Fusion on a Chip: Microfluidics Meet Miniaturised Sensors

A special issue of Bioengineering (ISSN 2306-5354). This special issue belongs to the section "Biosignal Processing".

Deadline for manuscript submissions: 31 August 2024 | Viewed by 219

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Guest Editor
1. Institute for Health Innovation & Technology (iHealthtech), National University of Singapore (NUS), MD6, 14 Medical Drive, #14-01, Singapore 117599, Singapore
2. Department of Biomedical Engineering, National University of Singapore (NUS), 4 Engineering Drive 3, Singapore 117583, Singapore
Interests: wearable soft microtube sensors; cell-based diagnosis
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Special Issue Information

Dear Colleagues,

Microfluidics and sensing technologies have converged in a fascinating partnership, creating powerful tools for diverse applications in bioengineering and healthcare. From sorting cells, mixing reagents, or analysing blood samples, microfluidic platforms promise efficiency, portability, affordability, and scalability. The seamless integration of microfluidic platforms with next-generation miniaturised sensors could drive real-time monitoring, diagnostics, and personalised medicine.

Despite rapid development in this field, many challenges remain–how do we fit a complex network of microchannels and sensors into a chip that is the size of a postage stamp? How can we automate sample collection and processing? How do we ensure biocompatibility, long-term stability, and reliability? How do we package the reagents for testing in remote areas? And, as we embrace artificial intelligence, what role can it play in orchestrating real-time feedback and data acquisition?

This special issue aims to put a spotlight on recent developments in integrating microfluidic and sensing technologies and their pivotal role in shaping the landscape of precision diagnostics. We invite contributions focusing on novel microfabrication methods, smart miniaturised devices, lab-on-a-chip, and the role of artificial intelligence in controlling fluid behaviour. We welcome submissions spanning the integration of optical, electrochemical, mechanical, and other biosensors. We aim to offer an insightful panorama of the dynamic landscape of this interdisciplinary field and its promise of transformative advancements in accessible healthcare and beyond.

Dr. Ali Asgar Bhagat
Guest Editor

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Keywords

  • lab-on-a-chip
  • microfluidics fabrication
  • MEMS
  • point-of-care diagnostics
  • biosensors
  • materials

Published Papers (1 paper)

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10 pages, 16522 KiB  
Article
Metered-Dose Inhaler Spacer with Integrated Spirometer for Home-Based Asthma Monitoring and Drug Uptake
by Cheuk-Yan Au, Kelleen J. X. Koh, Hui Fang Lim and Ali Asgar Saleem Bhagat
Bioengineering 2024, 11(6), 552; https://doi.org/10.3390/bioengineering11060552 - 29 May 2024
Viewed by 130
Abstract
This work introduces Spiromni, a single device incorporating three different pressurised metered-dose inhaler (pMDI) accessories: a pMDI spacer, an electronic monitoring device (EMD), and a spirometer. While there are devices made to individually address the issues of technique, adherence and monitoring, respectively, for [...] Read more.
This work introduces Spiromni, a single device incorporating three different pressurised metered-dose inhaler (pMDI) accessories: a pMDI spacer, an electronic monitoring device (EMD), and a spirometer. While there are devices made to individually address the issues of technique, adherence and monitoring, respectively, for asthma patients as laid out in the Global Initiative for Asthma’s (GINA) global strategy for asthma management and prevention, Spiromni was designed to address all three issues using a single, combination device. Spiromni addresses the key challenge of measuring both inhalation and exhalation profiles, which are different by an order of magnitude. Moreover, the innovative design prevents exhalation from entering the spacer chamber and prevents medication loss during inhalation using umbrella valves without a loss in flow velocity. Apart from recording the peak exhalation flow rate, data from the sensors allow us to extract other key lung volume and capacities measures similar to a medical pulmonary function test. We believe this low-cost portable multi-functional device will benefit both asthma patients and clinicians in the management of the disease. Full article
(This article belongs to the Special Issue Fusion on a Chip: Microfluidics Meet Miniaturised Sensors)
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