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Article

Social Interaction in Adolescent Rats with Neonatal Ethanol Exposure: Impact of Sex and CE-123, a Selective Dopamine Reuptake Inhibitor

by
Justyna Socha
1,
Pawel Grochecki
1,
Irena Smaga
2,
Joanna Jastrzębska
2,
Olga Wronikowska-Denysiuk
3,
Marta Marszalek-Grabska
4,
Tymoteusz Slowik
5,
Robert Kotlinski
6,
Małgorzata Filip
2,
Gert Lubec
7 and
Jolanta H. Kotlinska
1,*
1
Department of Pharmacology and Pharmacodynamics, Medical University of Lublin, Chodzki 4a, 20-093 Lublin, Poland
2
Department of Drug Addiction Pharmacology, Maj Institute of Pharmacology Polish Academy of Sciences, Smetna 12, 31-343 Krakow, Poland
3
Independent Laboratory of Behavioral Studies, Chair of Biomedical Sciences, Medical University of Lublin, Chodzki 4a, 20-093 Lublin, Poland
4
Department of Experimental and Clinical Pharmacology, Medical University, Jaczewskiego 8b, 20-090 Lublin, Poland
5
Experimental Medicine Center, Medical University, Jaczewskiego 8, 20-090 Lublin, Poland
6
Clinical Department of Cardiac Surgery, University of Rzeszow, 35-601 Rzeszow, Poland
7
Department of Neuroproteomics, Paracelsus Medical University, 5020 Salzburg, Austria
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2024, 25(2), 1041; https://doi.org/10.3390/ijms25021041
Submission received: 20 December 2023 / Revised: 8 January 2024 / Accepted: 10 January 2024 / Published: 15 January 2024
(This article belongs to the Special Issue Role of Dopamine in Health and Disease: Biological Aspect 2.0)
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Abstract

Children with fetal alcohol spectrum disorders (FASDs) demonstrate deficits in social functioning that contribute to early withdrawal from school and delinquency, as well as the development of anxiety and depression. Dopamine is involved in reward, motivation, and social behavior. Thus, we evaluated whether neonatal ethanol exposure (in an animal model of FASDs) has an impact on social recognition memory using the three-chamber social novelty discrimination test during early and middle adolescence in male and female rats, and whether the modafinil analog, the novel atypical dopamine reuptake inhibitor CE-123, can modify this effect. Our study shows that male and female rats neonatally exposed to ethanol exhibited sex- and age-dependent deficits in social novelty discrimination in early (male) and middle (female) adolescence. These deficits were specific to the social domain and not simply due to more general deficits in learning and memory because these animals did not exhibit changes in short-term recognition memory in the novel object recognition task. Furthermore, early-adolescent male rats that were neonatally exposed to ethanol did not show changes in the anxiety index but demonstrated an increase in locomotor activity. Chronic treatment with CE-123, however, prevented the appearance of these social deficits. In the hippocampus of adolescent rats, CE-123 increased BDNF and decreased its signal transduction TrkB receptor expression level in ethanol-exposed animals during development, suggesting an increase in neuroplasticity. Thus, selective dopamine reuptake inhibitors, such as CE-123, represent interesting drug candidates for the treatment of deficits in social behavior in adolescent individuals with FASDs.
Keywords: adolescence; neonatal ethanol exposure; social behavior; selective dopamine reuptake inhibitor; CE-123 adolescence; neonatal ethanol exposure; social behavior; selective dopamine reuptake inhibitor; CE-123

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MDPI and ACS Style

Socha, J.; Grochecki, P.; Smaga, I.; Jastrzębska, J.; Wronikowska-Denysiuk, O.; Marszalek-Grabska, M.; Slowik, T.; Kotlinski, R.; Filip, M.; Lubec, G.; et al. Social Interaction in Adolescent Rats with Neonatal Ethanol Exposure: Impact of Sex and CE-123, a Selective Dopamine Reuptake Inhibitor. Int. J. Mol. Sci. 2024, 25, 1041. https://doi.org/10.3390/ijms25021041

AMA Style

Socha J, Grochecki P, Smaga I, Jastrzębska J, Wronikowska-Denysiuk O, Marszalek-Grabska M, Slowik T, Kotlinski R, Filip M, Lubec G, et al. Social Interaction in Adolescent Rats with Neonatal Ethanol Exposure: Impact of Sex and CE-123, a Selective Dopamine Reuptake Inhibitor. International Journal of Molecular Sciences. 2024; 25(2):1041. https://doi.org/10.3390/ijms25021041

Chicago/Turabian Style

Socha, Justyna, Pawel Grochecki, Irena Smaga, Joanna Jastrzębska, Olga Wronikowska-Denysiuk, Marta Marszalek-Grabska, Tymoteusz Slowik, Robert Kotlinski, Małgorzata Filip, Gert Lubec, and et al. 2024. "Social Interaction in Adolescent Rats with Neonatal Ethanol Exposure: Impact of Sex and CE-123, a Selective Dopamine Reuptake Inhibitor" International Journal of Molecular Sciences 25, no. 2: 1041. https://doi.org/10.3390/ijms25021041

APA Style

Socha, J., Grochecki, P., Smaga, I., Jastrzębska, J., Wronikowska-Denysiuk, O., Marszalek-Grabska, M., Slowik, T., Kotlinski, R., Filip, M., Lubec, G., & Kotlinska, J. H. (2024). Social Interaction in Adolescent Rats with Neonatal Ethanol Exposure: Impact of Sex and CE-123, a Selective Dopamine Reuptake Inhibitor. International Journal of Molecular Sciences, 25(2), 1041. https://doi.org/10.3390/ijms25021041

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