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Article

Two Different Approaches for Oral Administration of Voriconazole Loaded Formulations: Electrospun Fibers versus β-Cyclodextrin Complexes

by
Panoraia I. Siafaka
1,
Neslihan Üstündağ Okur
2,
Mariza Mone
1,
Spyridoula Giannakopoulou
1,
Sevda Er
3,
Eleni Pavlidou
4,
Evangelos Karavas
5 and
Dimitrios N. Bikiaris
1,*
1
Laboratory of Polymer Chemistry and Technology, Department of Chemistry, Aristotle University of Thessaloniki, 54 124 Thessaloniki, Greece
2
School of Pharmacy, Department of Pharmaceutical Technology, Istanbul Medipol University, Beykoz, 34810 Istanbul, Turkey
3
School of Pharmacy, Department of Microbiology, Istanbul Medipol University, Beykoz, 34810 Istanbul, Turkey
4
Department of Physics, Aristotle University of Thessaloniki, 54 124 Thessaloniki, Greece
5
Pharmathen S.A, Dervenakion Str. 6, 153 51 Attiki, Greece
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2016, 17(3), 282; https://doi.org/10.3390/ijms17030282
Submission received: 24 January 2016 / Revised: 24 January 2016 / Accepted: 19 February 2016 / Published: 25 February 2016
(This article belongs to the Special Issue Drug Delivery and Antimicrobial Agents)
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Abstract

In this work, a comparison between two different preparation methods for the improvement of dissolution rate of an antifungal agent is presented. Poly(ε-caprolactone) (PCL) electrospun fibers and β-cyclodextrin (β-CD) complexes, which were produced via an electrospinning process and an inclusion complexation method, respectively, were addressed for the treatment of fungal infections. Voriconazole (VRCZ) drug was selected as a model drug. PCL nanofibers were characterized on the basis of morphology while phase solubility studies for β-CDs complexes were performed. Various concentrations (5, 10, 15 and 20 wt %) of VRCZ were loaded to PCL fibers and β-CD inclusions to study the in vitro release profile as well as in vitro antifungal activity. The results clearly indicated that all formulations showed an improved VRCZ solubility and can inhibit fungi proliferation.
Keywords: PCL; fibers; inclusion complexation; voriconazole drug; antifungal PCL; fibers; inclusion complexation; voriconazole drug; antifungal
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MDPI and ACS Style

Siafaka, P.I.; Üstündağ Okur, N.; Mone, M.; Giannakopoulou, S.; Er, S.; Pavlidou, E.; Karavas, E.; Bikiaris, D.N. Two Different Approaches for Oral Administration of Voriconazole Loaded Formulations: Electrospun Fibers versus β-Cyclodextrin Complexes. Int. J. Mol. Sci. 2016, 17, 282. https://doi.org/10.3390/ijms17030282

AMA Style

Siafaka PI, Üstündağ Okur N, Mone M, Giannakopoulou S, Er S, Pavlidou E, Karavas E, Bikiaris DN. Two Different Approaches for Oral Administration of Voriconazole Loaded Formulations: Electrospun Fibers versus β-Cyclodextrin Complexes. International Journal of Molecular Sciences. 2016; 17(3):282. https://doi.org/10.3390/ijms17030282

Chicago/Turabian Style

Siafaka, Panoraia I., Neslihan Üstündağ Okur, Mariza Mone, Spyridoula Giannakopoulou, Sevda Er, Eleni Pavlidou, Evangelos Karavas, and Dimitrios N. Bikiaris. 2016. "Two Different Approaches for Oral Administration of Voriconazole Loaded Formulations: Electrospun Fibers versus β-Cyclodextrin Complexes" International Journal of Molecular Sciences 17, no. 3: 282. https://doi.org/10.3390/ijms17030282

APA Style

Siafaka, P. I., Üstündağ Okur, N., Mone, M., Giannakopoulou, S., Er, S., Pavlidou, E., Karavas, E., & Bikiaris, D. N. (2016). Two Different Approaches for Oral Administration of Voriconazole Loaded Formulations: Electrospun Fibers versus β-Cyclodextrin Complexes. International Journal of Molecular Sciences, 17(3), 282. https://doi.org/10.3390/ijms17030282

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