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Article

Synthesis and Pharmacological Activities of Some New Triazolo- and Tetrazolopyrimidine Derivatives

by
Saleh A. Bahashwan
1,
Ahmed A. Fayed
2,3,*,
Abd El-Galil E. Amr
3,4,
Eman M. Flefel
3 and
Atef Kalmouch
3,5
1
Pharmacology and Toxicology Department, College of Pharmacy, Taibah University, Al-Madinah Al-Munawara 3893, Saudi Arabia
2
Respiratory Department (Applied Organic & Biochemistry Division), College of Medical Rehabilitation Sciences, Taibah University, Al-Madinah Al-Munawara 3893, Saudi Arabia
3
National Research Center, Dokki, Cairo, Dokki 12622, Egypt
4
Pharmaceutical Chemistry Department, Drug Exploration & Development Chair (DEDC), College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia
5
Deanship of Academic Services Preparatory Years, Health Science Track, Taibah University, Al Madinah Al-Monawarah 344, Saudi Arabia
*
Author to whom correspondence should be addressed.
Molecules 2013, 18(12), 15051-15063; https://doi.org/10.3390/molecules181215051
Submission received: 27 September 2013 / Revised: 21 November 2013 / Accepted: 29 November 2013 / Published: 6 December 2013
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Abstract

A new series of fused triazolo- and tetrazolopyrimidine derivatives 2–14 were synthesized and their anti-inflammatory and ulcerogenic activities were evaluated. The pharmacological screening showed that many of these obtained compounds have good anti-inflammatory activities, comparable to the reference drug. The toxicity of the compounds was also assayed via the determination of their LD50 values. The structures of newly synthesized compounds were confirmed by IR, 1H-NMR, MS spectral data and elemental analysis.
Keywords: pyrazolopyrimidines; thienopyrimidines; triazolo- and tetrazolopyrimidines; anti-inflammatory and ulcerogenic activities pyrazolopyrimidines; thienopyrimidines; triazolo- and tetrazolopyrimidines; anti-inflammatory and ulcerogenic activities

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MDPI and ACS Style

Bahashwan, S.A.; Fayed, A.A.; Amr, A.E.-G.E.; Flefel, E.M.; Kalmouch, A. Synthesis and Pharmacological Activities of Some New Triazolo- and Tetrazolopyrimidine Derivatives. Molecules 2013, 18, 15051-15063. https://doi.org/10.3390/molecules181215051

AMA Style

Bahashwan SA, Fayed AA, Amr AE-GE, Flefel EM, Kalmouch A. Synthesis and Pharmacological Activities of Some New Triazolo- and Tetrazolopyrimidine Derivatives. Molecules. 2013; 18(12):15051-15063. https://doi.org/10.3390/molecules181215051

Chicago/Turabian Style

Bahashwan, Saleh A., Ahmed A. Fayed, Abd El-Galil E. Amr, Eman M. Flefel, and Atef Kalmouch. 2013. "Synthesis and Pharmacological Activities of Some New Triazolo- and Tetrazolopyrimidine Derivatives" Molecules 18, no. 12: 15051-15063. https://doi.org/10.3390/molecules181215051

APA Style

Bahashwan, S. A., Fayed, A. A., Amr, A. E.-G. E., Flefel, E. M., & Kalmouch, A. (2013). Synthesis and Pharmacological Activities of Some New Triazolo- and Tetrazolopyrimidine Derivatives. Molecules, 18(12), 15051-15063. https://doi.org/10.3390/molecules181215051

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