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Sensors 2013, 13(3), 3169-3203; doi:10.3390/s130303169

Opening up the Window into “Chemobrain”: A Neuroimaging Review

1,*  and 2
1 Memory and Aging Center, Neurology, UCSF, Sandler Neuroscience Center, 675 Nelson Rising Lane, San Francisco, CA 94158, USA 2 School of Psychology, University of Ottawa, Vanier Hall, 136 Jean Jacques Lussier, Ottawa, ON K1N 6N5, Canada
* Author to whom correspondence should be addressed.
Received: 1 January 2013 / Revised: 5 February 2013 / Accepted: 16 February 2013 / Published: 6 March 2013
(This article belongs to the Special Issue Medical & Biological Imaging)
View Full-Text   |   Download PDF [278 KB, 21 June 2014; original version 21 June 2014]


As more chemotherapy-treated cancer patients are reaching survivorship, side-effects such as cognitive impairment warrant research attention. The advent of neuroimaging has helped uncover a neural basis for these deficits. This paper offers a review of neuroimaging investigations in chemotherapy-treated adult cancer patients, discussing the benefits and limitations of each technique and study design. Additionally, despite the assumption given by the chemobrain label that chemotherapy is the only causative agent of these deficits, other factors will be considered. Suggestions are made on how to more comprehensively study these cognitive changes using imaging techniques, thereby promoting generalizability of the results to clinical applications. Continued investigations may yield better long-term quality of life outcomes by supporting patients’ self-reports, and revealing brain regions being affected by chemotherapy.
Keywords: chemotherapy; cognitive impairment; chemobrain; neuroimaging; cancer survivorship issues chemotherapy; cognitive impairment; chemobrain; neuroimaging; cancer survivorship issues
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Scherling, C.S.; Smith, A. Opening up the Window into “Chemobrain”: A Neuroimaging Review. Sensors 2013, 13, 3169-3203.

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