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Sensors 2013, 13(4), 4624-4639; doi:10.3390/s130404624

A Wireless and Batteryless Microsystem with Implantable Grid Electrode/3-Dimensional Probe Array for ECoG and Extracellular Neural Recording in Rats

1 Department of Bioengineering, University of California, Los Angeles, CA 90095, USA 2 Department of Electrical and Computer Engineering, National Chiao-Tung University, 1001 Ta Hseuh Rd., Hsinchu City 30010, Taiwan 3 Department of Medicine, China Medical University, No.91, Hsueh-Shih Road, Taichung City 40402, Taiwan
* Author to whom correspondence should be addressed.
Received: 21 January 2013 / Revised: 21 March 2013 / Accepted: 28 March 2013 / Published: 8 April 2013
(This article belongs to the Section Biosensors)
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This paper presents the design and implementation of an integrated wireless microsystem platform that provides the possibility to support versatile implantable neural sensing devices in free laboratory rats. Inductive coupled coils with low dropout regulator design allows true long-term recording without limitation of battery capacity. A 16-channel analog front end chip located on the headstage is designed for high channel account neural signal conditioning with low current consumption and noise. Two types of implantable electrodes including grid electrode and 3D probe array are also presented for brain surface recording and 3D biopotential acquisition in the implanted target volume of tissue. The overall system consumes less than 20 mA with small form factor, 3.9 × 3.9 cm2 mainboard and 1.8 × 3.4 cm2 headstage, is packaged into a backpack for rats. Practical in vivo recordings including auditory response, brain resection tissue and PZT-induced seizures recording demonstrate the correct function of the proposed microsystem. Presented achievements addressed the aforementioned properties by combining MEMS neural sensors, low-power circuit designs and commercial chips into system-level integration.
Keywords: microsystem; wireless; neural electrode array; biopotentials microsystem; wireless; neural electrode array; biopotentials
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Chang, C.-W.; Chiou, J.-C. A Wireless and Batteryless Microsystem with Implantable Grid Electrode/3-Dimensional Probe Array for ECoG and Extracellular Neural Recording in Rats. Sensors 2013, 13, 4624-4639.

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