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Sensors 2012, 12(5), 5940-5950; doi:10.3390/s120505940

A Fast Response Highly Selective Probe for the Detection of Glutathione in Human Blood Plasma

Department of Chemistry, Portland State University, Portland, OR 97201, USA
Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of Ministry of Education, Institute of Analytical Sciences, College of Chemistry & Materials Science, Northwest University, Xi’an 710069, China
Author to whom correspondence should be addressed.
Received: 11 April 2012 / Revised: 1 May 2012 / Accepted: 3 May 2012 / Published: 8 May 2012
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A fluorescent probe for glutathione (GSH) detection was developed. Our study indicates a possible mechanism which couples a conjugate addition and micelle-catalyzed large membered ring formation/elimination sequence. This method enables excellent selectivity towards GSH over other biological thiols such as cysteine (Cys) and homocysteine (Hcy). The proposed method is precise with a relative standard deviation (R.S.D) lower than 6% (n = 3) and has been successfully applied to determine GSH in human plasma with recoveries between 99.2% and 102.3%.
Keywords: fluorescent probe; glutathione; micelle-catalyzed; selectivity fluorescent probe; glutathione; micelle-catalyzed; selectivity

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Guo, Y.; Yang, X.; Hakuna, L.; Barve, A.; Escobedo, J.O.; Lowry, M.; Strongin, R.M. A Fast Response Highly Selective Probe for the Detection of Glutathione in Human Blood Plasma. Sensors 2012, 12, 5940-5950.

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