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Sensors 2008, 8(12), 8291-8320; doi:10.3390/s8128291
Review

Imprinting of Molecular Recognition Sites on Nanostructures and Its Applications in Chemosensors

, ,  and *
Key Laboratory of Biomimetic Sensing & Advanced Robot Technology, Institute of Intelligent Machines, Chinese Academy of Sciences, Hefei, Anhui 230031, P.R. China
* Author to whom correspondence should be addressed.
Received: 7 November 2008 / Revised: 21 November 2008 / Accepted: 9 December 2008 / Published: 15 December 2008
(This article belongs to the Special Issue Molecular Recognition and Sensors, Including Molecular Imprinting)
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Abstract

Biological receptors including enzymes, antibodies and active proteins have been widely used as the detection platform in a variety of chemo/biosensors and bioassays. However, the use of artificial host materials in chemical/biological detections has become increasingly attractive, because the synthetic recognition systems such as molecularly imprinted polymers (MIPs) usually have lower costs, higher physical/chemical stability, easier preparation and better engineering possibility than biological receptors. Molecular imprinting is one of the most efficient strategies to offer a synthetic route to artificial recognition systems by a template polymerization technique, and has attracted considerable efforts due to its importance in separation, chemo/biosensors, catalysis and biomedicine. Despite the fact that MIPs have molecular recognition ability similar to that of biological receptors, traditional bulky MIP materials usually exhibit a low binding capacity and slow binding kinetics to the target species. Moreover, the MIP materials lack the signal-output response to analyte binding events when used as recognition elements in chemo/biosensors or bioassays. Recently, various explorations have demonstrated that molecular imprinting nanotechniques may provide a potential solution to these difficulties. Many successful examples of the development of MIP-based sensors have also been reported during the past several decades. This review will begin with a brief introduction to the principle of molecular imprinting nanotechnology, and then mainly summarize various synthesis methodologies and recognition properties of MIP nanomaterials and their applications in MIP-based chemosensors. Finally, the future perspectives and efforts in MIP nanomaterials and MIP-based sensors are given.
Keywords: Molecularly imprinted polymers; Nanostructures; Chemical detection; Sensors Molecularly imprinted polymers; Nanostructures; Chemical detection; Sensors
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Guan, G.; Liu, B.; Wang, Z.; Zhang, Z. Imprinting of Molecular Recognition Sites on Nanostructures and Its Applications in Chemosensors. Sensors 2008, 8, 8291-8320.

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