Search Results (1,728)

This study investigates how virtual reality systems can support inclusive access to culturally restricted sacred heritage sites. Two extended reality (XR) approaches were developed and deployed in a real-world setting: a VR360 virtual tour and an AI-driven immersive virtual reality prototype with conversational interaction. A research-in-the-wild, between-subjects study was conducted with 136 participants using mixed methods, including standardized questionnaires (System Usability Scale, User Engagement Scale, and Igroup Presence Questionnaire), retrospective interviews, and exhibition staff observations. The results reveal clear trade-offs between the two systems. The VR360 system demonstrated higher usability and operational reliability, requiring minimal supervision and technical resources, whereas the AI-driven immersive VR system supported embodied exploration and conversational inquiry, which was associated with higher spatial presence and helped visitors address questions during exploration. Qualitative findings further indicate that conversational interaction enhanced user experience but also introduced greater technical complexity and staffing requirements. Overall, the study provides empirical insights for designing and deploying XR systems in heritage contexts and highlights how different levels of immersion and interaction influence usability, presence, and operational feasibility when supporting inclusive access to culturally restricted sites. Full article

Religious heritage occupies a distinctive position at the intersection of sacred practice and cultural governance. While existing scholarship often interprets conflicts surrounding religious heritage through value pluralism or sacred–secular opposition, less attention has been paid to how heritagization reshapes religion within regulatory regimes. Drawing on 39 in-depth interviews conducted across Buddhist, Catholic, Protestant, and Confucian contexts in South Korea, this article examines how religious practitioners and heritage experts conceptualize living religious heritage and negotiate governance structures. The findings demonstrate that stakeholders frequently challenge the binary opposition. Instead, they articulate a relational continuum in which ritual continuity sustains heritage significance and historical depth legitimizes religious practice. Tensions arise primarily from regulatory rigidity, fragmented institutional authority, and procedural exclusion rather than doctrinal incompatibility. Heritage designation emerges as an institutional process that contributes to reconfiguring religious authority, spatial control, and public legitimacy within secular administrative frameworks. By conceptualizing religious heritage governance as a site of negotiated rearticulation rather than value conflict, this study contributes to debates on sacred–secular entanglement, religion and governance, and the institutional reshaping of religion in contemporary societies. Full article

Online social platforms increasingly function as informal self-help environments for individuals experiencing depression, offering spaces for emotional expression and peer support outside traditional clinical settings. However, how coping strategies and psychological engagement states—individuals’ emotional and cognitive involvement in managing their condition—are reflected through online self-disclosure remains poorly understood. We analyzed a large-scale dataset from Reddit depression-related communities to investigate how different psycho-linguistic profiles and coping orientations emerge from users’ language. We collected posts and comments from over 300,000 users across six depression-focused subreddits over two years. User-generated text was characterized through multiple psychological and linguistic dimensions capturing emotions, sentiment, subjectivity, and related features, then aggregated at the user-month level and analyzed using unsupervised clustering techniques. Our analysis identifies four distinct groups characterized by different emotional profiles and dominant coping orientations. These states exhibit meaningful correspondences with established theoretical frameworks, including the Coping Orientations to Problems Experienced model and the Patient Health Engagement model. Our findings demonstrate that large-scale textual data from online communities can provide interpretable insights into coping behaviors and engagement patterns, offering a complementary perspective to traditional approaches for studying mental health. Full article

In late Ming China, landscape (shanshui 山水) painting could function not only as a scenic representation but also as a pictorial means of making sacred space perceptible. This article examines Wu Bin’s hanging scroll Fanghu Tu 方壺圖 (1626; Palace Museum, Beijing) and asks how the painting renders Daoist sacred space visible through relations of distance, access, concealment, and uneven disclosure. To avoid treating “Daoist aesthetics” as a general label, the analysis uses schema and pictorial organization as limited descriptive terms for the structuring of spatial experience within the image. The close reading identifies two recurrent pictorial formations brought into relation in Fanghu Tu: a sea-boundary, distant-view configuration that emphasizes separation and delay, and a pavilion-centered enclosure that produces a more concentrated middle field. It then shows how layered waves and broken shoreline, cloud and mist, middle-zone enclosure, and the thinning legibility of the upper peaks prevent the scene from stabilizing into a single resolved destination. Read in relation to late Ming discussions of cultivated “strangeness” (qi 奇) in landscape painting, these features suggest that Daoist sacred space in Fanghu Tu takes shape as an uneven and mediated experience, structured through provisional concentration, interrupted visibility, and renewed distance. The article argues that late Ming landscape painting could render Daoist-inflected sacred spatial experience visible not only through iconography, but also through the pictorial distribution of visibility, access, and reorientation. Full article

This paper is the first attempt to interpret the visual ‘construemes’ by the constructivist poet Alexei N. Chicherin, published in the anthology Mena vsekh which appeared in Moscow in1924. ‘Construemes’ can be considered the most enigmatic artifacts of the Russian avant-garde. Although ‘construemes’ can be easily confused with meaningless visual zaum (‘the transrational’), Chicherin’s actions and the very nature of his personality prevent one from interpreting ‘construemes’ as actionist endeavors to scandalize or a ‘play on nonsense’. Analysis of the poet’s treatise Kan-Fun published in Moscow in 1926 required finding the key to deciphering the ‘construemes’, reveals the positivist nature of Chicherin’s visual–phonological exercises. In the treatise, the poet argues for the primacy of the eye and vision. He illustrates synthetic ‘signs’ or ‘pictograms’ with the quotidian example of propaganda posters, capable of influencing millions more effectively than words alone. The study emphasizes the enigmatic nature of the titles of Chicherin’s books, the Nietzschean subtexts of his self-presentation, encrypted allusions to the esoteric and magical tradition of the Tarot, and religious symbolism. Sixteen illustrations help the understanding of Chicherin’s logic behind the creation of his four ‘construemes’, including the most mysterious composition called ‘Raman’ (‘the shortest Kan-Fun Novel in the world’). The structure of this text synthesizes the verbal, visual–graphic, acoustic (phonological symbols) and musical (notes) levels. The article also examines Chicherin’s proven techniques: the appropriation of the sacred dimension and self-presentation as an actor possessing genuine knowledge and capable of competing alone with the entire literary environment. Full article

Background: research suggests that adolescents with a migrant background may be particularly vulnerable to behavioral addictions, including problematic gaming and Internet use. Methods: we compared Italian (ITA) and non-Italian (WIC) students on Internet Gaming Disorder (IGD) and Internet Addiction (IA) and examined whether coping strategies and interpersonal-relationship quality were associated with these outcomes, using robust linear models estimated with the GENLIN procedure in IBM SPSS Statistics 31 and regression-based models on observed variables. A total of 535 students (64.5% female; aged 9–18) completed the Video Games Addiction Questionnaire (VGA), the Internet Addiction Test (IAT), the Children’s Coping Strategies Checklist–Revised (CCSC), and the Assessment of Interpersonal Relations (AIR). Results: robust generalized linear models showed that WIC adolescents reported significantly higher IGD levels than their Italian peers, while no differences emerged for IA. Gender differences were evident only in unadjusted models, with males reporting higher IGD and females higher IA; however, these effects were not significant once age and nationality were considered simultaneously. Age was positively associated with IA but not with IGD. Avoidance coping was associated with higher levels of both IGD and IA, whereas active coping was negatively associated with IGD. Relationship quality was not associated with IGD but showed protective effects for IA: better relationships with mothers and with both male and female peers were associated with lower IA scores. Overall, the findings highlight that IGD and IA follow partially distinct developmental patterns. Migrant background emerged as a specific vulnerability factor for IGD, while IA appears more closely linked to age-related processes, coping styles, and interpersonal-relationship quality. Conclusions: the results call for differentiated prevention and intervention approaches targeting the distinct etiological mechanisms of each problematic behavior, focusing on coping and migration-related stress and belonging for IGD, and on strengthening coping repertoires and relational resources for IA. Full article

High-density cities face dual challenges of aging populations and climate change, driving widespread renewal of aging residential communities. Current practices, however, often treat sustainability goals (e.g., energy efficiency, carbon reduction) and age-friendly design objectives (e.g., accessibility, social inclusion), often guided by frameworks like the World Health Organization’s (WHO) age-friendly cities initiative, as separate or conflicting agendas, leading to fragmented policies and suboptimal outcomes. This study addresses this gap by proposing and testing a framework for “Sustainable-Age-friendly Coordinated Renewal” (SACR). Through a mixed-methods case study of a typical old community in the humid subtropical city of Guangzhou, China, we investigate how green infrastructure and low-carbon interventions can be synergistically designed to enhance both environmental performance and the well-being of elderly residents. A “Coordinated Renewal Strategy Package” was developed, incorporating ecological shading, sponge city facilities, energy retrofits, and accessible slow-traffic systems. Post-intervention simulation and evaluation indicated significant improvements in microclimate (e.g., reduced mean radiant temperature and Physiological Equivalent Temperature (PET)) and marked increases in outdoor activity duration and social interaction frequency among elderly residents. This study concludes that a human-centric, needs-based design approach is key to unlocking synergistic benefits. The proposed SACR framework and evaluation matrix offer a practical tool for urban planners, architects, and policymakers to holistically assess and implement community renewal projects, contributing to more resilient, inclusive, and sustainable urban futures by addressing localized challenges like the Urban Heat Island (UHI) effect. Full article

This article posits that Islamic fairy tales function as a mystical bridge of speech, a discursive passage that, within the siyasatnama tradition, summons the subject toward ethico-political responsibility, while in Sufi narrative, it carries the seeker beyond the limits of language toward a transformative silence. Reading Indo-Persian and Ottoman siyasatnama texts alongside the Sufi classics of Attar and Rumi, the article traces this movement across both traditions. In the siyasatnama context, the fairy tale translates divine commandments into a set of virtues, such as justice, mercy, and compassion, that regulate the conduct of both ruler and subject, framing governance as an ethical response to a sacred truth. Conversely, in Sufi narrative, the fairy tale operates within a similar ethical–pedagogical grammar but directs the subject toward a fundamentally different ontological end: The dissolution of the self. Here, speech becomes a threshold to be crossed and narrative a cage to be surrendered, allowing the seeker to enter the silence in which divine love is realized. Ultimately, the article proposes that mystical transcendence does not signify a withdrawal from the ethical sphere; instead, it constitutes its most profound enactment, manifested either through the responsible exercise of power or its radical renunciation in love. Full article

Borderline ovarian tumors often affect women of reproductive age for whom fertility preservation may be a major concern. While fertility-sparing surgery is widely accepted, the safety of controlled ovarian stimulation for oocyte cryopreservation after surgery remains uncertain due to potential recurrence risk. This retrospective single-center cohort study explored the association between controlled ovarian stimulation following fertility-sparing surgery and both recurrence risk and reproductive outcomes. Patients treated between January 2011 and June 2024 were included. Baseline characteristics, surgical details, and reproductive outcomes were compared using non-parametric and exact tests. Progression-free survival was assessed with Kaplan–Meier estimates and Cox proportional hazards models, modeling stimulation as a time-dependent covariate, and using a 10-month landmark analysis to account for immortal time bias. Of 45 included patients, 19 underwent ovarian stimulation after surgery, with a median interval of 9.9 months to stimulation. Median follow-up was 34.4 months. Recurrence occurred in 21.1% of stimulated patients versus 38.5% of non-stimulated patients (p = 0.338). After adjustment for time-dependent exposure, ovarian stimulation was not associated with increased recurrence risk (HR 0.95, 95% CI 0.22–4.09; p = 0.944). Eleven patients (24.4%) achieved at least one pregnancy, 81.8% of which were spontaneous. Controlled ovarian stimulation for oocyte cryopreservation after fertility-sparing surgery for borderline ovarian tumors did not show an increased recurrence risk, although larger studies are needed. Full article

Background: A paediatric cancer diagnosis is a profound stressor for the entire family system. Although coping strategies are well-studied, their link to the quality of the parent–child attachment relationship remains less explored. In this study, we investigated whether dyadic attachment dynamics—specifically closeness and conflict between parent and child—are associated with the use of adaptive or maladaptive coping strategies in caregivers of children undergoing active treatment for oncohaematological diseases. Methods: We conducted a multicentre, cross-sectional study across three Italian paediatric oncohaematology centres. A total of 165 caregivers of 91 paediatric patients aged 3–17 years completed self-report measures assessing parent–child relationship quality (Child–Parent Relationship Scale-CPRS), coping strategies (COPE-NVI), perceived social support (MSPSS), and resilience (RS-14). We tested whether the quality of the parent–child attachment relationship is associated with caregivers’ coping strategies. We hypothesised that Attachment Closeness would be associated with adaptive coping (Positive Attitude, Social Support, Problem Orientation), whereas Attachment Conflict would be associated with maladaptive coping (Avoidance). We conducted multiple linear regression models, adjusted for key covariates and with robust standard errors clustered at the family level, to test these hypotheses. Results: Higher levels of emotional closeness (CPRS) were significantly associated with greater use of adaptive coping strategies, specifically Positive Attitude (β = 0.20, p = 0.049) and Problem Orientation (β = 0.26, p = 0.002), even after controlling for sociodemographic factors, social support, and resilience. Conversely, higher levels of relational conflict were significantly associated with greater use of the maladaptive Avoidance strategy (β = 0.14, p = 0.015). The hypothesis linking closeness to Social Support seeking was not supported. Conclusions: The findings suggest that the parent–child attachment relationship is a significant correlate of caregiver coping strategies in caregivers of children with cancer. Interventions aimed at supporting the caregiver–child dyad by fostering emotional closeness and reducing conflict may promote more adaptive parental coping mechanisms, thereby enhancing family resilience and psychological adjustment throughout the treatment journey. Full article

Sol–gel phase transitions are complex far-from-equilibrium processes characterized by limited reproducibility, whose origin remains poorly understood and rarely quantified. We investigated the thermally induced sol–gel transition of agar using turbidimetry. A phenomenological model was applied to extract key kinetic parameters (maximum absorbance, maximum rate, and characteristic times) from 96 independent replicates. Variability was quantified and compared with that of an enzymatic reaction exhibiting similar sigmoidal kinetics, allowing for separation of experimental, intrinsic, and nonergodic contributions. Agar gelation displays markedly higher variability. The total variability (CV ≈ 16%) exceeds both the experimental error (1–2%) and the nonergodic contribution (≈2%), demonstrating that it predominantly arises from intrinsic process dynamics. Variability increases sharply during early stages of gelation and then evolves more gradually, indicating that stochastic nucleation and network formation pathways drive divergent kinetic trajectories despite identical initial conditions. Variability in gelation is therefore not a measurement artifact but an intrinsic hallmark of the sol–gel transition. This inherent stochasticity limits the predictive power of deterministic models, particularly at meso- and microscopic scales, and should be considered a fundamental feature of gel-forming systems. Our approach provides a quantitative framework for characterizing variability in phase transitions and may be extended to more complex biological and soft matter systems. Full article

Non-small cell lung cancer (NSCLC) remains the leading cause of cancer-related mortality globally. While multi-modal artificial intelligence (AI) models offer significant predictive potential, their translation into routine clinical practice is delayed by the “black box” nature of complex algorithms and the fragmentation of heterogeneous data. We present LANTERN-XGB, a hierarchical machine learning workflow designed to bridge this gap by generating interpretable “digital human avatars” for precision oncology. The methodology employs a multi-stage scalable tree boosting system (XGBoost) architecture utilizing shapley additive explanations (SHAP) for rigorous hierarchical feature selection, missing value management, and patient-specific decision support. The workflow was developed and benchmarked using a retrospective cohort of 437 patients with clinical N0 NSCLC, followed by validation on a prospective dataset (n = 100) and an independent external dataset (n = 100). The pipeline integrates diverse data modalities to predict occult lymph node metastasis (OLM). LANTERN-XGB identified a robust consensus signature driven by non-linear interactions among CT textural fragmentation, PET metabolic heterogeneity, tumor density distribution, and systemic clinical modulators. Exploratory transcriptomic pathway analysis (GSVA) revealed that high-risk predictions strongly correlate with systemic molecular dysregulation, such as the enrichment of immune-inflammatory signaling and metabolic stress pathways. The model achieved robust discrimination in external validation (AUC ≈ 0.77), performing comparably to state-of-the-art nomogram benchmarks. Crucially, the LANTERN-XGB framework demonstrated superior utility in handling diagnostic ambiguity; local force plots allowed for the correct reclassification of “borderline” prediction by visualizing feature interactions that standard linear models fail to capture. LANTERN-XGB provides a validated, open-source framework that successfully balances predictive power with clinical transparency. By empowering clinicians to visualize and verify the logic behind AI predictions, this workflow offers a pragmatic path for integrating reliable multi-modal avatars into daily medical decision-making. Full article

This study offers a comparative analysis of the symbolism of the soul’s ascent in Gregory of Nyssa’s De vita Moysis and Giovanni Pico della Mirandola’s Oratio. Rather than attempting to establish a linear or exclusive dependence, it focuses on a series of Mosaic themes that articulate a dynamic conception of perfection in both authors. Beginning with Moses as a paradigm of virtuous life, the paper examines the shared anthropology of desire underlying Nyssen’s notion of unending progress and Pico’s sacra ambitio. It then traces the ordered sequence of symbols as it develops in Gregory’s treatise: light and darkness, the mountain of the knowledge of God, Jacob’s ladder, the tabernacle, the eagle, death as consummation, and divine friendship. Through the interplay of these symbols both thinkers configure spiritual growth as an ever-deepening participation in divine unity and truth. Particular attention is given to integration of the classical disciplines of the ancient philosophical curriculum within the Mosaic itinerary, as well as to the conception of truth as gradually apprehensible but ultimately inexhaustible. The paper concludes by pondering the results of the comparative study and reflecting on Pico’s way of assimilating the wide variety of sources in his project of philosophical concord. Full article

Relics and mortal remains attributed to saints and martyrs, long venerated within Christian tradition, represent a unique area of scientific inquiry conducted under canonical procedures aimed at verifying authenticity, ensuring preservation, and promoting public devotion. This study focuses on the canonical recognition of the bone remains preserved in the Specus Martyrum of Atripalda (ancient Abellinum), attributed to Saint Hipolystus and the martyrs Crescentius and Irenaeus. The investigation was promoted by the Diocese of Avellino in preparation for the Hipolystian Jubilee commemorating 1720 years since their martyrdom (1 May 303 A.D.). A multidisciplinary approach was applied, combining historical analysis of sources such as the Martyrologium Hieronymianum (5th century), the Passio Sancti Hipolysti (9th century, edited in the Acta Sanctorum) and another Passio written by the Bishop Ruggero (13th century), with anthropological, radiographic, and radiocarbon (¹⁴C) analyses. The skeletal remains were examined through recognition, lateralization, cataloging, and evaluation of morphological and anthropometric features. The results identified elements compatible with an elderly male and two subadult individuals, consistent with the traditional identities of the martyrs. Despite the challenges posed by commingling, fragmentation, and environmental degradation, the investigation demonstrated how scientific rigor can effectively support canonical processes, offering a methodological framework for the verification of relics and contributing to the preservation of religious and cultural heritage. Full article

Heart failure (HF) is a systemic syndrome in which cardiac dysfunction is closely linked to multiorgan involvement, including the gastrointestinal tract. Increasing evidence highlights the relevance of the gut–heart axis in HF pathophysiology, whereby intestinal hypoperfusion, congestion, and barrier dysfunction promote gut microbiota dysbiosis, systemic inflammation, and adverse cardiovascular outcomes. In parallel, the advent of novel HF therapies, particularly sodium–glucose cotransporter 2 inhibitors (SGLT2i) and the angiotensin receptor–neprilysin inhibitor sacubitril/valsartan, has markedly improved clinical outcomes across HF phenotypes. Beyond their established cardiovascular benefits, these therapies may exert pleiotropic effects that extend to the intestinal environment and the gut microbiota. Through integrated actions on hemodynamics, neurohormonal activation, metabolic pathways, and inflammatory processes, recent data suggest that novel HF drugs may indirectly influence the gut-microbial composition and function. Conversely, the gut microbiota may modulate drug efficacy and result in interindividual variability in therapeutic responses, suggesting a bidirectional interaction between pharmacological treatment and the gut ecosystem. This narrative review summarizes current evidence of gut microbiota alterations in HF and critically examines emerging data on interactions between the gut microbiota and novel HF therapies, focusing on SGLT2 inhibitors and sacubitril/valsartan. Understanding this crosstalk may support the development of microbiota-informed, personalized therapeutic strategies in heart failure. Full article