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Molecules 2013, 18(4), 4477-4486; doi:10.3390/molecules18044477

Chemical Constituents from the Leaves of Annona reticulata and Their Inhibitory Effects on NO Production

Department of Chemistry, Vinh University, Vinh 42000, Vietnam
Department of Biotechnology, National Formosa University, Yunlin 632, Taiwan
Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, China Medical University, Taichung 404, Taiwan
Department of Chemistry, National Cheng Kung University, Tainan 701, Taiwan
Department of Natural Science, Hong Duc University, Thanhhoa 41000, Vietnam
These authors contributed equally to this work.
Author to whom correspondence should be addressed.
Received: 24 January 2013 / Revised: 3 April 2013 / Accepted: 12 April 2013 / Published: 16 April 2013
(This article belongs to the Section Natural Products)
View Full-Text   |   Download PDF [231 KB, uploaded 18 June 2014]   |  


In the present study, the chemical investigation of the leaves of Annona reticulata has resulted in the identification of nine compounds, including annonaretin A, (1), a new triterpenoid. The purified compounds were subjected to the examination of their effects on NO inhibition in LPS-activated mouse peritoneal macrophages and most of them exhibited significant NO inhibition, with IC50 values in the range of 48.6 ± 1.2 and 99.8 ± 0.4 μM. View Full-Text
Keywords: Annona; triterpenoid; diterpenoid; NO inhibition; iNOS; macrophage Annona; triterpenoid; diterpenoid; NO inhibition; iNOS; macrophage

Figure 1

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Thang, T.D.; Kuo, P.-C.; Huang, G.-J.; Hung, N.H.; Huang, B.-S.; Yang, M.-L.; Luong, N.X.; Wu, T.-S. Chemical Constituents from the Leaves of Annona reticulata and Their Inhibitory Effects on NO Production. Molecules 2013, 18, 4477-4486.

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