Search Results (1,150)

Nieuwerkerk Volcano, located in the Banda Sea, Indonesia, is a submarine volcano whose entire edifice lies beneath sea level. Its proximity to several inhabited islands raises significant concerns regarding potential impacts from future volcanic hazards. Despite historical unrest recorded in 1925 and 1927, a comprehensive geological and geophysical understanding of Nieuwerkerk remains notably limited, with the last research expedition being in 1930. This study seeks to advance our understanding of the geomorphological structure and subsurface characteristics of the region, contributing to a preliminary hazard assessment and delineating key directions for future geoscientific investigation. The data were obtained during our most recent expedition conducted in 2022. High-resolution multibeam bathymetry data were analyzed to delineate the volcano’s morphology, while marine magnetic survey data were processed to interpret magnetic anomalies associated with its structure beneath volcano. Our updated morphological analysis reveals the following: (1) Nieuwerkerk Volcano is among the largest submarine volcanic edifices in the Banda Sea (length = 80 km, width = 30 km, height = 3460 m); (2) there is the presence of twin peaks (depth~300m); (3) there are indications of sector collapse (diameter = 10–12 km); (4) there are significant fault lineaments; and (5) there are landslide deposits, suggesting a complex volcanic edifice shaped by various constructive and destructive processes. The magnetic data show a low magnetic anomaly beneath the surface, where one of the indications is the presence of active magma. These findings significantly enhance our understanding of Nieuwerkerk’s current condition and volcanic evolution for an initial assessment of potential hazards, including future eruptions, edifice collapse, and landslides, which could subsequently trigger tsunamis. Further investigation, including comprehensive geophysical surveys covering the entire Nieuwerkerk area, rock sample analysis, visual seafloor observation, and seawater characterization, is crucial for a comprehensive understanding of its magmatic system and a more robust hazard assessment. This research highlights the critical need for detailed investigations of active submarine volcanoes, particularly those with sparse historical records and close proximity to populated areas, within tectonically complex settings such as the Banda Sea. Full article

The Tokara Islands, a volcanic archipelago located south of Japan’s main islands, experienced earthquake swarm activity in 2025. Public concern has emerged regarding the potential triggering of the anticipated Nankai Trough earthquake, which the Japan Meteorological Agency has dismissed; however, the underlying mechanisms of this seismic activity remain inadequately explained. This study employs Exploratory Data Analysis (EDA) to characterise the statistical properties of the swarm and compare them with historical patterns. Earthquake intervals followed exponential distributions, but swarm events exhibited distinctive short intervals that clearly distinguished them from background seismicity. Similarly, whilst earthquake magnitudes conformed to normal distributions, swarm events demonstrated low mean values and reduced variability, characteristics markedly different from regional background activity. The frequency and magnitude distributions of the 2025 swarm demonstrate remarkable similarity to two previous swarms that occurred in 2021. All the episodes coincided with volcanic activity at Suwanose Island, located approximately 10 km from the epicentral region, suggesting a causal relationship between magmatic processes and seismic activity. Statistical analysis reveals that the earthquake swarm exhibits exceptionally low magnitude scale, characteristics consistent with magma-driven seismicity rather than tectonic stress accumulation. The parameter contrasted markedly with pre-seismic conditions observed before the 2011 Tohoku earthquake, where it was substantially elevated. Our findings indicate that the current seismic activity represents localised volcanic-related processes rather than precursory behaviour associated with major tectonic earthquakes. These results demonstrate the utility of statistical seismology in distinguishing between volcanic and tectonic seismic processes for hazard assessment purposes. Full article

To constrain Tianchi Volcano basalt petrogenesis, this study focuses on tholeiitic basalts from the CZK06 drill core on the northern slope. Using elemental geochemistry and Mg isotope analyses, we investigate magma evolution, petrogenesis, and mantle source properties. The tholeiitic basalts formed during the Pliocene-Early Pleistocene shield-forming stage, recording three stages of basaltic volcanism (Phases I to III). Classified as sodium-series basalts, they exhibit geochemical affinities with EM1-type OIB. Their δ²⁶Mg values (−0.420‰ to −0.150‰) show a substantially wider range than N-MORB. Their geochemical compositions are primarily controlled by source region characteristics and partial melting degree, with minor additional influences from fractional crystallization and crustal contamination. Fractional crystallization intensity shows a progressive increase from Phase I to III. Integrated with geochemical tracing studies of Changbaishan basalts, we propose that the tholeiitic basalts are derived predominantly from the partial melting of carbonatized pyroxenite, which originated from subducted ancient clay-rich altered oceanic crust. The carbonate melts driving the carbonatization were generated by low-pressure melting of recent oceanic sediments, transported by the deeply subducted carbonate-rich Pacific Plate within the Mantle Transition Zone. The tholeiitic magma formed in the Low-Velocity Zone at depths of 160–180 km beneath the lithospheric mantle. Full article

The Lunayyir Volcanic Field (Harrat Lunayyir), located on the western boundary of the Arabian Microplate, comprises a Quaternary volcanic region featuring approximately 150 volcanoes formed from around 700 vents. In 2009, a significant volcano-seismic event occurred, resulting in the formation of a nearly 20 km long fissure. Geophysical modeling has demonstrated that this area lies above an eruptible magma system, unequivocally confirming ongoing volcanic activity. Recent geological mapping and age determinations have further established the field as a young Quaternary volcanic landscape. Notably, the 2009 event provided critical evidence of the region’s volcanic activity and underscored the potential to connect its volcanic geoheritage with hazard mitigation strategies. The volcanic field displays diverse features, including effusive eruptions—primarily pāhoehoe and ‘a‘ā lava flows—and explosive structures such as spatter ramparts and multi-crater scoria cones. While effusive eruptions are most common and exert long-term impacts, explosive eruptions tend to be less intense; however, some events have reached a Volcanic Explosivity Index (VEI) of 4, distributing ash up to 250 km. Recognizing the geoheritage and geodiversity of the area may enhance resilience to volcanic hazards through geoconservation, educational initiatives, managed visitation, and establishment of a geoheritage reserve to preserve site conditions. Hazards associated with this dispersed monogenetic volcanic field manifest with recurrence intervals ranging from centuries to millennia, presenting challenges for effective communication. Although eruptions are infrequent, they have the potential to impact regional infrastructure. Documentation of volcanic geoheritage supports hazard communication efforts. Within the northern development sector, 26 geosites have been identified, 22 of which pertain to the Quaternary basaltic volcanic field, each representing a specific hazard and contributing vital information for resilience planning. Full article

Zanthoxylum armatum DC. (Z. armatum) is a versatile plant species valued for its aroma oil and nutritional components. However, the variability of chemical composition in Z. armatum fruits in the field remains largely unknown, and it is still unclear how harvest parameters affect the aroma and nutritional quality of the fruits. To address this gap, Z. armatum fruits from varying harvest times, tree ages, and fruiting positions were analyzed for physicochemical properties, nutrients, minerals, aroma profiles, and antioxidant activity. A quality assessment method was developed based on key Z. armatum fruit parameters. Results showed significant differences in the size, weight, total phenol, flavonoid and sanshool content of Z. armatum fruit from different harvest parameters. Z. armatum fruits contained abundant minerals, showing diverse harvest-condition variations. In vitro antioxidant assays showed higher ABTS/DPPH scavenging activity and reducing capacity (23–54 mg/g). HS-SPME-GC-MS identified 64 aroma compounds, encompassing terpenes, alcohols, etc. Linalool was the predominant constituent (46.65%). PLS-DA and Volcano plot analyses highlighted significant differences in VOCs among harvest times and tree ages, while fruit positions showed minimal impact. The Mantel test identified aroma-active compounds associated with antioxidant activity. These findings facilitate a science-based harvesting strategy to standardize Z. armatum fruit quality and marketability. Full article

Mount Etna has a well-documented history of frequent eruptions and seismic activity, periodically causing significant damage to urban areas. On 26 December 2018, a Mw 4.9 shallow earthquake struck the volcano’s eastern flank, severely damaging approximately 3000 buildings. The post-earthquake recovery strategy aimed to enhance community resilience by addressing the hazardous nature of the affected territory. This objective was achieved through measures such as relocation and public use transformation. In areas impacted by active faults, the relocation of damaged buildings was encouraged, while cleared zones were repurposed for public use, transformed into gardens and open-air parking spaces. Despite these efforts, some relocated individuals experienced psychological distress. To address this challenge, government planners played a pivotal role in disseminating scientifically accurate information, raising public awareness, and facilitating adaptation. The approach implemented on Etna was later adopted in other post-earthquake recovery programs in Italy, evolving into a replicable strategy for risk mitigation in disaster-prone areas. Full article

Background/Objectives: Gout, a complex metabolic disorder of increasing global incidence, remains incompletely understood in its pathogenesis. Current diagnostic approaches exhibit significant limitations, including insufficient specificity and the requirement for invasive joint aspiration, highlighting the need for non-invasive, sensitive biomarkers for early detection. Methods: Urine metabolites were extracted from 28 healthy controls, 13 asymptomatic hyperuricemia (HUA) patients, and 29 acute gouty arthritis (AGA) patients. The extracted metabolites were analyzed by UHPLC-MS/MS for untargeted metabolomics. Differential metabolites were screened by partial least squares discriminant analysis (PLS-DA) and volcano plot analysis. Pathway analysis determined the core disorder pathway of gout progression. Results: A total of 278 differential metabolites associated with gout progression were identified. The most pronounced metabolic alterations were observed between the AGA and control groups, indicative of substantial metabolic reprogramming during disease transition. Metabolic pathway analysis revealed four significantly dysregulated pathways: histidine metabolism, nicotinate and nicotinamide metabolism, phenylalanine metabolism, and tyrosine metabolism. Receiver operating characteristic (ROC) curve analysis revealed that three urine markers with high diagnostic efficacy—oxoamide, 3-methylindole, and palmitic acid—exhibited progressive alterations across the disease continuum. Conclusions: This metabolomics study identified core regulatory metabolites and newly discovered metabolic pathways underlying gout pathogenesis, along with novel urinary biomarkers capable of predicting HUA-to-AGA progression. The aberrant levels of key metabolites in the disordered pathway implicate neuroimmune dysregulation, energy metabolism disruption, and oxidative stress in gout pathogenesis. These findings provide new foundations and strategies for the daily monitoring and prevention of gout. Full article

Gold mineralisation at Ity (Ivory Coast) is spatially associated with skarns formed at contacts between carbonate-rich Birimian volcano-sedimentary rocks and felsic intrusions, whereas at Dahapleu, a nearby skarn-free prospect, gold occurs in structurally controlled shear zones. Gold occurs as native gold in pyrite or as a Bi–Te–Au–Ag telluride assemblage. Fluid inclusion data indicate that Ity formed through a hybrid model: a mesothermal orogenic gold system dominated by CO₂–CH₄ fluids at >350 °C, superimposed on earlier skarn mineralisation characterised by saline fluids. At Dahapleu, no skarn fluids were identified, but volatile-rich inclusions with more variable signatures (CO₂, CO₂–CH₄, CO₂–N₂) indicate metamorphic fluids circulating in convective, fault-related systems and recording distinct fluid–rock interactions. The Ity–Dahapleu mineralising system thus displays fluid inclusion characteristics typical of mesothermal orogenic gold systems, likely at higher temperatures than most West African Birimian deposits. Overall, the Ity system reflects a long-lived thermal anomaly driving fluid circulation and metal deposition, with successive favourable events: rapid exhumation of hot lithospheric crust, granite intrusion, and skarn formation, followed by shear deformation and hydrothermal activity. Full article

Shallow gas reservoirs exhibit low formation pressure and gas injection levels, leading to low-resistivity contrast between gas-bearing reservoirs and fully water-saturated layers. Gas-bearing formation identification and water saturation estimation face great challenges. To improve the accuracy of shallow gas reservoir identification and logging evaluation, it is essential to analyze the genesis mechanisms underlying the low-resistivity contrast. This study used the HJ Formation, a typical shallow gas reservoir located in the BY Sag of the eastern South China Sea Basin as an example. Combining the results of nuclear magnetic resonance (NMR), full rock mineral analysis and X-ray diffraction of clay minerals in the laboratory, it was determined that the genesis mechanism for the low-resistivity contrast in the gas-bearing reservoir was due to the high irreducible water saturation (S_wi) and the cation-induced supplementary conductivity. Afterwards, we integrated three methods, density–neutron correlation, calculation of the apparent formation water resistivity, and cross-plots of conventional and gas-logging curves, to identify shallow gas reservoirs. In addition, we also established a Waxman–Smits-based model to estimate water saturation. Compared with the typical Archie’s equation, the predicted water saturation curve using the Waxman–Smits-based model was more reasonable. The established methods and models can be used in target shallow gas reservoir evaluations, and it also has reference value for other types of oilfields with similar physical characteristics. Full article

The present study explores the sustainable potential of volcanic ash sourced from the active Sakurajima volcano (Japan) as an eco-friendly alternative to Portland cement—a binder known for its high carbon emissions—in concrete and mortar production. The abundant pyroclastic material, currently a waste burden for the residents of Sakurajima and the Kagoshima Bay region, presents a unique opportunity for valorization in line with circular economy principles. Rather than treating this ash as a disposal problem, the research investigates its transformation into a valuable supplementary cementitious material (SCM), contributing to more sustainable construction practices. The investigation focused on the material characterization of the ash (including chemical composition, morphology, and PSD) and its pozzolanic activity index, which is a key indicator of its suitability as a cement replacement. Mortars were prepared with 25% of the commercial binder replaced by volcanic ash—both in its raw form and after mechanical activation—and tested for compressive strength after 28 and 90 days of water curing. Additional assessments included workability of the fresh mix (flow table test), apparent density, and flexural strength of the hardened composites. Tests results showed that the applied volcanic ash did not influence the workability of the mix and showed negligible effect on the apparent density (changes of up to 3.3%), although the mechanical strength was deteriorated (decrease by 15–33% after 7 days, and by 25–26% after 28 days). However, further investigation revealed that the simple mechanical grinding significantly enhances the pozzolanic reactivity of Sakurajima ash. The ground ash achieved a 28-day activity index of 81%, surpassing the 75% threshold set by EN 197-1 and EN 450-1 standards for type II mineral additives. These findings underscore the potential for producing low-carbon mortars and concretes using locally sourced volcanic ash, supporting both emissions reduction and sustainable resource management in construction. Full article

Volcano-tectonic seismic events (VT) are quite rare at Stromboli, numbering about ten events per year and generally with low magnitude. Using a dataset of 98 events from the 2005–2024 period, we report an improved relocation of VT events here. Relocated earthquakes are mainly distributed on the island and in an area located SSW of Stromboli. These VT events are related to the activation of seismogenic structures by a stress increase related to magma ascent. The shallowest seismicity (4–5 km) is positioned under the Stromboli summit, with a high occurrence in 2006–2007 and in 2019–2024, suggesting a major recharge of the HP magma reservoir. The deepest VT seismicity affects a depth of 7–12 km located in the submerged edifice SSW of the summit and is attributable to the dynamics of the LP magma reservoir, which was more active in 2006–2014 and much less so in the successive years. The increase in the occurrence rate of VT shallow seismicity seems to precede the most significant Stromboli activities, such as the 2007 and 2024 lava effusions followed by paroxysms. For these episodes, VT seismicity would appear to indicate a recharging in the first 4–5 km during the months preceding them, thereby representing a medium–short-term warning signal. Full article

Background/Objectives: The aim of this study was to explore the effects of diets with different protein levels on the metabolite composition and metabolic pathways of the longest dorsal muscle of Tibetan pigs, in order to provide a metabolic basis for optimizing the nutritional regulation strategy of Tibetan pigs. Methods: A total of 32 healthy 180-day-old depopulated male Tibetan pigs were randomly divided into four groups and fed diets with protein levels of 10%, 12%, 14%, and 16%, respectively, with a feeding cycle of 8 weeks. The longest dorsal muscle samples were collected, and their metabolic profiles were systematically analyzed by LC-MS non-targeted metabolomics. Results: The TIC plots of the quality control samples were highly overlapped, indicating a stable instrumental detection process and good consistency of sample processing. Principal component analysis and orthogonal partial least squares discriminant analysis revealed significant metabolic differences between groups with different protein levels. A total of multiple differential metabolites was obtained based on VIP value and p-value screening, and Venn diagram analysis revealed a total of 11 metabolites among the three comparative groups, suggesting that they may have key roles in the protein regulation process. Volcano plots further clarified the number and trend of significantly up- and down-regulated metabolites in each group. KEGG pathway enrichment analysis showed that, with the elevation of protein level, the metabolic pathway response showed a tendency of expanding from basal energy metabolism to the complex network of amino acid synthesis, steroidogenesis, endocrine signaling, and detoxification pathways, especially in the high-protein-treated group. Conclusions: The study showed that different protein intake levels could significantly regulate the metabolites and key metabolic pathways in the longest muscle of Tibetan pigs, which provided theoretical support for the scientific formulation of a protein supply program to optimize the quality and growth performance of Tibetan pork. Full article

Background/Objectives: Nonsteroidal anti-inflammatory drugs (NSAIDs) are commonly associated with gastrointestinal (GI) adverse events. This study aimed to assess the incidence and patterns of NSAID-induced GI disorders using the FDA Adverse Event Reporting System (FAERS) database and to compare the risks among different NSAIDs. Methods: NSAID-related reports were extracted from FAERS, focusing on 21 ulcer-related GI events with ≥1000 reports each, based on MedDRA v26.0. The number of reports, reporting odds ratios, and p-values were calculated and visualized using a volcano plot. Principal component analysis(PCA) was carried out to reduce the dimensionality of the dataset and revealed under-lying patterns in the data.PCA was performed to identify patterns related to risk, severity, and injury site, whereas hierarchical clustering was used to group NSAIDs based on these patterns. Hierarchical cluster analysis is a method of grouping similar data to generate a classification. Results: Statistically significant signals were identified for 19 of the 21 GI-related adverse events, including the serious condition of perforation. PCA revealed that the first component represented risk, the second severity, and the third the site of injury (upper vs. lower GI tract). Cyclooxygenase-2 (COX-2) selective NSAIDs (e.g., celecoxib, rofecoxib) were associated with a lower incidence but greater severity, primarily in the upper GI tract. Conversely, nonselective NSAIDs (e.g., acetylsalicylic acid, lornoxicam) showed higher incidence rates, though the events were generally milder. In our dataset, acetylsalicylic acid had the highest incidence, whereas meloxicam showed the highest severity. Clustering analysis revealed three distinct NSAID groups with differing patterns in risk, severity, and affected GI site. Mild adverse events may be underreported in FAERS. Dosage-related effects were not assessed in this study. Conclusions: NSAIDs differ significantly in their gastrointestinal adverse event profiles, attributable to COX selectivity. When selecting an NSAID, both the likelihood and the nature of potential GI harm should be considered. Full article

Improving the catalytic performance of the oxygen evolution reaction (OER) for water splitting in acidic media is crucial for the production of clean and renewable hydrogen energy. Herein, we study the OER electrocatalytic properties of various active sites on four exposed (110) and ($\overline{1}$10) surfaces of Sn-doped RuO₂ (Sn/RuO₂) with antiferromagnetic arrangements in acidic environments. The Sn/RuO₂ bulk structure with the Cm space group exhibits favorable thermodynamic stability. The coordinatively unsaturated metal (M_cus) sites distributed on the right branch of the volcano plot are generally more active than the bridge-bonded lattice oxygen (O_br) sites located on the left. Different from the conventional knowledge that the most active site is located in the nearest neighbor of the doped atom, it has a lower OER overpotential when the active site is 3.6 Å away from the doped Sn atom. Among the sites studied, the 46-Ru_cus site exhibits the optimal OER catalytic performance. The inherent factors affecting the OER activity of each site on the Sn/RuO₂ surface are further analyzed, including the center of the d/p band at the active sites, the average electrostatic potential of the ions, and the number of transferred electrons. This work provides a reminder for the selection of active sites used to evaluate catalytic performance, which will benefit the development of efficient OER electrocatalysts. Full article

Background: Upper tract urothelial carcinoma (UTUC) is a rare and aggressive malignancy with limited prognostic tools to predict disease progression. Due to its low incidence, the molecular pathogenesis of UTUC remains poorly understood, and few studies have explored transcriptomic profiling in this setting. Identifying gene expression biomarkers associated with progression may help improve risk stratification and guide postoperative management. Methods: In this study, we applied a machine learning approach to gene expression data from radical nephroureterectomy (RNU) specimens of 17 consecutive patients with pT2 or pT3 UTUC treated at our institution. RNA was extracted from formalin-fixed paraffin-embedded tissues and sequenced using the Ion AmpliSeq™ Transcriptome Human Gene Expression Kit on an Illumina HiSeq 2500 platform. Differential gene expression was assessed using DESeq2, and results were visualized with volcano plots. Predictive power was evaluated through logistic regression and receiver operating characteristic (ROC) analysis. Gene Ontology enrichment analysis was used to explore biological pathways. Results: A total of 76 genes were differentially expressed between progressive and non-progressive patients. A random forest classifier identified ten key genes with prognostic potential. Validation with logistic regression yielded an area under the ROC curve (AUC) of 0.88, indicating high discriminative ability. These genes were associated with immune regulation, cell cycle control, and tumor progression. Conclusions: This pilot study demonstrates the potential of integrating machine learning with transcriptomic analysis to identify prognostic biomarkers in UTUC. Further validation in larger, independent cohorts is needed to confirm these findings and support their clinical application. Full article