Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
3.6
3.6
Journals
Diagnostics
Special Issues
Respiratory Diseases: Diagnosis and Management
share announcement

Respiratory Diseases: Diagnosis and Management

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Pathology and Molecular Diagnostics".

Deadline for manuscript submissions: 30 August 2024 | Viewed by 3187

Special Issue Editors

Dr. Ori Wand

E-Mail Website
Guest Editor
Division of Pulmonary Medicine, Barzilai University Medical Center, Ashkelon, Israel
Interests: interstitial lung diseases; chronic obstructive pulmonary disease; asthma; COVID-19; lung cancer; interventional pulmonology
Dr. Shimon Izhakian

E-Mail Website
Guest Editor
Pulmonary Institute, Beilinson Hospital, Rabin Medical Center, Petah Tikva 4941492, Israel
Interests: respiratory infections; page therapy; lung transplantation; bronchiectasis; non-tuberculous mycobacteria

Special Issue Information

Dear Colleagues,

There has been tremendous progress in the management of respiratory diseases in recent years. Pulmonary and respiratory medicine is moving towards personalized medicine, which encompasses advances in diagnostic capabilities, improved phenotyping and endotyping of common illnesses, and the introduction of novel therapies.

Biological treatments have revolutionized the management of severe asthma. These medications are tailored for individuals with severe asthma according to widely available biomarkers, with the ambitious goal of inducing disease remission. A plethora of studies have led to an improved understanding of the pathophysiology of COPD, allowing us to contemplate how to promote its prevention and possibly change the disease course. Thoracic oncology is also a constantly evolving field. Current technologies allow for screening at-risk individuals to detect early-stage lung cancer. Molecular studies of neoplasms have led to targeted therapies, which can change the outlook of patients with advanced as well as local malignancy.

Those are just some examples of the possibilities currently available for physicians and patients in the ever-growing field of respiratory medicine. Additional significant advances have led to progress in the diagnosis and management of respiratory infections, interstitial lung diseases and pulmonary fibrosis, pulmonary hypertension, and hereditary diseases such as cystic fibrosis and primary ciliary dyskinesia, to name a few.

With this Special Issue, we aim to provide readers with an updated overview of exciting novelties in respiratory medicine and promote interest and discussion in this field.

Dr. Ori Wand
Dr. Shimon Izhakian
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Diagnostics is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • interstitial lung diseases
  • chronic obstructive pulmonary disease
  • asthma
  • COVID-19
  • lung cancer
  • interventional pulmonology

Published Papers (3 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

Jump to: Other

11 pages, 207 KiB  
Article
NSCLC Digital PCR Panel Returns Low-Input Sample Results Where Sequencing Fails
by Leah Rowland Herdt, Paige Berroteran, Malini Rajagopalan, Bradley A. Brown and Jerrod J. Schwartz
Diagnostics 2024, 14(3), 243; https://doi.org/10.3390/diagnostics14030243 - 24 Jan 2024
Viewed by 1605
Abstract
Molecular diagnostics has drastically improved the survival rate of patients diagnosed with non-small cell lung cancer (NSCLC) over the last 10 years. Despite advancements in molecular testing, targeted therapies, and national guideline recommendations, more than half of NSCLC patients in the United States [...] Read more.
Molecular diagnostics has drastically improved the survival rate of patients diagnosed with non-small cell lung cancer (NSCLC) over the last 10 years. Despite advancements in molecular testing, targeted therapies, and national guideline recommendations, more than half of NSCLC patients in the United States either never receive testing or patient care is not informed via molecular testing. Here, we sought to explore the relationship between DNA/RNA input, the molecular testing method, and test success rates. On a shared set of low-input reference test materials (n = 3), we ran both a hybrid capture-based, next-generation sequencing (NGS) assay and a multiplexed digital PCR (dPCR) panel. The dPCR panel was highly sensitive and specific for low-input samples in dilution studies ranging from 40 to 1 ng DNA and from 20 to 2.5 ng RNA, while NGS had up to an 86% loss in sensitivity as contrived sample inputs were serially diluted. The dPCR panel also demonstrated a high PPA (>95%) at diluted inputs as low as 15/7.5 ng DNA/RNA on 23 banked clinical samples with the same NGS hybrid capture assay at a high input. These data suggest that digital PCR is an accurate and effective way of identifying clinically relevant NSCLC mutations at low nucleotide input and quality. Full article
(This article belongs to the Special Issue Respiratory Diseases: Diagnosis and Management)

Other

Jump to: Research

4 pages, 431 KiB  
Comment
Myositis “Diaphragm Cramp” as a Potential Cause of Respiratory Arrests in Infants. Comment on Salfi, N.C.M. et al. Fatal Deterioration of a Respiratory Syncytial Virus Infection in an Infant with Abnormal Muscularization of Intra-Acinar Pulmonary Arteries: Autopsy and Histological Findings. Diagnostics 2024, 14, 601
by Dov Jordan Gebien
Diagnostics 2024, 14(10), 1061; https://doi.org/10.3390/diagnostics14101061 - 20 May 2024
Viewed by 568
Abstract
This Letter to the Editor provides additional information regarding the tragic case of a 6-month-old in Italy with respiratory syncytial virus who deteriorated and died unexpectedly from rapid respiratory insufficiency [...] Full article
(This article belongs to the Special Issue Respiratory Diseases: Diagnosis and Management)
►▼ Show Figures

Figure 1

10 pages, 9060 KiB  
Case Report
Fatal Deterioration of a Respiratory Syncytial Virus Infection in an Infant with Abnormal Muscularization of Intra-Acinar Pulmonary Arteries: Autopsy and Histological Findings
by Nunzio Cosimo Mario Salfi, Gianluca Vergine, Maurizio Poloni, Sara Metalli, Barbara Bigucci, Francesca Facondini, Gianmatteo Pedrazzi, Francesca Masciopinto, Laura Bernabè, Vittorio Sambri and Maria Paola Bonasoni
Diagnostics 2024, 14(6), 601; https://doi.org/10.3390/diagnostics14060601 - 12 Mar 2024
Cited by 1 | Viewed by 792
Abstract
Respiratory syncytial virus (RSV) infection represents a global and noteworthy cause of hospitalization and death in infants of less than 1 year of age. The typical clinical manifestation is bronchiolitis, an inflammatory process of the small airways. The symptoms are usually a brief [...] Read more.
Respiratory syncytial virus (RSV) infection represents a global and noteworthy cause of hospitalization and death in infants of less than 1 year of age. The typical clinical manifestation is bronchiolitis, an inflammatory process of the small airways. The symptoms are usually a brief period of low-grade fever, cough, coryza, breathing difficulties, and reduced feeding. The progression of the disease is difficult to predict, even in previous healthy subjects. Symptoms may also be subtle and underestimated, thus leading to sudden unexpected infant death (SUID). In these cases, RSV infection is discovered at autopsy, either histologically or through real-time reverse transcription polymerase chain reaction (RT-PCR) performed on nasopharyngeal swabs. Herein, we describe a case of RSV infection in a 6-month-old infant with no risk factors, who rapidly deteriorated and unexpectedly died of respiratory insufficiency in a hospital setting. RT-PCR on nasopharyngeal swabs revealed RSV. The autopsy showed diffuse lymphogranulocytic bronchitis and bronchiolitis, and multiple foci of acute pneumonia. Abnormal muscularization of the intra-acinar pulmonary arteries was also observed, which likely contributed to worsening the lung impairment. Full article
(This article belongs to the Special Issue Respiratory Diseases: Diagnosis and Management)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-3
Back to TopTop