Next Article in Journal
Retraction: Sasidharan et al. Evaluation of the Hepatoprotective Effects of Lantadene A, a Pentacyclic Triterpenoid of Lantana Plants against Acetaminophen-induced Liver Damage. Molecules 2012, 17, 13937-13947
Previous Article in Journal
First-Principles Elucidation of the Surface Chemistry of the C2Hx (x = 0–6) Adsorbate Series on Fe(100)
Article Menu

Export Article

Open AccessArticle
Molecules 2013, 18(4), 3825-3838; doi:10.3390/molecules18043825

Effects of Freshwater Clam Extract Supplementation on Time to Exhaustion, Muscle Damage, Pro/Anti-Inflammatory Cytokines, and Liver Injury in Rats after Exhaustive Exercise

1
Department of Biological Science and Technology, National Chiao Tung University, Hsinchu 30068, Taiwan
2
Holistic Education Center, Mackay Medical College, New Taipei City 25245, Taiwan
3
Department of Orthopedics, Buddhist Tzu Chi General Hospital, Hualien 97004, Taiwan
4
Intensive Care Unit, Buddhist Tzu Chi General Hospital, Taipei Branch, Taipei 23142, Taiwan
5
Department of Nursing, St. Mary's Medicine, Nursing and Management College, Yi-Lan 26644, Taiwan
6
Department of Nursing, Tzu Chi University, Hualien 97004, Taiwan
7
Department of Nephrology, Buddhist Tzu Chi General Hospital, Hualien 97004, Taiwan
*
Authors to whom correspondence should be addressed.
Received: 5 February 2013 / Revised: 22 March 2013 / Accepted: 22 March 2013 / Published: 26 March 2013
(This article belongs to the Section Natural Products)
View Full-Text   |   Download PDF [546 KB, uploaded 18 June 2014]   |  

Abstract

The potent anti-inflammatory activities and tissue-protective effects of freshwater clams (Corbicula fluminea) have been well reported. The aim of this study was to determine the effects of freshwater clam extract (FCE) supplementation on time to exhaustion, muscle damage, pro- and anti-inflammatory cytokines, and liver injury in rats after exhaustive exercise. Thirty-two rats were divided into four groups: sedentary control (SC); SC group with FCE supplementation (SC+FCE); exhaustive exercise (E); and E group with FCE supplementation (E+FCE). The SC+FCE and E+FCE groups were treated with gavage administration of 20 mg/kg for seven consecutive days. Blood samples were collected for the evaluation of biochemical parameters. The cytokine levels of TNF-α and IL-10 were also examined. Twenty-four hours after exhaustive exercise, the rat livers were removed for H & E staining. The FCE supplementation could extend the time to exhaustion in exercised rats. The levels of CPK, LDH, AST, ALT, lactate, TNF-α and H & E stains of the liver injury were significantly decreased in the E+FCE group, but the blood glucose and IL-10 were significantly higher in comparison with the E group. This study suggests that FCE supplementation may improve endurance performance and reduce exercise-induced muscle damage, inflammatory stress and liver injury. View Full-Text
Keywords: Corbicula fluminea; anti-inflammatory; endurance performance; blood glucose Corbicula fluminea; anti-inflammatory; endurance performance; blood glucose
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Huang, K.-C.; Wu, W.-T.; Yang, F.-L.; Chiu, Y.-H.; Peng, T.-C.; Hsu, B.-G.; Liao, K.-W.; Lee, R.-P. Effects of Freshwater Clam Extract Supplementation on Time to Exhaustion, Muscle Damage, Pro/Anti-Inflammatory Cytokines, and Liver Injury in Rats after Exhaustive Exercise. Molecules 2013, 18, 3825-3838.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top