Next Article in Journal
Natural Products as a Source of Anti-Inflammatory Agents Associated with Inflammatory Bowel Disease
Previous Article in Journal
Supercritical Fluid Extraction of Plant Flavors and Fragrances
Molecules 2013, 18(6), 7239-7252; doi:10.3390/molecules18067239

Enhancement of the Controlled-Release Properties of Chitosan Membranes by Crosslinking with Suberoyl Chloride

Department of Environmental Sciences & Engineering, College of Resources & Environmental Sciences, China Agricultural University, Beijing 100193, China
* Author to whom correspondence should be addressed.
Received: 6 May 2013 / Revised: 7 June 2013 / Accepted: 17 June 2013 / Published: 19 June 2013
(This article belongs to the Section Natural Products)
View Full-Text   |   Download PDF [1125 KB, uploaded 18 June 2014]   |  


A novel crosslinking agent, suberoyl chloride, was used to crosslink N-phthaloyl acylated chitosan and improves the properties of chitosan membranes. Membranes with different crosslinking degrees were synthesized. The derivatives were characterized by Fourier transform infrared spectroscopy and 13C solid state nuclear magnetic resonance spectroscopy, which indicated that the crosslinking degrees ranged from 0 to 7.4%. The permeabilities of various plant nutrients, including macroelements (N, P, K), microelements (Zn2+ and Cu2+), and a plant growth regulator (naphthylacetic acid), were varied by moderate changes in crosslinking degree, indicating that the controlled-release properties can be regulated in this way. The film-forming ability of native chitosan was maintained, whilst mechanical properties, hydrophobicity and controlled permeability were improved. These dramatic improvements occurred with a small amount of added suberoyl chloride; excessive crosslinking led to membranes with unwanted poor permeability. Thus, both the mechanical properties and permeability of the crosslinked membrane can be optimized.
Keywords: chitosan; crosslink; N-phthaloylation; hydrophobicity; controlled release chitosan; crosslink; N-phthaloylation; hydrophobicity; controlled release
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
EndNote |
MDPI and ACS Style

Chen, C.; Gao, Z.; Qiu, X.; Hu, S. Enhancement of the Controlled-Release Properties of Chitosan Membranes by Crosslinking with Suberoyl Chloride. Molecules 2013, 18, 7239-7252.

View more citation formats

Related Articles

Article Metrics

For more information on the journal, click here


[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert