Search Results (742)

Recent advances in cardiovascular imaging have revolutionized the assessment and management of abdominal aortic aneurysm (AAA) through the integration of sophisticated haemodynamic biomarkers. This comprehensive review evaluates the clinical utility and mechanistic significance of multiple biomarkers in AAA pathogenesis, progression, and treatment outcomes. Advanced cardiac imaging modalities, including four-dimensional magnetic resonance imaging (4D MRI), computational fluid dynamics (CFD), and specialized echocardiography, enable precise quantification of critical haemodynamic parameters. Wall shear stress (WSS) emerges as a fundamental biomarker, with values below 0.4 Pa indicating pathological conditions and increased risk for aneurysm progression. Time-averaged wall shear stress (TAWSS), typically maintaining values above 1.5 Pa in healthy arterial segments, provides crucial information about sustained haemodynamic forces affecting the vessel wall. The oscillatory shear index (OSI), ranging from 0 (unidirectional flow) to 0.5 (purely oscillatory flow), quantifies directional changes in WSS during cardiac cycles. In AAA, elevated OSI values between 0.3 and 0.4 correlate with disturbed flow patterns and accelerated disease progression. The relative residence time (RRT), combining TAWSS and OSI, identifies regions prone to thrombosis, with values exceeding 2–3 Pa⁻¹ indicating increased risk. The endothelial cell activation potential (ECAP), calculated as OSI/TAWSS, serves as an integrated metric for endothelial dysfunction risk, with values above 0.2–0.3 Pa⁻¹ suggesting increased inflammatory activity. Additional biomarkers include the volumetric perivascular characterization index (VPCI), which assesses vessel wall inflammation through perivascular tissue analysis, and pulse wave velocity (PWV), measuring arterial stiffness. Central aortic systolic pressure and the aortic augmentation index provide essential information about cardiovascular load and arterial compliance. Novel parameters such as particle residence time, flow stagnation, and recirculation zones offer detailed insights into local haemodynamics and potential complications. Implementation challenges include the need for specialized equipment, standardized protocols, and expertise in data interpretation. However, the potential for improved patient outcomes through more precise risk stratification and personalized treatment planning justifies continued development and validation of these advanced assessment tools. Full article

Rocket launches constitute a major anthropogenic source of disturbance in the near-Earth space environment, inducing significant ionospheric perturbations through both chemical and dynamic mechanisms. This study presents a systematic analysis of ionospheric disturbances—specifically, electron density depletion and traveling ionospheric disturbances (TIDs)—triggered by four rocket launches from China’s Jiuquan Satellite Launch Center between 2023 and 2025. Using high-rate, multi-constellation GNSS data from 370 ground stations and BeiDou GEO satellites, we extracted total electron content (TEC) signals and applied advanced detection methods, including the Multi-Rolling-Multi-Image-Tracking (MRMIT) algorithm for depletion identification and a parametric integration framework for quantitative comparison. Our results reveal that all launches produced rapid TEC depletions, evolving along the rocket trajectory and peaking within approximately 30 min. Launch mass was the dominant factor controlling depletion intensity, while propellant chemistry (UDMH-based vs. liquid oxygen/methane) and local time/background TEC levels modulated the recovery rate and spatial extent. Additionally, distinct TIDs exhibiting wave-like and V-shaped structures were observed, propagating outward from the trajectory with latitudinal variations in amplitude and waveform. These findings highlight the critical roles of rocket attributes and ambient ionospheric conditions in shaping disturbance characteristics. The study underscores the value of multi-source GNSS networks and novel methodologies in monitoring anthropogenic space weather effects, with implications for GNSS performance and sustainable space operations. Full article

To address the limitations of traditional elasticity theory in analyzing the dynamic response of soft coal under external impact, this study establishes a vibration control equation with an analytical solution based on Hamiltonian mechanics. Key control parameters within the equation were solved to determine the theoretical dominant vibration modes and natural frequencies of the weakest coal layer. Triangular and rectangular waves were transformed via FFT to analyze their harmonic components, and the superposition of the first four harmonics was selected as the input impact signal. The modal and natural frequency changes during the fragmentation of the central weak zone under external impact were simulated, and the dynamic displacement response was analyzed. The results indicate a strong response frequency range of 4.4–5.2 Hz, with the rectangular wave identified as the most effective response waveform. A similarity simulation platform was constructed, and experimental data showed that the velocity and displacement response trend of the coal mass aligned closely with theoretical predictions. Therefore, in actual underground operations, emphasis should be placed on monitoring low-frequency vibrations in mines, minimizing rectangular wave disturbances in the low-frequency range, and implementing pressure relief measures in high-risk zones to reduce the likelihood of coal and gas outbursts. By separately modeling high-risk zones and analyzing their dynamic response under external impact, this study explains the outburst mechanism of the weakest layer in soft coal from a dynamic perspective. Combining theoretical and experimental approaches, it provides a new theoretical basis for understanding and preventing coal and gas outbursts. Full article

Comparative experiments on trapping major rice pests using different methods showed that a light-transmitting three-combination trapping method, using different combinations of color plates + insect sex pheromones + transmitting (shielding) light covers + solar-powered automatic insect-attracting ultraviolet lamps, demonstrated significant positive attraction and synergistic effects on the simultaneous capture of multiple pests, including rice Sogatella furcifera, Laodelphax striatellus, Chilo suppressalis, and Sesamia inferens and rice leafhoppers, Sitobion miscanthi, Cnaphalocrocis exigua, Parnara guttata, and Naranga aenescens. In addition, the light-transmitting three-combination trapping method has a low benefit-harm ratio and is not easily disturbed by non-target flies (Muscadomestica). The ultraviolet light and transmitting cover in the device had a negative effect on attracting the Cnaphalocrocis medinalis, resulting in a highly significant or significant decrease in its capture rate. The results also showed that the light-shielding double-combination trapping method, which lacks ultraviolet lamp waves and transmitting covers, had no significant difference in the capture rate and insect benefit-harm ratio of C. medinalis adults compared with the glue-type sex lure method, confirming that C. medinalis has a significant negative tendency characteristic to ultraviolet lamp waves and transmitting covers. Therefore, the light-shielding double-combination trapping method using color plates and insect sex pheromones is recommended for monitoring the weakly phototactic C. medinalis. The light-transmitting three-combination trapping method is preferred for the simultaneous capture of multiple major rice pests besides C. medinalis. This study provides a scientific basis for the rational and effective application of multi-source physical and chemical trapping for monitoring and pest control of major crop pests. Full article

Coal seams, as critical components of open-pit mine slopes, are subjected to both quasi-static and dynamic loading disturbances during mining operations, with their mechanical properties directly influencing the slope stability. Consequently, to clarify the mechanical properties and failure mechanisms of coal seams affected by the strain rate under the static–dynamic loading conditions, the mineral composition and meso-structural characteristics of lignite were analyzed in this study, and uniaxial compression tests with different quasi-static loading rates and dynamic compression tests with different impact velocities were conducted. The results indicate that there is an obvious horizontal bedding structure in lignite, which leads to differences in mechanical response and failure mechanism at different strain rates. Under the quasi-static loading, lignite exhibits significantly lower strain-rate sensitivity than compared to dynamic impact conditions. The Poisson’s ratio difference between the bedding matrix and the lignite will produce interfacial friction, which gradually decreases with the increase in the distance from the interface, thus promoting the transformation of lignite from multi-crack tensile shear mixed fracture to single-crack splitting failure. Under the dynamic impact conditions, low-impact velocities induce stress wave reflection at bedding interfaces due to wave impedance disparity between the matrix and lignite, generating tensile strains that result in bedding-plane delamination failure; at higher velocities, incomplete energy absorption by the rock specimen leads to fragmentation failure of lignite. These findings are of great significance for the stability analysis of open-pit slopes. Full article

This paper addresses the path tracking problem of underactuated unmanned surface vessels (USVs) in the presence of unknown external disturbances. A fixed-time adaptive integral sliding mode control (AISMC) method, incorporating a nonlinear disturbance observer (NDO), is proposed. Initially, a three-degree-of-freedom dynamic model of the USV is developed, accounting for external disturbances and model uncertainties. Based on the vessel’s longitudinal and transverse dynamic position errors, a virtual control law is designed to ensure fixed-time convergence, thereby enhancing the position error convergence speed. Next, a fixed-time NDO is introduced to estimate real-time external perturbations, such as wind, waves, and currents. The observed disturbances are fed back into the control system for compensation, thereby improving the system’s disturbance rejection capability. Furthermore, a sliding mode surface is designed using a symbolic function to address the issue of sliding mode surface parameter selection, leading to the development of the adaptive integral sliding mode control strategy. Finally, compared with traditional SMC and PID, the proposed AISMC-NDO offers higher accuracy, faster convergence, and improved robustness in complex marine environments. Full article

In the paper we consider the pulsed disturbances caused in the ionosphere by an extreme G5-level geomagnetic superstorm on 10 May 2024, and by the X1.0 and M-class solar flares on 8 May 2024, which preceded the storm. Particular attention is paid to the short-term delays and the sequence of disturbance appearance in the ionosphere and geomagnetic field during these extreme events. The results of a continuous Doppler sounding of the ionosphere on an inclined radio path with a sampling frequency of 25 Hz were used, as well as the data of a ground-based mid-latitude fluxgate magnetometer LEMI-008, and an induction magnetometer IMS-008, which operated with a sampling frequency of 66.6 Hz. Ionization of the ionosphere by the intense X-ray and extreme ultraviolet radiation of solar flares was accompanied by the equally sudden and similarly timed disturbances in the Doppler frequency shift (DFS) of the ionospheric signal, which had an amplitude of 2.0–5.8 Hz. The largest pulsed burst in DFS was registered 68 s after an X1.0 flare on 8 May 2024 at the time when the change of the X-ray flux was at its maximum. Following onto the effect in the ionosphere, a disturbance in the geomagnetic field appeared with a time delay of 35 s. This disturbance is a secondary one that arose as a consequence of the ionosphere response to the solar flare. It was likely driven by the contribution of ionospheric currents and electric fields, which modified the Earth’s magnetic field. On 10 May 2024, a G5-level geomagnetic superstorm with a sudden commencement triggered an impulsive reaction in the ionosphere. A response in DFS at the calculated reflection altitude of the sounding radio wave of 267.5 km was detected 58 s after the commencement of the storm. The sudden impulsive changes in Doppler frequencies showed a bipolar character, reflecting complex dynamic transformations in the ionosphere at the geomagnetic storm. Consequently, the DFS amplitude initially rose to 5.5 Hz over 86 s, and then its sharp drop to $-3.2$ Hz followed. Using the instruments that operated in a mode with a high temporal resolution allowed us to identify for the first time the impulsive nature of the ionospheric reaction, the time delays, and the sequence of disturbance appearances in the ionosphere and geomagnetic field in response to the X1.0 solar flare on 8 May 2024 as well as to the sudden commencement of the extreme G5-level geomagnetic storm on 10 May 2024. Full article

Objectives: In this study, our aim is to summarise the available data on the correlation between sarcopenia and sleep disturbances as a consequence of changes in the myokine concentrations. Methods: Our research was conducted by searching through PubMed, Mendeley and Google Scholar. In our analysis, 63 studies are included from the years 2011 to 2025. Among these studies, there are clinical trials, cross-sectional studies, reviews, systematic reviews and meta-analyses. Discussion: There is vast evidence confirming that sleep disturbances are more common among sarcopenic patients. On the other hand, sarcopenia is frequently observed among people with worse quality of sleep. It is also well documented that sarcopenia leads to changes in the myokine serum concentrations, and similar changes are observed among people suffering from sleep disturbances. Sarcopenic patients have lower levels of irisin, BDNF (brain-derived neurotrophic factor), meteorin and IL-15 (interleukin 15) and higher concentrations of FGF-21 (fibroblast growth factor 21) and interleukins 1β, 6 and 10. Lower levels of irisin, BDNF and meteorin, and higher levels of FGF-21 and interleukins 6 and 10, lead to sleep disturbances, like insomnia, reduction of REM (rapid eye movement) sleep time and lower slow-wave activity during the NREM (non-rapid eye movement) sleep phase. These changes are also observed in obstructive sleep apnea (OSA). More severe OSA is correlated with lower levels of irisin and meteorin and higher levels of FGF-21 and interleukins 6 and 8. Conclusions: Taking into account the similarities in the myokine concentration changes in sarcopenia and in sleep disturbances, it may be concluded that alterations in the myokine levels induced by sarcopenia provoke sleep disturbances. However, it is necessary to further investigate these correlations to understand them better. Full article

With the increasing deployment of unmanned surface vessels (USVs) in complex marine operations such as ocean monitoring, search and rescue, and military reconnaissance, precise heading control under environmental disturbances and system delays has become a critical challenge. This paper presents an advanced robust heading control strategy for USVs operating under these demanding conditions. The proposed approach integrates three key innovations: (1) an enhanced Smith predictor for accurate time-delay compensation, (2) a variable-universe fuzzy PID controller with self-adaptive scaling domains that dynamically adjust to error magnitude and rate of change, and (3) a hybrid metaheuristic optimization algorithm combining beetle antennae search, harmony search, and genetic algorithm (BAS-HSA-GA) for optimal parameter tuning. Through comprehensive simulations using a Nomoto first-order time-delay model under combined white noise and second-order wave disturbances, the system demonstrates superior performance with over 90% reduction in steady-state heading error and ≈30% faster settling time compared to conventional PID and single-optimization fuzzy PID methods. Field trials under sea-state 4 conditions confirm 15–25% lower tracking error in realistic operating scenarios. The controller’s stability is rigorously verified through Lyapunov analysis, while comparative studies show significant improvements in S-shaped path tracking performance, achieving better IAE/ITAE metrics than DRL, ANFC, and ACO approaches. This work provides a comprehensive solution for high-precision, delay-resilient USV heading control in dynamic marine environments. Full article

In industrial scenarios, the control of permanent magnet synchronous servo motors is mostly achieved with proportional–integral controllers, which require manual adjustment of control parameters. At the same time, the performance of the servo system is usually disturbed by internal characteristic changes, load changes, and external factors. Therefore, preset control parameters may not achieve the desired optimal performance. Many scholars use intelligent algorithms, such as neural networks, to adaptively tune control parameters. However, the offline pre-training of neural networks is often time- and resource-consuming. Due to the lack of a model pre-training process in the neural network online self-tuning process, randomly setting the initial network weight seriously affects the position tracking performance of the servo control system in the start-up phase. In this paper, the physical model and the traditional frequency domain-tuning method of the three-closed-loop permanent magnet synchronous servo system are analyzed. Combined with the neural network PI control parameter self-tuning method and physical symmetry, a physical information-driven optimization framework is proposed. To demonstrate its superiority, the neural network PI controller and the proposed optimization framework are used to control the single-axis sine wave trajectory. The results show that the optimization framework proposed can effectively improve the position tracking control performance of the servo control system in the start-up phase by setting the threshold of the servo control parameters, reduce the position tracking control error to 0.75 rads in the start-up phase, and reduce the position tracking drop caused by a sudden load by 25%. This method achieves the independent optimization adjustment of control parameters under position tracking control, providing a reference for the intelligent control of permanent magnet synchronous servo motors. Full article

Block caving is a cost-effective mining method that enables the highly efficient mining of thick and large ore bodies. During ore extraction in block caving operations, the ore-drawing roadways require especially high safety standards. However, the complex in situ stress conditions and cyclic loading from caved ore significantly deteriorate the stability of the surrounding rock. This makes rock mass control particularly challenging, such that it is crucial to study an effective method for maintaining the long-term stability of the roadways. This research proposes a comprehensive approach combining laboratory rock mechanics testing, numerical simulation, and field engineering validation to design effective support strategies for disturbance-affected roadways. Laboratory tests provide accurate mechanical parameters for the rock mass, the numerical simulations allow for the comprehensive analysis of deformation–failure mechanisms under disturbance conditions, and field validation ensures the reliability and practical applicability of the proposed support method. This study focuses on a −285 m ore-drawing roadway in the western section of the Yanqianshan Iron Mine. The in situ stress distribution was characterized through rock mechanics testing and acoustic emission monitoring. The propagation mechanisms of ore-drawing disturbance waves within the rock mass were analyzed, and numerical simulations revealed the deformation patterns and failure modes under dynamic disturbance, upon which the support scheme was designed. The results demonstrate that the designed bolt–mesh–shotcrete support scheme can effectively control surrounding rock deformation within 5 mm and resists the deformation induced by cyclic disturbances. This study provides valuable technical support for stability management in block caving mines with similar conditions. Full article

The Hunga-Tonga volcanic eruption on 15 January 2022, produced significant atmospheric and ionospheric disturbances that may degrade global navigation satellite system (GNSS) and precise point positioning (PPP) accuracy. Using data from the GEONET GNSS network and Soratena barometric pressure sensors across Japan, we analyzed the eruption’s effects through the gradient ionospheric index (GIX) and the rate of TEC index (ROTI) to characterize the propagation and effects of these disturbances on ionospheric total electron content (TEC) gradients. Our analysis identified two separate ionospheric disturbance events. The first event, coinciding with the arrival of atmospheric Lamb waves, was characterized by wave-like pressure anomalies, differential TEC (dTEC) fluctuations, and modest horizontal gradients of vertical TEC (VTEC). In contrast, the second, more pronounced disturbance was driven by equatorial plasma bubbles (EPBs), which generated severe ionospheric irregularities and large TEC gradients. Further analysis revealed that these two disturbances had markedly different impacts on GNSS positioning accuracy. The Lamb wave–induced disturbance mainly caused moderate TEC fluctuations with limited effects on positioning accuracy, and mid-latitude stations maintained both average and 95th percentile positioning ($\mathrm{p}\mathrm{p}\mathrm{p},{\mathrm{P}}_{95}$) errors below 0.1 m throughout the event. In contrast, the EPB-driven disturbance had a substantial impact on low-latitude regions, where the average horizontal PPP error peaked at 0.5 m and the horizontal and vertical $\mathrm{p}\mathrm{p}\mathrm{p},{\mathrm{P}}_{95}$ errors exceeded 1 m. Our findings reveal two episodes of spatial-gradient enhancement and successfully estimate the propagation speed and direction of the Lamb waves, supporting the potential application of ionospheric gradient monitoring in forecasting GNSS performance degradation. Full article

Silty seabed sediments in the subaqueous delta of the Yellow River are heavily contaminated with petroleum-derived polycyclic aromatic hydrocarbons (PAHs). Storm-induced sediment resuspension and liquefaction are key mechanisms responsible for the remobilization of PAHs into the overlying water column. In this study, laboratory-scale wave flume experiments were conducted to simulate PAH release under three hydrodynamic scenarios: (i) static diffusion (Stage I), (ii) low-intensity wave action (5 cm wave height, Stage II), and (iii) high-intensity wave action (12 cm wave height, Stage III). Results revealed a strong positive correlation between suspended particulate matter (SPM) and PAH concentrations in the aqueous phase during sediment disturbance. In particular, sediment liquefaction significantly enhanced PAH release, with concentrations up to five times higher than those under static conditions. Furthermore, liquefaction facilitated vertical migration of PAHs within sediments, resulting in reductions in PAH levels below the original background concentrations. The release dynamics varied notably among PAH species: low-molecular-weight (2–3 ring) PAHs, with lower hydrophobicity, were primarily detected in the aqueous phase, while medium- and high-molecular-weight PAHs remained predominantly associated with sediment particles. These findings underscore the critical role of hydrodynamic disturbances—especially sediment liquefaction—in influencing PAH mobility and offer important implications for pollution risk assessment and coastal management in storm-impacted deltaic environments. Full article

Background: Acute SARS-CoV-2 infection may induce cardiac arrhythmias associated with viral myocarditis, which typically disappear in the convalescent phase after healing of the myocardial inflammation. Methods: We report the case of a 37-year-old woman with a childhood history of atrial septal defect repair and stable normofrequent atrial rhythm, who presented two months post-COVID-19 with palpitations and dizziness. Diagnostic evaluation included cardiac magnetic resonance imaging (CMR), 24 h Holter electrocardiogram (ECG) monitoring, and laboratory assessments over a 3-year period. Results: CMR suggested subacute myocarditis, and Holter ECG revealed multiple discernible complex cardiac arrhythmias including atrial bradycardia, intermittent junctional rhythm (JR), atrial fibrillation (AF), and non-sustained ventricular tachycardia. Laboratory results showed a moderate but transient increase in lactate dehydrogenase, persistently mildly elevated N-terminal pro–B-type natriuretic peptide (NT-proBNP), and immunoglobulin A (IgA), with all other cardiac, inflammatory, immunologic, and organ function parameters remaining normal. In spite of chaotic cardiac rhythm with alternating JR, AF, and atrial normofrequent rhythm with frequent blocked supraventricular beats and increasing atrioventricular conduction time, no therapeutic intervention was necessary during follow-up, and a conservative treatment approach was agreed with the patient. Two years post-COVID-19 infection, the patient returned to a normofrequent atrial rhythm with a markedly prolonged PQ time (500 ms) and a different P wave morphology compared to pre-COVID, without other rhythm disturbances. Conclusions: This case demonstrates a rare pattern of post-viral arrhythmias first emerging in the convalescent phase and resolving spontaneously after two years. It underscores the need for long-term rhythm surveillance following COVID-19, even in patients with prior structural heart disease and a stable baseline rhythm. Full article

Branched glycerol dialkyl glycerol tetraethers (brGDGTs) are promising molecular biomarkers widely applied in paleoenvironmental reconstructions, including temperature and pH. However, knowledge of the microorganisms responsible for brGDGT production in marine environments remains limited, which constrains the further development and application of brGDGT-based proxies for reconstructing past marine conditions. In this study, both ‘living’ intact polar lipid-derived brGDGTs (IPL-brGDGTs) and ‘fossil’ core brGDGTs (CL-brGDGTs), together with bacterial community compositions, were analysed in multiple sediment cores collected along a nearshore-to-offshore transect in the East China Sea (ECS). The potential correlations between brGDGT distributions and bacterial community compositions at varying sediment depths across an environmental gradient were also explored. Results revealed that IPL-brGDGTs were predominantly biosynthesised in situ, whereas CL-brGDGTs reflected a mixture of marine autochthonous production and terrestrial inputs. Potential brGDGT-producing bacteria in nearshore environments were primarily composed of chemolithoautotrophic taxa (e.g., Gammaproteobacteria and Dehalococcoidia) and chemoheterotrophic taxa (e.g., Alphaproteobacteria, Bacilli, and Actinobacteria). In contrast, offshore regions were dominated by chemoheterotrophic hypoxic bacteria (e.g., Anaerolineae and Phycisphaerae) and facultatively anaerobic chemolithoautotrophic bacteria (e.g., Gammaproteobacteria and Desulfobacteria). A significant difference in bacterial community composition and IPL-brGDGT distribution was observed at a depth of 17 cm, likely due to physical disturbance in near-surface sediments, such as wave action, tidal forces, and storm events. Variance partitioning analysis (VPA) revealed that the bacterial community composition alone accounted for 14.1% of the variation in IPL-brGDGTs and 6.5% in CL-brGDGTs, further suggesting that the distribution of brGDGTs is primarily influenced by the composition of the bacterial community in the nearshore-to-offshore sedimentary ecosystems of the ECS. These findings regarding the potential biosynthesis of brGDGTs in coastal habitats advance our understanding of the microbial mechanisms that regulate brGDGT distribution in marine ecosystems. Moreover, they emphasise the importance of considering physical disturbance effects when interpreting sedimentary brGDGT records for paleoenvironmental reconstructions in marginal seas, such as the ECS. Full article