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Sensors 2007, 7(4), 420-437; doi:10.3390/s7040420
Article

Modifications of Poly(o-phenylenediamine) Permselective Layer on Pt-Ir for Biosensor Application in Neurochemical Monitoring

1, 1, 1, 1, 1, 1, 1, 2,*  and 1,*
1 UCD School of Chemistry and Chemical Biology, University College Dublin, Belfield, Dublin 4, Ireland 2 Sensors Development Unit, BioAnalytics Laboratory, Department of Chemistry, National University of Ireland, Maynooth, Co, Kildare, Ireland
* Authors to whom correspondence should be addressed.
Received: 27 March 2007 / Accepted: 10 April 2007 / Published: 12 April 2007
(This article belongs to the Special Issue Amperometric Sensors and Techniques for Neurochemical Monitoring)
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Abstract

Reports that globular proteins could enhance the interference blocking ability ofthe PPD (poly(o-phenylenediamine) layer used as a permselective barrier in biosensordesign, prompted this study where a variety of modifying agents were incorporated into PPDduring its electrosynthesis on Pt-Ir electrodes. Trapped molecules, including fibrous proteinsand β-cyclodextrin, altered the polymer/modifier composite selectivity by affecting thesensitivity to both H2O2 (signal molecule in many enzyme-based biosensors) and thearchetypal interference species, ascorbic acid. A comparison of electrochemical properties ofPt and a Pt-Ir alloy suggests that the benefits of the latter, more rigid, metal can be exploitedin PPD-based biosensor design without significant loss of backward compatibility withstudies involving pure Pt.
Keywords: Platinum-iridium electrodes; Polymer electrosynthesis; Cyclic voltammetry; Amperometry; Proteins; Cyclodextrins; Ascorbate; Hydrogen peroxide; Brain analysis. Platinum-iridium electrodes; Polymer electrosynthesis; Cyclic voltammetry; Amperometry; Proteins; Cyclodextrins; Ascorbate; Hydrogen peroxide; Brain analysis.
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Kirwan, S.M.; Rocchitta, G.; McMahon, C.P.; Craig, J.D.; Killoran, S.J.; O’Brien, K.B.; Serra, P.A.; Lowry, J.P.; O’Neill, R.D. Modifications of Poly(o-phenylenediamine) Permselective Layer on Pt-Ir for Biosensor Application in Neurochemical Monitoring. Sensors 2007, 7, 420-437.

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