Search Results (971)

The evaluation of the fracturing effect of coalbed methane (CBM) wells is crucial for the efficient development of CBM reservoirs. Currently, studies focusing on the evaluation of the hydraulic fracture stimulation effect of coal seams and the integrated analysis of “drilling-fracturing-monitoring” are relatively insufficient. Therefore, this paper takes three drainage and production wells in the coalbed methane block on the northwest wing of the Xiangxia anticline in the Bijie Experimental Zone of Guizhou Province as the research objects. In view of the complex geological characteristics of this area, such as multiple and thin coal seams, high gas content, and high stress and low permeability, the paper systematically summarizes the results of drilling and fracturing engineering practices of the three drainage and production wells in the area, including the application of key technologies such as a two-stage wellbore structure and the “bentonite slurry + low-solid-phase polymer drilling fluid” system to ensure wellbore stability, low-solid-phase polymer drilling fluid for wellbore protection, and staged temporary plugging fracturing. On this basis, a study on microseismic signal acquisition and tomographic energy inversion based on a ground dense array was carried out, achieving four-dimensional dynamic imaging and quantitative interpretation of the fracturing fractures. The results show that the fracturing fractures of the three drainage and production wells all extend along the direction of the maximum horizontal principal stress, with azimuths concentrated between 88° and 91°, which is highly consistent with the results of the in situ stress calculation from the previous drilling engineering. The overall heterogeneity of the reservoir leads to the asymmetric distribution of fractures, with the transformation intensity on the east side generally higher than that on the west side, and the maximum stress deformation influence radius reaching 150 m. The overall transformation effect of each well is good, with the effective transformation volume ratio of fracturing all exceeding 75%, and most of the target coal seams are covered by the fracture network, significantly improving the fracture connectivity. From the perspective of the transformed planar area per unit fluid volume, although there are numerical differences among the three wells, they are all within the effective transformation range. This study shows that microseismic fracture monitoring technology can provide a key basis for the optimization of fracturing technology and the evaluation of the production increase effect, and offers a solution to the problem of evaluating the hydraulic fracture stimulation effect of coal seams. Full article

One of the main challenges when working with time series captured online using sensors is the appearance of noise or null values, generally caused by sensor failures or temporary disconnections. These errors compromise data reliability and can lead to incorrect decisions. Particularly in the treatment of diabetes mellitus, where medical decisions depend on continuous glucose monitoring (CGM) systems provided by modern sensors, the presence of corrupted data can pose a significant risk to patient health. This work presents an approach that encompasses online detection and imputation of anomalous data using physiological inputs (insulin and carbohydrate intake), which enables decision-making in automatic glucose monitoring systems or for glucose control purposes. Four deep neural network architectures are proposed: CNN-LSTM, GRU, 1D-CNN, and Transformer-LSTM, under a controlled fault injection protocol and compared with the ARIMA model and the Temporal Convolutional Network (TCN). The obtained performance is compared using regression (MAE, RMSE, MARD) and classification (accuracy, precision, recall, F1-score, AUC) metrics. Results show that the CNN-LSTM network is the most effective for fault detection, achieving an F1-score of 0.876 and an accuracy of 0.979. Regarding data imputation, the 1D-CNN network obtained the best performance, with an MAE of 2.96 mg/dL and an RMSE of 3.75 mg/dL. Then, validation on the OhioT1DM dataset, containing real CGM data with natural sensor disconnections, showed that the CNN–LSTM model accurately detected anomalies and reliably imputed missing glucose segments under real-world conditions. Full article

Background: Progressive heart failure cardiogenic shock (HFCS) often requires escalation to temporary or durable mechanical circulatory support (MCS) as a bridge to transplant (BTT). Following the 2018 UNOS allocation changes, our center revised its BTT strategy to optimize support and shorten wait times. At our institution, the Impella 5.5 with SmartAssist via the axillary approach was selectively used for patients who remained refractory to guideline-directed medical therapy, failed single-inotrope therapy, and were not considered suitable durable LVAD candidates by our multidisciplinary heart team. We compared transplant-related outcomes of BTT patients supported with Impella 5.5 versus durable LVAD. Methods: We performed a single-center retrospective review of all heart and heart/kidney transplant candidates at Mayo Clinic Florida from October 2018 to February 2021. INTERMACS profile, baseline characteristics, and perioperative data were collected at the time of device implantation and throughout the transplant hospitalization. Results: A total of 87 heart and 4 heart–kidney transplants were completed. Forty-five patients (49%) required MCS as BTT: 27 (60%) with a durable LVAD and 18 (40%) with an Impella 5.5. All eighteen patients with Impella 5.5 as BTT (100%) were transplanted compared to nineteen patients with durable LVAD (70%), p = 0.001. The median time from listing to transplant was substantially shorter with Impella (32 vs. 696 days, p < 0.001), and this difference persisted across INTERMACS profiles. UNOS status at transplant was more urgent for Impella than LVAD (p < 0.001). Transplant surgery following Impella support required shorter cardiopulmonary bypass time (181 vs. 219 min, p < 0.001) and resulted in lower postoperative vasoactive-inotropic requirements (7.9 vs. 13, p = 0.003). No patients in the Impella group died or were delisted while awaiting transplant, whereas 5 LVAD patients (26%) died or were removed due to LVAD complications (p < 0.001). Conclusions: Our data demonstrates that the use of the Impella 5.5 as BTT was associated with significantly shorter waitlist time, higher transplantation rates, reduced perioperative morbidity, and lower postoperative vasoactive support compared with durable LVAD as BTT. These benefits were achieved despite a higher severity of illness at transplantation in the Impella cohort. Full article

Historic floors, including mosaics, stone slabs, and decorated pavements, are fragile elements that can be easily damaged during restoration works. Risks arise from falling tools, concentrated loads of scaffolding or equipment, and the repeated passage of workers. Traditional protection methods, such as plywood sheets, mats, multilayer systems, or modular plastic panels, have been applied in different sites but often present limitations in adaptability to irregular surfaces, in moisture control, and in long-term reversibility. This paper introduces an innovative approach developed within the 3D-EcoCore project. The proposed solution consists of a bio-inspired modular sandwich system manufactured by 3D printing with biodegradable polymers. Each module contains a Voronoi-inspired cellular core, shaped to match the geometry of the floor obtained from digital surveys, and an upper flat skin that provides a safe and resistant surface. The design ensures mechanical protection, adaptability to uneven pavements, and the possibility to integrate ventilation gaps, cable pathways, and monitoring systems. Beyond heritage interventions, the system also supports routine architectural maintenance by enabling safe, reversible protection during inspections and minor repairs. The solution is strictly temporary and non-substitutive, fully aligned with conservation principles of reversibility, recognizability, and minimal intervention. The Ninfeo Ponari in Cassino is presented as a guiding example, showing how multilevel knowledge and thematic mapping become essential inputs for the tailored design of the modules. The paper highlights both the technical innovation of the system and the methodological contribution of a knowledge-based design process, opening future perspectives for durability assessment, pilot installations, and the integration of artificial intelligence to optimise core configurations. Full article

As a fundamental information carrier in Industrial Internet of Things (IIoT), electromagnetic spectrum data presents critical challenges for efficient spectrum sensing and situational awareness in smart industrial cognitive radio systems. Addressing sparse sampling limitations caused by energy-constrained transceiver nodes in Unmanned Aerial Vehicle (UAV) spectrum monitoring, this paper proposes a compressive sensing-based 3D spectrum tensor completion framework for extrapolative reconstruction in obstructed areas (e.g., building occlusions). First, a Sparse Coding Neural Gas (SCNG) algorithm constructs an overcomplete dictionary adaptive to wide-range spectral fluctuations. Subsequently, a Bag of Pursuits-optimized Orthogonal Matching Pursuit (BoP-OOMP) framework enables adaptive key-point sampling through multi-path tree search and temporary orthogonal matrix dimensionality reduction. Finally, a Neural Gas competitive learning strategy leverages intermediate BoP solutions for gradient-weighted dictionary updates, eliminating computational redundancy. Benchmark results demonstrate 43.2% reconstruction error reduction at sampling ratios r ≤ 20% across full-space measurements, while achieving decoupling of highly correlated overlapping subspaces—validating superior estimation accuracy and computational efficiency. Full article

Background and Clinical Significance: Tandem pathology at the dominant-hemisphere middle cerebral artery (MCA)—combining a wide-neck bifurcation aneurysm that shares the neck with both M2 origins and a short dorsal M1 fusiform dilation embedded in the lenticulostriate belt—compresses the therapeutic margin and complicates device-first pathways. We aimed to describe an anatomy-led, microscope-only sequence designed to secure an immediate branch-definitive result at the fork and to remodel dorsal M1 without perforator compromise, and to place these decisions within a pragmatic perioperative framework. Case Presentation: A 37-year-old right-handed man with reproducible, load-sensitive cortical association and capsulostriate signs underwent high-fidelity digital subtraction angiography (DSA) with 3D rotational reconstructions. Through a left pterional approach, vein-respecting Sylvian dissection achieved gravity relaxation. Reconstruction proceeded in sequence: a fenestrated straight clip across the bifurcation neck with the superior M2 encircled to preserve both M2 ostia, followed by a short longitudinal clip parallel to M1 to reshape the fusiform segment while keeping each lenticulostriate mouth visible and free. Temporary occlusion windows were brief (bifurcation 2 min 30 s; M1 < 2 min). No neuronavigation, intraoperative fluorescence, micro-Doppler, or intraoperative angiography was used. No perioperative antiplatelets or systemic anticoagulation were administered and venous thromboembolism prophylaxis followed institutional practice. The bifurcation dome collapsed immediately with round, mobile M2 orifices, and dorsal M1 regained near-cylindrical geometry with patent perforator ostia under direct inspection. Emergence was neurologically intact, headaches abated, and preoperative micro-asymmetries resolved without new deficits. The early course was uncomplicated. Non-contrast CT at three months showed structurally preserved dominant-hemisphere parenchyma without infarction or hemorrhage. Lumen confirmation was scheduled at 12 months. Conclusions: In dominant-hemisphere tandem MCA disease, staged, perforator-sparing clip reconstruction can restore physiologic branch and perforator behavior while avoiding prolonged antiplatelet exposure and device-related branch uncertainty. A future-facing pathway pairs subtle clinical latency metrics with high-fidelity angiography, reports outcomes in branch- and perforator-centric terms, and, where available, incorporates patient-specific hemodynamic simulation and noninvasive lumen surveillance to guide timing, technique, and follow-up. Full article

The management of antithrombotic agents in patients undergoing urgent gastrointestinal (GI) endoscopy presents a common and complex clinical challenge. The use of anticoagulants and antiplatelet therapies, especially in older patients with significant comorbidities, has increased substantially in recent decades due to the rising prevalence of cardiovascular and thromboembolic diseases. Balancing the risk of ongoing hemorrhage against the potentially life-threatening consequences of thrombosis remains a delicate and critical clinical decision. This review provides a practical, evidence-based approach to the periprocedural management of antithrombotic therapy in urgent endoscopy, particularly in the context of acute GI bleeding. We summarize the indications, pharmacokinetics, and reversal strategies for commonly used agents, including warfarin, direct oral anticoagulants (DOACs), low-molecular-weight heparin, aspirin, and P2Y12 inhibitors. Risk stratification is discussed in detail, considering both the urgency and bleeding risk of endoscopic procedures, as well as the thromboembolic risk associated with temporary drug interruption. Special considerations are given to high-risk patients, such as those with recent coronary stents, mechanical heart valves, or atrial fibrillation with elevated stroke risk scores. Close consultation and collaboration with other specialties, including cardiology and hematology, is often essential to optimize patient outcomes. Recommendations based on real-world clinical experience alongside formal guideline directives aim to support safe and timely endoscopic intervention without compromising systemic thrombotic protection, especially in emergent situations. Full article

In recent years the Government of the Sultanate of Oman has planned the construction of recharge dams in the semi-desert region of Wilayat Ibri, according to the growing domestic water demand for drinking and agricultural use. For this reason, the Engineering Company SERING International planned the construction of rockfill dams, well positioned according to the local morphological and geological context. Using temporary floodwaters and releasing them slowly downstream, these dams increase the water flow of the Aflaj. The latter is the existing traditional irrigation system devised to manage the scarce water resources of the Sultanate. In this paper, we describe the IBRI 14 Dam, namely Wadi Sulayf Dam, with a total length of about 3200 m and lying close to the settlements of Ibri Town, the largest one among those projected. This paper shows the criteria that guided the design studies of the dam linked to the geological and geotechnical features of the area, the main dam characteristic and the activities developed until the work was completed in 2020. This work represents an interesting and useful case study about the complete cycle of realization of a dam, in particular considering that it had been affected by huge flooding during the construction but reporting no significant damage. Full article

Hydrogen embrittlement (HE) can degrade the mechanical integrity of steel pipes, increasing failure risks in naval fuel systems. This study assesses HE effects on ASTM A131 and A36 steels through tensile testing and numerical modeling. Tests conducted with varying exposure times to hydrogen revealed that A131 outperformed A36 in terms of mechanical strength. However, both materials experienced property degradation after six hours. After nine hours, a transient increase in strength occurred, due to temporary microstructural hardening, though the overall trend remained a decline. The maximum reductions in ultimate tensile strength and toughness were 19% and 47% for A131 and 39% and 61% for A36, respectively. Additionally, microstructural analysis revealed the presence of inclusions, intergranular decohesion and micro-crack, in specimens exposed for longer periods. Finally, a combined GTN-PLNIH numerical model was implemented, demonstrating its effectiveness in predicting the mechanical behavior of structures exposed to hydrogen. Full article

Biodegradable zinc-based alloys have recently emerged as promising candidates for temporary biomedical implants due to their favorable biocompatibility, appropriate degradation rate, and relatively simple processing. In this study, the Zn-0.1Mg alloy was investigated after being processed by means of a two-step equal-channel angular pressing (ECAP) route, consisting of the first pass at 150 °C followed by a second pass at room temperature. The mechanical properties were evaluated using uniaxial tensile tests at different strain rates, while the microstructure and phase composition were analyzed using synchrotron hard X-ray diffraction and transmission electron microscopy (TEM). The processed alloy exhibited a remarkable enhancement in both strength and ductility compared to the annealed state. At the lowest applied strain rate, a fracture elongation of up to 240% was achieved at room temperature, representing a unique manifestation of superplasticity under ambient conditions. Diffraction analysis confirmed the stability of the supersaturated Zn matrix with minor Mg₂Zn₁₁ intermetallic phase. TEM observations revealed an ultrafine-grained microstructure and activation of non-basal slip systems, which enabled efficient plastic flow. These findings demonstrate that controlled severe plastic deformation provides an effective pathway for tailoring Zn-Mg alloys, opening opportunities for their use in the next generation of bioresorbable low-to-moderate load orthopedic fixation devices, e.g., plates, screws, suture anchors and craniofacial miniplates. Full article

Background: Despite advances in temporary mechanical circulatory support (tMCS), patients with cardiogenic shock (CS) who are treated with a microaxial flow pump (mAFP; Impella^®, Abiomed) still have a high mortality rate. A dysregulated systemic inflammatory response significantly contributes to multiorgan failure in this population. CytoSorb^® hemadsorption has emerged as a potential adjunctive therapy for modulating inflammation, but data on its use in CS are limited. Methods: This retrospective, single-center study used propensity score matching analysis (1:1 matching; n = 15 per group) to compare the outcomes of patients receiving mAFP support with and without concomitant CytoSorb therapy. Baseline data (T0), including comorbidities and clinical status at ICU admission, were collected for all patients. In the CytoSorb group, data were collected at two additional time points: 24 h before the start of CytoSorb therapy (T1), and 24 h after its completion (T2). At these time points, laboratory values and parameters on respiratory, hemodynamic, and organ function were assessed. Corresponding data were also collected for matched patients in the non-CytoSorb group at equivalent time points relative to their matched counterparts. Results: In the propensity score-matched cohort, patients treated with CytoSorb exhibited significant improvements between T1 and T2. Specifically, reductions were observed in the vasoactive-inotropic score (p = 0.035), procalcitonin levels (p = 0.041), peak inspiratory pressure (p = 0.036), and positive end-expiratory pressure (p = 0.016). Flow rates through the mAFP declined significantly (p = 0.014), suggesting stabilization of hemodynamics. These changes were not observed in the non-CytoSorb group, where most parameters remained unchanged or exhibited less pronounced trends. We observed a lower in-hospital mortality rate in the CytoSorb group (33.3% versus 46.7%), though the difference was not significant, potentially due to limited statistical power. Conclusions: CytoSorb hemadsorption in mAFP-supported CS was associated with improved hemodynamic stability and reduced inflammatory burden. These findings suggest a potential therapeutic benefit of adjunctive hemadsorption in this high-risk population. Full article

For the design of stormwater pumping stations, there is often uncertainty regarding the selection of an appropriate rainfall event to determine the required pumping capacity and temporary storage volume for managing extreme events of a given magnitude. To account for the risk of system failure, the return period is considered, as recommended based on the size of the catchment’s drainage area or other considerations, depending on the local regulations of a country. This study focused on analysing the direct runoff volume from the catchment, the storage volume required for the operation of the pumping system, and the order of magnitude of the design flow rate. The results indicate that a rainfall event with a duration of at least twice the time of concentration should be used. The design flow rate should range between 50% and 70% of the peak discharge, and designing for flow rates near the peak is not advisable, as it can lead to intermittent pump operation and result in an oversized installed capacity. The methodology developed in this research was applied to the Coastal Protection Project located in the city of Cartagena, Colombia, which includes a 2045.6-m-long box culvert with a cross-sectional area of 2 × 2 m, and three pumping stations, each equipped with three pumps rated at 0.75 m³/s, for a total installed capacity of 6.75 m³/s. Full article

The Sistine Chapel, originally designed to accommodate papal ceremonies, featured a system for hanging tapestries that ensured they were deployed according to the liturgical calendar. These textiles not only served as temporary decorative elements but also contributed to the acoustical environment. Historical records suggest that Renaissance popes, particularly Leo X, were attuned to the impact of textiles on sound, experimenting with their placement to optimize acoustics for sermons and polyphonic music. Given the lack of direct historical acoustical measurements, this study employs a computational simulation approach to model the chapel’s acoustics with and without the presence of tapestries and human occupancy. A crucial first step involved characterizing the absorption coefficients of surface finishings in order to obtain a reliable model of the space and investigate modifications induced by tapestries. The study revealed that the presence of tapestries reduced reverberation time at mid-frequencies from 7.4 s to 5.1 s in the empty chapel and from 4.1 s to 3.4 s when occupied. The results corroborate historical observations, who noted the effects of tapestries on vocal clarity in papal ceremonies. The findings demonstrate that textiles played a significant role in controlling acoustics within the Sistine Chapel, complementing the liturgical experience. Full article

Burn injury represents a complex trauma involving numerous local and systemic pathological alterations, which are frequently exacerbated by the phenomenon of burn wound conversion or secondary deepening. Conventional clinical management relies heavily on the application of skin grafts, which primarily serve to provide temporary wound coverage and environmental isolation. However, such grafting procedures often prove insufficiently effective and fail to prevent the progression of the burn wound. While contemporary tissue engineering strategies aim to correct specific pathological processes, they fall short of achieving complete and functional restoration of the skin. Consequently, there is a pressing need for the development of novel therapeutic interventions capable of exerting a multifactorial influence on the regeneration process. A promising avenue of research involves microRNA-based therapeutics. These RNA molecules function as master regulators of gene expression, capable of simultaneously modulating entire clusters of genes implicated in wound regeneration and the prevention of burn wound conversion. Therapeutic strategies focused on the targeted delivery of microRNAs to the wound bed hold the potential for creating effective treatment modalities that surpass existing options and effectively prevent burn deepening. This review consolidates current knowledge on the pathogenesis of burn wounds, elucidates the complex interplay between genes and microRNAs during tissue regeneration and describes both existing and experimental microRNA-based delivery approaches aimed at minimizing burn-related complications and enhancing the quality of tissue repair. Full article

Clay minerals and other flocculants are used to mitigate the effects of some species that produce harmful algal blooms due to their physical and chemical characteristics. In this study, we applied calcium bentonite clay (Bca) and zeolite (Ze) to flocculate and remove cells of the dinoflagellate Gymnodinium catenatum (Graham), a producer of paralyzing toxins. The flocculants were characterized by scanning electron microscopy (SEM) in combination with an energy-dispersive X-ray spectroscopy (EDS) microanalysis system. During experiments, Bca and Ze were suspended in distilled water, deionized water, and seawater at concentrations of 0.25, 0.5, 1.0, 1.5, 2.0, 2.5, and 4.0 gL⁻¹. The percentage of removal efficiency (RE%) of biomass indicators of G. catenatum was calculated. The cell number and concentration of chlorophyll a and peridinin were analyzed using high-performance liquid chromatography (HPLC-UV and HPLC-DAD). The external effects on cells of G. catenatum were recorded. As a result, the maximum RE% of Bca was 79% with respect to the total number of cells, chlorophyll a was 69% and peridinin of 73%. The RE% of Ze was less than 40%. In the matrix of sedimented Bca, malformation of cells was observed, inhibiting their swimming, as well as death and rupture of cells with temporary cyst formation after 72 h. We conclude that Bca, suspended in deionized and distilled water, was more efficient in flocculating cells of G. catenatum. Full article