Next Article in Journal
Solid State Gas Sensor Research in Germany – a Status Report
Previous Article in Journal
RoPEUS: A New Robust Algorithm for Static Positioning in Ultrasonic Systems
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Sensors
Volume 9
Issue 6
10.3390/s90604309
sensors-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

Development of Membrane Selective Electrode for Determination of the Antipsychotic Sulpiride in Pharmaceuticals and Urine

by
Mª Soledad García
*,
Joaquín A. Ortuño
,
Mª Isabel Albero
and
Mustafa Salem Abuherba
Department of Analytical Chemistry, Faculty of Chemistry, University of Murcia, 30071-Murcia, Spain
*
Author to whom correspondence should be addressed.
Sensors 2009, 9(6), 4309-4322; https://doi.org/10.3390/s90604309
Submission received: 20 April 2009 / Revised: 27 May 2009 / Accepted: 1 June 2009 / Published: 3 June 2009
(This article belongs to the Section Chemical Sensors)
Browse Figures
Versions Notes

Abstract

The construction and electrochemical response characteristics of a poly(vinyl chloride) (PVC) membrane selective electrode for the determination of sulpiride (SPD) are described. The sensing membrane comprised an ion-exchanger formed between the protonated drug and tetraphenylborate (TPB-) in a plasticized PVC matrix. The influence of membrane composition on the electrode response was studied. The electrode showed a fast, stable and Nernstian response over a sulpiride concentration range (1 × 10-4– 1 × 10-2 M) with a mean slope of 58.4 ± 0.9 mV dec-1 of concentration, a mean detection limit of 4.2 × 10-5 ± 1.2 × 10-5 M, a wide working pH range (2 – 8) and a fast response time (< 15 s). The electrode showed good selectivity towards sulpiride with respect to some inorganic and organic compounds. When the electrode was applied to the determination of sulpiride in pharmaceuticals and human urine, a high percentage of recovery was attained with no need for sample pretreatment procedures because of the lack of interfering matrix effects.
Keywords: ion-selective electrode; sulpiride determination; pharmaceuticals; urine ion-selective electrode; sulpiride determination; pharmaceuticals; urine

Share and Cite

MDPI and ACS Style

García, M.S.; Ortuño, J.A.; Albero, M.I.; Abuherba, M.S. Development of Membrane Selective Electrode for Determination of the Antipsychotic Sulpiride in Pharmaceuticals and Urine. Sensors 2009, 9, 4309-4322. https://doi.org/10.3390/s90604309

AMA Style

García MS, Ortuño JA, Albero MI, Abuherba MS. Development of Membrane Selective Electrode for Determination of the Antipsychotic Sulpiride in Pharmaceuticals and Urine. Sensors. 2009; 9(6):4309-4322. https://doi.org/10.3390/s90604309

Chicago/Turabian Style

García, Mª Soledad, Joaquín A. Ortuño, Mª Isabel Albero, and Mustafa Salem Abuherba. 2009. "Development of Membrane Selective Electrode for Determination of the Antipsychotic Sulpiride in Pharmaceuticals and Urine" Sensors 9, no. 6: 4309-4322. https://doi.org/10.3390/s90604309

APA Style

García, M. S., Ortuño, J. A., Albero, M. I., & Abuherba, M. S. (2009). Development of Membrane Selective Electrode for Determination of the Antipsychotic Sulpiride in Pharmaceuticals and Urine. Sensors, 9(6), 4309-4322. https://doi.org/10.3390/s90604309

Article Metrics

Back to TopTop