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Int. J. Mol. Sci. 2012, 13(12), 16658-16667; doi:10.3390/ijms131216658
Article

XRCC3 Gene Polymorphism Is Associated with Survival in Japanese Lung Cancer Patients

1,* , 1
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1 Faculty of Health Sciences, Kobe University Graduate School of Health Sciences, Kobe 654-0142, Japan 2 Department of General Thoracic Surgery, Hyogo Cancer Center, Akashi 673-0021, Japan 3 Department of Thoracic Oncology, Hyogo College of Medicine, Nishinomiya 663-8501, Japan 4 Division of Diabetes and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan
* Author to whom correspondence should be addressed.
Received: 28 September 2012 / Revised: 7 November 2012 / Accepted: 28 November 2012 / Published: 5 December 2012
(This article belongs to the Section Biochemistry, Molecular Biology and Biophysics)
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Abstract

We focused on OGG1 Ser326Cys, MUTYH Gln324His, APEX1 Asp148Glu, XRCC1 Arg399Gln, and XRCC3 Thr241Met and examined the relationship between the different genotypes and survival of Japanese lung cancer patients. A total of 99 Japanese lung cancer patients were recruited into our study. Clinical data were collected, and genotypes of the target genes were identified by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Survival analysis to verify the impact of these gene polymorphisms on the clinical outcome of lung cancer showed that lung squamous cell carcinoma patients with the Thr/Met genotype at XRCC3 had a significantly shorter survival time than those with the Thr/Thr genotype (13 months versus 48 months; log-rank test, p < 0.0001). Cox regression analysis showed that the carriers of XRCC3 genotypes were at a significantly higher risk [adjusted hazard ratio (HR) = 9.35, 95% confidence interval (CI) = 2.52–34.68, p = 0.001; adjusted HR = 9.05, 95% CI = 1.89–44.39, p = 0.006]. Our results suggest that XRCC3 Thr241Met may act as a favorable prognostic indicator for lung squamous cell carcinoma patients.
Keywords: gene polymorphisms; lung cancer; survival; DNA repair; XRCC3 gene polymorphisms; lung cancer; survival; DNA repair; XRCC3
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Osawa, K.; Nakarai, C.; Uchino, K.; Yoshimura, M.; Tsubota, N.; Takahashi, J.; Kido, Y. XRCC3 Gene Polymorphism Is Associated with Survival in Japanese Lung Cancer Patients. Int. J. Mol. Sci. 2012, 13, 16658-16667.

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