Occurrence, Toxicity, Metabolism, Analysis Methods and Control Strategies of Mycotoxins (2nd Edition)

A special issue of Toxins (ISSN 2072-6651). This special issue belongs to the section "Mycotoxins".

Deadline for manuscript submissions: 30 April 2026 | Viewed by 755

Special Issue Editor

State Key Laboratory of Rice Biology and Breeding, China National Rice Research Institute, Hangzhou 310006, China
Interests: mycotoxins; rice disease; fumonisins; pathogenicity; detoxication; biocontrol
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Following on from the first Special Issue on the topic, “Occurrence, Toxicity, Metabolism, Analysis Methods and Control Strategies of Mycotoxins”.

Mycotoxins, the poisonous chemical compounds produced by certain filamentous fungi, have been a global concern as food safety hazards. They occur all over the world and are closely associated with food commodities, especially agricultural crops. Currently, 400 mycotoxins have been identified, and these mycotoxins contaminate about 25% of world’s food production. The most important and dangerous are aflatoxins, ochratoxins, fumonisins, deoxynivalenol, zearalenone, trichothecenes, patulin, and ergot alkaloids. The effects of exposure to mycotoxins pose adverse impacts to human and animal health as well as economic development and international trade. Multiple disciplines have driven research on mycotoxins, making it a truly interdisciplinary area of scientific endeavor. The elucidation of the biochemistry, physiology, and genetics of mycotoxin has been greatly sped up over the past decade. Understanding of pathogenic fungal–host crosstalk remains a challenge, partly because mycotoxin biosynthesis strongly depends on physicochemical parameters and environmental conditions. It is necessary and crucial to develop the analytical techniques to detect and quantify mycotoxins. Preventative measures for crop diseases as well as mycotoxins contamination should be employed to manage pathogens and mycotoxins for farmers or feed managers.

This Special Issue of Toxins aims to highlight the following areas:

  • Status of mycotoxin occurrence and co-occurrence in agro-food systems and ecological niches;
  • Biological characteristic of fungal ecology and secondary metabolism of toxigenic fungi;
  • Genetic constitution, biochemical pathways and regulatory mechanisms of mycotoxins biosynthesis;
  • Influence of biological, chemical, physiological and environmental factors on toxin production;
  • Toxicological effects of mycotoxins such as virulence factors on plant, animal, and human;
  • Novel strategies to discover new mycotoxins as well as their physiological function;
  • Advanced analytical methods for detection and quantification of mycotoxin in food and feed;
  • Chemical, physical, and biological techniques for degradation or detoxification of mycotoxins;
  • Efficient management approaches in pre-harvest, during harvest, storage, and processing.

Dr. Ling Wang
Guest Editor

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Keywords

  • mycotoxin
  • filamentous fungi
  • secondary metabolism
  • toxic mechanism
  • metabolic regulation
  • pathogenicity/ virulence
  • analytical methods
  • detection and quantification
  • degradation or detoxification
  • control strategies

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Published Papers (1 paper)

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Research

18 pages, 2090 KB  
Article
Regulation of FpvelC on Conidiation, Pathogenicity and Secondary Metabolism in Fusarium proliferatum
by Ling Wang, Shaoqing Tang, Weiyang Liao, Zhonghua Sheng, Shikai Hu, Gui’ai Jiao, Gaoneng Shao, Lihong Xie and Peisong Hu
Toxins 2025, 17(9), 433; https://doi.org/10.3390/toxins17090433 - 30 Aug 2025
Viewed by 573
Abstract
The velvet complex is a master regulator of multiple physiological processes in filamentous fungi. In this study, we characterized the functions of velvet gene FpvelC in Fusarium proliferatum, which was the causative agent of rice spikelet rot disease. Compared with the wild-type [...] Read more.
The velvet complex is a master regulator of multiple physiological processes in filamentous fungi. In this study, we characterized the functions of velvet gene FpvelC in Fusarium proliferatum, which was the causative agent of rice spikelet rot disease. Compared with the wild-type Fp9 strain, deletion of FpvelC hindered conidiation, leading to a low level of trehalose content but excessive accumulation of chitin in conidia. Lack of FpvelC resulted in increased sensitivity to oxidative stress and decreased expression of antioxidant genes. Notably, ΔFpvelC exhibited attenuated pathogenicity on rice and maize, failure to produce invasive hyphae, and downregulation of genes encoding xylanases and xyloglucanases during infection processes. Nevertheless, disruption of FpvelC enhanced production of fumonisin B1 (FB1) and fusaric acid concomitantly; transcripts of the clustering genes responsible for the two mycotoxins’ biosynthesis were significantly increased. Additionally, the absence of FpvelC was displayed as more sensitive to rapamycin than the Fp9 strain, accompanied with less intracellular glutamine. Overall, FpvelC played versatile roles in conidiation, response to oxidative stress, pathogenicity and mycotoxins production in F. proliferatum. Full article
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