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Diagnostics
Special Issues
Advances in the Diagnosis and Management of Pediatric Diseases
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Advances in the Diagnosis and Management of Pediatric Diseases

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Pathology and Molecular Diagnostics".

Deadline for manuscript submissions: 31 October 2024 | Viewed by 151

Special Issue Editor

Dr. Elena Tarca

E-Mail Website
Guest Editor
Department of Surgery II—Pediatric Surgery, University of Medicine and Pharmacy “Gr. T. Popa”, 700115 Iasi, Romania
Interests: pediatric surgery; pediatric orthopedy; urology; neonatology; maternofetal medicine
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The physiopathology of children differs from that of adults, making it sometimes challenging to diagnose and treat pediatric patients. The broad and diverse spectrum of pediatric patients becomes apparent when we examine patients from the newborn stage, which can include premature birth, through to the age of eighteen, or from very low birth weight to one hundred kilograms in weight.

In this Special Issue, we can include original articles, reviews and case reports on several important topics, as follows:

-Pediatric surgery is a fascinating specialty due to the diversity of pathology but also due to the particularities of each individual child, and the clinical presentation can be a real challenge in order to establish a definite diagnosis and a correct treatment. Traumatology and pediatric oncology are two medical subfields distinct from those encountered in adults, with special peculiarities and challenges.

-Congenital malformations are a broad and intriguing subject that is frequently linked to chromosomal abnormalities, extremely low birth weight and premature birth. The diagnosis of these malformations and their inclusion in certain syndromes is as difficult as the management of these special cases.

We extend an invitation to researchers in all pediatric specialties to share their findings from pediatric patient studies in this Special Issue.

Dr. Elena Tarca
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Diagnostics is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • pediatrics
  • pediatric surgery
  • neonatal medicine
  • congenital malformations
  • pediatric trauma
  • pediatric oncology

Published Papers (1 paper)

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20 pages, 4316 KiB  
Systematic Review
Diagnosis and Management of Simple and Complicated Meconium Ileus in Cystic Fibrosis, a Systematic Review
by Mădălina Andreea Donos, Gabriela Ghiga, Laura Mihaela Trandafir, Elena Cojocaru, Viorel Țarcă, Lăcrămioara Ionela Butnariu, Valentin Bernic, Eugenia Moroșan, Iulia Cristina Roca, Dana Elena Mîndru and Elena Țarcă
Diagnostics 2024, 14(11), 1179; https://doi.org/10.3390/diagnostics14111179 (registering DOI) - 4 Jun 2024
Abstract
The early management of neonates with meconium ileus (MI) and cystic fibrosis (CF) is highly variable across countries and is not standardized. We conducted a systematic review according to the Preferred Reporting Items for Systematic Reviews and Meta-analyses statement. The protocol was registered [...] Read more.
The early management of neonates with meconium ileus (MI) and cystic fibrosis (CF) is highly variable across countries and is not standardized. We conducted a systematic review according to the Preferred Reporting Items for Systematic Reviews and Meta-analyses statement. The protocol was registered in PROSPERO (CRD42024522838). Studies from three providers of academic search engines were checked for inclusion criteria, using the following search terms: meconium ileus AND cystic fibrosis OR mucoviscidosis. Regarding the patient population studied, the inclusion criteria were defined using our predefined PICOT framework: studies on neonates with simple or complicated meconium which were confirmed to have cystic fibrosis and were conservatively managed or surgically treated. Results: A total of 566 publications from the last 10 years were verified by the authors of this review to find the most recent and relevant data, and only 8 met the inclusion criteria. Prenatally diagnosed meconium pseudocysts, bowel dilation, and ascites on ultrasound are predictors of neonatal surgery and risk factor for negative 12-month clinical outcomes in MI-CF newborns. For simple MI, conservative treatment with hypertonic solutions enemas can be effective in more than 25% of cases. If repeated enemas fail to disimpact the bowels, the Bishop–Koop stoma is a safe option. No comprehensive research has been conducted so far to determine the ideal surgical protocol for complicated MI. We only found three studies that reported the types of stomas performed and another study comparing the outcomes of patients depending on the surgical management; the conclusions are contradictory especially since the number of cases analyzed in each study was small. Between 18% and 38% of patients with complicated MI will require reoperation for various complications and the mortality rate varies between 0% and 8%. Conclusion: This study reveals a lack of strong data to support management decisions, unequivocally shows that the care of infants with MI is not standardized, and suggests a great need for international collaborative studies. Full article
(This article belongs to the Special Issue Advances in the Diagnosis and Management of Pediatric Diseases)
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