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14 pages, 12742 KB  
Article
Grounded L-Shaped Corner-Embraced Patch Array Polarization Conversion Metasurface Compatible with Multiband and Broadband Characteristics
by Shi Kong, Yifei Zhang, Ziheng Fu and Rui Yang
Micromachines 2025, 16(11), 1240; https://doi.org/10.3390/mi16111240 (registering DOI) - 30 Oct 2025
Abstract
We propose a linear polarization rotator metasurface composed of a grounded array of L-shaped corner-embraced patches. Both simulation and experimental results confirm that the metasurface achieves a polarization conversion ratio exceeding 90% across four distinct frequency bands: 5.7–6.2 GHz, 7.0–8.7 GHz, 11.2–13.9 GHz, [...] Read more.
We propose a linear polarization rotator metasurface composed of a grounded array of L-shaped corner-embraced patches. Both simulation and experimental results confirm that the metasurface achieves a polarization conversion ratio exceeding 90% across four distinct frequency bands: 5.7–6.2 GHz, 7.0–8.7 GHz, 11.2–13.9 GHz, and 16.7–18.0 GHz, with near-unity conversion efficiency at four resonance points. Furthermore, the metasurface demonstrates effective polarization conversion over an ultra-wide frequency range from 5.5 to 18.1 GHz. The combination of multiband and broadband characteristics makes this design highly valuable for advanced applications in complex electromagnetic environments, including multifunctional radar systems requiring multiband capabilities and wireless communication systems demanding ultra-wideband performance. Full article
32 pages, 9507 KB  
Article
Forensic Investigation of the Seepage-Induced Flow Failure at La Luciana Tailings Storage Facility (1960 Spain)
by Aldo Onel Oliva-González, Joanna Butlanska, José Antonio Fernández-Merodo and Roberto Lorenzo Rodríguez-Pacheco
Minerals 2025, 15(11), 1131; https://doi.org/10.3390/min15111131 - 29 Oct 2025
Abstract
This study presents a forensic investigation of the catastrophic failure of the La Luciana Tailings Storage Facility (TSF) in Reocín, Spain, in 1960. The collapse released approximately 300,000 m3 of tailings, causing 18 fatalities, extensive flooding of farmland and lakes, and the [...] Read more.
This study presents a forensic investigation of the catastrophic failure of the La Luciana Tailings Storage Facility (TSF) in Reocín, Spain, in 1960. The collapse released approximately 300,000 m3 of tailings, causing 18 fatalities, extensive flooding of farmland and lakes, and the contamination of the Besaya River, leading to long-term environmental degradation. The analysis integrates historical documentation, cartographic evidence, in situ testing, laboratory analyses, and numerical modelling to reconstruct the failure sequence and identify its causes. Geotechnical characterization based on cone penetration tests (CPTs), shear wave velocity profiles, and laboratory testing revealed pronounced heterogeneity, with alternating contractive and dilative layers. Hydraulic analyses indicate permeabilities from 10−5 m/s in sand dam materials to 10−9 m/s in fine-grained pond deposits, with evidence of capillary saturation exceeding 20 m, favouring excess pore-pressure accumulation. Limited equilibrium and finite element analyses show that when the decant pond was within ~20 m of the dam, the factor of safety dropped to unity, triggering retrogressive flowslides consistent with field evidence. The results underline critical lessons for TSF governance: maintaining unsaturated tailings, ensuring efficient drainage and decant systems, and monitoring pond proximity to the dam. These are essential to prevent flow failures. This research also demonstrates a replicable forensic methodology applicable to other historical TSF failures, enhancing predictive models and informing modern frameworks such as the EU Directive 2006/21/EC and the Global Industry Standard on Tailings Management (GISTM). Full article
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24 pages, 392 KB  
Article
Supercommuting Maps on Incidence Algebras with Superalgebra Structures
by Nof T. Alharbi
Symmetry 2025, 17(11), 1817; https://doi.org/10.3390/sym17111817 - 28 Oct 2025
Abstract
Let R be a 2-torsion-free and n!-torsion-free commutative ring with unity, and let X be a locally finite preordered set. We endow the incidence algebra I(X,R) with a superalgebra structure via a nontrivial idempotent, which decomposes [...] Read more.
Let R be a 2-torsion-free and n!-torsion-free commutative ring with unity, and let X be a locally finite preordered set. We endow the incidence algebra I(X,R) with a superalgebra structure via a nontrivial idempotent, which decomposes I(X,R) into even and odd parts A0A1. Our main result shows that if any two directed edges in each connected component of the complete Hasse diagram (X,D) lie in one cycle, then every supercommuting map on I(X,R) is proper. A supercommuting map θ:I(X,R)I(X,R) is defined by the condition [θ(x),x]s=0 for all xI(X,R), where [a,b]s=ab(1)|a||b|ba is the supercommutator. We prove that such maps must take the form θ(x)=λx+μ(x), where λZs(I(X,R)) (the supercenter) and μ:I(X,R)Zs(I(X,R)) is an R-linear map. This generalizes the known results on commuting maps of incidence algebras and other associative algebras. Full article
(This article belongs to the Special Issue Symmetry in Lie Groups and Lie Algebras)
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21 pages, 1929 KB  
Article
Obstacle Avoidance Algorithm for Multi-Robot Formation Based on Affine Transformation
by Qiaolong Zhang, Yanhong Su, Youhang Zhou, Jing Sun, Zhe Zhou, Zilin Wan and Wenna Deng
Symmetry 2025, 17(11), 1816; https://doi.org/10.3390/sym17111816 - 28 Oct 2025
Viewed by 35
Abstract
Aiming at the problem that obstacle avoidance flexibility and formation integrity are difficult to coexist in multi-robot formation motion, a path-deformation mapping mechanism is proposed, which deeply integrates artificial potential field and affine transformation, and drives formation adaptive adjustment in real time through [...] Read more.
Aiming at the problem that obstacle avoidance flexibility and formation integrity are difficult to coexist in multi-robot formation motion, a path-deformation mapping mechanism is proposed, which deeply integrates artificial potential field and affine transformation, and drives formation adaptive adjustment in real time through path information. By using the non-uniform scaling characteristics of the affine transformation, the limitation of traditional conformal transformation is broken through, and the unity of flexibility and integrity is realized. The effectiveness of the algorithm is verified by experiments, which provide a practical solution for cooperative obstacle avoidance of multi-robot systems in complex environments. In order to verify the performance of the algorithm, a numerical simulation is carried out, and an experimental platform composed of seven omnidirectional mobile robots is built for physical verification. The simulation and experimental results show that the formation can complete the obstacle avoidance task in the complex static obstacle environment, and the average formation tracking error is maintained below 0.05 m. Compared with the traditional local obstacle avoidance or formation switching method, this algorithm significantly improves the fluency of the obstacle avoidance process and the integrity of the formation while ensuring a success rate of 100% obstacle avoidance. Full article
(This article belongs to the Section Computer)
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23 pages, 3352 KB  
Article
Characterization of the Optical Properties of Biomass-Burning Aerosols in Two High Andean Cities, Huancayo and La Paz, and Their Effect on Radiative Forcing
by Cesar Victoria-Barros and René Estevan Arredondo
Atmosphere 2025, 16(11), 1240; https://doi.org/10.3390/atmos16111240 - 28 Oct 2025
Viewed by 126
Abstract
Atmospheric aerosols are known to alter the Earth’s radiative balance and influence climate. However, accurately quantifying the magnitude of aerosol-induced radiative forcing remains challenging. We characterize optical properties of biomass-burning (BB) and non-biomass-burning (NB) aerosols and quantify BB aerosol radiative forcing at two [...] Read more.
Atmospheric aerosols are known to alter the Earth’s radiative balance and influence climate. However, accurately quantifying the magnitude of aerosol-induced radiative forcing remains challenging. We characterize optical properties of biomass-burning (BB) and non-biomass-burning (NB) aerosols and quantify BB aerosol radiative forcing at two AERONET (AErosol RObotic NETwork) sites in Huancayo (Peru) and La Paz (Bolivia) during 2015–2021. From AERONET data, we derive aerosol optical depth (AOD), Ångström exponent (AE), single-scattering albedo (SSA), and asymmetry parameter (ASY). We then employ the SBDART model to calculate aerosol radiative forcing (ARF) on monthly and multiannual timescales. BB aerosols peak in September (AOD: 0.230 at Huancayo; 0.235 at La Paz), while NB aerosols reach maxima in September at Huancayo (0.109) and November at La Paz (0.104). AE values exceeding unity for BB aerosols indicate fine-mode dominance. Huancayo exhibited the highest BB ARF in November: +16.4 W m−2 at the top of the atmosphere (TOA), –18.6 W m−2 at the surface (BOA), and +35.1 W m−2 within the atmospheric column (ATM). This was driven by elevated AOD and high scattering efficiency. At La Paz, where SSA data was only available for September, BBARF values were also significant (+15.16 at TOA, –17.52 at BOA, and +32.73 W m−2 within the ATM). This result underscores the importance of quantifying the ARF, particularly over South America where data is scarce. Full article
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9 pages, 179 KB  
Proceeding Paper
Intelligence as the Capacity to Overcome the Complexity of Information: Search for Unity in the Diverse Forms of Intelligence
by Marcin J. Schroeder
Proceedings 2025, 126(1), 14; https://doi.org/10.3390/proceedings2025126014 - 27 Oct 2025
Abstract
The same term “intelligence” is used in different contexts as if there were a consensus on its meaning, even if already within the paradigmatic subject of human intelligence, the dominating view is that there are multiple (two, three, eight, or more) intelligences depending [...] Read more.
The same term “intelligence” is used in different contexts as if there were a consensus on its meaning, even if already within the paradigmatic subject of human intelligence, the dominating view is that there are multiple (two, three, eight, or more) intelligences depending on the diverse criteria for being intelligent. This multiplicity increases when non-human agents are considered. This short paper serves as a preliminary report on a more comprehensive study, currently at the stage of preparation for publication, with the purpose to seek a uniform characteristic of intelligence formulated in terms of information and its complexity behind and above its diverse manifestations and instantiations in multiple contexts, including those of its human, animal, or other natural forms, as well as characteristics of artifacts. The proposed view of intelligence as the capacity to overcome the complexity of information unifies these manifestations, and not only sets foundations for their systematic study in already considered instances, but also allows effective seeking of its not-yet-known manifestations. Due to the limited volume of this paper, the focus is on the motivations for and feasibility of the more extensive study, with only an outline of the proposed view of a general concept of intelligence. Full article
21 pages, 304 KB  
Article
Non-Global Lie Higher Derivations on Triangular Algebras Without Assuming Unity
by Xinfeng Liang and Yujiao Sun
Axioms 2025, 14(11), 790; https://doi.org/10.3390/axioms14110790 - 27 Oct 2025
Viewed by 59
Abstract
This work establishes a unified structural theory for non-global Lie higher derivations on triangular algebras T, without assuming the existence of a unit element. The primary contribution is the introduction of extreme non-global Lie higher derivations and the proof that every non-global [...] Read more.
This work establishes a unified structural theory for non-global Lie higher derivations on triangular algebras T, without assuming the existence of a unit element. The primary contribution is the introduction of extreme non-global Lie higher derivations and the proof that every non-global Lie higher derivation on T admits a unique decomposition into three components: a higher derivation, an extreme non-global Lie higher derivation, and a central map vanishing on all commutators [x,y], where x,yT satisfy xy=0. This general framework is then explicitly applied to describe such derivations on two significant classes of algebras: upper triangular matrix algebras over faithful algebras and over semiprime algebras. By encompassing both unital and non-unital cases within a single characterization, the theory developed here not only generalizes numerous earlier results but also substantially expands the scope of the existing research landscape. Full article
28 pages, 4508 KB  
Article
Mixed Reality-Based Multi-Scenario Visualization and Control in Automated Terminals: A Middleware and Digital Twin Driven Approach
by Yubo Wang, Enyu Zhang, Ang Yang, Keshuang Du and Jing Gao
Buildings 2025, 15(21), 3879; https://doi.org/10.3390/buildings15213879 - 27 Oct 2025
Viewed by 99
Abstract
This study presents a Digital Twin–Mixed Reality (DT–MR) framework for the immersive and interactive supervision of automated container terminals (ACTs), addressing the fragmented data and limited situational awareness of conventional 2D monitoring systems. The framework employs a middleware-centric architecture that integrates heterogeneous [...] Read more.
This study presents a Digital Twin–Mixed Reality (DT–MR) framework for the immersive and interactive supervision of automated container terminals (ACTs), addressing the fragmented data and limited situational awareness of conventional 2D monitoring systems. The framework employs a middleware-centric architecture that integrates heterogeneous subsystems—covering terminal operation, equipment control, and information management—through standardized industrial communication protocols. It ensures synchronized timestamps and delivers semantically aligned, low-latency data streams to a multi-scale Digital Twin developed in Unity. The twin applies level-of-detail modeling, spatial anchoring, and coordinate alignment (from Industry Foundation Classes (IFCs) to east–north–up (ENU) coordinates and Unity space) for accurate registration with physical assets, while a Microsoft HoloLens 2 device provides an intuitive Mixed Reality interface that combines gaze, gesture, and voice commands with built-in safety interlocks for secure human–machine interaction. Quantitative performance benchmarks—latency ≤100 ms, status refresh ≤1 s, and throughput ≥10,000 events/s—were met through targeted engineering and validated using representative scenarios of quay crane alignment and automated guided vehicle (AGV) rerouting, demonstrating improved anomaly detection, reduced decision latency, and enhanced operational resilience. The proposed DT–MR pipeline establishes a reproducible and extensible foundation for real-time, human-in-the-loop supervision across ports, airports, and other large-scale smart infrastructures. Full article
(This article belongs to the Special Issue Digital Technologies, AI and BIM in Construction)
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25 pages, 782 KB  
Article
Degenerate Fractals: A Formal and Computational Framework for Zero-Dimension Attractors
by Ion Andronache
Mathematics 2025, 13(21), 3407; https://doi.org/10.3390/math13213407 - 26 Oct 2025
Viewed by 634
Abstract
This paper analyzes the extreme limit of iterated function systems (IFSs) when the number of contractions drops to one and the resulting attractors reduce to a single point. While classical fractals have a strictly positive fractal dimension, the degenerate case D=0 [...] Read more.
This paper analyzes the extreme limit of iterated function systems (IFSs) when the number of contractions drops to one and the resulting attractors reduce to a single point. While classical fractals have a strictly positive fractal dimension, the degenerate case D=0 has been little explored. Starting from the question “what happens to a fractal when its complexity collapses completely?”, Moran’s similarity equation becomes tautological (rs=1 with solution s=dimM=0) and that only the Hausdorff and box-counting definitions allow an exact calculation. Based on Banach’s fixed point theorem and these definitions, we prove that the attractor of a degenerate IFS is a singleton with dimH=dimB=0. We develop a reproducible computational methodology to visualize the collapse in dimensions 1–3 (the Iterated Line Contraction—1D/Iterated Square Contraction—2D/Iterated Cube Contraction—3D families), including deterministic and stochastic variants, and we provide a Python script 3.9. The theoretical and numerical results show that the covering box-counting retains unity across all generations, confirming the zero-dimension element and the stability of the phenomenon under moderate perturbations. We conclude that degenerate fractals are an indispensable benchmark for validating fractal dimension estimators and for studying transitions to attractors with positive dimensions. Full article
(This article belongs to the Special Issue Advances in Fractal Geometry and Applications)
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14 pages, 5708 KB  
Article
Integrative Taxonomic Analysis Doubles Number of Species in the Central Asian Butterfly Genus Lyela (Lepidoptera, Nymphalidae, Satyrinae)
by Vladimir A. Lukhtanov
Insects 2025, 16(11), 1089; https://doi.org/10.3390/insects16111089 - 24 Oct 2025
Viewed by 372
Abstract
Lyela Swinhoe, 1908 is a small Central Asian butterfly genus, in which three species were previously recognized based on comparison of wing patterns. The present study, based on an extensive population sample across the entire range of Lyela and using integrative taxonomy methods, [...] Read more.
Lyela Swinhoe, 1908 is a small Central Asian butterfly genus, in which three species were previously recognized based on comparison of wing patterns. The present study, based on an extensive population sample across the entire range of Lyela and using integrative taxonomy methods, confirmed the monophyly of the genus and revealed the paraphyly of the most widespread species, Lyela myops sensu auct. The genus is shown to include six species, L. myops (Staudinger, 1881) (Kazakhstan, northern Kyrgyzstan, northwestern China, and southwestern Mongolia), L. tashkumirica Lukhtanov, 2024, stat. nov. (Fergana Valley in Kyrgyzstan), L. babatagi Tshikolovets, 1998, stat. nov. (southern Uzbekistan and eastern Turkmenistan), L. tekkensis (Staudinger, 1886), stat. nov. (southwestern Turkmenistan and northeastern Iran), L. macmahoni Swinhoe, 1908 (Pakistan and Afghanistan), and L. amirica Wyatt, 1961 (Afghanistan). Each of these species represents a monophyletic unity with respect to the COI gene and is separated from the other species by a distinct barcoding gap and structural differences in the male genitalia. Full article
(This article belongs to the Section Insect Systematics, Phylogeny and Evolution)
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27 pages, 2231 KB  
Article
A Digital Model-Based Serious Game for PID-Controller Education: One-Axis Drone Model, Analytics, and Student Study
by Raul Brumar, Stelian Nicola and Horia Ciocârlie
Multimodal Technol. Interact. 2025, 9(11), 111; https://doi.org/10.3390/mti9110111 - 24 Oct 2025
Viewed by 196
Abstract
This paper presents a serious game designed to support the teaching of PID controllers. The game couples a visually clear Unity scene with a physics-accurate digital model of a drone with a single degree of freedom (called a one-axis drone) and helps prepare [...] Read more.
This paper presents a serious game designed to support the teaching of PID controllers. The game couples a visually clear Unity scene with a physics-accurate digital model of a drone with a single degree of freedom (called a one-axis drone) and helps prepare students to meet the demands of Industry 4.0 and 5.0. An analytics back-end logs system error at 10 Hz and interaction metrics, enabling instructors to diagnose common tuning issues from a plot and to provide actionable hints to students. The design process that led to choosing the one-axis drone and turbulence application via “turbulence balls” is explained, after which the implementation is described. The proposed solution is evaluated in a within-subjects study performed with 21 students from mixed technical backgrounds across two short, unsupervised tinkering sessions of up to 10 min framed by four quizzes of both general and theoretical content. Three questions shaped the analysis: (i) whether error traces can be visualized by instructors to generate actionable hints for students; (ii) whether brief, unsupervised play sessions yield measurable gains in knowledge or stability; and (iii) whether efficiency of tuning improves without measurable changes in tune performance. Results show that analysis of plotted error values exposes recognizable issues with PID tunes that map to concrete hints provided by the instructor. When it comes to unsupervised play sessions, no systematic pre/post improvement in quiz scores or normalized area under absolute error was observed. However, it required significantly less effort from students in the second session to reach the same tune performance, indicating improved tuning efficiency. Overall, the proposed serious game with the digital twin-inspired one-axis drone and custom analytics back-end has emerged as a practical, safe, and low-cost auxiliary tool for teaching PID controllers, helping bridge the gap between theory and practice. Full article
(This article belongs to the Special Issue Video Games: Learning, Emotions, and Motivation)
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23 pages, 8650 KB  
Article
Feasibility Study on the “New Traditional” Model and Energy-Saving Strategy for Chinese–Korean Vernacular Living Under the Construction of Border Villages
by Weiming Chu, Junjie Xiang and Changjie Jin
Buildings 2025, 15(21), 3838; https://doi.org/10.3390/buildings15213838 - 23 Oct 2025
Viewed by 326
Abstract
In the context of China’s rural revitalization strategy, improving the livability and sustainability of traditional dwellings in border regions has become a critical priority. This study examines Chinese–Korean houses in border villages, where field investigations and quantitative analysis reveal persistent challenges: poor indoor [...] Read more.
In the context of China’s rural revitalization strategy, improving the livability and sustainability of traditional dwellings in border regions has become a critical priority. This study examines Chinese–Korean houses in border villages, where field investigations and quantitative analysis reveal persistent challenges: poor indoor thermal comfort and high energy consumption due to outdated building envelopes and inefficient heating systems. To address these issues, we propose an integrated retrofitting solution that combines building-integrated photovoltaics (BIPV) and ground-source heat pump (GSHP) technologies. Unlike previous studies focusing on isolated applications, our approach emphasizes the synergistic integration of active energy generation and high-efficiency thermal regulation, while preserving the architectural and cultural identity of traditional dwellings. Pilot results demonstrate significant improvements in PMV (Predicted Mean Vote) and economic viability, and achieve a high level of esthetic and cultural compatibility. Modular BIPV integration provides on-site renewable electricity without altering roof forms, while GSHP ensures stable, efficient heating and cooling year-round. This solution offers a replicable, regionally adaptive model for low-carbon rural housing transformation. By aligning technological innovation with cultural preservation and socioeconomic feasibility, the study contributes to a new paradigm of rural development, supporting ecological sustainability, ethnic unity, and border stability. Full article
(This article belongs to the Section Building Energy, Physics, Environment, and Systems)
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20 pages, 2554 KB  
Article
The Intersections of Buddhism and Contemporary Korean Visual Culture
by Mina Kim
Religions 2025, 16(11), 1337; https://doi.org/10.3390/rel16111337 - 23 Oct 2025
Viewed by 303
Abstract
Religion has played a significant role in shaping social cohesion by providing stability and support that transcends the human capacity to resolve individual desires, aspirations, and concerns while contributing to national identity and unity. Religion has also become an inseparable element of human [...] Read more.
Religion has played a significant role in shaping social cohesion by providing stability and support that transcends the human capacity to resolve individual desires, aspirations, and concerns while contributing to national identity and unity. Religion has also become an inseparable element of human history, and the human desire to embody religious imagery has been with human history. Art has historically visualized the complex and subtle relationship between humans and religion directly and profoundly. In this way, religious works have provided a lens for examining how religious ideas permeate everyday life and influence cultural practices. This study explores how Buddhist philosophy and esthetics have influenced and coexisted in contemporary Korean artistic expression to emphasize the rich intersections between Buddhism and modern and contemporary Korean artworks. The concept of consilience, which refers to the integration of knowledge across diverse domains, aims to explain how Buddhist thought has transcended human conflict and promoted harmonious coexistence within Korean visual culture. The dynamic interplay between traditional Buddhist values and contemporary visual practices produces a rich cultural synthesis that highlights the importance of preserving Korea’s artistic heritage and expands and fosters the development of global visual culture today. Full article
(This article belongs to the Special Issue Religious Conflict and Coexistence in Korea)
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21 pages, 1214 KB  
Article
Wave Scattering and Trapping by C-Type Floating Breakwaters in the Presence of Bottom-Standing Perforated Semicircular Humps
by Prakash Kar, Harekrushna Behera and Dezhi Ning
Mathematics 2025, 13(21), 3372; https://doi.org/10.3390/math13213372 - 23 Oct 2025
Viewed by 152
Abstract
In this paper, the propagation of surface gravity waves over multiple bottom-standing porous semicircular humps is examined in the absence and presence of double floating C-type detached asymmetric breakwaters. Both wave scattering and trapping phenomena are investigated within the framework of small-amplitude [...] Read more.
In this paper, the propagation of surface gravity waves over multiple bottom-standing porous semicircular humps is examined in the absence and presence of double floating C-type detached asymmetric breakwaters. Both wave scattering and trapping phenomena are investigated within the framework of small-amplitude linear water wave theory, with the governing problem numerically solved using the multi-domain Boundary Element Method (BEM) in finite-depth water. A detailed parametric analysis is conducted to evaluate the effects of key physical parameters, including hump radius, porosity, spacing between adjacent humps, and the separation between the two C-type detached breakwaters. The study presents results for reflection and transmission coefficients, free-surface elevations, and the horizontal and vertical forces acting on the first perforated semicircular hump, as well as on the shore-fixed wall. The findings highlight the significant role of porous humps in altering Bragg scattering characteristics. For larger wavenumbers, wave reflection increases notably in the presence of a vertical shore-fixed wall, while it tends to vanish in its absence. Reflection is also observed to decrease with an increase in semicircle radius. Furthermore, as the wavenumber approaches zero, the vertical force on multiple permeable semicircles converges to zero, whereas for impermeable semicircles, it approaches unity. In addition, the horizontal force acting on the shore-fixed wall diminishes rapidly with increasing porosity of the semicircular humps. Full article
(This article belongs to the Section E: Applied Mathematics)
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27 pages, 1269 KB  
Review
Pharmacogenomics Applied to Acute Leukemias: Identifying Clinically Relevant Genetic Variants
by Flávia Melo Cunha de Pinho Pessoa, Isabelle Magalhães Farias, Beatriz Maria Dias Nogueira, Caio Bezerra Machado, Igor Valentim Barreto, Anna Karolyna da Costa Machado, Guilherme Passos de Morais, Leidivan Sousa da Cunha, Deivide de Sousa Oliveira, André Pontes Thé, Rodrigo Monteiro Ribeiro, Patrícia Maria Pontes Thé, Manoel Odorico de Moraes Filho, Maria Elisabete Amaral de Moraes and Caroline Aquino Moreira-Nunes
Biomedicines 2025, 13(11), 2581; https://doi.org/10.3390/biomedicines13112581 - 22 Oct 2025
Viewed by 314
Abstract
Acute leukemias are highly aggressive hematologic malignancies that demand intensive chemotherapy regimens. However, drug toxicity remains a major barrier to treatment success and patient survival. In this context, pharmacogenomics offers a promising strategy by identifying single-nucleotide variants (SNVs) that influence drug metabolism, efficacy, [...] Read more.
Acute leukemias are highly aggressive hematologic malignancies that demand intensive chemotherapy regimens. However, drug toxicity remains a major barrier to treatment success and patient survival. In this context, pharmacogenomics offers a promising strategy by identifying single-nucleotide variants (SNVs) that influence drug metabolism, efficacy, and toxicity, ultimately impacting treatment outcomes. This study analyzed data from the ClinPGx/PharmGKB database to identify clinically annotated variants related to chemotherapy response in Acute Myeloid Leukemia (AML) and Acute Lymphoblastic Leukemia (ALL). A total of 24 variants were curated for AML and 57 for ALL. Among these, nonsynonymous variants were most frequent in ALL (31.6%), while synonymous variants predominated in AML (33.3%). Although traditionally considered neutral, synonymous and intronic variants may influence gene expression through regulatory or splicing mechanisms. The analysis revealed clinically significant variants associated with chemotherapy response, particularly in the ABCB1 gene, observed in 12.5% of AML and 10.5% of ALL cases. Several variants, particularly TPMT, NUDT15, ABCC1, SLC28A3, and RARG, were associated with severe adverse effects such as myelotoxicity, mucositis, cardiotoxicity, and hepatotoxicity. This study reinforces the importance of genetic variants in modulating the therapeutic response and toxicity to chemotherapy drugs in acute leukemias. Analysis of ClinPGx/PharmGKB data emphasizes ABCB1 as a potential resistance marker and supports pre-treatment genotyping of genes like TPMT and NUDT15 to prevent severe toxicities. Future advances should include the expansion of pharmacogenetic studies in underrepresented populations and the clinical validation of new markers in prospective trials, aiming to consolidate precision medicine as a routine part of the therapeutic management of acute leukemias. Full article
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