying annealing, air cooling, water quenching, and artificial aging to modify material properties. Mechanical characterization was performed through Brinell hardness, as well as tensile and Charpy impact testing, complemented by metallographic analysis. Air cooling from temperatures near the transformation point at 275 °C produced a visually refined and homogeneous microstructure (qualitative assessment by OM/SEM), resulting in simultaneous increases in hardness and toughness. Water quenching from this range yielded a metastable state with high toughness but low hardness, while subsequent natural aging significantly increased strength and reduced toughness. Artificial aging indicated precipitation hardening behavior similar to that of aluminum alloys. Although property improvements were achieved, the targeted combination of high toughness and high strength was not fully realized. The findings suggest that controlled artificial aging, alternative quenching media and grain refinement strategies could further enhance performance, providing a basis for tailoring ZEP1510 for demanding engineering applications. Full article

Objective: In the isokinetic literature, relatively limited attention has been paid to muscles of the wrist. Therefore, the objective of this study was to present an isokinetic profile of these muscles comprising the flexors (F); extensors (E); and ulnar (U) and radial (R) deviators. Method: The dominant-side F, E, U and R in 40 healthy participants (20 women and 20 men) were tested concentrically (Con) and eccentrically (Ecc) using a single speed of 90°/s. Results: Men were significantly stronger than women in both the Con and Ecc tests, as indicated by both the absolute (Nm) and the bodyweight-normalized (Nm/kgbw) representations. However, the bodyweight-normalized women/men strength ratio (78.6 ± 8.0%) was significantly higher than the absolute strength ratio (64.1 ± 6.6%). For both the Con and Ecc tests, and irrespective of the representation (absolute or normalized), the U was the strongest muscle group, followed successively by the F, R and E. This rank order was highly significant statistically. The eccentric/concentric strength ratios, E/C_F and E/C_U, were significantly higher in men than in women, with no remarkable inter-sex differences for E/C_E and for E/C_R. A correlational analysis, which included all pairs of basic isokinetic outcome parameters (e.g., the PM of F_con), was performed with respect to ‘sex’ using a nonparametric bootstrap procedure, revealing that men had significantly higher overall correlation coefficients compared to women. Conclusions: The consistency of the main findings with respect to both the sex of the participants and the various strength ratios supports the use of the current protocol. The observed strength order (U > F > R > E) may assist clinicians in setting preliminary return-to-function targets after wrist rehabilitation. Full article