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The metropolitan agglomeration in and around Bucharest, Romania’s capital and largest city, has experienced significant growth in recent decades, both economically and demographically. With over two million residents in its metropolitan area, Bucharest faces urban mobility challenges characterized by congested roads, overcrowded public transport routes, limited parking, and air pollution. This study evaluates the potential of AI-driven adaptive traffic signal control to address these challenges using an agent-based simulation approach. The authors focus on Bucharest’s north-western part, a critical congestion area. A detailed road network was derived from OpenStreetMap and calibrated with empirical traffic data from TomTom Junction Analytics and Route Monitoring (corridor-level speeds and junction-level turn ratios). Using the MATSim framework, the authors implemented and compared fixed-time and adaptive signal control scenarios. The adaptive approach uses a decentralized, demand-responsive algorithm to minimize delays and queue spillback in real time. Simulation results indicate that adaptive signal control significantly improves network-wide average speeds, reduces congestion peaks, and flattens the number of en-route agents throughout the day, compared to fixed-time plans. While simplifications remain in the model, such as generalized signal timings and the exclusion of pedestrian movements, these findings suggest that deploying adaptive traffic management systems could deliver substantial operational benefits in Bucharest’s urban context. This work demonstrates a scalable methodology combining open geospatial data, commercial traffic analytics, and agent-based simulation to rigorously evaluate AI-based traffic management strategies, offering evidence-based guidance for urban mobility planning and policy decisions. Full article

Traffic violations, the primary cause of road accidents, threaten public safety by disrupting traffic flow and causing substantial casualties and economic losses. Accurate spatiotemporal prediction of violations offers critical insights for proactive traffic management. While Graph Attention Network (GAT) methods excel in spatiotemporal forecasting, their practical deployment is hindered by prohibitive computational costs when handling dynamic large-scale data. To address this issue, we propose a Lightweight Traffic Violation Prediction with Graph Attention Distillation (LTVPGA) model, transferring spatial topology comprehension from a complex GAT to an efficient multilayer perceptron (MLP) via knowledge distillation. Our core contribution lies in topology-invariant knowledge transfer, where spatial relation priors distilled from the teacher’s attention heads enable the MLP student to bypass explicit graph computation. This approach achieves significant efficiency gains for large-scale data—notably accelerated inference time and reduced memory overhead—while preserving modeling capability. We conducted a performance comparison between LTVPGA, Conv-LSTM, and GATR (teacher model). LTVPGA achieved revolutionary efficiency: consuming merely 15% memory and 0.6% training time of GATR while preserving nearly the same accuracy. This capacity enables practical deployment without sacrificing fidelity, providing a scalable solution for intelligent transportation governance. Full article

Traffic flow prediction is a critical component of intelligent transportation systems, playing a vital role in alleviating congestion, improving road resource utilization, and supporting traffic management decisions. Although deep learning methods have made remarkable progress in this field in recent years, current studies still face challenges in modeling complex spatio-temporal dependencies, adapting to anomalous events, and generalizing to large-scale real-world scenarios. To address these issues, this paper proposes a novel traffic flow prediction model. The proposed approach simultaneously leverages temporal and frequency domain information and introduces adaptive graph convolutional layers to replace traditional graph convolutions, enabling dynamic capture of traffic network structural features. Furthermore, we design a frequency–temporal multi-head attention mechanism for effective multi-scale spatio-temporal feature extraction and develop a cross-multi-scale graph fusion strategy to enhance predictive performance. Extensive experiments on real-world datasets, PeMS and Beijing, demonstrate that our method significantly outperforms state-of-the-art (SOTA) baselines. For example, on the PeMS20 dataset, our model achieves a 53.6% lower MAE, a 12.3% lower NRMSE, and a 3.2% lower MAPE than the best existing method (STFGNN). Moreover, the proposed model achieves competitive computational efficiency and inference speed, making it well-suited for practical deployment. Full article

Background: Adipose-derived extracellular vesicles (adiposomes) are emerging as key mediators of inter-organ communication, yet their molecular composition and role in obesity-related pathophysiology remain underexplored. This study integrates clinical phenotyping with proteomic analysis of visceral adipose-derived adiposomes to identify obesity-linked molecular disruptions. Methods: Seventy-five obese and forty-seven lean adults were extensively profiled for metabolic, inflammatory, hepatic, and vascular parameters. Adiposomes isolated from visceral fat underwent mass spectrometry-based proteomic analysis, followed by differential abundance, pathway enrichment, regulatory network modeling, and clinical association testing. Results: Obese individuals exhibited widespread cardiometabolic dysfunction. Proteomics revealed 64 adiposomal proteins with differential abundance. Upregulated proteins (e.g., CRP, C9, APOC1) correlated with visceral adiposity, systemic inflammation, and endothelial dysfunction. In contrast, downregulated proteins (e.g., ADIPOQ, APOD, TTR, FGB, FGG) were associated with enhanced nitric oxide bioavailability and vascular protection, suggesting loss of homeostatic signaling. Network analyses identified TNF and IL1 as key upstream regulators driving inflammatory and oxidative stress pathways. Decision tree and random forest models accurately classified obesity, hypertension, diabetes, dyslipidemia, and hepatic steatosis (AUC = 0.908–0.994), identifying predictive protein signatures related to complement activation, inflammation, and lipid transport. Conclusion: Obesity alters adiposome proteomic cargo, reflecting and potentially mediating systemic inflammation, metabolic dysregulation, and vascular impairment. Full article

In recent years, digital twin technology has demonstrated remarkable potential in intelligent transportation systems, leveraging its capabilities of high-precision virtual mapping and real-time dynamic simulation of physical entities. By integrating multi-source data, it constructs virtual replicas of vehicles, roads, and infrastructure, enabling in-depth analysis and optimal decision-making for traffic scenarios. In vehicular networks, existing information caching and transmission systems suffer from low real-time information update and serious transmission delay accumulation due to outdated storage mechanism and insufficient interference coordination, thus leading to a high age of information (AoI). In response to this issue, we focus on pairwise road side unit (RSU) collaboration and propose a digital twin-integrated framework to jointly optimize information caching and communication power allocation. We model the tradeoff between information freshness and resource utilization to formulate an AoI-minimization problem with energy consumption and communication rate constraints, which is solved through deep reinforcement learning within digital twin systems. Simulation results show that our approach reduces the AoI by more than 12 percent compared with baseline methods, validating its effectiveness in balancing information freshness and communication efficiency. Full article

Transportation safety studies identify and analyze different contributing factors affecting the safety of road users using virtual reality (VR) traffic simulations in game engines (e.g., Unity). They often either use simplified VR traffic simulation or develop a more advanced simulation requiring substantial technical expertise and resources. The Simulation of Urban Mobility (SUMO) software is widely employed in the field, offering extensive traffic simulation rules such as car-following models, lane changing models, and right-of-way rules. In this study, we develop an open-source virtual reality traffic co-simulation by integrating two different simulation software, SUMO and Unity, and developing a virtual reality traffic simulation where a VR user in Unity interacts with traffic generated by SUMO. In our methodology, we first explain the process of creating road networks. Next, we programmatically integrate SUMO and Unity. Finally, we measure how well this system works using two indicators: the real-time factor (RTF) and frames per second (FPS). RTF compares SUMO’s simulation time to Unity’s simulation time each second, while FPS counts how many images Unity draws each second. Our results showed that our proposed VR traffic simulation can create a realistic traffic environment generated by SUMO under various traffic densities. This work offers a new platform for driver-behavior research and digital-twin applications. Full article

Against the backdrop of green and sustainable development, green innovation has become a central issue of concern for both society and academia. Based on regional innovation system and network theories, this study conceptualizes the urban knowledge base as a network structure rather than a simple collection of isolated knowledge elements. Using green patent licensing data, a multi-layer network is constructed, and the Exponential Random Graph Model (ERGM) is employed to examine the impact of urban knowledge network structures on city-level innovation diffusion. The study finds that in the green ICT field, cities’ deep embedding in knowledge networks weakens their ability to absorb external innovations, while broad embedding facilitates the introduction of external innovations. In the green transportation field, deep embedding in knowledge networks enhances the absorption of external innovations, whereas broad embedding has no significant effect. In both fields, knowledge combination potential and knowledge uniqueness promote the outward diffusion of local innovations but weaken the inflow of external innovations. This study not only offers theoretical insights into innovation diffusion at the city level but also provides guidance for policymakers in developing targeted urban sustainable development strategies. Full article

The growing concern about climate change and increased carbon emissions has promoted the electric vehicle market. Lithium-Ion Batteries (LIBs) are now the prevailing technology in electromobility, and large amounts will soon reach their end-of-life (EoL). Most counties have not designed sustainable reverse logistics networks to collect, remanufacture and recycle EoL electric vehicle batteries (EVBs). This study is focused on estimating the future EoL LIBs generation through dynamic material flow analysis using a three parameter Weibull distribution function under two scenarios for battery lifetime and then designing a reverse logistics network for the region of Attica (Greece), based on a generalizable modeling framework, to handle the discarded batteries up to 2040. The methodology considers three different battery handling strategies such as recycling, remanufacturing, and disposal. According to the estimated LIB waste generation in Attica, the designed network would annually manage between 5300 and 9600 tons of EoL EVBs by 2040. The optimal location for the collection and recycling centers considers fixed costs, processing costs, transportation costs, carbon emission tax and the number of EoL EVBs. The economic feasibility of the network is also examined through projected revenues from the sale of remanufactured batteries and recovered materials. The resulting discounted payback period ranges from 6.7 to 8.6 years, indicating strong financial viability. This research underscores the importance of circular economy principles and the management of EoL LIBs, which is a prerequisite for the sustainable promotion of the electric vehicle industry. Full article

Understanding how congestion forms and propagates over space and time is essential for improving the operational efficiency of urban traffic systems. Recent developments in causal emergence theory indicate that the causal structures underlying dynamic models are scale-dependent. Most existing studies on traffic congestion evolution focus on a single, fixed scale, which risks overlooking clearer causal patterns at other scales and thus limiting predictive power and practical applicability. To address this, we develop a multiscale congestion evolution modeling framework grounded in causal emergence theory. Within this framework we build dynamical models at multiple spatiotemporal scales using dynamic Bayesian networks (DBNs) and quantify the causal strength of these models using effective information (EI) and singular value decomposition (SVD)-based diagnostics. Using road networks from three central Kunshan regions, we validate the proposed framework across 24 spatiotemporal scales and five demand scenarios. Across all three regions and the tested scales, we observe evidence of causal emergence in congestion evolution dynamics. When results are pooled across regions and scenarios, models built at the 10 min/150 m scale exhibit stronger and more coherent causal structure than models at other scales. These findings demonstrate that the proposed framework can identify and help build dynamical models of congestion evolution at appropriate spatiotemporal scales, thereby supporting the development of proactive traffic management and effective resilience enhancement strategies for urban transport systems. Full article

Urban logistics face complexity due to traffic congestion, fleet heterogeneity, warehouse constraints, and driver workload balancing, especially in the Heterogeneous Multi-Trip Vehicle Routing Problem with Time Windows and Time-Varying Networks (HMTVRPTW-TVN). We develop a mixed-integer linear programming (MILP) model with dual-peak time discretization and exact linearization for heterogeneous fleet coordination. Given the NP-hard nature, we propose a Hyper-Heuristic based on Cumulative Reward Q-Learning (HHCRQL), integrating reinforcement learning with heuristic operators in a Markov Decision Process (MDP). The algorithm dynamically selects operators using a four-dimensional state space and a cumulative reward function combining timestep and fitness. Experiments show that, for small instances, HHCRQL achieves solutions within 3% of Gurobi’s optimum when customer nodes exceed 15, outperforming Large Neighborhood Search (LNS) and LNS with Simulated Annealing (LNSSA) with stable, shorter runtime. For large-scale instances, HHCRQL reduces gaps by up to 9.17% versus Iterated Local Search (ILS), 6.74% versus LNS, and 5.95% versus LNSSA, while maintaining relatively stable runtime. Real-world validation using Shanghai logistics data reduces waiting times by 35.36% and total transportation times by 24.68%, confirming HHCRQL’s effectiveness, robustness, and scalability. Full article

The rapid expansion of bike-sharing systems has introduced significant management challenges related to spatial-temporal demand fluctuations and inefficient e-fence capacity allocation. This study proposes a Spatio-Temporal Graph Attention Transformer Network (STGATN), a novel hybrid deep learning framework for dynamic demand forecasting in bike-sharing e-fence systems. The model integrates Graph Convolutional Networks to capture complex spatial dependencies among urban functional zones, Bi-LSTM networks to model temporal patterns with periodic variations, and attention mechanisms to dynamically incorporate weather impacts. By constructing a city-level graph based on POI-derived e-fences and implementing multi-source feature fusion through Transformer architecture, the STGATN effectively addresses the limitations of static capacity allocation strategies. The experimental results from Shenzhen’s Nanshan District demonstrate the performance, with the STGATN model achieving an overall Mean Absolute Error (MAE) of 0.0992 and a Coefficient of Determination (R²) of 0.8426. This significantly outperforms baseline models such as LSTM (R²: 0.6215) and a GCN (R²: 0.5488). Ablation studies confirm the model’s key components are critical; removing the GCN module decreased R² by 12 percentage points to 0.7411, while removing the weather attention mechanism reduced R² by nearly 5 percentage points to 0.8034. The framework provides a scientific basis for dynamic e-fence capacity management, advancing spatio-temporal prediction methodologies for sustainable transportation. Full article

Photocatalysis is an emerging technology that harnesses light energy to facilitate chemical reactions. It has garnered considerable attention in the field of catalysis due to its promising applications in environmental remediation and sustainable energy generation. Recently, researchers have been exploring innovative techniques to improve the surface reactivity of ferroelectric materials for catalytic purposes, leveraging their distinct properties to enhance photocatalytic efficiency. With their switchable polarization and improved charge transport capabilities, ferroelectric materials show promise as effective photocatalysts for various reactions, including carbon dioxide (CO₂) reduction. Through a blend of experimental studies and theoretical modeling, researchers have shown that these materials can effectively convert CO₂ into valuable products, contributing to efforts to reduce greenhouse gas emissions and promote a cleaner environment. An artificial neural network (ANN) was employed to analyze parameter relationships and their impacts in this study, demonstrating its ability to manage training data errors and its applications in fields like speech and image recognition. This research also examined changes in charge separation, light absorption, and surface area related to variations in band gap and polarization, confirming prediction accuracy through linear regression analysis. Full article

The Multi-Mode Model (MMM) is a physics-based anomalous transport model integrated into TRANSP for predicting electron and ion thermal transport, electron and impurity particle transport, and toroidal and poloidal momentum transport. While MMM provides valuable predictive capabilities, its computational cost, although manageable for standard simulations, is too high for real-time control applications. MMMnet, a neural network-based surrogate model, is developed to address this challenge by significantly reducing computation time while maintaining high accuracy. Trained on TRANSP simulations of DIII-D discharges, MMMnet incorporates an updated version of MMM (9.0.10) with enhanced physics, including isotopic effects, plasma shaping via effective magnetic shear, unified correlation lengths for ion-scale modes, and a new physics-based model for the electromagnetic electron temperature gradient mode. A key advancement is MMMnet’s ability to predict all six transport coefficients, providing a comprehensive representation of plasma transport dynamics. MMMnet achieves a two-order-of-magnitude speed improvement while maintaining strong correlation with MMM diffusivities, making it well-suited for real-time tokamak control and scenario optimization. Full article

Brain tumors elicit complex neuropsychiatric disturbances that frequently occur prior to radiological detection and hinder differentiation from major psychiatric disorders. These syndromes stem from tumor-dependent metabolic reprogramming, neuroimmune activation, neurotransmitter dysregulation, and large-scale circuit disruption. Dinucleotide hypermethylation (e.g., IDH-mutant gliomas), through the accumulation of 2-hydroxyglutarate (2-HG), execute broad DNA and histone hypermethylation, hypermethylating serotonergic and glutamatergic pathways, and contributing to a treatment-resistant cognitive-affective syndrome. High-grade gliomas promote glutamate excitotoxicity via system Xc⁻ transporter upregulation that contributes to cognitive and affective instability. Cytokine cascades induced by tumors (e.g., IL-6, TNF-α, IFN-γ) lead to the breakdown of the blood–brain barrier (BBB), which is thought to amplify neuroinflammatory processes similar to those seen in schizophrenia spectrum disorders and autoimmune encephalopathies. Frontal gliomas present with apathy and disinhibition, and temporal tumors lead to hallucinations, emotional lability, and episodic memory dysfunction. Tumor-associated neuropsychiatric dysfunction, despite increasing recognition, is underdiagnosed and commonly misdiagnosed. This paper seeks to consolidate the mechanistic understanding of these syndromes, drawing on perspectives from neuroimaging, molecular oncology, neuroimmunology, and computational psychiatry. Novel approaches, including lesion-network mapping, exosomal biomarkers or AI-based predictive modeling, have projected early detection and precision-targeted interventions. In the context of the limitations of conventional psychotropic treatments, mechanistically informed therapies, including neuromodulation, neuroimmune-based interventions, and metabolic reprogramming, are essential to improving psychiatric and oncological outcomes. Paraneoplastic neuropsychiatric syndromes are not due to a secondary effect, rather, they are manifestations integral to the biology of a tumor, so they require a new paradigm in both diagnosis and treatment. And defining their molecular and circuit-level underpinnings will propel the next frontier of precision psychiatry in neuro-oncology, cementing the understanding that psychiatric dysfunction is a core influencer of survival, resilience, and quality of life. Full article

Robust, reliable, and secure communications are essential for efficient railway operation and keeping employees and passengers safe. The Future Railway Mobile Communication System (FRMCS) is a global standard aimed at providing innovative, essential, and high-performance communication applications in railway transport. In comparison with the legacy communication system (GSM-R), it provides high data rates, ultra-high reliability, and low latency. The FRMCS architecture will also benefit from cloud computing, following the principles of the cloud-native 5G core network design based on Network Function Virtualization (NFV). In this paper, an approach to the management of virtualized FRMCS applications is presented. First, the key management functionality related to the virtualized FRMCS application is identified based on an analysis of the different use cases. Next, this functionality is synthesized as RESTful services. The communication between application management and the services is designed as Application Programing Interfaces (APIs). The APIs are formally verified by modeling the management states of an FRMCS application instance from different points of view, and it is mathematically proved that the management state models are synchronized in time. The latency introduced by the designed APIs, as a key performance indicator, is evaluated through emulation. Full article